{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T21:03:14Z","timestamp":1765486994677,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:00:00Z","timestamp":1698883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271518","81971158","81671306","2019020701011470"],"award-info":[{"award-number":["82271518","81971158","81671306","2019020701011470"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wuhan Science and Technology plan projec","award":["82271518","81971158","81671306","2019020701011470"],"award-info":[{"award-number":["82271518","81971158","81671306","2019020701011470"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Objective: This retrospective study was performed to evaluate the feasibility and safety of surgically clipping intracranial aneurysms using a transcranial neuroendoscopic approach. Methods: A total of 229 patients with cerebral aneurysms were included in our study, all of whom were treated with clamping surgery at Wuhan University People\u2019s Hospital. They were divided into neuroendoscopic and microscopic groups, according to whether or not neuroendoscopy was used for the clamping surgery. We statistically analyzed the patients\u2019 baseline data, surgical outcomes, and complications, which were then evaluated to assess the treatment effect. Results: The baseline characteristics were not statistically significant, except for gender, for which the proportions of female patients in the two groups were 69 (56.1%) and 46 (43.4%). There were no patients with incomplete aneurysm clamping or parent vessel occlusion in the neuroendoscopic group, and there were 4 (3.8%) and 2 (1.9%) in the microscopic group, respectively; however, there was no statistically significant difference in the comparison of the two groups. The mean operative times of the two groups were 181 min and 154 min, respectively, and were statistically different. However, the mRS scores of the two groups showed no significant difference in patient prognosis. The differences in complications (including limb hemiplegia, hydrocephalus, vision loss, and intracranial infection) were not statistically significant, except for cerebral ischemia, for which the proportions of patients in the two groups were 8 (6.5%) and 16 (15.1%). Conclusions: Neuroendoscopy can provide clear visualization and multi-angle views during aneurysm clipping, which is helpful for ensuring adequate clipping and preventing complications.<\/jats:p>","DOI":"10.3390\/brainsci13111544","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T09:16:21Z","timestamp":1698916581000},"page":"1544","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Surgical Clipping of Intracranial Aneurysms Using a Transcranial Neuroendoscopic Approach"],"prefix":"10.3390","volume":"13","author":[{"given":"Zhiyang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan 430060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9173-1241","authenticated-orcid":false,"given":"Pan","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan 430060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuwei","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan 430060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan 430060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan 430060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lun","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan 430060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xiantao First People\u2019s Hospital Affiliated to Changjiang University, Xiantao 433000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan 430060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"818789","DOI":"10.3389\/fcvm.2022.818789","article-title":"Serum IL-1, Pyroptosis and Intracranial Aneurysm Wall Enhancement: Analysis Integrating Radiology, Serum Cytokines and Histology","volume":"9","author":"Liu","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e323","DOI":"10.3346\/jkms.2020.35.e323","article-title":"National Trends in the Treatment of Ruptured Cerebral Aneurysms in Korea Using an Age-adjusted Method","volume":"35","author":"Park","year":"2020","journal-title":"J. Korean Med. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1136\/neurintsurg-2020-016303","article-title":"Derivo embolization device in the treatment of unruptured intracranial aneurysms: A prospective multicenter study","volume":"13","author":"Taschner","year":"2021","journal-title":"J. Neurointerv. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"666481","DOI":"10.3389\/fneur.2021.666481","article-title":"Clinical and Angiographic Outcomes After Stent-Assisted Coiling of Cerebral Aneurysms With Laser-Cut and Braided Stents: A Comparative Analysis of the Literatures","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1756286420987939","DOI":"10.1177\/1756286420987939","article-title":"Atorvastatin and growth, rupture of small unruptured intracranial aneurysm: Results of a prospective cohort study","volume":"14","author":"Wang","year":"2021","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"021908","DOI":"10.1117\/1.NPh.9.2.021908","article-title":"Continuous blood flow visualization with laser speckle contrast imaging during neurovascular surgery","volume":"9","author":"Miller","year":"2022","journal-title":"Neurophotonics"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"15492","DOI":"10.1038\/s41598-020-72309-8","article-title":"Physiologic blood flow is turbulent","volume":"10","author":"Saqr","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"6629","DOI":"10.1038\/s41598-020-63574-8","article-title":"Virtual monoenergetic images and post-processing algorithms effectively reduce CT artifacts from intracranial aneurysm treatment","volume":"10","author":"Zopfs","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.wneu.2020.08.147","article-title":"Endoscopic Ipsilateral Interhemispheric Approach for Resection of Selected Deep Medial Brain Tumors","volume":"144","author":"McKinnon","year":"2020","journal-title":"World Neurosurg."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Wimmer, B., Mangesius, S., Seppi, K., Iglseder, S., Di Pauli, F., Ortler, M., Gizewski, E., Poewe, W., and Wenning, G.K. (2020). Symptomatic hemiparkinsonism due to extensive middle and posterior fossa arachnoid cyst: Case report. BMC Neurol., 20.","DOI":"10.1186\/s12883-020-01670-y"},{"key":"ref_11","first-page":"ONSE162","article-title":"The expanded endonasal approach for an endoscopic transnasal clipping and aneurysmorrhaphy of a large vertebral artery aneurysm: Technical case report","volume":"59","author":"Kassam","year":"2006","journal-title":"Neurosurgery"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.wneu.2015.06.032","article-title":"Endoscopic Endonasal Clipping of Intracranial Aneurysms: Surgical Technique and Results","volume":"84","author":"Gardner","year":"2015","journal-title":"World Neurosurg."},{"key":"ref_13","first-page":"889","article-title":"Safety and effectiveness of endoscopic endonasal intracranial aneurysm clipping: A systematic review","volume":"44","author":"Hardesty","year":"2020","journal-title":"Neurosurg. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e935850","DOI":"10.12659\/MSM.935850","article-title":"Early Enteral Nutrition Can Reduce Incidence of Postoperative Hydrocephalus in Patients with Severe Hypertensive Intracerebral Hemorrhage","volume":"28","author":"Cai","year":"2022","journal-title":"Med. Sci. Monit."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e378","DOI":"10.1016\/j.wneu.2023.01.032","article-title":"Effect of Surgical Clipping versus Endovascular Coiling on the Incidence of Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage: A Multicenter Observational Cohort Study with Propensity Score Matching","volume":"172","author":"Hu","year":"2023","journal-title":"World Neurosurg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3171\/jns.1977.46.3.0398","article-title":"Neurosurgical endoscopy using the side-viewing telescope","volume":"46","author":"Apuzzo","year":"1977","journal-title":"J. Neurosurg."},{"key":"ref_17","first-page":"362","article-title":"Transsphenoidal operation on craniopharyngiomas with extrasellar extensions. The advantage of the operating endoscope [proceedings]","volume":"28","author":"Halves","year":"1979","journal-title":"Acta Neurochir. Suppl."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/BF01417688","article-title":"Endoscopically assisted microneurosurgery","volume":"134","author":"Matula","year":"1995","journal-title":"Acta Neurochir."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.wneu.2016.02.099","article-title":"Historical Perspective and the Role of Endoscopy in Intracranial Aneurysm Surgery","volume":"88","author":"Prevedello","year":"2016","journal-title":"World Neurosurg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"S130","DOI":"10.1016\/j.wneu.2014.07.038","article-title":"The supraorbital endoscopic approach for aneurysms","volume":"82","author":"Reisch","year":"2014","journal-title":"World Neurosurg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"195","DOI":"10.4193\/Rhino13.165","article-title":"The ventral route to intracranial aneurysm: From the origin towards modern transsphenoidal surgery. An historical review and current perspective","volume":"52","author":"Ensenat","year":"2014","journal-title":"Rhinology"},{"key":"ref_22","first-page":"310","article-title":"Anterior communicating artery aneurysm clipped via an endoscopic endonasal approach: Technical note","volume":"68","author":"Froelich","year":"2011","journal-title":"Neurosurg."},{"key":"ref_23","first-page":"503","article-title":"Endoscopic endonasal skull base surgery for vascular lesions: A systematic review of the literature","volume":"60","author":"Gardnerl","year":"2016","journal-title":"J. Neurosurg. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"469","DOI":"10.2176\/nmc.ra.2014-0428","article-title":"The Roles of Endoscope in Aneurysmal Surgery","volume":"55","author":"Yoshioka","year":"2015","journal-title":"Neurol. Med. Chir."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"653589","DOI":"10.3389\/fneur.2021.653589","article-title":"Hemodynamic and Morphological Parameters of Ruptured Mirror Posterior Communicating Artery Aneurysms","volume":"12","author":"Yuan","year":"2021","journal-title":"Front. Neurol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"731129","DOI":"10.3389\/fneur.2021.731129","article-title":"U-Shaped Association of Aspect Ratio and Single Intracranial Aneurysm Rupture in Chinese Patients: A Cross-Sectional Study","volume":"12","author":"Yin","year":"2021","journal-title":"Front. Neurol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"580877","DOI":"10.3389\/fneur.2020.580877","article-title":"Treatment of Intracranial Pseudoaneurysms With a Novel Covered Stent: A Series of 19 Patients With Midterm Follow-Up","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"674966","DOI":"10.3389\/fneur.2021.674966","article-title":"Flow Diversion for Intracranial Aneurysms Beyond the Circle of Willis","volume":"12","author":"Yu","year":"2021","journal-title":"Front. 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