{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:18:31Z","timestamp":1760149111916,"version":"build-2065373602"},"reference-count":10,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PRIN","award":["20178S4EK9"],"award-info":[{"award-number":["20178S4EK9"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>COVID-19 survivors have been reported to be at risk of long-term neuropsychiatric sequalae; however, prospective evidence in this regard is lacking. We prospectively assessed the occurrence of mental-health-domain-related symptoms over a 24-month period following COVID-19 onset in a cohort of 230 patients. Of them, 36.1% were still presenting with at least one symptom 24 months later. Across the study period, a significant reduction in overall symptoms from the onset was observed (p &lt; 0.001); however, symptom prevalence was unchanged between the 12- and 24-month follow-ups across most symptomatic domains. At the 24-month follow-up, mental-health-domain-related symptoms only were higher than at the onset and were the most frequently reported symptoms. Dyspnea at the onset predicted both symptoms of psychiatric disorders (OR = 3.26, 95% CI = 1.22\u20138.70, and p = 0.019) and a lack of concentration and focus (OR = 3.17, 95% CI = 1.40\u20137.16, and p = 0.005) 24 months post-infection, with the number of comorbidities at the onset also predicting the occurrence of a lack of concentration and focus (OR = 1.52, 95% CI = 1.12\u20132.08, and p = 0.008). The findings of this study may have important public health implications, as they underlie the fact that COVID-19 survivors are still in need of neuropsychiatric support two years after infection.<\/jats:p>","DOI":"10.3390\/brainsci13071034","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T01:41:36Z","timestamp":1688694096000},"page":"1034","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["COVID-19 Survivors Are Still in Need of Neuropsychiatric Support Two Years after Infection"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6139-1920","authenticated-orcid":false,"given":"Marco","family":"Colizzi","sequence":"first","affiliation":[{"name":"Unit of Psychiatry, Department of Medicine (DAME), University of Udine, 33100 Udine, Italy"},{"name":"Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, London SE5 8AF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4640-679X","authenticated-orcid":false,"given":"Maddalena","family":"Peghin","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division, Department of Medicine (DAME), University of Udine, and Friuli Centrale University Health Service (ASUFC), 33100 Udine, Italy"},{"name":"Infectious and Tropical Diseases Unit, Department of Medicine and Surgery, University of Insubria-ASST-Sette Laghi, 21110 Varese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0445-9578","authenticated-orcid":false,"given":"Maria","family":"De Martino","sequence":"additional","affiliation":[{"name":"Division of Medical Statistic, Department of Medicine (DAME), University of Udine, 33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Bontempo","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division, Department of Medicine (DAME), University of Udine, and Friuli Centrale University Health Service (ASUFC), 33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4829-1831","authenticated-orcid":false,"given":"Stefania","family":"Chiappinotto","sequence":"additional","affiliation":[{"name":"Department of Medicine (DAME), School of Nursing, University of Udine, 33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3818-9676","authenticated-orcid":false,"given":"Federico","family":"Fonda","sequence":"additional","affiliation":[{"name":"Department of Medicine (DAME), School of Nursing, University of Udine, 33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6391-1720","authenticated-orcid":false,"given":"Miriam","family":"Isola","sequence":"additional","affiliation":[{"name":"Division of Medical Statistic, Department of Medicine (DAME), University of Udine, 33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Tascini","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division, Department of Medicine (DAME), University of Udine, and Friuli Centrale University Health Service (ASUFC), 33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Balestrieri","sequence":"additional","affiliation":[{"name":"Unit of Psychiatry, Department of Medicine (DAME), University of Udine, 33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3508-844X","authenticated-orcid":false,"given":"Alvisa","family":"Palese","sequence":"additional","affiliation":[{"name":"Department of Medicine (DAME), School of Nursing, University of Udine, 33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1017\/S0033291721000015","article-title":"The psychological impact of COVID-19 pandemic lockdowns: A review and meta-analysis of longitudinal studies and natural experiments","volume":"51","author":"Prati","year":"2021","journal-title":"Psychol. 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