{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:07:23Z","timestamp":1793106443437,"version":"4.5.0"},"reference-count":67,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PNRR Project","award":["H23C22000370006-T4Y S5G4PP1"],"award-info":[{"award-number":["H23C22000370006-T4Y S5G4PP1"]}]},{"name":"PNRR Project","award":["RED2022-134577-T"],"award-info":[{"award-number":["RED2022-134577-T"]}]},{"name":"MCIN\/AEI\/10.13039\/501100011033","award":["H23C22000370006-T4Y S5G4PP1"],"award-info":[{"award-number":["H23C22000370006-T4Y S5G4PP1"]}]},{"name":"MCIN\/AEI\/10.13039\/501100011033","award":["RED2022-134577-T"],"award-info":[{"award-number":["RED2022-134577-T"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>\u03b2-carotene is a powerful antioxidant and dietary precursor of vitamin A whose role in maintaining mental health and cognitive performance, either alone or in combination with other dietary compounds, has been a topic of recent research. However, its effectiveness is still unclear. This systematic review, conducted according to the PRISMA guideline and assisted by the MySLR platform, addressed this issue. A total of 16 eligible original research articles were identified. Dietary intake or \u03b2-carotene serum levels were associated with improved measures of cognitive function in 7 out of 10 epidemiological studies included. In intervention studies, \u03b2-carotene consumption alone did not promote better cognitive function in the short term, but only in a long-term intervention with a mean duration of 18 years. However, all but one intervention study suggested the beneficial effects of \u03b2-carotene supplementation at doses ranging from 6 mg to 50 mg per day in combination with a multicomplex such as vitamin E, vitamin C, zinc, or selenium for a period of 16 weeks to 20 years. Despite the current limitations, the available evidence suggests a potential association between \u03b2-carotene dietary\/supplementary intake and the maintenance of cognitive function. The \u03b2-carotene most probably does not act alone but in synergy with other micronutrients.<\/jats:p>","DOI":"10.3390\/brainsci13101468","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T10:43:10Z","timestamp":1697539390000},"page":"1468","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["The Effect of Beta-Carotene on Cognitive Function: A Systematic Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5161-057X","authenticated-orcid":false,"given":"Diana Marisol","family":"Abrego-Guandique","sequence":"first","affiliation":[{"name":"Department of Health Sciences, University of Magna Graecia Catanzaro, 88100 Catanzaro, Italy"},{"name":"Galascreen Laboratories, University of Calabria, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8698-0630","authenticated-orcid":false,"given":"Maria Luisa","family":"Bonet","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Nutrition, and Biotechnology (LBNB), Universitat de les Illes Balears, 07122 Palma, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Illes Balears (IdISBa), 07120 Palma, Spain"},{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn), 07122 Palma, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Caroleo","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Magna Graecia Catanzaro, 88100 Catanzaro, Italy"},{"name":"Galascreen Laboratories, University of Calabria, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1668-7690","authenticated-orcid":false,"given":"Roberto","family":"Cannataro","sequence":"additional","affiliation":[{"name":"Galascreen Laboratories, University of Calabria, 87036 Rende, Italy"},{"name":"Research Division, Dynamical Business & Science Society, DBSS International SAS, Bogota 110311, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9349-5203","authenticated-orcid":false,"given":"Paola","family":"Tucci","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4460-9371","authenticated-orcid":false,"given":"Joan","family":"Ribot","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Nutrition, and Biotechnology (LBNB), Universitat de les Illes Balears, 07122 Palma, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Illes Balears (IdISBa), 07120 Palma, Spain"},{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn), 07122 Palma, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0562-0597","authenticated-orcid":false,"given":"Erika","family":"Cione","sequence":"additional","affiliation":[{"name":"Galascreen Laboratories, University of Calabria, 87036 Rende, Italy"},{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"ref_1","first-page":"22","article-title":"Encyclopedia of Quality of Life and Well-being Research","volume":"29","author":"Robinson","year":"2015","journal-title":"Ref. 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