{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:13:50Z","timestamp":1790201630766,"version":"4.1.0"},"reference-count":45,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Bachground In this study, we hypothesize that mindfulness-based interventions (MBIs) may improve well-being and the related outcomes in Alzheimer\u2019s dementia patients (AD-P) at an early stage. MBIs consist of the practice of consciously observing the psychic contents in the present moment (thoughts, sensations, feelings, and other events). This attention allows one to become aware of the psychic contents and integrate them, thus favoring the quality of life and an increase in the mood of practitioners. Methods The randomized controlled study enrolled 22 AD-P at an early stage (age \u2265 60 years) treated with MBIs and 22 patients without treatment (six months of MBI training). Tests (T0\u2013T1 six months): Mini-Mental State Examination (MMPI); Spiritual Well-Being (SWB); Beck Depression Inventory (BDI); SF36. Test-Caregiver: Everyday Cognition scales (ECOG). Results AD-P with mindfulness: Improvement of ECOG (p = 0.026), quality of life (p &lt; 0.001), spiritual well-being (p &lt; 0.001); decrease in depression BDI (p &lt; 0.001). The MMSE remains unchanged. The control group of untreated patients showed a significant worsening in all these dimensions. Conclusions MBI training is effective in increasing quality of life and preventing worsening in patients with early-stage Alzheimer\u2019s dementia.<\/jats:p>","DOI":"10.3390\/brainsci13030484","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T06:52:13Z","timestamp":1678690333000},"page":"484","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effects of Mindfulness-Based Interventions (MBIs) in Patients with Early-Stage Alzheimer\u2019s Disease: A Pilot Study"],"prefix":"10.3390","volume":"13","author":[{"given":"M. V.","family":"Giulietti","sequence":"first","affiliation":[{"name":"Scientific and Technological Area, Department of Neurology, INRCA-IRCCS National Institute of Health and Science on Aging, 60124 Ancona, Italy"},{"name":"Department of Mental Health, ASP Basilicata, 85100 Potenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8714-9013","authenticated-orcid":false,"given":"R.","family":"Spatuzzi","sequence":"additional","affiliation":[{"name":"Department of Mental Health, ASP Basilicata, 85100 Potenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2130-3070","authenticated-orcid":false,"given":"P.","family":"Fabbietti","sequence":"additional","affiliation":[{"name":"Biostatistical Center, INRCA-IRCCS National Institute of Science and Health on Aging, 60124 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Vespa","sequence":"additional","affiliation":[{"name":"Scientific and Technological Area, Department of Neurology, INRCA-IRCCS National Institute of Health and Science on Aging, 60124 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2017). 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