{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:45:50Z","timestamp":1789436750692,"version":"build-2803163510"},"reference-count":40,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T00:00:00Z","timestamp":1677888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>A growing body of literature shows there are sex differences in the patterns of brain activity during long-term memory. However, there is a paucity of evidence on sex differences in functional brain connectivity. We previously identified sex differences in the patterns of connections with the hippocampus, a medial temporal lobe (MTL) subregion, during spatial long-term memory. The perirhinal\/entorhinal cortex, another MTL subregion, plays a critical role in item memory. In the current functional magnetic resonance imaging (fMRI) study, we investigated perirhinal\/entorhinal functional connectivity and the role of sex during item memory. During the study phase, abstract shapes were presented to the left or right of fixation. During the test phase, abstract shapes were presented at fixation, and the participants classified each item as previously \u201cold\u201d or \u201cnew\u201d. An entorhinal region of interest (ROI) was identified by contrasting item memory hits and misses. This ROI was connected to regions generally associated with visual memory, including the right inferior frontal gyrus (IFG) and visual-processing regions (the bilateral V1, bilateral cuneus, and left lingual gyrus). Males produced greater connectivity than females with the right IFG\/insula and the right V1\/bilateral cuneus. Broadly, these results contribute to a growing body of literature supporting sex differences in the brain.<\/jats:p>","DOI":"10.3390\/brainsci13030446","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T03:22:05Z","timestamp":1678072925000},"page":"446","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Entorhinal Cortex Functional Connectivity during Item Long-Term Memory and the Role of Sex"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8730-3917","authenticated-orcid":false,"given":"Dylan S.","family":"Spets","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2948-6174","authenticated-orcid":false,"given":"Scott D.","family":"Slotnick","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neuroscience, Boston College, Chestnut Hill, MA 02467, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.neuro.30.051606.094328","article-title":"The medial temporal lobe and recognition memory","volume":"30","author":"Eichenbaum","year":"2007","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.tics.2007.08.001","article-title":"Imaging recollection and familiarity in the medial temporal lobe: A three-component model","volume":"11","author":"Diana","year":"2007","journal-title":"Trends Cogn. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/cercor\/11.6.490","article-title":"Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging","volume":"11","author":"Goldstein","year":"2001","journal-title":"Cereb. Cortex"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1002\/hipo.23319","article-title":"Sex differences in hippocampal connectivity during spatial long-term memory","volume":"31","author":"Spets","year":"2021","journal-title":"Hippocampus"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.neuroimage.2019.06.027","article-title":"Different patterns of cortical activity in females and males during spatial long-term memory","volume":"199","author":"Spets","year":"2019","journal-title":"Neuroimage"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/17588928.2020.1806810","article-title":"Are there sex differences in brain activity during long-term memory? A systematic review and fMRI activation likelihood estimation meta-analysis","volume":"12","author":"Spets","year":"2021","journal-title":"Cogn. Neurosci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"103581","DOI":"10.1016\/j.bandc.2019.103581","article-title":"Similar patterns of cortical activity in females and males during item memory","volume":"135","author":"Spets","year":"2019","journal-title":"Brain Cogn."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1073\/pnas.1316909110","article-title":"Sex differences in the structural connectome of the human brain","volume":"111","author":"Ingalhalikar","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1093\/cercor\/bhy109","article-title":"Sex Differences in the Adult Human Brain: Evidence from 5216 UK Biobank Participants","volume":"28","author":"Ritchie","year":"2018","journal-title":"Cereb. Cortex"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.neuroimage.2010.02.046","article-title":"Intrinsic connectivity between the hippocampus and posteromedial cortex predicts memory performance in cognitively intact older individuals","volume":"51","author":"Wang","year":"2010","journal-title":"Neuroimage"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.nicl.2014.02.010","article-title":"Deficits in episodic memory retrieval reveal impaired default mode network connectivity in amnestic mild cognitive impairment","volume":"4","author":"Dunn","year":"2014","journal-title":"Neuroimage Clin."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4920","DOI":"10.1523\/JNEUROSCI.4281-13.2014","article-title":"Aberrant functional connectivity in dissociable hippocampal networks is associated with deficits in memory","volume":"34","author":"Voets","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.arr.2013.01.006","article-title":"Perturbations of neural circuitry in aging, mild cognitive impairment, and Alzheimer\u2019s disease","volume":"12","author":"Leal","year":"2013","journal-title":"Ageing Res. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0197-4580(97)00056-0","article-title":"Frequency of stages of Alzheimer-related lesions in different age categories","volume":"18","author":"Braak","year":"1997","journal-title":"Neurobiol. Aging"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1212\/WNL.58.12.1791","article-title":"Phases of A beta-deposition in the human brain and its relevance for the development of AD","volume":"58","author":"Thal","year":"2002","journal-title":"Neurology"},{"key":"ref_17","first-page":"225","article-title":"Female Sex and Alzheimer\u2019s Risk: The Menopause Connection","volume":"5","author":"Scheyer","year":"2018","journal-title":"J. Prev. Alzheimers Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"105957","DOI":"10.1016\/j.bandc.2023.105957","article-title":"Impaired cognitive performance in older adults is associated with deficits in item memory and memory for object features","volume":"166","author":"Fritch","year":"2023","journal-title":"Brain Cogn."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.brainres.2014.01.029","article-title":"Source recognition by stimulus content in the MTL","volume":"1553","author":"Park","year":"2014","journal-title":"Brain Res."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Park, H., Leal, F., Spann, C., and Abellanoza, C. (2013). The effect of object processing in content-dependent source memory. BMC Neurosci., 14.","DOI":"10.1186\/1471-2202-14-71"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1162\/jocn.2008.20104","article-title":"Selective and shared contributions of the hippocampus and perirhinal cortex to episodic item and associative encoding","volume":"20","author":"Staresina","year":"2008","journal-title":"J. Cogn. Neurosci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1073\/pnas.0337195100","article-title":"Multiple routes to memory: Distinct medial temporal lobe processes build item and source memories","volume":"100","author":"Davachi","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/nn1252","article-title":"A sensory signature that distinguishes true from false memories","volume":"7","author":"Slotnick","year":"2004","journal-title":"Nat. Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1016\/j.neuropsychologia.2006.06.021","article-title":"The nature of memory related activity in early visual areas","volume":"44","author":"Slotnick","year":"2006","journal-title":"Neuropsychologia"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Macmillian, N.A., and Creelman, C.D. (2004). Detection Theory: A User\u2019s Guide, Cambridge University Press.","DOI":"10.4324\/9781410611147"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1016\/j.neuroimage.2011.10.018","article-title":"Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion","volume":"59","author":"Power","year":"2012","journal-title":"Neuroimage"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Spets, D.S., and Slotnick, S.D. (2020). Thalamic Functional Connectivity during Spatial Long-Term Memory and the Role of Sex. Brain Sci., 10.","DOI":"10.3390\/brainsci10120898"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.neuroimage.2012.03.068","article-title":"A generalized form of context-dependent psychophysiological interactions (gPPI): A comparison to standard approaches","volume":"61","author":"McLaren","year":"2012","journal-title":"Neuroimage"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1080\/17588928.2017.1319350","article-title":"Cluster success: FMRI inferences for spatial extent have acceptable false-positive rates","volume":"8","author":"Slotnick","year":"2017","journal-title":"Cogn. Neurosci."},{"key":"ref_30","unstructured":"Whitfield-Gabrieli, S. (2023, February 10). Available online: https:\/\/web.mit.edu\/swg\/software.htm."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"5065","DOI":"10.1523\/JNEUROSCI.3550-16.2017","article-title":"Age-Related Effects and Sex Differences in Gray Matter Density, Volume, Mass, and Cortical Thickness from Childhood to Young Adulthood","volume":"37","author":"Gennatas","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.neuroimage.2007.03.053","article-title":"Sexual dimorphism of brain developmental trajectories during childhood and adolescence","volume":"36","author":"Lenroot","year":"2007","journal-title":"Neuroimage"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.dcn.2013.02.003","article-title":"Sex differences and structural brain maturation from childhood to early adulthood","volume":"5","author":"Koolschijn","year":"2013","journal-title":"Dev. Cogn. Neurosci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1101\/lm.918309","article-title":"Sex influences on the neurobiology of learning and memory","volume":"16","author":"Andreano","year":"2009","journal-title":"Learn. Mem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nrn2113","article-title":"The cortical organization of speech processing","volume":"8","author":"Hickok","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0278-2626(03)00103-9","article-title":"Visuospatial processing and the right-hemisphere interpreter","volume":"53","author":"Corballis","year":"2003","journal-title":"Brain Cogn."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neures.2014.02.012","article-title":"Entorhinal cortex and consolidated memory","volume":"84","year":"2014","journal-title":"Neurosci. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/(SICI)1096-9861(19980216)391:3<293::AID-CNE2>3.0.CO;2-X","article-title":"Perirhinal and postrhinal cortices of the rat: Interconnectivity and connections with the entorhinal cortex","volume":"391","author":"Burwell","year":"1998","journal-title":"J. Comp. Neurol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41583-019-0213-6","article-title":"Perirhinal circuits for memory processing","volume":"20","author":"Miyashita","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1093\/cercor\/bhz287","article-title":"A Fast Visual Recognition Memory System in Humans Identified Using Intracerebral ERP","volume":"30","author":"Despouy","year":"2020","journal-title":"Cereb. Cortex"}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/13\/3\/446\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:48:07Z","timestamp":1760122087000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/13\/3\/446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,4]]},"references-count":40,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["brainsci13030446"],"URL":"https:\/\/doi.org\/10.3390\/brainsci13030446","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,4]]}}}