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Winkle College of Pharmacy","award":["DOD W81XWH-22-1-0849"],"award-info":[{"award-number":["DOD W81XWH-22-1-0849"]}],"id":[{"id":"https:\/\/ror.org\/01e3m7079","id-type":"ROR","asserted-by":"crossref"}]},{"name":"University of Cincinnati Office of Research","award":["#25230 MJR"],"award-info":[{"award-number":["#25230 MJR"]}],"id":[{"id":"https:\/\/ror.org\/01e3m7079","id-type":"ROR","asserted-by":"crossref"}]},{"name":"University of Cincinnati Office of Research","award":["D101017-6250305002-1-L62381"],"award-info":[{"award-number":["D101017-6250305002-1-L62381"]}],"id":[{"id":"https:\/\/ror.org\/01e3m7079","id-type":"ROR","asserted-by":"crossref"}]},{"name":"University of Cincinnati Office of Research","award":["DOD W81XWH-22-1-0849"],"award-info":[{"award-number":["DOD W81XWH-22-1-0849"]}],"id":[{"id":"https:\/\/ror.org\/01e3m7079","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Traumatic brain injury (TBI) is a pervasive public health crisis that severely impacts the quality of life of affected individuals. Like peripheral forms of trauma, TBI results from extraordinarily heterogeneous environmental forces being imparted on the cranial space, resulting in heterogeneous disease pathologies. This has made therapies for TBI notoriously difficult to develop, and currently, there are no FDA-approved pharmacotherapies specifically for the acute or chronic treatment of TBI. TBI is associated with changes in cognition and can precipitate the onset of debilitating psychiatric disorders like major depressive disorder (MDD), generalized anxiety disorder (GAD), and post-traumatic stress disorder (PTSD). Complicating these effects of TBI, FDA-approved pharmacotherapies utilized to treat these disorders often fail to reach the desired level of efficacy in the context of neurotrauma. Although a complicated association, decades of work have linked central serotonin (5-HT) neurotransmission as being involved in the etiology of a myriad of neuropsychiatric disorders, including MDD and GAD. 5-HT is a biogenic monoamine neurotransmitter that is highly conserved across scales of biology. Though the majority of 5-HT is isolated to peripheral sites such as the gastrointestinal (GI) tract, 5-HT neurotransmission within the CNS exerts exquisite control over diverse biological functions, including sleep, appetite and respiration, while simultaneously establishing normal mood, perception, and attention. Although several key studies have begun to elucidate how various forms of neurotrauma impact central 5-HT neurotransmission, a full determination of precisely how TBI disrupts the highly regulated dynamics of 5-HT neuron function and\/or 5-HT neurotransmission has yet to be conceptually or experimentally resolved. The purpose of the current review is, therefore, to integrate the disparate bodies of 5-HT and TBI research and synthesize insight into how new combinatorial research regarding 5-HT neurotransmission and TBI may offer an informed perspective into the nature of TBI-induced neuropsychiatric complications.<\/jats:p>","DOI":"10.3390\/brainsci14010051","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T03:43:00Z","timestamp":1704426180000},"page":"51","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Strain in the Midbrain: Impact of Traumatic Brain Injury on the Central Serotonin System"],"prefix":"10.3390","volume":"14","author":[{"given":"Christopher J.","family":"O\u2019Connell","sequence":"first","affiliation":[{"name":"Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan S.","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor M.","family":"Peach","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen D.","family":"Traubert","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana C.","family":"Schwierling","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle A.","family":"Notorgiacomo","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3277-3062","authenticated-orcid":false,"given":"Matthew J.","family":"Robson","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA"},{"name":"Neuroscience Graduate Program, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,5]]},"reference":[{"key":"ref_1","unstructured":"Centers for Disease Control and Prevention (2023, September 15). TBI Data and Statistics|Concussion|Traumatic Brain Injury|CDC Injury Center, Available online: https:\/\/cdc.gov\/traumaticbraininjury\/data\/."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.bbi.2012.06.008","article-title":"Neuroinflammation after traumatic brain injury: Opportunities for therapeutic intervention","volume":"26","author":"Kumar","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"ref_3","unstructured":"Centers for Disease Control and Prevention (2018\u20132019). 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