{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:02:30Z","timestamp":1760148150939,"version":"build-2065373602"},"reference-count":43,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>This study aimed to determine whether peripapillary retinal nerve fiber layer (pRNFL) and ganglion cell\u2013inner plexiform layer (GCIPL) thickness thresholds for single-time-point swept-source optical coherence tomography (SS-OCT) measures can differentiate the clinical outcomes of treatment-na\u00efve people with multiple sclerosis (pwMS). A total of 275 patients with the clinically isolated syndrome (n = 23), benign MS (n = 8), relapsing\u2013remitting MS (n = 185), secondary progressive MS (n = 28), primary progressive MS (n = 31), and with no history of optic neuritis were included. The mean Expanded Disability Status Scale (EDSS) score was 3.0 \u00b1 1.6. The cut-off values of pRNFL (87 \u00b5m and 88 \u00b5m) and GCIPL (70 \u00b5m) thicknesses have been adopted from previous studies using spectral-domain OCT. PwMS with pRNFL \u226487 \u00b5m and \u226488 \u00b5m had a longer disease duration, more advanced disability, and more frequently progressive MS variants compared to those with greater pRNFL thicknesses. In distinguishing pwMS with disability greater than or equal to the mean EDSS score (EDSS \u2265 3) from those with less severe disability, GCIPL thickness &lt;70 \u00b5m had the highest sensitivity, while pRNFL thickness \u226487 \u00b5m had the greatest specificity. The optimal cut-off values differentiating patients with EDSS \u2265 3 from those with less severe disability was 63 \u00b5m for GCIPL thickness and 93.5 \u00b5m for pRNFL thickness. In conclusion, pRNFL and GCIPL thickness thresholds for single-time-point SS-OCT measurements may be helpful in differentiating the disability status of treatment-na\u00efve pwMS.<\/jats:p>","DOI":"10.3390\/brainsci13040591","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T02:30:20Z","timestamp":1680229820000},"page":"591","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Swept-Source Optical Coherence Tomography Thresholds in Differentiating Clinical Outcomes in a Real-World Cohort of Treatment-Na\u00efve Multiple Sclerosis Patients"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2995-6148","authenticated-orcid":false,"given":"\u0141ukasz","family":"Rzepi\u0144ski","sequence":"first","affiliation":[{"name":"Department of Neurology, 10th Military Research Hospital and Polyclinic, Powsta\u0144c\u00f3w Warszawy 5, 85-681 Bydgoszcz, Poland"},{"name":"Sanitas\u2014Neurology Outpatient Clinic, Dworcowa 110, 85-010 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Kucharczuk","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, 10th Military Research Hospital and Polyclinic, Powsta\u0144c\u00f3w Warszawy 5, 85-681 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magda","family":"Tkaczy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Surgery, 10th Military Research Hospital and Polyclinic, Powsta\u0144c\u00f3w Warszawy 5, 85-681 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Parisi","sequence":"additional","affiliation":[{"name":"IRCCS\u2014Fondazione Bietti, Via Livenza 3, 00198 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3724-2391","authenticated-orcid":false,"given":"Andrzej","family":"Grzybowski","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Warmia and Mazury, \u017bo\u0142nierska 18, 10-561 Olsztyn, Poland"},{"name":"Institute for Research in Ophthalmology, Foundation for Ophthalmology Development, Mickiewicza 24\/3B, 60-836 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.3389\/fimmu.2018.03116","article-title":"Pathogenic Mechanisms Associated With Different Clinical Courses of Multiple Sclerosis","volume":"9","author":"Lassmann","year":"2019","journal-title":"Front. 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