{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:18:09Z","timestamp":1791263889697,"version":"4.1.0"},"reference-count":118,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>The purpose of this study is to investigate the risk factors of intracranial complications in adult patients with Pott Puffy Tumor (PPT). A systematic review was conducted of clinical studies from January 1983 to December 2022 that reported on PPT adult patients. The full-text articles were reviewed for the patients\u2019 ages, sex, cultured organisms, surgical procedures, clinical sequalae, and underlying diseases that may affect the onset of intracranial complications in PPT adult patients. A total of 106 studies were included. Medical data were reviewed for 125 patients (94 males, 31 females). The median age was 45 years. A total of 52% had comorbidities, mostly head trauma (24.5%), sinus\/neurosurgical operations (22.4%), immunosuppression conditions (13.3%), diabetes mellitus (9.1%), cocaine use (7.1%), or dental infections (6.1%). A total of 28 cultures revealed Streptococcus (22.4%), 24 contained staphylococci (19.2%), and 22 cultures contained other pathogens (17.6%). An amount of 30.4% developed intracranial complications, with the most common being epidural abscesses or empyemas (55.3%), as well as subdural (15.7%) and extradural lesions (13.2%). Age, DM, and immunosuppression conditions are significantly associated with intracranial complications (p &lt; 0.001, p = 0.018 and p = 0.022, respectively). Streptococcus infection is associated with intracranial complications (p = 0.001), although Staphylococcus and other microorganisms are not. Surgical intervention, mainly ESS, and broad-spectrum antibiotics remain the cornerstones of treatment.<\/jats:p>","DOI":"10.3390\/brainsci13040587","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T02:08:01Z","timestamp":1680228481000},"page":"587","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["A Systematic Review of Intracranial Complications in Adults with Pott Puffy Tumor over Four Decades"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5748-091X","authenticated-orcid":false,"given":"Giorgos","family":"Sideris","sequence":"first","affiliation":[{"name":"2<sup>nd<\/sup> ENT Department, Attikon University Hospital, 124 62 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstathia","family":"Davoutis","sequence":"additional","affiliation":[{"name":"2<sup>nd<\/sup> ENT Department, Attikon University Hospital, 124 62 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6420-9415","authenticated-orcid":false,"given":"Evangelos","family":"Panagoulis","sequence":"additional","affiliation":[{"name":"2<sup>nd<\/sup> ENT Department, Attikon University Hospital, 124 62 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavlos","family":"Maragkoudakis","sequence":"additional","affiliation":[{"name":"2<sup>nd<\/sup> ENT Department, Attikon University Hospital, 124 62 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Nikolopoulos","sequence":"additional","affiliation":[{"name":"2<sup>nd<\/sup> ENT Department, Attikon University Hospital, 124 62 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Delides","sequence":"additional","affiliation":[{"name":"2<sup>nd<\/sup> ENT Department, Attikon University Hospital, 124 62 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3171\/jns.1992.76.2.0319","article-title":"Percivall Pott: An 18th century neurosurgeon","volume":"76","author":"Flamm","year":"1992","journal-title":"J. Neurosurg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.amjmed.2008.08.018","article-title":"Pott\u2019s puffy tumor","volume":"121","author":"Forgie","year":"2008","journal-title":"Am. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"rjz099","DOI":"10.1093\/jscr\/rjz099","article-title":"Potts puffy tumour: A rare but important diagnosis","volume":"2019","author":"Hasan","year":"2019","journal-title":"J. Surg. Case Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/lary.27757","article-title":"Pott\u2019s puffy tumor in children: A review of the literature","volume":"130","author":"Koltsidopoulos","year":"2020","journal-title":"Laryngoscope"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"284","DOI":"10.4274\/balkanmedj.2016.1304","article-title":"A Pott\u2019s Puffy Tumor Associated with Epidural-Cutaneous Fistula and Epidural Abscess: Case Report","volume":"34","year":"2017","journal-title":"Balkan Med. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1007\/s00405-011-1660-5","article-title":"The Pott\u2019s puffy tumor: A dangerous sign for intracranial complications","volume":"268","author":"Ketenci","year":"2011","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_7","first-page":"243","article-title":"An abscess on the forehead","volume":"75","year":"2007","journal-title":"Am. Fam. Physician"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.jemermed.2008.04.050","article-title":"Pott\u2019s puffy tumor and epidural abscess arising from pansinusitis","volume":"41","author":"Bannon","year":"2011","journal-title":"J. Emerg. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1093\/clinids\/23.6.1305","article-title":"Pott\u2019s puffy tumor due to Haemophilus influenzae: Case report and review","volume":"23","author":"Verbon","year":"1996","journal-title":"Clin. Infect. Dis."},{"key":"ref_10","first-page":"143","article-title":"The Pott puffy tumor revisited: Neurosurgical implications of this unforgotten entity. Case report and review of the literature","volume":"105","author":"Kombogiorgas","year":"2006","journal-title":"J. Neurosurg."},{"key":"ref_11","first-page":"115","article-title":"Frontal osteomyelitis (Pott\u2019s puffy tumour) associated with Pasteurella multocida\u2014A case report and review of the literature","volume":"9","author":"Skomro","year":"1998","journal-title":"Can. J. Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1017\/S0022215100131731","article-title":"Sinogenic intracranial complications","volume":"109","author":"Singh","year":"1995","journal-title":"J. Laryngol. Otol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1002\/lary.23490","article-title":"Evaluation of adult Pott\u2019s puffy tumor: Our five cases and 27 literature cases","volume":"122","author":"Akiyama","year":"2012","journal-title":"Laryngoscope"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1017\/S0022215100147759","article-title":"Intracranial complications of frontal sinusitis. A report of two cases","volume":"98","author":"Izquierdo","year":"1984","journal-title":"J. Laryngol. Otol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/archderm.1985.01660040132029","article-title":"Pott\u2019s puffy tumor. A clinical marker for osteomyelitis of the skull","volume":"121","author":"Koch","year":"1985","journal-title":"Arch Dermatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1288\/00005537-198909000-00002","article-title":"Endoscopic sinus surgery for mucoceles: A viable alternative","volume":"99","author":"Kennedy","year":"1989","journal-title":"Laryngoscope"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1017\/S0022215100113209","article-title":"Pott\u2019s puffy tumour reviewed","volume":"104","author":"Blackshaw","year":"1990","journal-title":"J. Laryngol. Otol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/00006565-199012000-00008","article-title":"Pott\u2019s puffy tumor: A complication of frontal sinusitis","volume":"6","author":"Pender","year":"1990","journal-title":"Pediatr. Emerg. Care"},{"key":"ref_19","first-page":"33","article-title":"Pott\u2019s puffy tumour and subdural empyema following frontal sinusitis","volume":"40","author":"Holder","year":"1991","journal-title":"West Indian Med. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1093\/clinids\/13.4.606","article-title":"Pott\u2019s puffy tumor: A complication of intranasal cocaine abuse","volume":"13","author":"Noskin","year":"1991","journal-title":"Rev. Infect. Dis."},{"key":"ref_21","first-page":"151","article-title":"Frontal bone osteomyelitis complicating frontal sinusitis caused by Haemophilus influenzae type a","volume":"29","author":"Milo","year":"1991","journal-title":"Rhinology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3171\/jns.1996.84.1.0110","article-title":"Pott\u2019s puffy tumor: The forgotten entity. Case report","volume":"84","author":"Babu","year":"1996","journal-title":"J. Neurosurg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1365-2133.1997.tb08777.x","article-title":"Pott\u2019s puffy tumour","volume":"136","author":"Bellaney","year":"1997","journal-title":"Br. J. Dermatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3810\/pgm.1999.04.713","article-title":"The puffy periorbital protrusion. Pott\u2019s puffy tumor","volume":"105","author":"Shah","year":"1999","journal-title":"Postgrad. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1001\/jama.283.10.1287","article-title":"Pott puffy tumor associated with intranasal methamphetamine","volume":"283","author":"Banooni","year":"2000","journal-title":"JAMA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1159\/000050395","article-title":"Intracranial complications of frontal sinusitis in children: Pott\u2019s puffy tumor revisited","volume":"35","author":"Bambakidis","year":"2001","journal-title":"Pediatr. Neurosurg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1159\/000056011","article-title":"A rare clinical entity: Pott\u2019s puffy tumor. A case report","volume":"34","author":"Talas","year":"2001","journal-title":"Pediatr. Neurosurg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1080\/02688690120082486","article-title":"Pott\u2019s puffy tumour: A delayed complication of surgery","volume":"15","author":"Karabatsou","year":"2001","journal-title":"Br. J. Neurosurg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1046\/j.1365-2273.2001.00499.x","article-title":"Intracranial complications of acute frontal sinusitis","volume":"26","author":"Lang","year":"2001","journal-title":"Clin. Otolaryngol. Allied Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1097\/00005537-200110000-00012","article-title":"Pott\u2019s puffy tumor and epidural abscess arising from dental sepsis: A case report","volume":"111","author":"Chandy","year":"2001","journal-title":"Laryngoscope"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/S0140-6736(02)08098-4","article-title":"Pott\u2019s puffy tumour","volume":"359","author":"Tattersall","year":"2002","journal-title":"Lancet"},{"key":"ref_32","first-page":"381","article-title":"Pott\u2019s puffy tumour","volume":"8","author":"Kung","year":"2002","journal-title":"Hong Kong Med. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1046\/j.1526-4610.2003.03173.x","article-title":"Headache caused by Pott\u2019s puffy tumor","volume":"43","author":"Chow","year":"2003","journal-title":"Headache"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S1473-3099(03)00805-3","article-title":"Pott\u2019s puffy tumour: A rare clinical entity","volume":"3","author":"Canbaz","year":"2003","journal-title":"Lancet Infect. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.otohns.2003.10.006","article-title":"Frontal sinus cutaneous fistula: A complication of Pott\u2019s puffy tumor","volume":"130","author":"Goldfarb","year":"2004","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/00005537-200402000-00002","article-title":"Use of the 70-degree diamond burr in the management of complicated frontal sinus disease","volume":"114","author":"Chandra","year":"2004","journal-title":"Laryngoscope"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/BF02974316","article-title":"Osteomyelitis of frontal bone","volume":"56","author":"Chaturvedil","year":"2004","journal-title":"Indian J. Otolaryngol. Head Neck Surg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e461","DOI":"10.1542\/peds.2004-2501","article-title":"Sinogenic intracranial empyema in children","volume":"116","author":"Adame","year":"2005","journal-title":"Pediatrics"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S1130-1473(05)70435-8","article-title":"Pott\u2019s puffy tumor of the vertex years after trauma in a diabetic patient: Case report","volume":"16","author":"Bademci","year":"2005","journal-title":"Neurocirugia"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1439-0507.2005.01078.x","article-title":"Primary frontal sinus aspergillosis: An uncommon occurrence","volume":"48","author":"Panda","year":"2005","journal-title":"Mycoses"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1258\/0022215054516304","article-title":"Pott\u2019s puffy tumour caused by mucormycosis","volume":"119","author":"Effat","year":"2005","journal-title":"J. Laryngol. Otol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.medmal.2006.08.005","article-title":"Pott\u2019s puffy tumor. A case report","volume":"37","author":"Kaabia","year":"2007","journal-title":"Med. Mal. Infect."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"114","DOI":"10.4103\/0022-3859.32212","article-title":"Pott\u2019s puffy tumor following an insect bite","volume":"53","author":"Raja","year":"2007","journal-title":"J. Postgrad. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/MEJ.0b013e32801482ea","article-title":"An unusual cause of headache: Pott\u2019s puffy tumour","volume":"14","author":"McDermott","year":"2007","journal-title":"Eur. J. Emerg. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"591","DOI":"10.5694\/j.1326-5377.2008.tb02190.x","article-title":"Headache of a diagnosis: Frontotemporal pain and inflammation associated with osteolysis","volume":"189","author":"Tacon","year":"2008","journal-title":"Med. J. Aust."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.bjps.2008.01.026","article-title":"Cutaneous fistula is a rare presentation of Pott\u2019s puffy tumour","volume":"61","author":"Minutilli","year":"2008","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1444-0938.2007.00234.x","article-title":"Pott\u2019s puffy tumour mimicking preseptal cellulitis","volume":"91","author":"Lamoreau","year":"2008","journal-title":"Clin. Exp. Optom."},{"key":"ref_48","first-page":"e1","article-title":"Pott\u2019s Puffy tumor after minor head trauma","volume":"26","author":"Hsia","year":"2008","journal-title":"Am. J. Emerg. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s10006-009-0155-7","article-title":"Pott\u2019s puffy tumour: A forgotten complication of frontal sinus disease","volume":"13","author":"Masterson","year":"2009","journal-title":"Oral Maxillofac. Surg."},{"key":"ref_50","first-page":"470","article-title":"A Pott\u2019s puffy tumour as a late complication of a frontal sinus reconstruction: Case report and literature review","volume":"47","author":"Collet","year":"2009","journal-title":"Rhinology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"815","DOI":"10.4103\/0028-3886.72206","article-title":"Recurrent Pott\u2019s puffy tumor, a rare clinical entity","volume":"58","author":"Upadhyay","year":"2010","journal-title":"Neurol. India"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/MAJ.0b013e3181bdb5b5","article-title":"Pott puffy tumor complicating frontal sinusitis","volume":"340","author":"Adejumo","year":"2010","journal-title":"Am. J. Med. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"bcr1220103649","DOI":"10.1136\/bcr.12.2010.3649","article-title":"Recurrent Pott\u2019s puffy tumour","volume":"2011","author":"Olaleye","year":"2011","journal-title":"BMJ Case Rep."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1136\/jnnp.2010.239327","article-title":"Neurological picture. Pott\u2019s puffy tumour: Harbinger of intracranial sepsis","volume":"82","author":"Bhatt","year":"2011","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_55","first-page":"56","article-title":"Complications of nose and paranasal sinus disease","volume":"23","author":"Sajid","year":"2011","journal-title":"J. Ayub Med. Coll. Abbottabad"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"133","DOI":"10.12659\/AJCR.883236","article-title":"A tumor that is not a tumor but it sure can kill!","volume":"13","author":"Grewal","year":"2012","journal-title":"Am. J. Case Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e190","DOI":"10.1016\/j.joms.2011.11.018","article-title":"Pott puffy tumor after maxillary tooth extraction","volume":"70","author":"Elyassi","year":"2012","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3342\/ceo.2012.5.2.112","article-title":"Endoscopic Endonasal Treatment of a Pott\u2019s Puffy Tumor","volume":"5","author":"Jung","year":"2012","journal-title":"Clin. Exp. Otorhinolaryngol."},{"key":"ref_59","first-page":"88","article-title":"Medical image. An unusual swelling of the forehead","volume":"125","author":"Welch","year":"2012","journal-title":"N. Z. Med. J."},{"key":"ref_60","first-page":"27","article-title":"Radiological findings in a rare case of eyelid swelling: Pott\u2019s puffy tumor","volume":"95","author":"Ozcan","year":"2012","journal-title":"JBR-BTR"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"342","DOI":"10.5606\/kbbihtisas.2012.065","article-title":"Treatment of Pott\u2019s Puffy tumor with balloon sinuplasty: Report of three cases","volume":"22","author":"Bozdemir","year":"2012","journal-title":"Kulak Burun Bogaz Ihtis. Derg."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.1097\/SCS.0b013e31824cdcc0","article-title":"Pott puffy tumor appearing with a frontocutaneous fistula","volume":"23","author":"Shin","year":"2012","journal-title":"J. Craniofac. Surg."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"79","DOI":"10.5144\/0256-4947.2012.26.5.1116","article-title":"Pott puffy tumor: A rare complication of sinusitis","volume":"33","author":"Muhammad","year":"2013","journal-title":"Ann. Saudi Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1017\/S0022215112001673","article-title":"Pott\u2019s puffy tumour and intracranial complications of frontal sinusitis in pregnancy","volume":"127","author":"Friedland","year":"2013","journal-title":"J. Laryngol. Otol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.amjoto.2012.12.018","article-title":"Anterior table remodeling after treatment for Pott\u2019s puffy tumor","volume":"34","author":"Sullivan","year":"2013","journal-title":"Am. J. Otolaryngol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"bcr2013202737","DOI":"10.1136\/bcr-2013-202737","article-title":"Forehead swelling and frontal headache: Pott\u2019s puffy tumour","volume":"2014","author":"Rajwani","year":"2014","journal-title":"BMJ Case Rep."},{"key":"ref_67","first-page":"1203","article-title":"Frontal epidural empyema (Pott\u2019s puffy tumor) associated with Mycoplasma and depression","volume":"55","author":"Ciobanu","year":"2014","journal-title":"Rom. J. Morphol. Embryol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"bcr2014204061","DOI":"10.1136\/bcr-2014-204061","article-title":"Pott\u2019s puffy tumour: An unforgettable complication of frontal sinusitis","volume":"2014","author":"Williams","year":"2014","journal-title":"BMJ Case Rep."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1001\/jamadermatol.2015.0874","article-title":"Pott\u2019s Puffy Tumor Caused by Chronic Sinusitis Resulting in Sinocutaneous Fistula","volume":"151","author":"Terui","year":"2015","journal-title":"JAMA Dermatol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"bcr2015211099","DOI":"10.1136\/bcr-2015-211099","article-title":"Pott\u2019s puffy tumour: A forgotten diagnosis","volume":"2015","author":"Ball","year":"2015","journal-title":"BMJ Case Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1097\/SCS.0000000000001484","article-title":"A patient with pott puffy tumor with pansinusitis and orbital involvement in an immunocompromised patient","volume":"26","author":"Hyun","year":"2015","journal-title":"J. Craniofac. Surg."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.anorl.2015.08.018","article-title":"Post-traumatic Pott\u2019s puffy tumour: A case report","volume":"133","author":"Ahmed","year":"2016","journal-title":"Eur. Ann. Otorhinolaryngol. Head Neck Dis."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3949\/ccjm.83a.15011","article-title":"A 60-year-old man with forehead swelling","volume":"83","author":"Miller","year":"2016","journal-title":"Cleve Clin. J. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"15","DOI":"10.7812\/TPP\/15-157","article-title":"Image Diagnosis: Pott Puffy Tumor","volume":"20","author":"Apostolakos","year":"2016","journal-title":"Perm. J."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1272\/jnms.83.211","article-title":"Pott\u2019s Puffy Tumor in an Adult: A Case Report and Review of Literature","volume":"83","author":"Tatsumi","year":"2016","journal-title":"J. Nippon. Med. Sch."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jns.2016.01.056","article-title":"Pneumocephalus associated with Pott\u2019s puffy tumor","volume":"362","author":"Sugiyama","year":"2016","journal-title":"J. Neurol. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/coa.12538","article-title":"Minimally invasive treatment of patients with Pott\u2019s puffy tumour with or without endocranial extension-a case series of six patients: Our Experience","volume":"41","author":"Hansen","year":"2016","journal-title":"Clin. Otolaryngol."},{"key":"ref_78","first-page":"62","article-title":"Pott\u2019s puffy tumor","volume":"130","author":"Bakshi","year":"2017","journal-title":"N. Z. Med. J."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/j.jcjo.2016.06.009","article-title":"Pott\u2019s puffy tumour presenting as a necrotic eyelid lesion","volume":"52","author":"Low","year":"2017","journal-title":"Can. J. Ophthalmol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1177\/0003489417698497","article-title":"Minimally Invasive Surgery for Pott\u2019s Puffy Tumor: Is It Time for a Paradigm Shift in Managing a 250-Year-Old Problem?","volume":"126","author":"Leong","year":"2017","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"e132","DOI":"10.1097\/IOP.0000000000000771","article-title":"Pott\u2019s Puffy Tumor: A Rare Presentation","volume":"33","author":"Ganapathy","year":"2017","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ejim.2017.04.025","article-title":"When the diagnosis is written on the forehead","volume":"47","author":"Pasin","year":"2018","journal-title":"Eur. J. Intern. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"bcr2017222294","DOI":"10.1136\/bcr-2017-222294","article-title":"A case of Pott\u2019s puffy tumour from primary dental infection","volume":"2017","author":"Geyton","year":"2017","journal-title":"BMJ Case Rep."},{"key":"ref_84","first-page":"55","article-title":"Pott Puffy Tumor","volume":"118","author":"Morris","year":"2018","journal-title":"J. Am. Osteopath. Assoc."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.clineuro.2018.06.034","article-title":"Pott\u2019s puffy tumor presenting as a frontal swelling under a Swiss army helmet","volume":"173","author":"Simonin","year":"2018","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e246","DOI":"10.1097\/INF.0000000000001927","article-title":"Complicated Fusobacterium Sinusitis: A Case Report","volume":"37","author":"Sheth","year":"2018","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1017\/S0022215119002093","article-title":"Pott\u2019s puffy tumour: Innovative technique in calvarial reconstruction","volume":"133","author":"Mettias","year":"2019","journal-title":"J. Laryngol. Otol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/02688697.2017.1330944","article-title":"Patient presenting with frontal subperiosteal abscess and headache: A case of Pott\u2019s puffy tumour","volume":"33","year":"2019","journal-title":"Br. J. Neurosurg."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"e94","DOI":"10.1097\/SCS.0000000000005100","article-title":"Recurrent Pott\u2019s Puffy Tumor Treated with Anterior Skull Base Resection With Reconstruction of the Anterolateral Thigh Flap","volume":"30","author":"Sekine","year":"2019","journal-title":"J. Craniofac. Surg."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e229755","DOI":"10.1136\/bcr-2019-229755","article-title":"A huge Pott\u2019s puffy tumour secondary to pansinusitis","volume":"12","author":"Dusu","year":"2019","journal-title":"BMJ Case Rep."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"E165","DOI":"10.1503\/cmaj.181025","article-title":"Acute sinusitis complicated with Pott puffy tumour","volume":"191","author":"Koltsidopoulos","year":"2019","journal-title":"CMAJ"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"NP101","DOI":"10.1177\/0145561319856858","article-title":"Frontocutaneous Fistula Secondary to Pott\u2019s Puffy Tumor","volume":"99","author":"Min","year":"2020","journal-title":"Ear Nose Throat J."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1007\/s00405-020-05980-2","article-title":"Draf III frontal sinus surgery for the treatment of Pott\u2019s puffy tumour in adults: Our case series and a review of frontal sinus anatomy risk factors","volume":"277","author":"Pendolino","year":"2020","journal-title":"Eur. Arch Otorhinolaryngol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"rjaa528","DOI":"10.1093\/jscr\/rjaa528","article-title":"Pott\u2019s puffy tumour in an immunosuppressed adult: Case report and systematic review of literature","volume":"2020","author":"Paw","year":"2020","journal-title":"J. Surg. Case Rep."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e00974","DOI":"10.1016\/j.idcr.2020.e00974","article-title":"Pott\u2019s puffy tumor caused by Actinomyces naeslundii","volume":"22","author":"Bean","year":"2020","journal-title":"IDCases"},{"key":"ref_96","first-page":"e10106","article-title":"Pott\u2019s Puffy Tumor: Intracranial Extension Not Requiring Neurosurgical Intervention","volume":"12","author":"Song","year":"2020","journal-title":"Cureus"},{"key":"ref_97","first-page":"e11781","article-title":"Pott Puffy Tumor in Adults: The \u03a4iming of Surgical \u0399ntervention","volume":"12","author":"Sideris","year":"2020","journal-title":"Cureus"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"e418","DOI":"10.1097\/SCS.0000000000006423","article-title":"Pott\u2019s Puffy Tumor and Intranasal Cocaine Abuse","volume":"31","author":"Pansini","year":"2020","journal-title":"J. Craniofac. Surg."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000506225","article-title":"A Rare Case of Palpebral Cellulitis, a Variation of Pott\u2019s Puffy Tumor","volume":"11","author":"Yamamoto","year":"2020","journal-title":"Case Rep. Ophthalmol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"144","DOI":"10.52964\/AMJA.0855","article-title":"Pott\u2019s Puffy Tumour: A rare but sinister cause of facial swelling","volume":"20","author":"Birks","year":"2021","journal-title":"Acute Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1001\/jamaophthalmol.2020.4092","article-title":"Progressive Eyelid Swelling in a Middle-aged Man","volume":"139","author":"Baker","year":"2021","journal-title":"JAMA Ophthalmol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1177\/1945892420959587","article-title":"Treatment of Frontal Sinus Osteomyelitis in the Age of Endoscopy","volume":"35","author":"Thompson","year":"2021","journal-title":"Am. J. Rhinol. Allergy"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"422","DOI":"10.5811\/cpcem.2021.6.52726","article-title":"The Use of Point-of-care Ultrasound in the Diagnosis of Pott\u2019s Puffy Tumor: A Case Report","volume":"5","author":"Shockey","year":"2021","journal-title":"Clin. Pract. Cases Emerg. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"NP186","DOI":"10.1177\/0145561320952203","article-title":"Odontogenic Sinusitis-Associated Pott\u2019s Puffy Tumor: A Case Report and Literature Review","volume":"101","author":"Min","year":"2022","journal-title":"Ear Nose Throat J."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s00106-021-01134-w","article-title":"Pott\u2019s puffy tumor: A need for interdisciplinary diagnosis and treatment. Pott\u2019s-Puffy-Tumor: Die Notwendigkeit einer interdisziplin\u00e4ren Diagnostik und Behandlung","volume":"70","author":"Linsler","year":"2022","journal-title":"HNO"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"e06692021","DOI":"10.1590\/0037-8682-0669-2021","article-title":"Pott\u2019s puffy tumor in coronavirus disease-2019 associated mucormycosis","volume":"55","author":"Arora","year":"2022","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"106975","DOI":"10.1016\/j.ijscr.2022.106975","article-title":"Misdiagnosed epidermoid cyst appears Potts Puffy Tumor: A case report and literature review","volume":"94","author":"Salemans","year":"2022","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_108","first-page":"e24922","article-title":"Pott\u2019s Puffy Tumor in an Adult Female: A Case Report in a Rare Demographic","volume":"14","author":"Hitt","year":"2022","journal-title":"Cureus"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"CASE22134","DOI":"10.3171\/CASE22134","article-title":"The rare presentation of a frontal mucocele complicated by a Pott\u2019s puffy tumor and an epidural-cutaneous fistula: Illustrative case","volume":"4","author":"Abbas","year":"2022","journal-title":"J. Neurosurg. Case Lessons"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"e127","DOI":"10.1097\/SCS.0000000000008010","article-title":"Pott Puffy Tumor Caused by Dental Infection: A Case Report and Literature Review","volume":"33","author":"Yang","year":"2022","journal-title":"J. Craniofac. Surg."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Lai, E.W., Bergman, Z., and Grumbine, F.L. (2022). Pott\u2019s Puffy Tumour with Eyelid Abscess. Can. J. Ophthalmol., in press.","DOI":"10.1016\/j.jcjo.2022.09.002"},{"key":"ref_112","first-page":"257","article-title":"Frontal Bone Osteomyelitis in Adult","volume":"20","author":"Kc","year":"2022","journal-title":"J. Nepal. Health Res. Counc."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"103529","DOI":"10.1016\/j.amjoto.2022.103529","article-title":"Pott\u2019s puffy tumor: A comprehensive review of the literature","volume":"43","author":"Rohde","year":"2022","journal-title":"Am. J. Otolaryngol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s11882-020-00917-5","article-title":"Common Cold and Acute Rhinosinusitis: Up-to-Date Management in 2020","volume":"20","author":"Jaume","year":"2020","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"103004","DOI":"10.1016\/j.amjoto.2021.103004","article-title":"Antibody deficiencies are more common in adult versus pediatric recurrent acute rhinosinusitis","volume":"42","author":"Makary","year":"2021","journal-title":"Am. J. Otolaryngol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1097\/00005537-199707000-00005","article-title":"Intracranial complications of sinusitis","volume":"107","author":"Giannoni","year":"1997","journal-title":"Laryngoscope"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1288\/00005537-199103000-00003","article-title":"Intracranial complications of paranasal sinusitis: A combined institutional review","volume":"101","author":"Clayman","year":"1991","journal-title":"Laryngoscope"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1093\/jpids\/piz098","article-title":"Incidence and Clinical Outcomes of Streptococcus anginosus in Acute Complicated Sinusitis: A Pediatric Cohort","volume":"10","author":"Troy","year":"2021","journal-title":"J. Pediatric Infect. Dis. Soc."}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/13\/4\/587\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:07:24Z","timestamp":1760123244000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/13\/4\/587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,30]]},"references-count":118,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["brainsci13040587"],"URL":"https:\/\/doi.org\/10.3390\/brainsci13040587","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,30]]}}}