{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:59:00Z","timestamp":1768442340531,"version":"3.49.0"},"reference-count":36,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background: Dropping objects from hands (DOH) is a common symptom of carpal tunnel syndrome (CTS). We evaluated the clinical, neurophysiological, and psychophysiological features of 120 CTS patients to elucidate the DOH pathophysiology. Forty-nine healthy controls were included. Methods: In the patients, the Boston Carpal Tunnel Questionnaire (BCTQ), the Douleur Neuropathique 4 questions (DN4), and a numeric rating scale for pain (NRS) were evaluated. In patients and controls, we evaluated bilateral median and ulnar motor and sensory nerve conduction studies, cutaneous silent period and cutaneomuscular reflexes (CMR) of the abductor pollicis brevis, cold-detection threshold (CDT) and heat-pain detection threshold (HPT) at the index, little finger, and dorsum of the hand, and vibratory detection threshold at the index and little finger by quantitative sensory testing. Results: CTS with DOH had higher BCTQ, DN4 and NRS, lower median sensory action potential, longer CMR duration, lower CDT and higher HPT at all tested sites than controls and CTS without DOH. Predictive features for DOH were abnormal CDT and HPT at the right index and dorsum (OR: 3.88, p: 0.03) or at the little finger (OR: 3.27, p: 0.04) and a DN4 higher than 4 (OR: 2.16, p &lt; 0.0001). Conclusions: Thermal hypoesthesia in median and extra-median innervated territories and neuropathic pain are predictive of DOH in CTS.<\/jats:p>","DOI":"10.3390\/brainsci13111576","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T05:04:56Z","timestamp":1699592696000},"page":"1576","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Psychophysiological and Neurophysiological Correlates of Dropping Objects from Hands in Carpal Tunnel Syndrome"],"prefix":"10.3390","volume":"13","author":[{"given":"Gianluca","family":"Isoardo","sequence":"first","affiliation":[{"name":"Department of Neurosciences & Mental Health, Hospital \u201cCitt\u00e0 della Salute e della Scienza di Torino\u201d, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3154-7634","authenticated-orcid":false,"given":"Eugenia","family":"Rota","sequence":"additional","affiliation":[{"name":"Neurology Unit, San Giacomo Hospital, Novi Ligure, ASL Alessandria, 15121 Alessandria, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Ciullo","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Turin, 10124 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Titolo","sequence":"additional","affiliation":[{"name":"UOD Reconstructive Microsurgery, Department of Orthopedics & Traumatology, Hospital \u201cCitt\u00e0 della Salute e della Scienza di Torino\u201d, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2963-8821","authenticated-orcid":false,"given":"Enrico","family":"Matteoni","sequence":"additional","affiliation":[{"name":"\u2018Rita Levi Montalcini\u2019 Department of Neuroscience, University of Turin, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9815-5446","authenticated-orcid":false,"given":"Ilaria","family":"Stura","sequence":"additional","affiliation":[{"name":"\u2018Rita Levi Montalcini\u2019 Department of Neuroscience, University of Turin, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5122-7243","authenticated-orcid":false,"given":"Andrea","family":"Calvo","sequence":"additional","affiliation":[{"name":"\u2018Rita Levi Montalcini\u2019 Department of Neuroscience, University of Turin, 10126 Turin, Italy"},{"name":"1st Neurology Unit, Department of Neurosciences & Mental Health, Hospital \u201cCitt\u00e0 della Salute e della Scienza di Torino\u201d, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Fontana","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Turin, 10124 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Battiston","sequence":"additional","affiliation":[{"name":"UOD Reconstructive Microsurgery, Department of Orthopedics & Traumatology, Hospital \u201cCitt\u00e0 della Salute e della Scienza di Torino\u201d, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Migliaretti","sequence":"additional","affiliation":[{"name":"Department of Public Health and Pediatric Sciences, University of Torino, 10126 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5020-6598","authenticated-orcid":false,"given":"Rita B.","family":"Ardito","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Turin, 10124 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6997-9283","authenticated-orcid":false,"given":"Mauro","family":"Adenzato","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Turin, 10124 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,10]]},"reference":[{"key":"ref_1","unstructured":"Dyck, P.J., and Thomas, P.K. 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