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The aetiology of DCD is believed to involve brain changes and environmental factors, with genetics also playing a role in its pathogenesis. Recent research has identified several candidate genes and genetic factors associated with motor impairment, including deletions, copy number variations, single nucleotide polymorphisms, and epigenetic modifications. This review provides an overview of the current knowledge in genetic research on DCD, highlighting the importance of continued research into the underlying genetic mechanisms. While evidence suggests a genetic contribution to DCD, the evidence is still in its early stages, and much of the current evidence is based on studies of co-occurring conditions. Further research to better understand the genetic basis of DCD could have important implications for diagnosis, treatment, and our understanding of the condition\u2019s aetiology.<\/jats:p>","DOI":"10.3390\/brainsci13060940","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T03:02:27Z","timestamp":1686538947000},"page":"940","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Advances in Genetics and Epigenetics of Developmental Coordination Disorder in Children"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9378-8033","authenticated-orcid":false,"given":"Haizhen","family":"You","sequence":"first","affiliation":[{"name":"Department of Women and Children\u2019s Health Care, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyao","family":"Shi","sequence":"additional","affiliation":[{"name":"Women and Children Health Care Institution of Pudong District, Shanghai 200021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Women and Children\u2019s Health Care, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyun","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Women and Children\u2019s Health Care, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Jones","sequence":"additional","affiliation":[{"name":"NTU Psychology, School of Social Sciences, Nottingham Trent University, Nottingham NG1 6AA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5115-7214","authenticated-orcid":false,"given":"Wenchong","family":"Du","sequence":"additional","affiliation":[{"name":"NTU Psychology, School of Social Sciences, Nottingham Trent University, Nottingham NG1 6AA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Women and Children\u2019s Health Care, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013). 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