{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:14:37Z","timestamp":1790082877854,"version":"4.0.1"},"reference-count":36,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"West China Hospital of Sichuan University","award":["ZYGD18020"],"award-info":[{"award-number":["ZYGD18020"]}]},{"name":"West China Hospital of Sichuan University","award":["ZYJC18006"],"award-info":[{"award-number":["ZYJC18006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background: Acute kidney injury (AKI) commonly develops among traumatic brain injury (TBI) patients and causes poorer outcomes. We perform this study to explore the relationship between serum magnesium and the risk of AKI among TBI. Methods: TBI patients recorded in the Medical Information Mart for Intensive Care-III database were eligible for this research. The restricted cubic spline (RCS) was utilized to fit the correlation between serum magnesium level and the AKI. Univariate and subsequent multivariate logistic regression analysis were utilized to explore risk factors of AKI and confirmed the correlation between serum magnesium and AKI. Results: The incidence of AKI in included TBI was 21.0%. The RCS showed that the correlation between magnesium level and risk of AKI was U-shaped. Compared with patients whose magnesium level was between 1.5 and 2.0 mg\/dL, those with a magnesium level of &lt;1.5 mg\/dL or &gt;2.0 mg\/dL had a higher incidence of AKI. Multivariate logistic regression confirmed age, chronic renal disease, ISS, serum creatinine, vasopressor, mechanical ventilation, and serum magnesium &lt;1.5 mg\/dL were independently related with the AKI in TBI. Conclusion: Abnormal low serum magnesium level is correlated with AKI development in TBI patients. Physicians should pay attention on renal function of TBI patients especially those with hypomagnesemia.<\/jats:p>","DOI":"10.3390\/brainsci13040593","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T03:31:38Z","timestamp":1680233498000},"page":"593","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Hypomagnesemia Is Associated with the Acute Kidney Injury in Traumatic Brain Injury Patients: A Pilot Study"],"prefix":"10.3390","volume":"13","author":[{"given":"Zhenjun","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoran","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"He","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/TA.0000000000002771","article-title":"The impact of non-neurological organ dysfunction on outcomes in severe isolated traumatic brain injury","volume":"89","author":"Astarabadi","year":"2020","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1097\/CCM.0000000000005055","article-title":"Association of Early Multiple Organ Dysfunction with Clinical and Functional Outcomes over the Year Following Traumatic Brain Injury: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study","volume":"49","author":"Krishnamoorthy","year":"2021","journal-title":"Crit. Care Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1097\/01.CCM.0000155911.01844.54","article-title":"Non-neurologic organ dysfunction in severe traumatic brain injury","volume":"33","author":"Zygun","year":"2005","journal-title":"Crit. Care Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"R115","DOI":"10.1186\/cc5007","article-title":"SOFA is superior to MOD score for the determination of non-neurologic organ dysfunction in patients with severe traumatic brain injury: A cohort study","volume":"10","author":"Zygun","year":"2006","journal-title":"Crit. Care"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.3109\/0886022X.2010.510234","article-title":"The incidence of acute kidney injury in patients with traumatic brain injury","volume":"32","author":"Moore","year":"2010","journal-title":"Ren. Fail."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.5301\/jn.5000282","article-title":"Neutrophil gelatinase-associated lipocalin as an early marker of acute kidney injury in patients with traumatic brain injury","volume":"26","author":"Li","year":"2013","journal-title":"J. Nephrol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3109\/02688697.2015.1016892","article-title":"Acute kidney injury in survivors of surgery for severe traumatic brain injury: Incidence, risk factors, and outcome from a tertiary neuroscience center in India","volume":"29","author":"Ahmed","year":"2015","journal-title":"Br. J. Neurosurg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s12028-011-9511-1","article-title":"Acute kidney injury in patients with severe traumatic brain injury: Implementation of the acute kidney injury network stage system","volume":"14","author":"Li","year":"2011","journal-title":"Neurocrit. Care"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/aas.13244","article-title":"Erythropoietin in traumatic brain injury associated acute kidney injury: A randomized controlled trial","volume":"63","author":"Skrifvars","year":"2019","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"R44","DOI":"10.1186\/cc11243","article-title":"Impact of non-neurological complications in severe traumatic brain injury outcome","volume":"16","author":"Corral","year":"2012","journal-title":"Crit. Care"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"194","DOI":"10.21037\/atm.2020.01.60","article-title":"An acute kidney injury prediction nomogram based on neurosurgical intensive care unit profiles","volume":"8","author":"An","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/01.ccx.0000155356.86241.c0","article-title":"Non-neurological organ dysfunction in neurocritical care: Impact on outcome and etiological considerations","volume":"11","author":"Zygun","year":"2005","journal-title":"Curr. Opin. Crit. Care"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/j.1365-2044.2007.04998.x","article-title":"Systemic complications after head injury: A clinical review","volume":"62","author":"Lim","year":"2007","journal-title":"Anaesthesia"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40560-020-00449-0","article-title":"Low-chloride- versus high-chloride-containing hypertonic solution for the treatment of subarachnoid hemorrhage-related complications: The ACETatE (A low ChloriE hyperTonic solution for brain Edema) randomized trial","volume":"8","author":"Sadan","year":"2020","journal-title":"J. Intensive Care"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1177\/0885066617748596","article-title":"Incidence, Risk Factors, and Outcome of Acute Kidney Injury in Neurocritical Care","volume":"35","author":"Stadler","year":"2020","journal-title":"J. Intensive Care Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1038\/s41598-017-04627-3","article-title":"The Incidence, Risk Factors and Outcomes of Postoperative Acute Kidney Injury in Neurosurgical Critically Ill Patients","volume":"7","author":"Deng","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_17","first-page":"167","article-title":"Basic biochemistry and physiology of magnesium: A brief review","volume":"10","author":"Altura","year":"1991","journal-title":"Magnes. Trace Elem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"378s","DOI":"10.3945\/an.112.003483","article-title":"Magnesium in disease prevention and overall health","volume":"4","author":"Volpe","year":"2013","journal-title":"Adv. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1053\/j.ajkd.2022.03.004","article-title":"Preoperative Ionized Magnesium Levels and Risk of Acute Kidney Injury After Cardiac Surgery","volume":"80","author":"Koh","year":"2022","journal-title":"Am. J. KidneyDis. Off. J. Natl. Kidney Found."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"10899","DOI":"10.12998\/wjcc.v9.i35.10899","article-title":"Serum magnesium level as a predictor of acute kidney injury in patients with acute pancreatitis","volume":"9","author":"Yu","year":"2021","journal-title":"World J. Clin. Cases"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s00467-021-05331-1","article-title":"Abnormal magnesium levels and their impact on death and acute kidney injury in critically ill children","volume":"37","author":"Morooka","year":"2022","journal-title":"Pediatr. Nephrol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7199","DOI":"10.2147\/CMAR.S262674","article-title":"The Effect of Admission Serum Magnesium on the Acute Kidney Injury Among Patients with Malignancy","volume":"12","author":"Shen","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"c179","DOI":"10.1159\/000339789","article-title":"KDIGO clinical practice guidelines for acute kidney injury","volume":"120","author":"Khwaja","year":"2012","journal-title":"Nephron Clin. Pract."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e176","DOI":"10.1097\/SCS.0000000000006130","article-title":"Risk Factors of Acute Gastrointestinal Failure in Critically Ill Patients with Traumatic Brain Injury","volume":"31","author":"Fu","year":"2020","journal-title":"J. Craniofacial Surg."},{"key":"ref_25","first-page":"237","article-title":"Traumatic brain injury causing intestinal dysfunction: A review","volume":"79","author":"Iftikhar","year":"2020","journal-title":"J. Clin.Neurosci. Off. J. Neurosurg. Soc. Australas."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1089\/neu.2020.7526","article-title":"Traumatic Brain Injury Induces Gastrointestinal Dysfunction and Dysbiosis of Gut Microbiota Accompanied by Alterations of Bile Acid Profile","volume":"39","author":"You","year":"2022","journal-title":"J. Neurotrauma"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.3109\/0886022X.2015.1057471","article-title":"Admission hypomagnesemia and hypermagnesemia increase the risk of acute kidney injury","volume":"37","author":"Cheungpasitporn","year":"2015","journal-title":"Ren. Fail."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Kostov, K., and Halacheva, L. (2018). Role of Magnesium Deficiency in Promoting Atherosclerosis, Endothelial Dysfunction, and Arterial Stiffening as Risk Factors for Hypertension. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19061724"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1681\/ASN.V1071616","article-title":"Hypomagnesemia","volume":"10","author":"Agus","year":"1999","journal-title":"J. Am. Soc.Nephrol. JASN"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1161\/01.HYP.9.4.379","article-title":"Evidence that prostacyclin mediates the vascular action of magnesium in humans","volume":"9","author":"Nadler","year":"1987","journal-title":"Hypertension"},{"key":"ref_31","first-page":"245","article-title":"New perspectives on the role of magnesium in the pathophysiology of the cardiovascular system. II. Experimental aspects","volume":"4","author":"Altura","year":"1985","journal-title":"Magnesium"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"267","DOI":"10.5414\/CNP59267","article-title":"Effects of hypokalemia and hypomagnesemia on zidovudine (AZT) and didanosine (ddI) nephrotoxicity in rats","volume":"59","author":"Seguro","year":"2003","journal-title":"Clin. Nephrol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10741-006-9191-7","article-title":"The nerve-heart connection in the pro-oxidant response to Mg-deficiency","volume":"11","author":"Kramer","year":"2006","journal-title":"Heart Fail. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s10787-019-00603-7","article-title":"The role of magnesium in different inflammatory diseases","volume":"27","author":"Shahi","year":"2019","journal-title":"Inflammopharmacology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/sj.ejcn.1601689","article-title":"Possible roles of magnesium on the immune system","volume":"57","author":"Tam","year":"2003","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.bbadis.2010.06.016","article-title":"Magnesium deficiency promotes a pro-atherogenic phenotype in cultured human endothelial cells via activation of NFkB","volume":"1802","author":"Baldoli","year":"2010","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/13\/4\/593\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:08:00Z","timestamp":1760123280000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/13\/4\/593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,31]]},"references-count":36,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["brainsci13040593"],"URL":"https:\/\/doi.org\/10.3390\/brainsci13040593","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,31]]}}}