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Unfortunately, there is as yet no cure for such a disease. Understanding the underlying mechanisms and the potential therapeutic strategies may help to delay the progression of OPG and rescue the visual morbidities. Here, we provide an overview of preclinical OPG studies and the regulatory pathways controlling OPG pathophysiology. We next discuss the role of microenvironmental cells (neurons, T cells, and tumor-associated microglia and macrophages) in OPG development. Last, we provide insight into potential therapeutic strategies for treating OPG and promoting axon regeneration.<\/jats:p>","DOI":"10.3390\/brainsci13101424","type":"journal-article","created":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T14:03:03Z","timestamp":1696687383000},"page":"1424","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Neuroimmune Regulation and Potential Therapeutic Strategies of Optic Pathway Glioma"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1552-3686","authenticated-orcid":false,"given":"Khushboo","family":"Irshad","sequence":"first","affiliation":[{"name":"Department of Symptom Research, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4606-075X","authenticated-orcid":false,"given":"Yu-Kai","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan"},{"name":"Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4850-2889","authenticated-orcid":false,"given":"Paul","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Louis J. 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