{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:09:56Z","timestamp":1789542596023,"version":"build-2803163510"},"reference-count":110,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,26]],"date-time":"2023-02-26T00:00:00Z","timestamp":1677369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["81870686"],"award-info":[{"award-number":["81870686"]}]},{"name":"National Natural Science Foundation of China","award":["2018-1-2021"],"award-info":[{"award-number":["2018-1-2021"]}]},{"name":"Capital Health Development Scientific Research Special Project","award":["81870686"],"award-info":[{"award-number":["81870686"]}]},{"name":"Capital Health Development Scientific Research Special Project","award":["2018-1-2021"],"award-info":[{"award-number":["2018-1-2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Optic nerve damage is a common cause of blindness. Optic nerve injury is often accompanied by fundus vascular disease, retinal ganglion cell apoptosis, and changes in retinal thickness. These changes can cause alterations in protein expression within neurons in the retina. Proteomics analysis offers conclusive evidence to decode a biological system. Furthermore, animal models of optic nerve injury made it possible to gain insight into pathological mechanisms, therapeutic targets, and effective treatment of such injuries. Proteomics takes the proteome as the research object and studies protein changes in cells and tissues. At present, a variety of proteomic analysis methods have been widely used in the research of optic nerve injury diseases. This review summarizes the application of proteomic research in optic nerve injury diseases and animal models of optic nerve injury. Additionally, differentially expressed proteins are summarized and analyzed. Various optic nerve injuries, including those associated with different etiologies, are discussed along with their potential therapeutic targets and future directions.<\/jats:p>","DOI":"10.3390\/brainsci13030404","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T02:22:16Z","timestamp":1677464536000},"page":"404","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Application of Proteomics Analysis and Animal Models in Optic Nerve Injury Diseases"],"prefix":"10.3390","volume":"13","author":[{"given":"Zhaoyang","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"You","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0309-1230","authenticated-orcid":false,"given":"Arif","family":"Mahmood","sequence":"additional","affiliation":[{"name":"Center for Medical Genetics and Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fancheng","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/cne.20571","article-title":"Proliferation, migration, neuronal differentiation, and long-term survival of new cells in the adult zebrafish brain","volume":"488","author":"Zupanc","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1523\/JNEUROSCI.12-04-01144.1992","article-title":"Synapse formation and preferential distribution in the granule cell layer by regenerating retinal ganglion cell axons guided to the cerebellum of adult hamsters","volume":"12","author":"Zwimpfer","year":"1992","journal-title":"J. Neurosci."},{"key":"ref_3","first-page":"70","article-title":"Maturation and plasticity of visual system: Neurogenesis, synaptogenesis, and myelogenesis. Report 2. Visual cortex and optic radiations","volume":"128","author":"Zueva","year":"2012","journal-title":"Vestn. Oftalmol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1167\/iovs.12-10089","article-title":"Measuring Retinal Nerve Fiber Layer Birefringence, Retardation, and Thickness Using Wide-Field, High-Speed Polarization Sensitive Spectral Domain OCT","volume":"54","author":"Zotter","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"11779","DOI":"10.1038\/s41598-017-12225-6","article-title":"A Novel Mouse Model of Traumatic Optic Neuropathy Using External Ultrasound Energy to Achieve Focal, Indirect Optic Nerve Injury","volume":"7","author":"Tao","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_6","unstructured":"Popovic, M.B. (2019). Biomechatronics, Elsevier."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"BSR20193256","DOI":"10.1042\/BSR20193256","article-title":"p38 promoted retinal micro-angiogenesis through up-regulated RUNX1 expression in diabetic retinopathy","volume":"40","author":"Zou","year":"2020","journal-title":"Biosci. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.18240\/ijo.2021.11.01","article-title":"Effect of anti-VEGF treatment on nonperfusion areas in ischemic retinopathy","volume":"14","author":"Zhu","year":"2021","journal-title":"Int. J. Ophthalmol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1002\/pmic.201500188","article-title":"Defining the proteome of human iris, ciliary body, retinal pigment epithelium, and choroid","volume":"16","author":"Zhang","year":"2016","journal-title":"Proteomics"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Youngblood, H., Robinson, R., Sharma, A., and Sharma, S. (2019). Proteomic Biomarkers of Retinal Inflammation in Diabetic Retinopathy. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20194755"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1167\/iovs.17-23678","article-title":"Proteomic Analysis of Early Diabetic Retinopathy Reveals Mediators of Neurodegenerative Brain Diseases","volume":"59","author":"Sundstrom","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5131","DOI":"10.1021\/acs.jproteome.5b00900","article-title":"Quantitative Proteomics Analysis of Vitreous Humor from Diabetic Retinopathy Patients","volume":"14","author":"Loukovaara","year":"2015","journal-title":"J. Proteome Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1167\/iovs.15-17841","article-title":"Apoptotic Retinal Ganglion Cell Death After Optic Nerve Transection or Crush in Mice: Delayed RGC Loss With BDNF or a Caspase 3 Inhibitor","volume":"57","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1167\/iovs.04-0535","article-title":"Gene and Protein Expression Changes in Human Trabecular Meshwork Cells Treated with Transforming Growth Factor-\u03b2","volume":"45","author":"Zhao","year":"2004","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s12974-022-02621-9","article-title":"Single-cell RNA sequencing reveals a landscape and targeted treatment of ferroptosis in retinal ischemia\/reperfusion injury","volume":"19","author":"Li","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1750-1326-8-21","article-title":"Progressive morphological changes and impaired retinal function associated with temporal regulation of gene expression after retinal ischemia\/reperfusion injury in mice","volume":"8","author":"Kim","year":"2013","journal-title":"Mol. Neurodegener."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3389\/fncel.2017.00254","article-title":"Optic Nerve Degeneration after Retinal Ischemia\/Reperfusion in a Rodent Model","volume":"11","author":"Renner","year":"2017","journal-title":"Front. Cell Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0165-0270(96)00098-2","article-title":"Complete transection of rat optic nerve while sparing the meninges and the vasculature: An experimental model for optic nerve neuropathy and trauma","volume":"70","author":"Solomon","year":"1996","journal-title":"J. Neurosci. Methods"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.exer.2012.03.013","article-title":"A mouse model of ocular blast injury that induces closed globe anterior and posterior pole damage","volume":"99","author":"Marchetta","year":"2012","journal-title":"Exp. Eye Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"8367","DOI":"10.1523\/JNEUROSCI.19-19-08367.1999","article-title":"Optic Nerve Crush: Axonal Responses in Wild-Type and bcl-2 Transgenic Mice","volume":"19","author":"Chierzi","year":"1999","journal-title":"J. Neurosci."},{"key":"ref_21","unstructured":"(2023, April 04). World Health Statistics 2022. Available online: https:\/\/www.who.int\/data\/gho\/publications\/world-health-statistics."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1080\/09286586.2019.1704794","article-title":"The Prevalence of Eye Injury in the United States, Estimates from a Meta-Analysis","volume":"27","author":"Swain","year":"2019","journal-title":"Ophthalmic Epidemiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1016\/S0161-6420(99)90361-5","article-title":"Epidemiology of ocular trauma in Australia","volume":"106","author":"McCarty","year":"1999","journal-title":"Ophthalmology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e61","DOI":"10.1111\/j.1755-3768.2011.02230.x","article-title":"Prevalence and incidence of ocular trauma in North China: The Beijing Eye Study","volume":"90","author":"Wang","year":"2011","journal-title":"Acta Ophthalmol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1136\/bjophthalmol-2017-310564","article-title":"Prevalence, subtypes, severity and determinants of ocular trauma: The Singapore Chinese Eye Study","volume":"102","author":"Wong","year":"2017","journal-title":"Br. J. Ophthalmol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/cge.14019","article-title":"Recalling the pathology of Parkinson\u2019s disease; lacking exact figure of prevalence and genetic evidence in Asia with an alarming outcome: A time to step-up","volume":"100","author":"Mahmood","year":"2021","journal-title":"Clin. Genet."},{"key":"ref_27","unstructured":"Salazar, J.J., Ram\u00edrez, A.I., De Hoz, R., Salobrar-Garcia, E., Rojas, P., Fern\u00e1ndez-Albarral, J.A., L\u00f3pez-Cuenca, I., Rojas, B., Trivi\u00f1o, A., and Ram\u00edrez, J.M. (2023, February 03). Anatomy of the Human Optic Nerve: Structure and Function. Optic Nerve [Internet]. Available online: https:\/\/www.intechopen.com\/chapters\/62850."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"661938","DOI":"10.3389\/fneur.2021.661938","article-title":"Retinal Ganglion Cells\u2014Diversity of Cell Types and Clinical Relevance","volume":"12","author":"Kim","year":"2021","journal-title":"Front. Neurol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1515\/revneuro-2013-0003","article-title":"Optic Neuropathies: Characteristic Features and Mechanisms of Retinal Ganglion Cell Loss","volume":"24","author":"You","year":"2013","journal-title":"Rev. Neurosci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"116","DOI":"10.21926\/obm.neurobiol.2201116","article-title":"Neuropathology and Therapeutics Addressing Glaucoma, a Prevalent Retina-Optic Nerve-Brain Disease that Causes Eyesight Impairment and Blindness","volume":"6","author":"Sharif","year":"2022","journal-title":"OBM Neurobiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"643685","DOI":"10.3389\/fnagi.2021.643685","article-title":"Transneuronal Degeneration in the Brain During Glaucoma","volume":"13","author":"You","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"100953","DOI":"10.1016\/j.preteyeres.2021.100953","article-title":"Adaptive responses to neurodegenerative stress in glaucoma","volume":"84","author":"Calkins","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.preteyeres.2011.11.002","article-title":"The molecular basis of retinal ganglion cell death in glaucoma","volume":"31","author":"Almasieh","year":"2012","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1056\/NEJM199412013312203","article-title":"Vascular endothelial growth factor in ocular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders","volume":"331","author":"Aiello","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e888","DOI":"10.1016\/S2214-109X(17)30293-0","article-title":"Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: A systematic review and meta-analysis","volume":"5","author":"Bourne","year":"2017","journal-title":"Lancet Glob. Health"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Zwierko, T., Jedziniak, W., Florkiewicz, B., Lesiakowski, P., \u015aliwiak, M., Kirkiewicz, M., and Lubi\u0144ski, W. (2022). Physical Activity Is Associated with Improved Visuomotor Processing in Older Adults with Moderate and Advanced Glaucomatous Visual Field Defect: A Cross-Sectional Study. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19031760"},{"key":"ref_37","first-page":"e11686","article-title":"Epidemiology of Glaucoma: The Past, Present, and Predictions for the Future","volume":"12","author":"Allison","year":"2020","journal-title":"Cureus"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1136\/bjo.86.2.238","article-title":"The definition and classification of glaucoma in prevalence surveys","volume":"86","author":"Foster","year":"2002","journal-title":"Br. J. Ophthalmol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.exer.2009.02.005","article-title":"Immunoregulation of retinal ganglion cell fate in glaucoma","volume":"88","author":"Wax","year":"2009","journal-title":"Exp. Eye Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"16067","DOI":"10.1038\/nrdp.2016.67","article-title":"Primary Open-Angle Glaucoma","volume":"2","author":"Weinreb","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_41","first-page":"102","article-title":"Anterior Segment Optic Coherence Tomography Changes Before and After Phacoemulsification in Primary Open-Angle Glaucoma","volume":"4","author":"Zirtiloglu","year":"2019","journal-title":"Beyoglu Eye J."},{"key":"ref_42","first-page":"254","article-title":"Spectral domain optical coherence tomography in glaucoma: Qualitative and quantitative analysis of the optic nerve head and retinal nerve fiber layer (an AOS thesis)","volume":"107","author":"Chen","year":"2009","journal-title":"Am. J. Ophthalmol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"5195","DOI":"10.1167\/iovs.17-22812","article-title":"Intraday Repeatability of Bruch\u2019s Membrane Opening-Based Neuroretinal Rim Measurements","volume":"58","author":"Enders","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.ophtha.2009.08.039","article-title":"Reproducibility of Retinal Nerve Fiber Layer and Macular Thickness Measurement with the RTVue-100 Optical Coherence Tomograph","volume":"117","author":"Garas","year":"2010","journal-title":"Ophthalmology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1097\/IJG.0000000000000787","article-title":"Reproducibility of Bruch\u2019s Membrane Opening-Minimum Rim Width Measurements with Spectral Domain Optical Coherence Tomography","volume":"6","author":"Park","year":"2017","journal-title":"J. Glaucoma"},{"key":"ref_46","first-page":"47","article-title":"Retinopatia cukrzycowa [Diabetic retinopathy]","volume":"23","author":"Bryk","year":"1981","journal-title":"Folia Med. Cracov."},{"key":"ref_47","first-page":"15","article-title":"Pokazateli lipidnogo obmena i ikh sviaz\u2019 s narusheniiami mikrotsirkuliatsii pri sakharnom diabete [Indicators of lipid metabolism and their relation to disorders of microcirculation in diabetes mellitus]","volume":"33","author":"Zhulkevich","year":"1987","journal-title":"Probl. Endokrinol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1007\/s00417-021-05298-7","article-title":"Prevalence, severity stages, and risk factors of diabetic retinopathy in 1464 adult patients with type 1 diabetes","volume":"259","author":"Zureik","year":"2021","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ophtha.2017.08.031","article-title":"OCT Biomarkers as Functional Outcome Predictors in Diabetic Macular Edema Treated with Dexamethasone Implant","volume":"125","author":"Zur","year":"2018","journal-title":"Ophthalmology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"531","DOI":"10.4103\/0974-9233.167809","article-title":"Imaging in Diabetic Retinopathy","volume":"22","year":"2015","journal-title":"Middle East Afr. J. Ophthalmol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1056\/NEJMra1909637","article-title":"Evaluation and Care of Patients with Diabetic Retinopathy","volume":"382","author":"Jampol","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e000130","DOI":"10.1136\/bmjophth-2017-000130","article-title":"The Efficacy of Sodium-Glucose Cotransporter 2 (SGLT2) inhibitors for the treatment of chronic diabetic macular oedema in vitrectomised eyes: A retrospective study","volume":"3","author":"Mieno","year":"2018","journal-title":"BMJ Open Ophthalmol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0022-2143(99)90116-6","article-title":"Growth factors VEGF and TGF-\u03b21 in peritoneal dialysis","volume":"134","author":"Zweers","year":"1999","journal-title":"J. Lab. Clin. Med."},{"key":"ref_54","first-page":"592","article-title":"Ischemic model of optic nerve injury","volume":"103","author":"Cioffi","year":"2005","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"346","DOI":"10.3389\/fneur.2020.00346","article-title":"The Biomechanics of Indirect Traumatic Optic Neuropathy Using a Computational Head Model With a Biofidelic Orbit","volume":"11","author":"Li","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.sjbs.2019.12.043","article-title":"Early diagnostic value of optical coherence tomography in the clinical prediction model for optic nerve injury in saddle space occupying patients","volume":"27","author":"Liu","year":"2020","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/01658107.2021.1887289","article-title":"Should \u201cRetro-ocular Pain, Photophobia and Visual Acuity Loss\u201d Be Recognised as a Distinct Entity? The ROPPVAL Syndrome","volume":"45","author":"Pellegrini","year":"2021","journal-title":"Neuro Ophthalmol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Zweifel, S.A., Foa, N., Wiest, M.R.J., Carnevali, A., Zaluska-Ogryzek, K., Rejdak, R., and Toro, M.D. (2021). Differences between Mycobacterium chimaera and tuberculosis Using Ocular Multimodal Imaging: A Systematic Review. J. Clin. Med., 10.","DOI":"10.3390\/jcm10214880"},{"key":"ref_59","first-page":"58","article-title":"Fundus analysis of autofluorescence of stale fundus haemorrhage in indocyanine green angiography","volume":"24","author":"Zuo","year":"2008","journal-title":"Yan Ke Xue Bao."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/j.ajem.2018.05.031","article-title":"Can emergency physicians accurately distinguish retinal detachment from posterior vitreous detachment with point-of-care ocular ultrasound?","volume":"36","year":"2018","journal-title":"Am. J. Emerg. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1001\/archopht.1968.03850040281009","article-title":"Corticosteroids in the Treatment of Optic Nerve Involvement: Associated With Thyroid Dysfunction","volume":"79","author":"Day","year":"1968","journal-title":"Arch. Ophthalmol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1056\/NEJM199202273260901","article-title":"A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis","volume":"326","author":"Beck","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"380","DOI":"10.4103\/ijo.IJO_1158_21","article-title":"Neuroprotection in glaucoma","volume":"70","author":"Vishwaraj","year":"2022","journal-title":"Indian J Ophthalmol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"941","DOI":"10.3109\/02713683.2012.691599","article-title":"A New and Reliable Animal Model for Optic Nerve Injury","volume":"37","author":"Yan","year":"2012","journal-title":"Curr. Eye Res."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Wang, X., Li, Y., He, Y., Liang, H.-S., and Liu, E.-Z. (2012). A Novel Animal Model of Partial Optic Nerve Transection Established Using an Optic Nerve Quantitative Amputator. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0044360"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"692609","DOI":"10.1155\/2012\/692609","article-title":"Animal Models of Glaucoma","volume":"2012","author":"Bouhenni","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"key":"ref_67","first-page":"2969","article-title":"Effect of intraocular pressure on optic disc topography, electroretinography, and axonal loss in a chronic pressure-induced rat model of optic nerve damage","volume":"43","author":"Chauhan","year":"2002","journal-title":"Investig. Ophthalmol. Vis Sci."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Liu, H., Perumal, N., Manicam, C., Mercieca, K., and Prokosch, V. (2020). Proteomics Reveals the Potential Protective Mechanism of Hydrogen Sulfide on Retinal Ganglion Cells in an Ischemia\/Reperfusion Injury Animal Model. Pharmaceuticals, 13.","DOI":"10.3390\/ph13090213"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"828","DOI":"10.3109\/02713683.2010.494240","article-title":"Distribution of Amyloid Precursor Protein and Amyloid-\u03b2 in Ocular Hypertensive C57BL\/6 Mouse Eyes","volume":"35","author":"McKinnon","year":"2010","journal-title":"Curr. Eye Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0014-4835(05)80131-9","article-title":"Chronic ocular hypertension following episcleral venous occlusion in rats","volume":"61","author":"Shareef","year":"1995","journal-title":"Exp. Eye Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1167\/iovs.09-3947","article-title":"The Microbead Occlusion Model: A Paradigm for Induced Ocular Hypertension in Rats and Mice","volume":"51","author":"Sappington","year":"2010","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0266-4356(91)90114-K","article-title":"The characteristics of midfacial fractures and the association with ocular injury: A prospective study","volume":"29","author":"Dutton","year":"1991","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_73","first-page":"2","article-title":"Indirect traumatic optic neuropathy","volume":"3","author":"Singman","year":"2016","journal-title":"Mil. Med. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1227\/00006123-198406000-00021","article-title":"Indirect Injury of the Optic Nerve","volume":"14","author":"Kline","year":"1984","journal-title":"Neurosurgery"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Yan, F., Guo, S., Chai, Y., Zhang, L., Liu, K., Lu, Q., Wang, N., and Li, S. (2017). Partial Optic Nerve Transection in Rats: A Model Established with a New Operative Approach to Assess Secondary Degeneration of Retinal Ganglion Cells. J. Vis. Exp., e56272.","DOI":"10.3791\/56272"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1167\/iovs.04-0832","article-title":"Retinal Ganglion Cell Apoptosis in Glaucoma Is Related to Intraocular Pressure and IOP-Induced Effects on Extracellular Matrix","volume":"46","author":"Guo","year":"2005","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Yap, T.E., Donna, P., Almonte, M.T., and Cordeiro, M.F. (2018). Real-Time Imaging of Retinal Ganglion Cell Apoptosis. Cells, 7.","DOI":"10.3390\/cells7060060"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1242\/jcs.01658","article-title":"Re-establishing the regenerativepotential of central nervous system axons in postnatal mice","volume":"118","author":"Cho","year":"2005","journal-title":"J. Cell Sci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1097\/SCS.0000000000006443","article-title":"Analysis of prognostic factors for theindirect traumatic optic neuropathy underwent endoscopictransnasal optic canal decompression","volume":"31","author":"Lin","year":"2020","journal-title":"J. Craniofac. Surg"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S0140-6736(80)92289-8","article-title":"PROSTACYCLIN IN CENTRAL RETINAL VEIN OCCLUSION","volume":"316","author":"Niton","year":"1980","journal-title":"Lancet"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"222","DOI":"10.5214\/ans.0972.7531.220406","article-title":"Modeling transient retinal ischemia in mouse by ligation of pterygopalatine artery","volume":"22","author":"Minhas","year":"2015","journal-title":"Ann. Neurosci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12014-021-09328-8","article-title":"A validated analysis pipeline for mass spectrometry-based vitreous proteomics: New insights into proliferative diabetic retinopathy","volume":"18","author":"Weber","year":"2021","journal-title":"Clin. Proteom."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nm1534","article-title":"Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation","volume":"13","author":"Gao","year":"2007","journal-title":"Nat. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12014-018-9187-z","article-title":"Change of ranibizumab-induced human vitreous protein profile in patients with proliferative diabetic retinopathy based on proteomics analysis","volume":"15","author":"Zou","year":"2018","journal-title":"Clin. Proteom."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.exer.2012.11.023","article-title":"Differentiating vitreous proteomes in proliferative diabetic retinopathy using high-performance liquid chromatography coupled to tandem mass spectrometry","volume":"108","author":"Wang","year":"2013","journal-title":"Exp. Eye Res."},{"key":"ref_86","first-page":"812","article-title":"Effects of phlorizin on diabetic retinopathy according to isobaric tags for relative and absolute quantification-based proteomics in db\/db mice","volume":"19","author":"Zhang","year":"2013","journal-title":"Mol. Vis."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"e631","DOI":"10.1002\/ctm2.631","article-title":"Proteomic profiles of the retina in an experimental unilateral optic nerve transection: Roles of M\u00fcller cell activation","volume":"12","author":"Yan","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3973","DOI":"10.1167\/iovs.11-8350","article-title":"Quantitative Retinal Protein Analysis after Optic Nerve Transection Reveals a Neuroprotective Role for Hepatoma-Derived Growth Factor on Injured Retinal Ganglion Cells","volume":"53","author":"Hollander","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Kwong, J., Caprioli, J., Sze, Y., Yu, F., Li, K., To, C., and Lam, T. (2021). Differential Retinal Protein Expression in Primary and Secondary Retinal Ganglion Cell Degeneration Identified by Integrated SWATH and Target-Based Proteomics. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22168592"},{"key":"ref_90","first-page":"2734","article-title":"Quantitative profiling of regional protein expression in rat retina after partial optic nerve transection using fluorescence difference two-dimensional gel electrophoresis","volume":"20","author":"Lam","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Tian, H., Wang, L., Cai, R., Zheng, L., and Guo, L. (2014). Identification of Protein Network Alterations upon Retinal Ischemia-Reperfusion Injury by Quantitative Proteomics Using a Rattus norvegicus Model. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0116453"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"104427","DOI":"10.1016\/j.jprot.2021.104427","article-title":"Proteomics analysis of N-methyl-d-aspartate-induced cell death in retinal and optic nerves","volume":"252","author":"Suo","year":"2021","journal-title":"J. Proteom."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e2100016","DOI":"10.1002\/prca.202100016","article-title":"Integrating SWATH-MS proteomics and transcriptome analysis to preliminarily identify three DEGs as biomarkers for proliferative diabetic retinopathy","volume":"16","author":"Wu","year":"2021","journal-title":"Proteom. \u2013Clin. Appl."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Winiarczyk, D., Winiarczyk, M., Winiarczyk, S., Michalak, K., and Adaszek, \u0141. (2020). Proteomic Analysis of Tear Film Obtained from Diabetic Dogs. Animals, 10.","DOI":"10.3390\/ani10122416"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3892\/br.2017.988","article-title":"Proteomic profile of the lens in a streptozotocin-induced diabetic rat model using shotgun proteomics","volume":"7","author":"Nagai","year":"2017","journal-title":"Biomed. Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1021\/pr500040a","article-title":"Comparative Proteomic Analysis of Histone Post-translational Modifications upon Ischemia\/Reperfusion-Induced Retinal Injury","volume":"13","author":"Zhao","year":"2014","journal-title":"J. Proteome Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"873","DOI":"10.3389\/fphar.2020.00873","article-title":"Exploration of Oxygen-Induced Retinopathy Model to Discover New Therapeutic Drug Targets in Retinopathies","volume":"11","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_98","first-page":"2156273","article-title":"Diabetic macular edema pathophysiology: Vasogenic versus inflammatory","volume":"2016","author":"Verges","year":"2016","journal-title":"J. Diabetes Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1016\/0042-6989(94)90024-8","article-title":"Immunohistochemical study of human retinal astroglia","volume":"34","author":"Ramirez","year":"1994","journal-title":"Vis. Res."},{"key":"ref_100","first-page":"574","article-title":"Vascular endothelial growth factor\/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model","volume":"145","author":"Miller","year":"1994","journal-title":"Am. J. Pathol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1096\/fj.06-7227rev","article-title":"Resolution of in flammation: State of the art, definitions and terms","volume":"21","author":"Serhan","year":"2007","journal-title":"FASEB J."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/nature04482","article-title":"Retinal angiogenesis in development and disease","volume":"438","author":"Gariano","year":"2005","journal-title":"Nature"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1167\/tvst.11.6.17","article-title":"Sema3A Antibody BI-X Prevents Cell Permeability and Cytoskeletal Collapse in HRMECs and Increases Tip Cell Density in Mouse Oxygen-Induced Retinopathy","volume":"11","author":"Zippel","year":"2022","journal-title":"Trans. Vis. Sci. Technol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/aos.14079","article-title":"Aqueous semaphorin 3A level correlates with retinal macular oedema and ganglion cell degeneration in patients with retinal vein occlusion","volume":"97","author":"Guo","year":"2019","journal-title":"Acta Ophthalmol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"362ra144","DOI":"10.1126\/scitranslmed.aaf9440","article-title":"Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy","volume":"8","author":"Oubaha","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/sj.cdd.4400872","article-title":"Increased expression and activation of poly(ADP-ribose) polymerase (PARP) contribute to retinal ganglion cell death following rat optic nerve transection","volume":"8","author":"Weise","year":"2001","journal-title":"Cell Death Differ."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"62","DOI":"10.17116\/oftalma201913502162","article-title":"Complex assessment of retinal ischemic damage in patients with retinal vein occlusion","volume":"135","author":"Zlobin","year":"2019","journal-title":"Vestnik Oftal\u2019mologii"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/sj.eye.6701576","article-title":"Animal models of optic nerve diseases","volume":"18","year":"2004","journal-title":"Eye"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1007\/s12031-022-01997-w","article-title":"Histological and Top-Down Proteomic Analyses of the Visual Pathway in the Cuprizone Demyelination Model","volume":"72","author":"Almuslehi","year":"2022","journal-title":"J. Mol. Neurosci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/02648725.1996.10647923","article-title":"Progress with proteome projects: Why all proteins expressed by a genome should be identified and how to do it","volume":"13","author":"Wilkins","year":"1996","journal-title":"Biotechnol. Genet. Eng. Rev."}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/13\/3\/404\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:42:56Z","timestamp":1760121776000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/13\/3\/404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,26]]},"references-count":110,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["brainsci13030404"],"URL":"https:\/\/doi.org\/10.3390\/brainsci13030404","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,26]]}}}