{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T22:11:43Z","timestamp":1763244703635,"version":"build-2065373602"},"reference-count":42,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171182","ZC20121","KJ20048","TJYXZDXK-052B"],"award-info":[{"award-number":["82171182","ZC20121","KJ20048","TJYXZDXK-052B"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Project of Tianjin Municipal Health Committee","award":["82171182","ZC20121","KJ20048","TJYXZDXK-052B"],"award-info":[{"award-number":["82171182","ZC20121","KJ20048","TJYXZDXK-052B"]}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["82171182","ZC20121","KJ20048","TJYXZDXK-052B"],"award-info":[{"award-number":["82171182","ZC20121","KJ20048","TJYXZDXK-052B"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Mild cognitive impairment (MCI) in multiple-system atrophy (MSA) patients is common but remains poorly characterized, and the related factors are unclear. This retrospective study included 200 consecutive patients with a clinical diagnosis of possible or probable MSA, 102 MSA patients with MCI (MSA-MCI), and 98 MSA patients with normal cognition (MSA-NC). Cognitive profiles were compared between MSA-MCI and MSA-NC patients using the MoCA. In addition, demographic as well as major motor and nonmotor symptom differences were compared between MSA-MCI and MSA-NC patients. The median MMSE score was 26 points. Overall, MSA-MCI was observed in 51% of patients, with predominant impairment in visuospatial, executive, and attention functions compared with MSA-NC patients. MSA-MCI patients were older (p = 0.015) and had a later onset age (p = 0.024) and a higher frequency of hypertension, motor onset, and MSA with the predominant parkinsonism (MSA-P) phenotype than MSA-NC patients. The positive rate of orthostatic hypotension (OH) in MSA-MCI patients was significantly decreased and depression\/anxiety was significantly increased compared with MSA-NC patients (p = 0.004). Multivariate logistic analysis showed that motor onset was independently associated with MCI in MSA patients. MSA-MCI patients had impairment in visuospatial, executive, and attention functions. More prominent memory impairment was observed in MSA-P than in MSA-C patients. Motor onset was independently associated with MCI in MSA patients. MCI was commonly presented in MSA with more prominent memory impairment in MSA-P. Future follow-up studies are warranted to identify more factors that influence cognitive impairment in MSA.<\/jats:p>","DOI":"10.3390\/brainsci13040582","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T02:23:46Z","timestamp":1680143026000},"page":"582","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Characteristics of Mild Cognitive Impairment and Associated Factors in MSA Patients"],"prefix":"10.3390","volume":"13","author":[{"given":"Zhihong","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Neurology and Tianjin Key Laboratory of Cerebrovascular Disease and Neurodegenerative Disease, Tianjin Dementia Institute, Tianjin Huanhu Hospital, Tianjin University, Tianjin 300350, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Second Hospital of Tianjin Medical University, Tianjin 300211, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology and Tianjin Key Laboratory of Cerebrovascular Disease and Neurodegenerative Disease, Tianjin Dementia Institute, Tianjin Huanhu Hospital, Tianjin University, Tianjin 300350, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology and Tianjin Key Laboratory of Cerebrovascular Disease and Neurodegenerative Disease, Tianjin Dementia Institute, Tianjin Huanhu Hospital, Tianjin University, Tianjin 300350, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology and Tianjin Key Laboratory of Cerebrovascular Disease and Neurodegenerative Disease, Tianjin Dementia Institute, Tianjin Huanhu Hospital, Tianjin University, Tianjin 300350, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peifei","family":"Jia","sequence":"additional","affiliation":[{"name":"Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin 300070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Neurology and Tianjin Key Laboratory of Cerebrovascular Disease and Neurodegenerative Disease, Tianjin Dementia Institute, Tianjin Huanhu Hospital, Tianjin University, Tianjin 300350, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing 100070, China"},{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/mds.870120203","article-title":"Multiple System Atrophy: A Review of 203 Pathologically Proven Cases","volume":"12","author":"Wenning","year":"1997","journal-title":"Mov. 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