{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:36:45Z","timestamp":1780317405487,"version":"3.54.1"},"reference-count":54,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871341"],"award-info":[{"award-number":["81871341"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271945"],"award-info":[{"award-number":["82271945"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background: Normal tension glaucoma (NTG) is considered a neurodegenerative disease with glaucomatous damage extending to diffuse brain areas. Therefore, this study aims to explore the abnormalities in the NTG structural network to help in the early diagnosis and course evaluation of NTG. Methods: The structural networks of 46 NTG patients and 19 age- and sex-matched healthy controls were constructed using diffusion tensor imaging, followed by graph theory analysis and correlation analysis of small-world properties with glaucoma clinical indicators. In addition, the network-based statistical analysis (NBS) method was used to compare structural network connectivity differences between NTG patients and healthy controls. Results: Structural brain networks in both NTG and NC groups exhibited small-world properties. However, the small-world index in the severe NTG group was reduced and correlated with a mean deviation of the visual field (MDVF) and retinal nerve fiber layer (RNFL) thickness. When compared to healthy controls, degree centrality and nodal efficiency in visual brain areas were significantly decreased, and betweenness centrality and nodal local efficiency in both visual and nonvisual brain areas were also significantly altered in NTG patients (all p &lt; 0.05, FDR corrected). Furthermore, NTG patients exhibited increased structural connectivity in the occipitotemporal area, with the left fusiform gyrus (FFG.L) as the hub (p &lt; 0.05). Conclusions: NTG exhibited altered global properties and local properties of visual and cognitive-emotional brain areas, with enhanced structural connections within the occipitotemporal area. Moreover, the disrupted small-world properties of white matter might be imaging biomarkers for assessing NTG progression.<\/jats:p>","DOI":"10.3390\/brainsci13111597","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T09:10:38Z","timestamp":1700212238000},"page":"1597","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Abnormal Topological Organization of White Matter Structural Networks in Normal Tension Glaucoma Revealed via Diffusion Tensor Tractography"],"prefix":"10.3390","volume":"13","author":[{"given":"Yin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiology, Eye & ENT Hospital of Fudan University, Fudan University, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linying","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Eye & ENT Hospital of Fudan University, Fudan University, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Huashan Hospital of Fudan University, Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhe","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Zhongshan Hospital of Fudan University, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Eye & ENT Hospital of Fudan University, Fudan University, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Zhongshan Hospital of Fudan University, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfeng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Eye & ENT Hospital of Fudan University, Fudan University, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghuai","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology & Visual Science, Eye & ENT Hospital of Fudan University, Fudan University, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuohua","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Eye & ENT Hospital of Fudan University, Fudan University, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.survophthal.2018.10.001","article-title":"Management of normal tension glaucoma","volume":"64","author":"Gittinger","year":"2019","journal-title":"Surv. Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.4103\/1673-5374.259600","article-title":"Normal tension glaucoma: From the brain to the eye or the inverse?","volume":"14","author":"Zhang","year":"2019","journal-title":"Neural Regen. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/hbm.23862","article-title":"Diffuse brain damage in normal tension glaucoma","volume":"39","author":"Giorgio","year":"2018","journal-title":"Hum. Brain Mapp."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/opo.12297","article-title":"Neurodegeneration beyond the primary visual pathways in a population with a high incidence of normal-pressure glaucoma","volume":"36","author":"Boucard","year":"2016","journal-title":"Ophthalmic Physiol. Opt."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"108951","DOI":"10.1016\/j.jneumeth.2020.108951","article-title":"The sensitivity of diffusion MRI to microstructural properties and experimental factors","volume":"347","author":"Afzali","year":"2021","journal-title":"J. Neurosci. Methods"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Schmidt, M.A., Knott, M., Heidemann, R., Michelson, G., Kober, T., Dorfler, A., and Engelhorn, T. (2018). Investigation of lateral geniculate nucleus volume and diffusion tensor imaging in patients with normal tension glaucoma using 7 tesla magnetic resonance imaging. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0198830"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1167\/iovs.17-23597","article-title":"White Matter Abnormalities and Correlation With Severity in Normal Tension Glaucoma: A Whole Brain Atlas-Based Diffusion Tensor Study","volume":"59","author":"Wang","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.31887\/DCNS.2018.20.2\/osporns","article-title":"Graph theory methods: Applications in brain networks","volume":"20","author":"Sporns","year":"2018","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1007\/s00330-016-4221-x","article-title":"Graph theoretical analysis reveals the reorganization of the brain network pattern in primary open angle glaucoma patients","volume":"26","author":"Wang","year":"2016","journal-title":"Eur. Radiol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Minosse, S., Garaci, F., Martucci, A., Lanzafame, S., Di Giuliano, F., Picchi, E., Cesareo, M., Mancino, R., Guerrisi, M., and Floris, R. (2019, January 23\u201327). Disruption of brain network organization in primary open angle glaucoma. Proceedings of the 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Berlin, Germany.","DOI":"10.1109\/EMBC.2019.8857290"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"102419","DOI":"10.1016\/j.nicl.2020.102419","article-title":"Reorganization of the structural connectome in primary open angle Glaucoma","volume":"28","author":"Garaci","year":"2020","journal-title":"NeuroImage Clin."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jpsychires.2020.08.004","article-title":"White matter structural network disturbances in first-episode, drug-naive adolescents with generalized anxiety disorder","volume":"130","author":"Yang","year":"2020","journal-title":"J. Psychiatr. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3389\/fnhum.2013.00042","article-title":"PANDA: A pipeline toolbox for analyzing brain diffusion images","volume":"7","author":"Cui","year":"2013","journal-title":"Front. Hum. Neurosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/1522-2594(200010)44:4<625::AID-MRM17>3.0.CO;2-O","article-title":"In vivo fiber tractography using DT-MRI data","volume":"44","author":"Basser","year":"2000","journal-title":"Magn. Reson. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1089\/brain.2018.0580","article-title":"Test-Retest Reliability of Graph Theoretic Metrics in Adolescent Brains","volume":"9","author":"Yuan","year":"2019","journal-title":"Brain Connect."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1148\/radiol.2017162696","article-title":"Disrupted Topologic Efficiency of White Matter Structural Connectome in Individuals with Subjective Cognitive Decline","volume":"286","author":"Shu","year":"2018","journal-title":"Radiology"},{"key":"ref_17","first-page":"386","article-title":"GRETNA: A graph theoretical network analysis toolbox for imaging connectomics","volume":"9","author":"Wang","year":"2015","journal-title":"Front. Hum. Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1093\/cercor\/bht004","article-title":"Efficiency of a \u201csmall-world\u201d brain network depends on consciousness level: A resting-state FMRI study","volume":"24","author":"Uehara","year":"2014","journal-title":"Cereb. Cortex"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.neuroimage.2009.10.003","article-title":"Complex network measures of brain connectivity: Uses and interpretations","volume":"52","author":"Rubinov","year":"2010","journal-title":"NeuroImage"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"631","DOI":"10.21037\/qims-22-450","article-title":"Functional-structural large-scale brain networks are correlated with neurocognitive impairment in acute mild traumatic brain injury","volume":"13","author":"Liu","year":"2023","journal-title":"Quant. Imaging Med. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.neuroimage.2010.06.041","article-title":"Network-based statistic: Identifying differences in brain networks","volume":"53","author":"Zalesky","year":"2010","journal-title":"NeuroImage"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.neuroimage.2007.10.060","article-title":"Studying the human brain anatomical network via diffusion-weighted MRI and Graph Theory","volume":"40","author":"Sotero","year":"2008","journal-title":"NeuroImage"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/WCO.0b013e32833aa567","article-title":"Graph theoretical modeling of brain connectivity","volume":"23","author":"He","year":"2010","journal-title":"Curr. Opin. Neurol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"12083","DOI":"10.1523\/JNEUROSCI.2965-15.2016","article-title":"The Segregation and Integration of Distinct Brain Networks and Their Relationship to Cognition","volume":"36","author":"Cohen","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.ajo.2006.05.004","article-title":"Baseline optical coherence tomography predicts the development of glaucomatous change in glaucoma suspects","volume":"142","author":"Lalezary","year":"2006","journal-title":"Am. J. Ophthalmol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coph.2012.10.009","article-title":"Neuroprotection and other novel therapies for glaucoma","volume":"13","author":"Nucci","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Sporns, O., Honey, C.J., and Kotter, R. (2007). Identification and classification of hubs in brain networks. PLoS ONE, 2.","DOI":"10.1371\/journal.pone.0001049"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.tics.2021.10.003","article-title":"Two \u2018what\u2019 pathways for action and object recognition","volume":"26","author":"Wurm","year":"2022","journal-title":"Trends Cogn. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1167\/iovs.04-1406","article-title":"The detection of both global motion and global form is disrupted in glaucoma","volume":"46","author":"McKendrick","year":"2005","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nrn2575","article-title":"Complex brain networks: Graph theoretical analysis of structural and functional systems","volume":"10","author":"Bullmore","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1037\/bul0000096","article-title":"Emotion and the prefrontal cortex: An integrative review","volume":"143","author":"Dixon","year":"2017","journal-title":"Psychol. Bull."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.neuron.2019.02.014","article-title":"Hippocampal Contributions to Model-Based Planning and Spatial Memory","volume":"102","author":"Vikbladh","year":"2019","journal-title":"Neuron"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"860","DOI":"10.3389\/fnins.2018.00860","article-title":"Abnormal Topology of the Structural Connectome in the Limbic Cortico-Basal-Ganglia Circuit and Default-Mode Network among Primary Insomnia Patients","volume":"12","author":"Wu","year":"2018","journal-title":"Front. Neurosci."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Frezzotti, P., Giorgio, A., Motolese, I., De Leucio, A., Iester, M., Motolese, E., Federico, A., and De Stefano, N. (2014). Structural and functional brain changes beyond visual system in patients with advanced glaucoma. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0105931"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/IJG.0b013e3182071b7e","article-title":"Prevalence of cognitive impairment, depression, and anxiety symptoms among older adults with glaucoma","volume":"21","author":"Yochim","year":"2012","journal-title":"J. Glaucoma"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.18240\/ijo.2021.11.11","article-title":"Individuals with and without normal tension glaucoma exhibit comparable performance on tests of cognitive function","volume":"14","author":"Cui","year":"2021","journal-title":"Int. J. Ophthalmol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"11671","DOI":"10.1038\/s41598-018-29489-1","article-title":"Illness uncertainty, anxiety and depression in Chinese patients with glaucoma or cataract","volume":"8","author":"Zhang","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"891384","DOI":"10.3389\/fncom.2022.891384","article-title":"Treatment Enhances Betweenness Centrality of Fronto-Parietal Network in Parkinson\u2019s Patients","volume":"16","author":"Liu","year":"2022","journal-title":"Front. Comput. Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.bbr.2009.03.012","article-title":"Parietal cortex and spatial cognition","volume":"202","author":"Sack","year":"2009","journal-title":"Behav. Brain Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1177\/1073858412440596","article-title":"The angular gyrus: Multiple functions and multiple subdivisions","volume":"19","author":"Seghier","year":"2013","journal-title":"Neuroscientist"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1126\/science.273.5281.1564","article-title":"The mental representation of hand movements after parietal cortex damage","volume":"273","author":"Sirigu","year":"1996","journal-title":"Science"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"18969","DOI":"10.1038\/srep18969","article-title":"Structural brain alterations in primary open angle glaucoma: A 3T MRI study","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1167\/iovs.14-14974","article-title":"Altered amplitude of low-frequency fluctuation in primary open-angle glaucoma: A resting-state FMRI study","volume":"56","author":"Li","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1073\/pnas.89.11.5063","article-title":"Crossmodal changes in the somatosensory vibrissa\/barrel system of visually deprived animals","volume":"89","author":"Rauschecker","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0166-2236(95)93948-W","article-title":"Compensatory plasticity and sensory substitution in the cerebral cortex","volume":"18","author":"Rauschecker","year":"1995","journal-title":"Trends Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"198701","DOI":"10.1103\/PhysRevLett.87.198701","article-title":"Efficient behavior of small-world networks","volume":"87","author":"Latora","year":"2001","journal-title":"Phys. Rev. Lett."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.1002\/hbm.23330","article-title":"Early changes of brain connectivity in primary open angle glaucoma","volume":"37","author":"Frezzotti","year":"2016","journal-title":"Hum. Brain Mapp."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.cortex.2009.02.025","article-title":"The orthography-specific functions of the left fusiform gyrus: Evidence of modality and category specificity","volume":"46","author":"Tsapkini","year":"2010","journal-title":"Cortex"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1093\/brain\/awf094","article-title":"Language-specific tuning of visual cortex functional properties of the Visual Word Form Area","volume":"125","author":"Cohen","year":"2002","journal-title":"Brain"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/brain\/123.2.291","article-title":"The visual word form area\u2014Spatial and temporal characterization of an initial stage of reading in normal subjects and posterior split-brain patients","volume":"123","author":"Cohen","year":"2000","journal-title":"Brain"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"105189","DOI":"10.1016\/j.bandl.2022.105189","article-title":"The relationship between reading abilities and the left occipitotemporal sulcus: A dual perspective study","volume":"235","author":"Abutalebi","year":"2022","journal-title":"Brain Lang."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1093\/brain\/awm121","article-title":"Whole brain functional connectivity in the early blind","volume":"130","author":"Liu","year":"2007","journal-title":"Brain"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.cortex.2021.05.001","article-title":"Exploring the neurobiology of reading through non-invasive brain stimulation: A review","volume":"141","author":"Turker","year":"2021","journal-title":"Cortex"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s11065-022-09534-7","article-title":"The Impact of Transcranial Magnetic Stimulation on Reading Processes: A Systematic Review","volume":"33","author":"Arrington","year":"2023","journal-title":"Neuropsychol. Rev."}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/13\/11\/1597\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:24:44Z","timestamp":1760131484000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/13\/11\/1597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,17]]},"references-count":54,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["brainsci13111597"],"URL":"https:\/\/doi.org\/10.3390\/brainsci13111597","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,17]]}}}