{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T07:07:40Z","timestamp":1774940860955,"version":"3.50.1"},"reference-count":37,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>This prospective study investigated white matter tracts associated with restless legs syndrome (RLS) severity in 69 patients with primary RLS using correlational tractography based on diffusion tensor imaging. Fractional anisotropy (FA) and quantitative anisotropy (QA) were analyzed separately to understand white matter abnormalities in RLS patients. Connectometry analysis revealed positive correlations between RLS severity and FA values in various white matter tracts, including the left and right cerebellum, corpus callosum forceps minor and major, corpus callosum body, right cingulum, and frontoparietal tract. In addition, connectometry analysis revealed that the FA of the middle cerebellar peduncle, left inferior longitudinal fasciculus, left corticospinal tract, corpus callosum forceps minor, right cerebellum, left frontal aslant tract, left dentatorubrothalamic tract, right inferior longitudinal fasciculus, left corticostriatal tract superior, and left cingulum parahippocampoparietal tract was negatively correlated with RLS severity in patients with RLS. However, there were no significant correlations between QA values and RLS severity. It is implied that RLS symptoms may be potentially reversible with appropriate treatment. This study highlights the importance of considering white matter alterations in understanding the pathophysiology of RLS and in developing effective treatment strategies.<\/jats:p>","DOI":"10.3390\/brainsci13111560","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T11:23:39Z","timestamp":1699356219000},"page":"1560","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Correlation of Diffusion Tensor Tractography with Restless Legs Syndrome Severity"],"prefix":"10.3390","volume":"13","author":[{"given":"Kang Min","family":"Park","sequence":"first","affiliation":[{"name":"Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan 48108, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keun Tae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Keimyung University School of Medicine, Daegu 42601, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Ah","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan 48108, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6127-1045","authenticated-orcid":false,"given":"Yong Won","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurology, Keimyung University School of Medicine, Daegu 42601, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.sleep.2014.03.025","article-title":"Restless legs syndrome\/Willis\u2013Ekbom disease diagnostic criteria: Updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria\u2014History, rationale, description, and significance","volume":"15","author":"Allen","year":"2014","journal-title":"Sleep Med."},{"key":"ref_2","first-page":"1351","article-title":"Review of Quality of Life Instruments for the Restless Legs Syndrome\/Willis-Ekbom Disease (RLS\/WED): Critique and Recommendations","volume":"10","author":"Walters","year":"2014","journal-title":"Sleep Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.sleep.2015.06.019","article-title":"Comparison of impact of insomnia on depression and quality of life in restless legs syndrome\/Willis\u2013Ekbom disease and primary insomnia patients","volume":"16","author":"Song","year":"2015","journal-title":"Sleep Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3988\/jcn.2022.18.3.290","article-title":"Alterations of Functional Connectivity in Patients with Restless Legs Syndrome","volume":"18","author":"Park","year":"2022","journal-title":"J. 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