{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:45:55Z","timestamp":1789440355448,"version":"build-2803163510"},"reference-count":48,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["23-25-00483"],"award-info":[{"award-number":["23-25-00483"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Naming decline is one of the most common symptoms of primary progressive aphasia (PPA). Most studies on anomia in PPA are performed without taking into account PPA variants, especially for action naming. Only limited data are available for the neuroanatomical basis of anomia considering differences in the pathogenesis of PPAs. The aim of our study is to investigate the associations between anomia severity for both noun and verb naming and gray matter (GM) atrophy, as well as accompanying functional connectivity (FC) changes in three PPA variants. A total of 17 patients with non-fluent (nfvPPA), 11 with semantic (svPPA), and 9 with logopenic (lvPPA) PPA variants were included in the study and underwent cognitive\/naming assessments and brain MRIs. Voxel-based morphometry was performed to evaluate GM volume. A resting-state functional MRI was applied to investigate FC changes in the identified GM areas. The study shows that different brain regions are involved in naming decline in each PPA variant with a predominantly temporal lobe involvement in svPPA, parietal lobe involvement in lvPPA, and frontal lobe involvement in nfvPPA. Separate data for object and action naming in PPA variants are provided. The obtained results mainly correspond to the current understanding of language processing and indicate that the evaluation of language impairments is preferable for each PPA variant separately. A further analysis of larger cohorts of patients is necessary to confirm these preliminary results.<\/jats:p>","DOI":"10.3390\/brainsci13121703","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T03:25:31Z","timestamp":1702265131000},"page":"1703","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Anomia: Deciphering Functional Neuroanatomy in Primary Progressive Aphasia Variants"],"prefix":"10.3390","volume":"13","author":[{"given":"Diliara R.","family":"Akhmadullina","sequence":"first","affiliation":[{"name":"Research Center of Neurology, 125367 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodion N.","family":"Konovalov","sequence":"additional","affiliation":[{"name":"Research Center of Neurology, 125367 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7214-583X","authenticated-orcid":false,"given":"Yulia A.","family":"Shpilyukova","sequence":"additional","affiliation":[{"name":"Research Center of Neurology, 125367 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina Yu.","family":"Fedotova","sequence":"additional","affiliation":[{"name":"Research Center of Neurology, 125367 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2704-6282","authenticated-orcid":false,"given":"Sergey N.","family":"Illarioshkin","sequence":"additional","affiliation":[{"name":"Research Center of Neurology, 125367 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"key":"ref_1","first-page":"745","article-title":"Primary Progressive Aphasia and Stroke Aphasia","volume":"24","author":"Grossman","year":"2018","journal-title":"Continuum"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","article-title":"Classification of primary progressive aphasia and its variants","volume":"76","author":"Hillis","year":"2011","journal-title":"Neurology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/ana.25333","article-title":"Prevalence of amyloid-\u03b2 pathology in distinct variants of primary progressive aphasia","volume":"84","author":"Bergeron","year":"2018","journal-title":"Ann. 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