{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:35:26Z","timestamp":1791419726622,"version":"4.3.3"},"reference-count":92,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health","award":["RF-2019-12369567"],"award-info":[{"award-number":["RF-2019-12369567"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>The concreteness effect (CE), namely a better performance with concrete compared to abstract concepts, is a constant feature in healthy people, and it usually increases in persons with aphasia (PWA). However, a reversal of the CE has been reported in patients affected by the semantic variant of Primary Progressive Aphasia (svPPA), a neurodegenerative disease characterized by anterior temporal lobe (ATL) atrophy. The present scoping review aims at identifying the extent of evidence regarding the abstract\/concrete contrast in Alzheimer\u2019s disease (AD) and svPPA and associated brain atrophy. Five online databases were searched up to January 2023 to identify papers where both concrete and abstract concepts were investigated. Thirty-one papers were selected and showed that while in patients with AD, concrete words were better processes than abstract ones, in most svPPA patients, there was a reversal of the CE, with five studies correlating the size of this effect with ATL atrophy. Furthermore, the reversal of CE was associated with category-specific impairments (living things) and with a selective deficit of social words. Future work is needed to disentangle the role of specific portions of the ATL in concept representation.<\/jats:p>","DOI":"10.3390\/brainsci13050765","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T03:34:53Z","timestamp":1683516893000},"page":"765","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Concrete and Abstract Concepts in Primary Progressive Aphasia and Alzheimer\u2019s Disease: A Scoping Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1817-2140","authenticated-orcid":false,"given":"Martina","family":"Mancano","sequence":"first","affiliation":[{"name":"Center for Mind\/Brain Sciences, University of Trento, 38068 Rovereto, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3659-6294","authenticated-orcid":false,"given":"Costanza","family":"Papagno","sequence":"additional","affiliation":[{"name":"Center for Mind\/Brain Sciences, University of Trento, 38068 Rovereto, Italy"},{"name":"CISMed Interdepartmental Center for Medical Sciences, University of Trento, 38122 Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1037\/0096-1523.1.2.130","article-title":"The Role of Semantic Information in Lexical Decisions","volume":"1","author":"James","year":"1975","journal-title":"J. Exp. Psychol. Hum. Percept. Perform."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1037\/0278-7393.21.5.1140","article-title":"Semantic Effects in Single-Word Naming","volume":"21","author":"Strain","year":"1995","journal-title":"J. Exp. Psychol. Learn. Mem. Cogn."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1037\/0894-4105.9.1.16","article-title":"Exploring the Loss of Semantic Memory in Semantic Dementia: Evidence from a Primed Monitoring Study","volume":"9","author":"Moss","year":"1995","journal-title":"Neuropsychology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/B978-0-12-823493-8.00018-3","article-title":"The Neural Correlates of Abstract and Concrete Words","volume":"187","author":"Papagno","year":"2022","journal-title":"Handb. Clin. Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/brain\/107.3.829","article-title":"Category Specific Semantic Impairments","volume":"107","author":"Warrington","year":"1984","journal-title":"Brain"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1212\/WNL.51.6.1546","article-title":"Frontotemporal Lobar Degeneration: A Consensus on Clinical Diagnostic Criteria","volume":"51","author":"Neary","year":"1998","journal-title":"Neurology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1093\/brain\/awr179","article-title":"Sensitivity of Revised Diagnostic Criteria for the Behavioural Variant of Frontotemporal Dementia","volume":"134","author":"Rascovsky","year":"2011","journal-title":"Brain"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","article-title":"Classification of Primary Progressive Aphasia and Its Variants","volume":"76","author":"Hillis","year":"2011","journal-title":"Neurology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0010-9452(08)70404-0","article-title":"Semantic Knowledge in Mild Cognitive Impairment and Mild Alzheimer\u2019s Disease","volume":"42","author":"Adlam","year":"2006","journal-title":"Cortex"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Nicol\u00e1s, I., Carro, J., Llorente, T.E., and Meil\u00e1n, J.J.G. (2019). The Deterioration of Semantic Networks in Alzheimer\u2019s Disease. Exon. Publ., 179\u2013191.","DOI":"10.15586\/alzheimersdisease.2019.ch11"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.neubiorev.2021.10.015","article-title":"Speech and Language Impairments in Behavioral Variant Frontotemporal Dementia: A Systematic Review","volume":"131","author":"Geraudie","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.neuropsychologia.2016.06.013","article-title":"Dissociation of Quantifiers and Object Nouns in Speech in Focal Neurodegenerative Disease","volume":"89","author":"Ash","year":"2016","journal-title":"Neuropsychologia"},{"key":"ref_13","unstructured":"Howard, D., and Patterson, K.E. (1992). The Pyramids and Palm Trees Test: A test for semantic access from words and pictures Thames Valley Company, Bury St. Edmunds."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1037\/h0084295","article-title":"Dual Coding Theory: Retrospect and Current Status","volume":"45","author":"Paivio","year":"1991","journal-title":"Can. J. Psychol. Rev. Can. De Psychol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1037\/0278-7393.9.1.82","article-title":"Differential Context Effects in the Comprehension of Abstract and Concrete Verbal Materials","volume":"9","author":"Schwanenflugel","year":"1983","journal-title":"J. Exp. Psychol. Learn. Mem. Cogn."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0361-3682(85)90022-4","article-title":"An Empirical Study of the Evidence for Contingency Theories of Management Accounting Systems in Conditions of Rapid Change","volume":"10","author":"Jones","year":"1985","journal-title":"Account. Organ. Soc."},{"key":"ref_17","unstructured":"Plaut, D.C., and Shallice, T. (1991, January 7\u201310). Effects of Word Abstractness in a Connectionist Model of Deep Dyslexia. Proceedings of the 13th annual meeting of the Cognitive Science Society, Chicago, IL, USA."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1093\/brain\/awh349","article-title":"Abstract and Concrete Concepts Have Structurally Different Representational Frameworks","volume":"128","author":"Crutch","year":"2005","journal-title":"Brain"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.neubiorev.2021.05.004","article-title":"The Multidimensionality of Abstract Concepts: A Systematic Review","volume":"127","author":"Conca","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bandl.2017.04.004","article-title":"Comprehension of Concrete and Abstract Words in Semantic Variant Primary Progressive Aphasia and Alzheimer\u2019s Disease: A Behavioral and Neuroimaging Study","volume":"170","author":"Joubert","year":"2017","journal-title":"Brain Lang."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"6430","DOI":"10.1073\/pnas.0607061104","article-title":"Social Concepts Are Represented in the Superior Anterior Temporal Cortex","volume":"104","author":"Zahn","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1080\/13554794.2021.1931345","article-title":"Different Types of Abstract Concepts: Evidence from Two Neurodegenerative Patients","volume":"27","author":"Conca","year":"2021","journal-title":"Neurocase"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.neuropsychologia.2011.12.023","article-title":"Comprehension of Concrete and Abstract Words in Patients with Selective Anterior Temporal Lobe Resection and in Patients with Selective Amygdalo-Hippocampectomy","volume":"50","author":"Loiselle","year":"2012","journal-title":"Neuropsychologia"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/02643294.2018.1477748","article-title":"Investigating the Functional Neuroanatomy of Concrete and Abstract Word Processing through Direct Electric Stimulation (DES) during Awake Surgery","volume":"36","author":"Orena","year":"2019","journal-title":"Cogn. Neuropsychol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1093\/cercor\/bhp055","article-title":"Where Is the Semantic System? A Critical Review and Meta-Analysis of 120 Functional Neuroimaging Studies","volume":"19","author":"Binder","year":"2009","journal-title":"Cereb. Cortex"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-021-94506-9","article-title":"An ALE Meta-Analytical Review of the Neural Correlates of Abstract and Concrete Words","volume":"11","author":"Bucur","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1037\/h0025327","article-title":"Concreteness, Imagery, and Meaningfulness Values for 925 Nouns","volume":"76","author":"Paivio","year":"1968","journal-title":"J. Exp. Psychol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0028-3932(75)90004-4","article-title":"The Effect of Word Imageability in Acquired Dyslexia","volume":"13","author":"Richardson","year":"1975","journal-title":"Neuropsychologia"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3758\/BF03337237","article-title":"Imageability and Concreteness","volume":"7","author":"Richardson","year":"1976","journal-title":"Bull. Psychon. Soc."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Boles, D.B. (1983). Dissociated Imageability, Concreteness, and Familiarity in Lateralized Word Recognition, Springer.","DOI":"10.3758\/BF03196988"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.cognition.2012.07.010","article-title":"Strength of Perceptual Experience Predicts Word Processing Performance Better than Concreteness or Imageability","volume":"125","author":"Connell","year":"2012","journal-title":"Cognition"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1080\/14640747508400525","article-title":"The Selective Impairment of Semantic Memory","volume":"27","author":"Warrington","year":"1975","journal-title":"Q. J. Exp. Psychol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1080\/02643299408251987","article-title":"Reversal of the Concreteness Effect in a Patient with Semantic Dementia","volume":"11","author":"Breedin","year":"1994","journal-title":"Cogn. Neuropsychol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.neuropsychologia.2009.01.019","article-title":"Reversed Concreteness Effect for Nouns in a Subject with Semantic Dementia","volume":"47","author":"Papagno","year":"2009","journal-title":"Neuropsychologia"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.neuropsychologia.2008.10.006","article-title":"Is a Plum a Memory Problem? Longitudinal Study of the Reversal of Concreteness Effect in a Patient with Semantic Dementia","volume":"47","author":"Macoir","year":"2009","journal-title":"Neuropsychologia"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.neuropsychologia.2016.02.025","article-title":"Cognitive and Anatomic Double Dissociation in the Representation of Concrete and Abstract Words in Semantic Variant and Behavioral Variant Frontotemporal Degeneration","volume":"84","author":"Cousins","year":"2016","journal-title":"Neuropsychologia"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.bandl.2016.11.003","article-title":"Dissociable Substrates Underlie the Production of Abstract and Concrete Nouns","volume":"165","author":"Cousins","year":"2017","journal-title":"Brain Lang."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"ENEURO.0197-18.2018","DOI":"10.1523\/ENEURO.0197-18.2018","article-title":"Longitudinal Changes in Semantic Concreteness in Semantic Variant Primary Progressive Aphasia (SvPPA)","volume":"5","author":"Cousins","year":"2018","journal-title":"eNeuro"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cortex.2021.01.012","article-title":"Automated Analysis of Lexical Features in Frontotemporal Degeneration","volume":"137","author":"Cho","year":"2021","journal-title":"Cortex"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1080\/02643290903512305","article-title":"Reversal of the Concreteness Effect in Semantic Dementia","volume":"26","author":"Bonner","year":"2009","journal-title":"Cogn. Neuropsychol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1037\/a0015452","article-title":"Comprehension of Concrete and Abstract Words in Semantic Dementia","volume":"23","author":"Jefferies","year":"2009","journal-title":"Neuropsychology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.cortex.2009.02.006","article-title":"The Role of the Anterior Temporal Lobes in the Comprehension of Concrete and Abstract Words: RTMS Evidence","volume":"45","author":"Pobric","year":"2009","journal-title":"Cortex"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Stockbridge, M.D., Venezia, J.H., Vitti, E., Tippett, D.C., and Hillis, A.E. (2022). Verb Frequency and Density Drive Naming Performance in Primary Progressive Aphasia. Aphasiology, 1\u201317.","DOI":"10.1080\/02687038.2022.2142036"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan\u2014A Web and Mobile App for Systematic Reviews","volume":"5","author":"Ouzzani","year":"2016","journal-title":"Syst. Rev."},{"key":"ref_46","unstructured":"Goodglass, H., Kaplan, E., and Barressi, B. (1983). Boston Diagnostic Aphasia Examination, Lea & Febiger."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1080\/02687030701191986","article-title":"Single-Word Semantic Judgements in Semantic Dementia: Do Phonology and Grammatical Class Count?","volume":"21","author":"Reilly","year":"2007","journal-title":"Aphasiology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cortex.2012.11.004","article-title":"Broadly Speaking: Vocabulary in Semantic Dementia Shifts towards General, Semantically Diverse Words","volume":"55","author":"Hoffman","year":"2014","journal-title":"Cortex"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.neuropsychologia.2015.03.023","article-title":"For Richer or Poorer? Imageability Effects in Semantic Dementia Patients\u2019 Reading Aloud","volume":"76","author":"Woollams","year":"2015","journal-title":"Neuropsychologia"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1037\/0894-4105.21.1.9","article-title":"Reversal of the Concreteness Effect for Verbs in Patients with Semantic Dementia","volume":"21","author":"Yi","year":"2007","journal-title":"Neuropsychology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.neuropsychologia.2014.09.041","article-title":"Abstract and Concrete Categories? Evidences from Neurodegenerative Diseases","volume":"64","author":"Rosa","year":"2014","journal-title":"Neuropsychologia"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1093\/cercor\/bhq288","article-title":"Reverse Concreteness Effects Are Not a Typical Feature of Semantic Dementia: Evidence for the Hub-and-Spoke Model of Conceptual Representation","volume":"21","author":"Hoffman","year":"2011","journal-title":"Cereb. Cortex"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.cortex.2012.05.007","article-title":"Be Concrete to Be Comprehended: Consistent Imageability Effects in Semantic Dementia for Nouns, Verbs, Synonyms and Associates","volume":"49","author":"Hoffman","year":"2013","journal-title":"Cortex"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1162\/jocn_a_00902","article-title":"Hemispheric Specialization within the Superior Anterior Temporal Cortex for Social and Nonsocial Concepts","volume":"28","author":"Pobric","year":"2016","journal-title":"J. Cogn. Neurosci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneuroling.2014.11.003","article-title":"Preservation of Lexical-Semantic Knowledge of Adjectives in the Semantic Variant of Primary Progressive Aphasia: Implications for Theoretical Models of Semantic Memory","volume":"34","author":"Macoir","year":"2015","journal-title":"J. Neurolinguistics"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1093\/arclin\/acab022","article-title":"Exploring Abstract Semantic Associations in the Frontotemporal Dementia Spectrum in a Dutch Population","volume":"37","author":"Poos","year":"2022","journal-title":"Arch. Clin. Neuropsychol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1037\/0894-4105.20.4.482","article-title":"Partial Knowledge of Abstract Words in Patients with Cortical Degenerative Conditions","volume":"20","author":"Crutch","year":"2006","journal-title":"Neuropsychology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1037\/a0029326","article-title":"Grief and Joy: Emotion Word Comprehension in the Dementias","volume":"26","author":"Hsieh","year":"2012","journal-title":"Neuropsychology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/geronj\/42.3.318","article-title":"Free Recall and Word Finding Ability in Normal Aging and Senile Dementia of the Alzheimer\u2019s Type: The Effect of Item Concreteness","volume":"42","author":"Rissenberg","year":"1987","journal-title":"J. Gerontol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S0028-3932(97)00046-8","article-title":"Automatic Semantic Priming of Nouns and Verbs in Patients with Alzheimer\u2019s Disease","volume":"35","author":"Bushell","year":"1997","journal-title":"Neuropsychologia"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1016\/j.neuropsychologia.2009.07.002","article-title":"Impaired Semantic Knowledge Underlies the Reduced Verbal Short-Term Storage Capacity in Alzheimer\u2019s Disease","volume":"47","author":"Peters","year":"2009","journal-title":"Neuropsychologia"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.cortex.2015.05.020","article-title":"An Exploration of the Semantic Network in Alzheimer\u2019s Disease: Influence of Emotion and Concreteness of Concepts","volume":"69","author":"Giffard","year":"2015","journal-title":"Cortex"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0093-934X(83)90059-7","article-title":"Word Production and Comprehension in Alzheimer\u2019s Disease: The Breakdown of Semantic Knowledge","volume":"19","author":"Martin","year":"1983","journal-title":"Brain Lang."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1177\/153331750301800604","article-title":"Memory for Emotional Stimuli in Patients with Alzheimer\u2019s Disease","volume":"18","author":"Fleming","year":"2003","journal-title":"Am. J. Alzheimer\u2019s Dis. Other Dement."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1006\/brcg.2001.1427","article-title":"Distinct Neurolinguistic Symptom Clusters in Alzheimer\u2019s Type Dementia and Primary Progressive Aphasia","volume":"48","author":"Westbury","year":"2002","journal-title":"Brain Cogn."},{"key":"ref_66","first-page":"47","article-title":"How to Assess Abstract Conceptual Knowledge: Construction, Standardization and Validation of a New Battery of Semantic Memory Tests","volume":"29","author":"Vinson","year":"2014","journal-title":"Funct. Neurol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1073\/pnas.0907307107","article-title":"Coherent Concepts Are Computed in the Anterior Temporal Lobes","volume":"107","author":"Sage","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/nrn2277","article-title":"Where Do You Know What You Know? The Representation of Semantic Knowledge in the Human Brain","volume":"8","author":"Patterson","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1080\/02643299308253469","article-title":"Deep Dyslexia: A Case Study of Connectionist Neuropsychology","volume":"10","author":"Plaut","year":"1993","journal-title":"Cogn. Neuropsychol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1093\/cercor\/bhq019","article-title":"The Ventral and Inferolateral Aspects of the Anterior Temporal Lobe Are Crucial in Semantic Memory: Evidence from a Novel Direct Comparison of Distortion-Corrected FMRI, RTMS, and Semantic Dementia","volume":"20","author":"Binney","year":"2010","journal-title":"Cereb. Cortex"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1162\/jocn_a_00244","article-title":"Both the Middle Temporal Gyrus and the Ventral Anterior Temporal Area Are Crucial for Multimodal Semantic Processing: Distortion-Corrected FMRI Evidence for a Double Gradient of Information Convergence in the Temporal Lobes","volume":"24","author":"Visser","year":"2012","journal-title":"J. Cogn. Neurosci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/ana.10825","article-title":"Cognition and Anatomy in Three Variants of Primary Progressive Aphasia","volume":"55","author":"Dronkers","year":"2004","journal-title":"Ann. Neurol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1162\/jocn_a_00908","article-title":"Semantics of the Visual Environment Encoded in Parahippocampal Cortex","volume":"28","author":"Bonner","year":"2016","journal-title":"J. Cogn. Neurosci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1002\/hbm.20950","article-title":"Neural Representation of Abstract and Concrete Concepts: A Meta-Analysis of Neuroimaging Studies","volume":"31","author":"Wang","year":"2010","journal-title":"Hum. Brain Mapp."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.neuropsychologia.2013.11.024","article-title":"When the Zebra Loses Its Stripes but Is Still in the Savannah: Results from a Semantic Priming Paradigm in Semantic Dementia","volume":"53","author":"Merck","year":"2014","journal-title":"Neuropsychologia"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1080\/02643290244000301","article-title":"Semantic Dementia with Category Specificity: Acomparative Case-Series Study","volume":"20","author":"Patterson","year":"2003","journal-title":"Cogn. Neuropsychol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1037\/0096-3445.120.4.339","article-title":"A Computational Model of Semantic Memory Impairment: Modality Specificity and Emergent Category Specificity","volume":"120","author":"Farah","year":"1991","journal-title":"J. Exp. Psychol. Gen."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.cortex.2014.09.001","article-title":"Differing Contributions of Inferior Prefrontal and Anterior Temporal Cortex to Concrete and Abstract Conceptual Knowledge","volume":"63","author":"Hoffman","year":"2015","journal-title":"Cortex"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/brain\/awn343","article-title":"Social Conceptual Impairments in Frontotemporal Lobar Degeneration with Right Anterior Temporal Hypometabolism","volume":"132","author":"Zahn","year":"2009","journal-title":"Brain"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.neurobiolaging.2007.05.014","article-title":"Atrophy Progression in Semantic Dementia with Asymmetric Temporal Involvement: A Tensor-Based Morphometry Study","volume":"30","author":"Brambati","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1093\/brain\/awv387","article-title":"On the Right Side? A Longitudinal Study of Left-versus Right-Lateralized Semantic Dementia","volume":"139","author":"Kumfor","year":"2016","journal-title":"Brain"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1016\/j.neuropsychologia.2008.02.019","article-title":"Longitudinal Studies of Semantic Dementia: The Relationship between Structural and Functional Changes over Time","volume":"46","author":"Bright","year":"2008","journal-title":"Neuropsychologia"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1093\/brain\/aws282","article-title":"The Degraded Concept Representation System in Semantic Dementia: Damage to Pan-Modal Hub, Then Visual Spoke","volume":"135","author":"Hoffman","year":"2012","journal-title":"Brain"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/hbm.10117","article-title":"Neural Representation of Verb Meaning: An FMRI Study","volume":"15","author":"Grossman","year":"2002","journal-title":"Hum. Brain Mapp."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1162\/jocn.2010.21414","article-title":"Neural Correlates of Abstract Verb Processing","volume":"23","author":"Gennari","year":"2011","journal-title":"J. Cogn. Neurosci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1007\/s00415-014-7314-y","article-title":"Action Verb Comprehension in Amyotrophic Lateral Sclerosis and Parkinson\u2019s Disease","volume":"261","author":"York","year":"2014","journal-title":"J. Neurol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.1093\/brain\/awaa313","article-title":"When Affect Overlaps with Concept: Emotion Recognition in Semantic Variant of Primary Progressive Aphasia","volume":"143","author":"Bertoux","year":"2020","journal-title":"Brain"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"20170122","DOI":"10.1098\/rstb.2017.0122","article-title":"The Multifaceted Abstract Brain","volume":"373","author":"Desai","year":"2018","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3389\/fpsyg.2014.00360","article-title":"Clustering, Hierarchical Organization, and the Topography of Abstract and Concrete Nouns","volume":"5","author":"Troche","year":"2014","journal-title":"Front. Psychol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"104173","DOI":"10.1016\/j.jml.2020.104173","article-title":"Sensorimotor and Interoceptive Dimensions in Concrete and Abstract Concepts","volume":"116","author":"Villani","year":"2021","journal-title":"J. Mem. Lang."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2307\/4149007","article-title":"The Distinctiveness of Emotion Concepts: A Comparison between Emotion, Abstract, and Concrete Words","volume":"117","author":"Altarriba","year":"2004","journal-title":"Am. J. Psychol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"578","DOI":"10.3758\/BF03200738","article-title":"Concreteness, Context Availability, and Imageability Ratings and Word Associations for Abstract, Concrete, and Emotion Words","volume":"31","author":"Altarriba","year":"1999","journal-title":"Behav. Res. Methods Instrum. 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