{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T21:17:58Z","timestamp":1793654278662,"version":"4.5.1"},"reference-count":198,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Reelin is an extracellular matrix glycoprotein involved in neuronal migration during embryonic brain development and synaptic plasticity in the adult brain. The role of Reelin in the developing central nervous system has been extensively characterized. Indeed, a loss of Reelin or a disruption in its signaling cascade leads to neurodevelopmental defects and is associated with ataxia, intellectual disability, autism, and several psychiatric disorders. In the adult brain, Reelin is critically involved in neurogenesis and synaptic plasticity. Reelin\u2019s signaling potentiates glutamatergic and GABAergic neurotransmission, induces synaptic maturation, and increases AMPA and NMDA receptor subunits\u2019 expression and activity. As a result, there is a growing literature reporting that a loss of function and\/or reduction of Reelin is implicated in numerous neurodegenerative diseases. The present review summarizes the current state of the literature regarding the implication of Reelin and Reelin-mediated signaling during aging and neurodegenerative disorders, highlighting Reelin as a possible target in the prevention or treatment of progressive neurodegeneration.<\/jats:p>","DOI":"10.3390\/brainsci13101479","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T02:54:43Z","timestamp":1697684083000},"page":"1479","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Reelin Signaling in Neurodevelopmental Disorders and Neurodegenerative Diseases"],"prefix":"10.3390","volume":"13","author":[{"given":"Aurelie","family":"Joly-Amado","sequence":"first","affiliation":[{"name":"Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neel","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin R.","family":"Nash","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/BF02996215","article-title":"Two new mutants, \u2018trembler\u2019 and \u2018reeler\u2019, with neurological actions in the house mouse (Mus musculus L.)","volume":"50","author":"Falconer","year":"1951","journal-title":"J. Genet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0012-1606(63)90040-X","article-title":"Analysis of the Postnatal Developmental Effects of \u201cReeler,\u201d a Neurological Mutation in Mice. A Study in Developmental Genetics","volume":"8","author":"Hamburgh","year":"1963","journal-title":"Dev. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/374719a0","article-title":"A protein related to extracellular matrix proteins deleted in the mouse mutant reeler","volume":"374","author":"Miao","year":"1995","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1006\/geno.1997.4983","article-title":"Genomic organization of the mouse reelin gene","volume":"46","author":"Royaux","year":"1997","journal-title":"Genomics"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1523\/JNEUROSCI.3408-03.2004","article-title":"The central fragment of Reelin, generated by proteolytic processing in vivo, is critical to its function during cortical plate development","volume":"24","author":"Jossin","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"12922","DOI":"10.1074\/jbc.M113.536326","article-title":"Cleavage within Reelin repeat 3 regulates the duration and range of the signaling activity of Reelin protein","volume":"289","author":"Koie","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Krstic, D., Rodriguez, M., and Knuesel, I. (2012). Regulated proteolytic processing of Reelin through interplay of tissue plasminogen activator (tPA), ADAMTS-4, ADAMTS-5, and their modulators. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0047793"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.neuroscience.2014.05.046","article-title":"Extracellular proteolysis of reelin by tissue plasminogen activator following synaptic potentiation","volume":"274","author":"Trotter","year":"2014","journal-title":"Neuroscience"},{"key":"ref_9","first-page":"305","article-title":"Determination of cleavage site of Reelin between its sixth and seventh repeat and contribution of meprin metalloproteases to the cleavage","volume":"159","author":"Sato","year":"2016","journal-title":"J. Biochem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"103401","DOI":"10.1016\/j.mcn.2019.103401","article-title":"A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum","volume":"100","author":"Yamakage","year":"2019","journal-title":"Mol. Cell Neurosci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1523\/JNEUROSCI.3632-16.2017","article-title":"Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin","volume":"37","author":"Ogino","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1074\/jbc.M106996200","article-title":"Reelin is a serine protease of the extracellular matrix","volume":"277","author":"Quattrocchi","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1248\/bpb.33.1047","article-title":"Re-evaluation of protease activity of reelin","volume":"33","author":"Kohno","year":"2010","journal-title":"Biol. Pharm. Bull."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/jb\/mvab015","article-title":"Regulation of Reelin functions by specific proteolytic processing in the brain","volume":"169","author":"Hattori","year":"2021","journal-title":"J. Biochem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1073\/pnas.95.6.3221","article-title":"Reelin is preferentially expressed in neurons synthesizing gamma-aminobutyric acid in cortex and hippocampus of adult rats","volume":"95","author":"Pesold","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.arr.2013.01.005","article-title":"Reelin signaling in development, maintenance, and plasticity of neural networks","volume":"12","author":"Stranahan","year":"2013","journal-title":"Ageing Res. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/nrn2009","article-title":"Reelin, lipoprotein receptors and synaptic plasticity","volume":"7","author":"Herz","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/cne.23691","article-title":"Reelin receptors ApoER2 and VLDLR are expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex","volume":"523","author":"Hirota","year":"2015","journal-title":"J. Comp. Neurol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Jossin, Y. (2020). Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Development and Maturation. Biomolecules, 10.","DOI":"10.3390\/biom10060964"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"7113","DOI":"10.1128\/MCB.00928-07","article-title":"Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth","volume":"27","author":"Jossin","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s00204-012-0801-y","article-title":"Reversible aberration of neurogenesis targeting late-stage progenitor cells in the hippocampal dentate gyrus of rat offspring after maternal exposure to acrylamide","volume":"86","author":"Ogawa","year":"2012","journal-title":"Arch. Toxicol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.tins.2010.06.001","article-title":"Role for Reelin in stabilizing cortical architecture","volume":"33","author":"Frotscher","year":"2010","journal-title":"Trends Neurosci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"7779","DOI":"10.1523\/JNEUROSCI.18-19-07779.1998","article-title":"Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouse","volume":"18","author":"Alcantara","year":"1998","journal-title":"J. Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0896-6273(00)80861-2","article-title":"Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation","volume":"24","author":"Hiesberger","year":"1999","journal-title":"Neuron"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"49958","DOI":"10.1074\/jbc.M209205200","article-title":"Reelin-mediated signaling locally regulates protein kinase B\/Akt and glycogen synthase kinase 3beta","volume":"277","author":"Beffert","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0092-8674(00)80782-5","article-title":"Reeler\/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2","volume":"97","author":"Trommsdorff","year":"1999","journal-title":"Cell"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"39944","DOI":"10.1074\/jbc.M205147200","article-title":"Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning","volume":"277","author":"Weeber","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1590\/S0100-879X2002001200007","article-title":"The role of reelin in the development and evolution of the cerebral cortex","volume":"35","author":"Tissir","year":"2002","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.bbr.2013.05.024","article-title":"Neurobehavioral performances and brain regional metabolism in Dab1(scm) (scrambler) mutant mice","volume":"252","author":"Jacquelin","year":"2013","journal-title":"Behav. Brain Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/39607","article-title":"Neuronal position in the developing brain is regulated by mouse disabled-1","volume":"389","author":"Howell","year":"1997","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/39601","article-title":"Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice","volume":"389","author":"Sheldon","year":"1997","journal-title":"Nature"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"112669","DOI":"10.1016\/j.celrep.2023.112669","article-title":"Reelin through the years: From brain development to inflammation","volume":"42","author":"Alexander","year":"2023","journal-title":"Cell Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1128\/MCB.24.3.1378-1386.2004","article-title":"Receptor clustering is involved in Reelin signaling","volume":"24","author":"Strasser","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0896-6273(00)80860-0","article-title":"Reelin is a ligand for lipoprotein receptors","volume":"24","author":"Homayouni","year":"1999","journal-title":"Neuron"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1101\/gad.13.6.643","article-title":"Reelin-induced tyrosine [corrected] phosphorylation of disabled 1 during neuronal positioning","volume":"13","author":"Howell","year":"1999","journal-title":"Genes. Dev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0960-9822(00)00608-4","article-title":"Dab1 tyrosine phosphorylation sites relay positional signals during mouse brain development","volume":"10","author":"Howell","year":"2000","journal-title":"Curr. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"9953","DOI":"10.1523\/JNEUROSCI.23-30-09953.2003","article-title":"Inhibition of SRC family kinases and non-classical protein kinases C induce a reeler-like malformation of cortical plate development","volume":"23","author":"Jossin","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0169-328X(03)00295-X","article-title":"Tyrosine phosphorylation of Disabled-1 is essential for Reelin-stimulated activation of Akt and Src family kinases","volume":"117","author":"Ballif","year":"2003","journal-title":"Mol. Brain Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0960-9822(02)01397-0","article-title":"Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development","volume":"13","author":"Arnaud","year":"2003","journal-title":"Curr. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"38772","DOI":"10.1074\/jbc.M306416200","article-title":"Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination","volume":"278","author":"Bock","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"20307","DOI":"10.1074\/jbc.M114.576249","article-title":"Reelin induces Erk1\/2 signaling in cortical neurons through a non-canonical pathway","volume":"289","author":"Lee","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s12565-008-0009-7","article-title":"Histological study in the brain of the reelin\/Dab1-compound mutant mouse","volume":"84","author":"Yamamoto","year":"2009","journal-title":"Anat. Sci. Int."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1096\/fj.02-0434fje","article-title":"Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor\/disabled-1\/glycogen synthase kinase-3beta cascade","volume":"17","author":"Ohkubo","year":"2003","journal-title":"FASEB J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1073\/pnas.051628498","article-title":"Synergistic contributions of cyclin-dependant kinase 5\/p35 and Reelin\/Dab1 to the positioning of cortical neurons in the developing mouse brain","volume":"98","author":"Ohshima","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0168-0102(97)00088-6","article-title":"A novel neurological mutant mouse, yotari, which exhibits reeler-like phenotype but expresses CR-50 antigen\/reelin","volume":"29","author":"Yoneshima","year":"1997","journal-title":"Neurosci. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/ng1257","article-title":"Interaction of reelin signaling and Lis1 in brain development","volume":"35","author":"Assadi","year":"2003","journal-title":"Nat. Genet."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e1242455","DOI":"10.1080\/23262133.2016.1242455","article-title":"How does Reelin signaling regulate the neuronal cytoskeleton during migration?","volume":"3","author":"Chai","year":"2016","journal-title":"Neurogenesis"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"841047","DOI":"10.3389\/fnmol.2022.841047","article-title":"LIS1 and NDEL1 Regulate Axonal Trafficking of Mitochondria in Mature Neurons","volume":"15","author":"Pandey","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bbrc.2009.01.039","article-title":"Mechanism and significance of specific proteolytic cleavage of Reelin","volume":"380","author":"Kohno","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"20544","DOI":"10.1074\/jbc.M702300200","article-title":"The extremely conserved C-terminal region of Reelin is not necessary for secretion but is required for efficient activation of downstream signaling","volume":"282","author":"Nakano","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"7625","DOI":"10.1523\/JNEUROSCI.0125-20.2020","article-title":"The Secreted Glycoprotein Reelin Suppresses the Proliferation and Regulates the Distribution of Oligodendrocyte Progenitor Cells in the Embryonic Neocortex","volume":"40","author":"Ogino","year":"2020","journal-title":"J. Neurosci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4471","DOI":"10.1038\/s41598-020-61380-w","article-title":"Physiological significance of proteolytic processing of Reelin revealed by cleavage-resistant Reelin knock-in mice","volume":"10","author":"Okugawa","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1523\/JNEUROSCI.1826-16.2016","article-title":"C-Terminal Region Truncation of RELN Disrupts an Interaction with VLDLR, Causing Abnormal Development of the Cerebral Cortex and Hippocampus","volume":"37","author":"Ha","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4776","DOI":"10.1523\/JNEUROSCI.4119-14.2015","article-title":"Importance of Reelin C-terminal region in the development and maintenance of the postnatal cerebral cortex and its regulation by specific proteolysis","volume":"35","author":"Kohno","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/cercor\/bht209","article-title":"A forward genetic screen in mice identifies mutants with abnormal cortical patterning","volume":"25","author":"Ha","year":"2015","journal-title":"Cereb. Cortex"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"110763","DOI":"10.1016\/j.cellsig.2023.110763","article-title":"Central repeat fragment of reelin leads to active reelin intracellular signaling and rescues cognitive deficits in a mouse model of reelin deficiency","volume":"109","author":"Li","year":"2023","journal-title":"Cell Signal"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1101\/lm.2153511","article-title":"Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density","volume":"18","author":"Rogers","year":"2011","journal-title":"Learn. Mem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"8209","DOI":"10.1523\/JNEUROSCI.1951-05.2005","article-title":"Reelin modulates NMDA receptor activity in cortical neurons","volume":"25","author":"Chen","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.celrep.2017.09.019","article-title":"GRIP1 Binds to ApoER2 and EphrinB2 to Induce Activity-Dependent AMPA Receptor Insertion at the Synapse","volume":"21","author":"Pfennig","year":"2017","journal-title":"Cell Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/B978-0-444-63486-3.00003-7","article-title":"Neural ECM molecules in synaptic plasticity, learning, and memory","volume":"214","author":"Senkov","year":"2014","journal-title":"Prog. Brain Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1152\/jn.00869.2006","article-title":"Reelin signaling facilitates maturation of CA1 glutamatergic synapses","volume":"97","author":"Qiu","year":"2007","journal-title":"J. Neurophysiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"12943","DOI":"10.1523\/JNEUROSCI.2561-06.2006","article-title":"Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus","volume":"26","author":"Qiu","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"4636","DOI":"10.1523\/JNEUROSCI.5284-09.2010","article-title":"Reelin regulates postnatal neurogenesis and enhances spine hypertrophy and long-term potentiation","volume":"30","author":"Pujadas","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.nlm.2005.11.001","article-title":"Cognitive disruption and altered hippocampus synaptic function in Reelin haploinsufficient mice","volume":"85","author":"Qiu","year":"2006","journal-title":"Neurobiol. Learn. Mem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1177\/0269881112463468","article-title":"Reelin supplementation recovers sensorimotor gating, synaptic plasticity and associative learning deficits in the heterozygous reeler mouse","volume":"27","author":"Rogers","year":"2013","journal-title":"J. Psychopharmacol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"10339","DOI":"10.1523\/JNEUROSCI.1917-08.2008","article-title":"The Reelin signaling pathway promotes dendritic spine development in hippocampal neurons","volume":"28","author":"Niu","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0896-6273(03)00819-5","article-title":"Reelin promotes hippocampal dendrite development through the VLDLR\/ApoER2-Dab1 pathway","volume":"41","author":"Niu","year":"2004","journal-title":"Neuron"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3233\/JAD-151193","article-title":"Reelin in Alzheimer\u2019s Disease, Increased Levels but Impaired Signaling: When More is Less","volume":"52","author":"Balmaceda","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.biopsych.2004.12.018","article-title":"Reelin signaling is impaired in autism","volume":"57","author":"Fatemi","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neuropharm.2012.08.015","article-title":"The involvement of Reelin in neurodevelopmental disorders","volume":"68","author":"Folsom","year":"2013","journal-title":"Neuropharmacology"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3389\/fncel.2016.00229","article-title":"Reelin and Neuropsychiatric Disorders","volume":"10","author":"Ishii","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/79246","article-title":"Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations","volume":"26","author":"Hong","year":"2000","journal-title":"Nat. Genet."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.neurobiolaging.2007.08.011","article-title":"Age-related accumulation of Reelin in amyloid-like deposits","volume":"30","author":"Knuesel","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/cercor\/bhq106","article-title":"Cognitive decline is associated with reduced reelin expression in the entorhinal cortex of aged rats","volume":"21","author":"Stranahan","year":"2011","journal-title":"Cereb. Cortex"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.neurobiolaging.2019.12.010","article-title":"Reelin in the Years: Decline in the number of reelin immunoreactive neurons in layer II of the entorhinal cortex in aged monkeys with memory impairment","volume":"87","author":"Long","year":"2020","journal-title":"Neurobiol. Aging"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.3233\/JAD-2010-1333","article-title":"Co-localization of Reelin and proteolytic AbetaPP fragments in hippocampal plaques in aged wild-type mice","volume":"19","author":"Doehner","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1111\/j.1460-9568.2009.06884.x","article-title":"Accumulation of reelin-positive plaques is accompanied by a decline in basal forebrain projection neurons during normal aging","volume":"30","author":"Madhusudan","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/WCO.0000000000000227","article-title":"Primary and secondary ataxias","volume":"28","author":"Teive","year":"2015","journal-title":"Curr. Opin. Neurol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.aanat.2016.01.010","article-title":"Cell death and neurodegeneration in the postnatal development of cerebellar vermis in normal and Reeler mice","volume":"207","author":"Castagna","year":"2016","journal-title":"Ann. Anat."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0165-3806(85)90254-8","article-title":"Observations on Golgi epithelial cells and granule cells in the cerebellum of the reeler mutant mouse","volume":"350","author":"Terashima","year":"1985","journal-title":"Brain Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0896-6273(02)00582-2","article-title":"Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice","volume":"33","author":"Magdaleno","year":"2002","journal-title":"Neuron"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neures.2023.03.004","article-title":"Postnatal injection of Reelin protein into the cerebellum ameliorates the motor functions in reeler mouse","volume":"194","author":"Ishii","year":"2023","journal-title":"Neurosci. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10048-018-0557-5","article-title":"Ataxia telangiectasia alters the ApoB and reelin pathway","volume":"19","author":"Schubert","year":"2018","journal-title":"Neurogenetics"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1126\/science.7792600","article-title":"A single ataxia telangiectasia gene with a product similar to PI-3 kinase","volume":"268","author":"Savitsky","year":"1995","journal-title":"Science"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1126\/science.280.5366.1089","article-title":"Requirement for Atm in Ionizing Radiation-Induced Cell Death in the Developing Central Nervous System","volume":"280","author":"Herzog","year":"1998","journal-title":"Science"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1126\/science.1140321","article-title":"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage","volume":"316","author":"Matsuoka","year":"2007","journal-title":"Science"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00415-018-9076-4","article-title":"Spinocerebellar ataxia: An update","volume":"266","author":"Sullivan","year":"2019","journal-title":"J. Neurol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"21319","DOI":"10.1073\/pnas.1218331110","article-title":"Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes","volume":"109","author":"McCullough","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1093\/brain\/awy137","article-title":"Clinical, genetic and neuropathological characterization of spinocerebellar ataxia type 37","volume":"141","author":"Ispierto","year":"2018","journal-title":"Brain"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ajhg.2017.06.007","article-title":"A Pentanucleotide ATTTC Repeat Insertion in the Non-coding Region of DAB1, Mapping to SCA37, Causes Spinocerebellar Ataxia","volume":"101","author":"Seixas","year":"2017","journal-title":"Am. J. Hum. Genet."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/humu.23704","article-title":"Mutational mechanism for DAB1 (ATTTC)(n) insertion in SCA37: ATTTT repeat lengthening and nucleotide substitution","volume":"40","author":"Loureiro","year":"2019","journal-title":"Hum. Mutat."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1750-1326-9-48","article-title":"Oligomeric Abeta-induced synaptic dysfunction in Alzheimer\u2019s disease","volume":"9","author":"Tu","year":"2014","journal-title":"Mol. Neurodegener."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.bbr.2008.02.016","article-title":"Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior","volume":"192","author":"Selkoe","year":"2008","journal-title":"Behav. Brain Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neurobiolaging.2022.07.009","article-title":"Whole genome analysis in APOE4 homozygotes identifies the DAB1-RELN pathway in Alzheimer\u2019s disease pathogenesis","volume":"119","author":"Leonenko","year":"2022","journal-title":"Neurobiol. Aging"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"7459","DOI":"10.1523\/JNEUROSCI.4872-08.2009","article-title":"Interaction of reelin with amyloid precursor protein promotes neurite outgrowth","volume":"29","author":"Hoe","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1523\/JNEUROSCI.3758-06.2007","article-title":"Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer\u2019s disease","volume":"27","author":"Chin","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"963","DOI":"10.3233\/JAD-2012-112069","article-title":"Reelin depletion is an early phenomenon of Alzheimer\u2019s pathology","volume":"30","author":"Herring","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"9228","DOI":"10.1523\/JNEUROSCI.0418-10.2010","article-title":"Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer\u2019s disease mice","volume":"30","author":"Kocherhans","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"5692","DOI":"10.1007\/s12035-015-9459-9","article-title":"The Role of Reelin Signaling in Alzheimer\u2019s Disease","volume":"53","author":"Yu","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"5573","DOI":"10.1073\/pnas.0601279103","article-title":"Reelin expression and glycosylation patterns are altered in Alzheimer\u2019s disease","volume":"103","author":"Burgaya","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Lidon, L., Urrea, L., Llorens, F., Gil, V., Alvarez, I., Diez-Fairen, M., Aguilar, M., Pastor, P., Zerr, I., and Alcolea, D. (2020). Disease-Specific Changes in Reelin Protein and mRNA in Neurodegenerative Diseases. Cells, 9.","DOI":"10.3390\/cells9051252"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/jnr.10554","article-title":"Altered levels of cerebrospinal fluid reelin in frontotemporal dementia and Alzheimer\u2019s disease","volume":"72","author":"Costell","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.nbd.2009.12.006","article-title":"Beta-amyloid controls altered Reelin expression and processing in Alzheimer\u2019s disease","volume":"37","author":"Cotrufo","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"31646","DOI":"10.1038\/srep31646","article-title":"The beta-amyloid peptide compromises Reelin signaling in Alzheimer\u2019s disease","volume":"6","author":"Balmaceda","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1038\/ncomms4443","article-title":"Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer\u2019s disease","volume":"5","author":"Pujadas","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1177\/07482337221150859","article-title":"Effect of the Reelin-Dab1 signaling pathway on the abnormal metabolism of Abeta protein induced by aluminum","volume":"39","author":"Liu","year":"2023","journal-title":"Toxicol. Ind. Health"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Ramsden, C.E., Zamora, D., Horowitz, M., Jahanipour, J., Keyes, G., Li, X., Murray, H.C., Curtis, M.A., Faull, R.M., and Sedlock, A. (2023). ApoER2-Dab1 disruption as the origin of pTau-related neurodegeneration in sporadic Alzheimer\u2019s disease. Res. Sq., preprint.","DOI":"10.21203\/rs.3.rs-2968020\/v1"},{"key":"ref_108","first-page":"ra67","article-title":"Reelin protects against amyloid beta toxicity in vivo","volume":"8","author":"Philips","year":"2015","journal-title":"Sci. Signal"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12920-018-0453-8","article-title":"Identification of exon skipping events associated with Alzheimer\u2019s disease in the human hippocampus","volume":"12","author":"Han","year":"2019","journal-title":"BMC Med. Genom."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/WAD.0000000000000002","article-title":"Reelin signaling pathway genotypes and Alzheimer disease in a Spanish population","volume":"29","author":"Bufill","year":"2015","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/s41591-023-02318-3","article-title":"Resilience to autosomal dominant Alzheimer\u2019s disease in a Reelin-COLBOS heterozygous man","volume":"29","author":"Lopera","year":"2023","journal-title":"Nat. Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1523\/JNEUROSCI.23-01-00187.2003","article-title":"Genetic modulation of tau phosphorylation in the mouse","volume":"23","author":"Brich","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Cuchillo-Ibanez, I., Balmaceda, V., Botella-Lopez, A., Rabano, A., Avila, J., and Saez-Valero, J. (2013). Beta-amyloid impairs reelin signaling. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0072297"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/s41420-023-01617-5","article-title":"New insight into protein glycosylation in the development of Alzheimer\u2019s disease","volume":"9","author":"Zhao","year":"2023","journal-title":"Cell Death Discov."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Rossi, D., Gruart, A., Contreras-Murillo, G., Muhaisen, A., Avila, J., Delgado-Garcia, J.M., Pujadas, L., and Soriano, E. (2020). Reelin reverts biochemical, physiological and cognitive alterations in mouse models of Tauopathy. Prog. Neurobiol., 186.","DOI":"10.1016\/j.pneurobio.2019.101743"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"113482","DOI":"10.1016\/j.bbr.2021.113482","article-title":"Reelin changes hippocampal learning in aging and Alzheimer\u2019s disease","volume":"414","author":"Marckx","year":"2021","journal-title":"Behav. Brain Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.1523\/JNEUROSCI.21-12-04125.2001","article-title":"Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer\u2019s disease","volume":"21","author":"Dineley","year":"2001","journal-title":"J. Neurosci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.neuron.2010.04.029","article-title":"Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5","volume":"66","author":"Renner","year":"2010","journal-title":"Neuron"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/nature07761","article-title":"Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers","volume":"457","author":"Lauren","year":"2009","journal-title":"Nature"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/nn1503","article-title":"Regulation of NMDA receptor trafficking by amyloid-beta","volume":"8","author":"Snyder","year":"2005","journal-title":"Nat. Neurosci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"5948","DOI":"10.1523\/JNEUROSCI.0157-10.2010","article-title":"Abeta-mediated NMDA receptor endocytosis in Alzheimer\u2019s disease involves ubiquitination of the tyrosine phosphatase STEP61","volume":"30","author":"Kurup","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0896-6273(02)00633-5","article-title":"Tyrosine phosphatase STEP is a tonic brake on induction of long-term potentiation","volume":"34","author":"Pelkey","year":"2002","journal-title":"Neuron"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"24274","DOI":"10.1074\/jbc.M111683200","article-title":"Striatal enriched phosphatase 61 dephosphorylates Fyn at phosphotyrosine 420","volume":"277","author":"Nguyen","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"8136925","DOI":"10.1155\/2016\/8136925","article-title":"Role of Striatal-Enriched Tyrosine Phosphatase in Neuronal Function","volume":"2016","author":"Kamceva","year":"2016","journal-title":"Neural Plast."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.tins.2006.06.007","article-title":"Synaptic plasticity: One STEP at a time","volume":"29","author":"Braithwaite","year":"2006","journal-title":"Trends Neurosci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"15938","DOI":"10.1073\/pnas.0908176106","article-title":"Reelin signaling antagonizes beta-amyloid at the synapse","volume":"106","author":"Durakoglugil","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_127","first-page":"7340","article-title":"Reelin Regulates Neuronal Excitability through Striatal-Enriched Protein Tyrosine Phosphatase (STEP61) and Calcium Permeable AMPARs in an NMDAR-Dependent Manner","volume":"41","author":"Durakoglugil","year":"2021","journal-title":"J. Neurosci."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Xu, J., Chatterjee, M., Baguley, T.D., Brouillette, J., Kurup, P., Ghosh, D., Kanyo, J., Zhang, Y., Seyb, K., and Ononenyi, C. (2014). Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer\u2019s disease. PLoS Biol., 12.","DOI":"10.1371\/journal.pbio.1001923"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nn.2785","article-title":"Abeta(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3beta","volume":"14","author":"Jo","year":"2011","journal-title":"Nat. Neurosci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"12211","DOI":"10.1523\/JNEUROSCI.3321-07.2007","article-title":"Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments","volume":"27","author":"Zhu","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"10639","DOI":"10.1074\/jbc.M806508200","article-title":"{beta}-Amyloid impairs AMPA receptor trafficking and function by reducing Ca2+\/calmodulin-dependent protein kinase II synaptic distribution","volume":"284","author":"Gu","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.neuron.2006.10.035","article-title":"AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss","volume":"52","author":"Hsieh","year":"2006","journal-title":"Neuron"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"11061","DOI":"10.1523\/JNEUROSCI.3034-05.2005","article-title":"Soluble beta-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses","volume":"25","author":"Roselli","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.nbd.2005.02.008","article-title":"Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses","volume":"20","author":"Almeida","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/jnr.22227","article-title":"Decreased levels of PSD95 and two associated proteins and increased levels of BCl2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation of Abeta, and neurodegeneration in a prodromal stage of Alzheimer\u2019s disease","volume":"88","author":"Sultana","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3233\/JAD-2007-11113","article-title":"Alterations in expression of glutamatergic transporters and receptors in sporadic Alzheimer\u2019s disease","volume":"11","author":"Jacob","year":"2007","journal-title":"J. Alzheimers Dis."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.neulet.2015.05.033","article-title":"Extracellular matrix protein reelin regulate dendritic spine density through CaMKIIbeta","volume":"599","author":"Kim","year":"2015","journal-title":"Neurosci. Lett."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s12035-008-8017-0","article-title":"Regulated proteolysis of APP and ApoE receptors","volume":"37","author":"Hoe","year":"2008","journal-title":"Mol. Neurobiol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1194\/jlr.R075507","article-title":"The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease","volume":"58","author":"Herz","year":"2017","journal-title":"J. Lipid Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"24521","DOI":"10.1074\/jbc.M600728200","article-title":"FE65 interaction with the ApoE receptor ApoEr2","volume":"281","author":"Hoe","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"35176","DOI":"10.1074\/jbc.M602162200","article-title":"DAB1 and Reelin effects on amyloid precursor protein and ApoE receptor 2 trafficking and processing","volume":"281","author":"Hoe","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"6288","DOI":"10.1074\/jbc.M704140200","article-title":"Fyn modulation of Dab1 effects on amyloid precursor protein and ApoE receptor 2 processing","volume":"283","author":"Hoe","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"4052","DOI":"10.1523\/JNEUROSCI.3993-06.2007","article-title":"Apolipoprotein receptor 2 and X11 alpha\/beta mediate apolipoprotein E-induced endocytosis of amyloid-beta precursor protein and beta-secretase, leading to amyloid-beta production","volume":"27","author":"He","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1750-1326-7-9","article-title":"FE65 as a link between VLDLR and APP to regulate their trafficking and processing","volume":"7","author":"Dumanis","year":"2012","journal-title":"Mol. Neurodegener."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"42","DOI":"10.5607\/en22044","article-title":"Reelin and APP Cooperatively Modulate Dendritic Spine Formation In Vitro and In Vivo","volume":"32","author":"Lee","year":"2023","journal-title":"Exp. Neurobiol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"12456","DOI":"10.1038\/s41598-017-12334-2","article-title":"Phosphorylation of FE65 at threonine 579 by GSK3beta stimulates amyloid precursor protein processing","volume":"7","author":"Lee","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1096\/fj.09-138123","article-title":"The cytoplasmic adaptor protein X11alpha and extracellular matrix protein Reelin regulate ApoE receptor 2 trafficking and cell movement","volume":"24","author":"Minami","year":"2010","journal-title":"FASEB J."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.tins.2014.08.011","article-title":"Synapse rearrangements upon learning: From divergent-sparse connectivity to dedicated sub-circuits","volume":"37","author":"Caroni","year":"2014","journal-title":"Trends Neurosci."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.cellsig.2012.11.001","article-title":"Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation","volume":"25","author":"Mizuno","year":"2013","journal-title":"Cell Signal"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.1093\/cercor\/bhw216","article-title":"Reelin Regulates the Maturation of Dendritic Spines, Synaptogenesis and Glial Ensheathment of Newborn Granule Cells","volume":"26","author":"Bosch","year":"2016","journal-title":"Cereb. Cortex"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Woo, J.A., Liu, T., Fang, C.C., Cazzaro, S., Kee, T., LePochat, P., Yrigoin, K., Penn, C., Zhao, X., and Wang, X. (2019). Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics. Commun. Biol., 2.","DOI":"10.1038\/s42003-019-0359-9"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1038\/cddis.2015.37","article-title":"RanBP9 at the intersection between cofilin and Abeta pathologies: Rescue of neurodegenerative changes by RanBP9 reduction","volume":"6","author":"Woo","year":"2015","journal-title":"Cell Death Dis."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41537-022-00278-0","article-title":"DNA methylation levels of RELN promoter region in ultra-high risk, first episode and chronic schizophrenia cohorts of schizophrenia","volume":"8","author":"Kho","year":"2022","journal-title":"Schizophrenia"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"03000605221100345","DOI":"10.1177\/03000605221100345","article-title":"Association between CpG island DNA methylation in the promoter region of RELN and positive and negative types of schizophrenia","volume":"50","author":"Zhou","year":"2022","journal-title":"J. Int. Med. Res."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41439-020-00125-7","article-title":"Rare single-nucleotide DAB1 variants and their contribution to Schizophrenia and autism spectrum disorder susceptibility","volume":"7","author":"Nawa","year":"2020","journal-title":"Hum. Genome Var."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"13046","DOI":"10.1038\/s41598-018-31390-w","article-title":"Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia","volume":"8","author":"Sobue","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"112","DOI":"10.12809\/eaap2168","article-title":"Correlation of Four Single Nucleotide Polymorphisms of the RELN Gene With Schizophrenia","volume":"31","author":"Ping","year":"2021","journal-title":"East. Asian Arch. Psychiatry"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1007\/s11033-019-04803-w","article-title":"Female gender specific association of the Reelin (RELN) gene rs7341475 variant with schizophrenia","volume":"46","author":"Sozuguzel","year":"2019","journal-title":"Mol. Biol. Rep."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.4238\/vol10-3gmr1343","article-title":"A new single-nucleotide mutation (rs362719) of the reelin (RELN) gene associated with schizophrenia in female Chinese Han","volume":"10","author":"Kuang","year":"2011","journal-title":"Genet. Mol.Res. GMR"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"24327","DOI":"10.1038\/srep24327","article-title":"Identification of RELN variation p.Thr3192Ser in a Chinese family with schizophrenia","volume":"6","author":"Zhou","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s12031-020-01696-4","article-title":"Association Between REELIN Gene Polymorphisms (rs7341475 and rs262355) and Risk of Schizophrenia: An Updated Meta-analysis","volume":"71","author":"Marzan","year":"2021","journal-title":"J. Mol. Neurosci."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"28636","DOI":"10.1038\/srep28636","article-title":"Mice that lack the C-terminal region of Reelin exhibit behavioral abnormalities related to neuropsychiatric disorders","volume":"6","author":"Sakai","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.bbr.2017.05.028","article-title":"Meta-analyses of RELN variants in neuropsychiatric disorders","volume":"332","author":"Chen","year":"2017","journal-title":"Behav. Brain Res."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/mp.2016.88","article-title":"High-resolution copy number variation analysis of schizophrenia in Japan","volume":"22","author":"Kushima","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.schres.2017.05.002","article-title":"Further evidence for the association between LRP8 and schizophrenia","volume":"215","author":"Xiao","year":"2020","journal-title":"Schizophr. Res."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1111\/jnc.15225","article-title":"Schizophrenia risk candidate EGR3 is a novel transcriptional regulator of RELN and regulates neurite outgrowth via the Reelin signal pathway in vitro","volume":"157","author":"Nie","year":"2021","journal-title":"J. Neurochem."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1097\/00001756-200110290-00014","article-title":"Altered levels of Reelin and its isoforms in schizophrenia and mood disorders","volume":"12","author":"Fatemi","year":"2001","journal-title":"Neuroreport"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Fatemi, S.H., Earle, J.A., and McMenomy, T. (2000). Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression. Mol. Psychiatry, 5.","DOI":"10.1038\/sj.mp.4000783"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/archpsyc.57.11.1061","article-title":"Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: A postmortem brain study","volume":"57","author":"Guidotti","year":"2000","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s41065-020-00158-6","article-title":"Exploring the mRNA expression level of RELN in peripheral blood of schizophrenia patients before and after antipsychotic treatment","volume":"157","author":"Yin","year":"2020","journal-title":"Hereditas"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"101995","DOI":"10.1016\/j.ajp.2020.101995","article-title":"Decreased serum levels of reelin in patients with schizophrenia","volume":"49","author":"Bai","year":"2020","journal-title":"Asian J. Psychiatr."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jpsychires.2016.12.020","article-title":"Reelin (RELN) DNA methylation in the peripheral blood of schizophrenia","volume":"88","author":"Norlelawati","year":"2017","journal-title":"J. Psychiatr. Res."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/pcn.12993","article-title":"Generation and analysis of novel Reln-deleted mouse model corresponding to exonic Reln deletion in schizophrenia","volume":"74","author":"Sawahata","year":"2020","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"113569","DOI":"10.1016\/j.bbr.2021.113569","article-title":"Mice with exonic RELN deletion identified from a patient with schizophrenia have impaired visual discrimination learning and reversal learning in touchscreen operant tasks","volume":"416","author":"Liao","year":"2022","journal-title":"Behav. Brain Res."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"844737","DOI":"10.3389\/fnana.2022.844737","article-title":"Reelin Alterations, Behavioral Phenotypes, and Brain Anomalies in Schizophrenia: A Systematic Review of Insights From Rodent Models","volume":"16","year":"2022","journal-title":"Front. Neuroanat."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1093\/cercor\/bhv334","article-title":"Dorsal Forebrain-Specific Deficiency of Reelin-Dab1 Signal Causes Behavioral Abnormalities Related to Psychiatric Disorders","volume":"27","author":"Imai","year":"2017","journal-title":"Cereb. Cortex"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1111\/j.1460-9568.2006.05083.x","article-title":"Altered cortico-striatal synaptic plasticity and related behavioural impairments in reeler mice","volume":"24","author":"Marrone","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00213-009-1483-x","article-title":"Reelin haploinsufficiency reduces the density of PV+ neurons in circumscribed regions of the striatum and selectively alters striatal-based behaviors","volume":"204","author":"Sgobio","year":"2009","journal-title":"Psychopharmacology"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1038\/npp.2011.153","article-title":"Overexpression of Reelin prevents the manifestation of behavioral phenotypes related to schizophrenia and bipolar disorder","volume":"36","author":"Teixeira","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1143319","DOI":"10.3389\/fncel.2023.1143319","article-title":"Adult-specific Reelin expression alters striatal neuronal organization: Implications for neuropsychiatric disorders","volume":"17","author":"Pardo","year":"2023","journal-title":"Front. Cell. Neurosci."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3389\/fncel.2020.00285","article-title":"Reelin Supplementation Into the Hippocampus Rescues Abnormal Behavior in a Mouse Model of Neurodevelopmental Disorders","volume":"14","author":"Ibi","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"35504","DOI":"10.1038\/srep35504","article-title":"Multivariate synaptic and behavioral profiling reveals new developmental endophenotypes in the prefrontal cortex","volume":"6","author":"Iafrati","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"6019","DOI":"10.1007\/s11033-022-07388-z","article-title":"SNP-PCR genotyping links alterations in the GABAA receptor (GABRG3: rs208129) and RELN (rs73670) genes to autism spectrum disorder among peadiatric Iraqi Arabs","volume":"49","author":"Ali","year":"2022","journal-title":"Mol. Biol. Rep."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s00702-021-02360-w","article-title":"Genetic risk factors for autism-spectrum disorders: A systematic review based on systematic reviews and meta-analysis","volume":"128","author":"Wei","year":"2021","journal-title":"J. Neural. Transm."},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Hernandez-Garcia, I., Chamorro, A.J., Ternavasio-de la Vega, H.G., Carbonell, C., Marcos, M., and Miron-Canelo, J.A. (2020). Association of Allelic Variants of the Reelin Gene with Autistic Spectrum Disorder: A Systematic Review and Meta-Analysis of Candidate Gene Association Studies. Int. J. Environ. Res. Public. Health, 17.","DOI":"10.3390\/ijerph17218010"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1002\/humu.23584","article-title":"Rare RELN variants affect Reelin-DAB1 signal transduction in autism spectrum disorder","volume":"39","author":"Magdalon","year":"2018","journal-title":"Hum. Mutat."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41398-022-01997-9","article-title":"Rare CACNA1H and RELN variants interact through mTORC1 pathway in oligogenic autism spectrum disorder","volume":"12","author":"Teles","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3389\/fpsyt.2020.00242","article-title":"Elevated Plasma Reelin Levels in Children With Autism","volume":"11","year":"2020","journal-title":"Front. Psychiatry"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0887-8994(96)00011-2","article-title":"Autism in Angelman syndrome: A population-based study","volume":"14","author":"Steffenburg","year":"1996","journal-title":"Pediatr. Neurol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1469-7610.2011.02455.x","article-title":"Longitudinal follow-up of autism spectrum features and sensory behaviors in Angelman syndrome by deletion class","volume":"53","author":"Peters","year":"2012","journal-title":"J. Child. Psychol. Psychiatry"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/ajmg.a.31074","article-title":"Angelman syndrome 2005: Updated consensus for diagnostic criteria","volume":"140","author":"Williams","year":"2006","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Jiang, Y.H., Wauki, K., Liu, Q., Bressler, J., Pan, Y., Kashork, C.D., Shaffer, L.G., and Beaudet, A.L. (2008). Genomic analysis of the chromosome 15q11-q13 Prader-Willi syndrome region and characterization of transcripts for GOLGA8E and WHCD1L1 from the proximal breakpoint region. BMC Genom., 9.","DOI":"10.1186\/1471-2164-9-50"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/nn1845","article-title":"Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of alphaCaMKII inhibitory phosphorylation","volume":"10","author":"Harris","year":"2007","journal-title":"Nat. Neurosci."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1111\/ejn.12893","article-title":"Reelin supplementation recovers synaptic plasticity and cognitive deficits in a mouse model for Angelman syndrome","volume":"41","author":"Hethorn","year":"2015","journal-title":"Eur. J. Neurosci."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"e01767","DOI":"10.1002\/brb3.1767","article-title":"Extracellular matrix proteins are time-dependent and regional-specific markers in experimental diffuse brain injury","volume":"10","author":"Griffiths","year":"2020","journal-title":"Brain Behav."},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Dal Pozzo, V., Crowell, B., Briski, N., Crockett, D.P., and D\u2019Arcangelo, G. (2020). Reduced Reelin Expression in the Hippocampus after Traumatic Brain Injury. Biomolecules, 10.","DOI":"10.3390\/biom10070975"},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Lopez-Font, I., Lennol, M.P., Iborra-Lazaro, G., Zetterberg, H., Blennow, K., and Saez-Valero, J. (2022). Altered Balance of Reelin Proteolytic Fragments in the Cerebrospinal Fluid of Alzheimer\u2019s Disease Patients. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23147522"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1111\/ejn.15971","article-title":"A novel Reelin construct, R36, recovered behavioural deficits in the heterozygous reeler mouse","volume":"57","author":"Morrill","year":"2023","journal-title":"Eur. J. Neurosci."}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/13\/10\/1479\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:09:34Z","timestamp":1760130574000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/13\/10\/1479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,19]]},"references-count":198,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["brainsci13101479"],"URL":"https:\/\/doi.org\/10.3390\/brainsci13101479","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,19]]}}}