{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:28:50Z","timestamp":1778113730104,"version":"3.51.4"},"reference-count":42,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Council","award":["NSTC 111-2410-H-431-010"],"award-info":[{"award-number":["NSTC 111-2410-H-431-010"]}]},{"name":"National Science and Technology Council","award":["YSVH110-09"],"award-info":[{"award-number":["YSVH110-09"]}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["NSTC 111-2410-H-431-010"],"award-info":[{"award-number":["NSTC 111-2410-H-431-010"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["YSVH110-09"],"award-info":[{"award-number":["YSVH110-09"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Cancer patients regularly suffer from the behavioral symptoms of chemotherapy-induced nausea and vomiting. Particularly, it is involved in Pavlovian conditioning. Lithium chloride (LiCl) was used as the unconditioned stimulus (US) and contingent with the tastant, for example, a saccharin solution (i.e., the conditioned stimulus; CS), resulted in conditioned taste aversion (CTA) to the CS intake. The present study employed an animal model of LiCl-induced CTA to imitate chemotherapy-induced nausea and vomiting symptoms. Recently, the basolateral amygdala (BLA) was shown to mediate LiCl-induced CTA learning; however, which brain mechanisms of the BLA regulate CTA by LiCl remain unknown. The present study was designed to test this issue, and 4% lidocaine or D2 blocker haloperidol were microinjected into BLA between the 0.1% saccharin solution intake and 0.15M LiCl. The results showed lidocaine microinjections into the BLA could attenuate the LiCl-induced CTA. Microinjections of haloperidol blunted the CTA learning by LiCl. Altogether, BLA via the sodium chloride ion channel and D2 receptors control LiCl-induced conditioned saccharin solution intake suppression. The findings can provide some implications and contributions to cancer chemotherapy-induced nausea and vomiting side effects, and will help to develop novel strategies to prevent the side effects of cancer chemotherapy.<\/jats:p>","DOI":"10.3390\/brainsci13040697","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T04:48:11Z","timestamp":1682052491000},"page":"697","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["D2 Receptors and Sodium Ion Channel Blockades of the Basolateral Amygdala Attenuate Lithium Chloride-Induced Conditioned Taste Aversion Applying to Cancer Chemotherapy Nausea and Vomiting"],"prefix":"10.3390","volume":"13","author":[{"given":"Zhi-Yue","family":"Gao","sequence":"first","affiliation":[{"name":"Yuanshan Branch, Taipei Veterans General Hospital, Yi-Lan County 26247, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung Ming","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Psychology, Fo Guang University, Yi-Lan 26247, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cai-N","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Psychology, Fo Guang University, Yi-Lan 26247, Taiwan"},{"name":"Department of Life Sciences, National Central University, Jhong-Li District, Taoyuan City 32001, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9794-7302","authenticated-orcid":false,"given":"Andrew Chih-Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Psychology, Fo Guang University, Yi-Lan 26247, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.autneu.2006.07.012","article-title":"Pavlovian conditioning of nausea and vomiting","volume":"129","author":"Stockhorst","year":"2006","journal-title":"Auton. 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