{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:42:51Z","timestamp":1790008971263,"version":"4.0.1"},"reference-count":119,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Due to similar manifestations, some authors have proposed a potential correlation between autism spectrum disorder (ASD) and obsessive\u2013compulsive disorder (OCD). This link has long been recognized and debated, with some authors arguing that these disorders frequently occur comorbid but distinct while others believe they are part of the same spectrum. The aim of our study was to explore the prevalence and correlates of autistic traits in 55 OCD patients and 55 matched controls and to assess possible autistic dimensions predictive of higher OCD symptoms. All participants were assessed with the Obsessive\u2013Compulsive Spectrum-Short Version (OBS-SV) and the Adult Autism Subthreshold Spectrum (AdAS Spectrum). The OCD group scored significantly higher in both questionnaires. Total OBS-SV scores and domains were significantly correlated with all AdAS Spectrum domains and total score. The AdAS Spectrum total, Verbal Communication and Inflexibility and adherence to routine domain scores were significant positive predictors of higher OBS-SV scores. Lastly, when two clusters of subjects (high and low\u00a0autism) were determined, Inflexibility and adherence to routine domain presented the greatest influence in forming the clusters. Our findings support the association between OCD and autistic traits in the adult population, supporting the hypothesis of a neurodevelopmental basis for these psychiatric conditions.<\/jats:p>","DOI":"10.3390\/brainsci14010064","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T04:38:51Z","timestamp":1704775131000},"page":"64","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Autistic Traits as Predictors of Increased Obsessive\u2013Compulsive Disorder Severity: The Role of Inflexibility and Communication Impairment"],"prefix":"10.3390","volume":"14","author":[{"given":"Liliana","family":"Dell\u2019Osso","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5437-7178","authenticated-orcid":false,"given":"Benedetta","family":"Nardi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Bonelli","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Amatori","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Alessandra","family":"Pereyra","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Massimetti","sequence":"additional","affiliation":[{"name":"UFSMA Val di Cornia, Azienda USL Toscana Nord Ovest, 54100 Massa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan Mirko","family":"Cremone","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9092-9144","authenticated-orcid":false,"given":"Stefano","family":"Pini","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Carpita","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s00406-004-0459-4","article-title":"Obsessive-compulsive severity spectrum in the community: Prevalence, comorbidity, and course","volume":"254","author":"Angst","year":"2004","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41398-023-02433-2","article-title":"The genetic epidemiology of obsessive-compulsive disorder: A systematic review and meta-analysis","volume":"13","author":"Radua","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0924-9338(01)00571-5","article-title":"Quality of life and disability in patients with obsessive-compulsive disorder","volume":"16","author":"Bobes","year":"2001","journal-title":"Eur. Psychiatry"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"152342","DOI":"10.1016\/j.comppsych.2022.152342","article-title":"The global assessment of OCD","volume":"118","author":"Pampaloni","year":"2022","journal-title":"Compr. Psychiatry"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2023). Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Association. [5th ed.]. Text Revision.","DOI":"10.1176\/appi.books.9780890425787"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/cpsp.12076","article-title":"Obsessive-compulsive disorder in the DSM-5","volume":"21","author":"Abramowitz","year":"2014","journal-title":"Clin. Psychol. Sci. Pract."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.psc.2014.06.004","article-title":"Obsessive-compulsive disorder","volume":"37","author":"Goodman","year":"2014","journal-title":"Psychiatr. Clin. N. Am."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/mp.2008.94","article-title":"The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication","volume":"15","author":"Ruscio","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/00004583-199804000-00020","article-title":"Is juvenile obsessive-compulsive disorder a developmental subtype of the disorder? A review of the pediatric literature","volume":"37","author":"Geller","year":"1998","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0193-953X(18)30205-3","article-title":"The epidemiology and clinical features of obsessive compulsive disorder","volume":"15","author":"Rasmussen","year":"1992","journal-title":"Psychiatr. Clin. N. Am."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.4103\/psychiatry.IndianJPsychiatry_521_18","article-title":"Course and outcome of obsessive-compulsive disorder","volume":"61","author":"Sharma","year":"2019","journal-title":"Indian J. Psychiatry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/da.22103","article-title":"Long-term outcome in adults with obsessive-compulsive disorder","volume":"30","author":"Bloch","year":"2013","journal-title":"Depress. Anxiety"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.4088\/JCP.08m04806blu","article-title":"A 2-year prospective follow-up study of the course of obsessive-compulsive disorder","volume":"71","author":"Eisen","year":"2010","journal-title":"J. Clin. Psychiatry"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1176\/foc.5.3.foc299","article-title":"Obsessive-compulsive disorder: An update for the clinician","volume":"5","author":"Koran","year":"2007","journal-title":"Focus"},{"key":"ref_16","first-page":"466","article-title":"Clinical and epidemiologic findings of significance to neuropharmacologic trials in OCD","volume":"24","author":"Rasmussen","year":"1988","journal-title":"Psychopharmacol. Bull."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1001\/archpsyc.56.2.121","article-title":"A 40-year follow-up of patients with obsessive-compulsive disorder","volume":"56","author":"Skoog","year":"1999","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_18","first-page":"11","article-title":"The epidemiology and differential diagnosis of obsessive compulsive disorder","volume":"55","author":"Rasmussen","year":"1994","journal-title":"J. Clin. Psychiatry"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/da.20042","article-title":"Anxiety and major depression comorbidity in a family study of obsessive-compulsive disorder","volume":"20","author":"Carter","year":"2004","journal-title":"Depress. Anxiety"},{"key":"ref_20","first-page":"1","article-title":"Prevalence of autism spectrum disorders\u2014Autism and developmental disabilities monitoring network, United States, 2006","volume":"58","author":"Rice","year":"2009","journal-title":"Morb. Mortal. Wkly. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss7201a1","article-title":"Early Identification of Autism Spectrum Disorder Among Children Aged 4 Years\u2014Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2020","volume":"72","author":"Shaw","year":"2023","journal-title":"MMWR Surveill. Summ."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s12264-017-0100-y","article-title":"An Overview of Autism Spectrum Disorder, Heterogeneity and Treatment Options","volume":"33","author":"Masi","year":"2017","journal-title":"Neurosci. Bull."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1136\/jnnp.2003.018713","article-title":"The cognitive neuroscience of autism","volume":"75","year":"2004","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s10567-011-0097-0","article-title":"Anxiety disorders in children and adolescents with autistic spectrum disorders: A meta-analysis","volume":"14","author":"Perrin","year":"2011","journal-title":"Clin. Child Fam. Psychol. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1744-859X-11-16","article-title":"Psychiatric comorbidities in asperger syndrome and high functioning autism: Diagnostic challenges","volume":"11","author":"Mazzone","year":"2012","journal-title":"Ann. Gen. Psychiatry"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Mazzone, L., and Vitiello, B. (2016). Psychiatric Symptoms and Comorbidities in Autism Spectrum Disorder, Springer.","DOI":"10.1007\/978-3-319-29695-1"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.comppsych.2016.11.001","article-title":"Adult Autism Subthreshold Spectrum (AdAS Spectrum): Validation of a questionnaire investigating subthreshold autism spectrum","volume":"73","author":"Gesi","year":"2017","journal-title":"Compr. Psychiatry"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1017\/S1092852915000450","article-title":"Adult autism spectrum as a transnosographic dimension","volume":"21","author":"Maj","year":"2016","journal-title":"CNS Spectr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"204","DOI":"10.2174\/1745017902016010204","article-title":"Defining the Optimal Threshold Scores for Adult Autism Subthreshold Spectrum (AdAS Spectrum) in Clinical and General Population","volume":"16","author":"Carmassi","year":"2020","journal-title":"Clin. Pract. Epidemiol. Ment. Health"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"112576","DOI":"10.1016\/j.psychres.2019.112576","article-title":"Measuring subthreshold autistic traits in the general population: Psychometric properties of the Adult Autism Subthreshold Spectrum (AdAS Spectrum) scale","volume":"281","author":"Donati","year":"2019","journal-title":"Psychiatry Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4253","DOI":"10.1007\/s10803-021-04904-1","article-title":"The Diagnosis of Autism: From Kanner to DSM-III to DSM-5 and beyond","volume":"51","author":"Rosen","year":"2021","journal-title":"J. Autism Dev. Disord."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1017\/S1092852919001615","article-title":"The broad autism phenotype in real-life: Clinical and functional correlates of autism spectrum symptoms and rumination among parents of patients with autism spectrum disorder","volume":"25","author":"Carpita","year":"2020","journal-title":"CNS Spectr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"346","DOI":"10.3389\/fnins.2016.00346","article-title":"The Broad Autism (Endo)Phenotype: Neurostructural and Neurofunctional Correlates in Parents of Individuals with Autism Spectrum Disorders","volume":"10","author":"Billeci","year":"2016","journal-title":"Front. Neurosci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"112605","DOI":"10.1016\/j.psychres.2019.112605","article-title":"Subthreshold autism spectrum in bipolar disorder: Prevalence and clinical correlates","volume":"281","author":"Carpita","year":"2019","journal-title":"Psychiatry Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.comppsych.2018.01.002","article-title":"Correlates of autistic traits among patients with borderline personality disorder","volume":"83","author":"Cremone","year":"2018","journal-title":"Compr. Psychiatry"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Dell\u2019Osso, L., Amatori, G., Cremone, I.M., Massimetti, E., Nardi, B., Gravina, D., Benedetti, F., Muscatello, M.R.A., Pompili, M., and Politi, P. (2023). Autistic and Catatonic Spectrum Symptoms in Patients with Borderline Personality Disorder. Brain Sci., 13.","DOI":"10.3390\/brainsci13081175"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1017\/S1092852920002011","article-title":"Eating disorders and autism spectrum: Links and risks","volume":"27","author":"Carpita","year":"2022","journal-title":"CNS Spectr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.2147\/NDT.S108912","article-title":"Historical evolution of the concept of anorexia nervosa and relationships with orthorexia nervosa, autism, and obsessive-compulsive spectrum","volume":"12","author":"Abelli","year":"2016","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1017\/S1092852921000420","article-title":"Investigating the relationship between orthorexia nervosa and autistic traits in a university population","volume":"27","author":"Carpita","year":"2022","journal-title":"CNS Spectr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1007\/s40519-022-01514-3","article-title":"Orthorexia and autism spectrum in University workers: Relationship with gender, body mass index and dietary habits","volume":"27","author":"Nardi","year":"2022","journal-title":"Eat. Weight Disord."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.1192\/j.eurpsy.2022.2334","article-title":"Investigating the relationship between autistic traits and symptoms and Catatonia Spectrum","volume":"65","author":"Amatori","year":"2022","journal-title":"Eur. Psychiatry"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1017\/S1092852921000808","article-title":"Autistic traits and camouflaging behaviors: A cross-sectional investigation in a University student population","volume":"27","author":"Cremone","year":"2022","journal-title":"CNS Spectr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1023\/A:1005653411471","article-title":"The autism-spectrum quotient (AQ): Evidence from Asperger syndrome\/high-functioning autism, males and females, scientists and mathematicians","volume":"31","author":"Wheelwright","year":"2001","journal-title":"J. Autism Dev. Disord."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Dell\u2019Osso, L., Buselli, R., Corsi, M., Baldanzi, S., Bertelloni, C.A., Marino, R., Gravina, D., Chiumiento, M., Veltri, A., and Massimetti, G. (2022). Do Autistic Traits Correlate with Post-Traumatic Stress and Mood Spectrum Symptoms among Workers Complaining of Occupational Stress?. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19073809"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Dell\u2019Osso, L., Cremone, I.M., Amatori, G., Cappelli, A., Cuomo, A., Barlati, S., Massimetti, G., Vita, A., Fagiolini, A., and Carmassi, C. (2021). Investigating the Relationship between Autistic Traits, Ruminative Thinking, and Suicidality in a Clinical Sample of Subjects with Bipolar Disorder and Borderline Personality Disorder. Brain Sci., 11.","DOI":"10.3390\/brainsci11050621"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Dell\u2019Osso, L., Bertelloni, C.A., Di Paolo, M., Avella, M.T., Carpita, B., Gori, F., Pompili, M., and Carmassi, C. (2019). Problematic Internet Use in University Students Attending Three Superior Graduate Schools in Italy: Is Autism Spectrum Related to Suicide Risk?. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16071098"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1124241","DOI":"10.3389\/fpsyt.2023.1124241","article-title":"Investigating suicidality across the autistic-catatonic continuum in a clinical sample of subjects with major depressive disorder and borderline personality disorder","volume":"14","author":"Nardi","year":"2023","journal-title":"Front. Psychiatry"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.2174\/0929867326666190328151539","article-title":"Microbiota, Immune System and Autism Spectrum Disorders: An Integrative Model towards Novel Treatment Options","volume":"27","author":"Carpita","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"ref_49","first-page":"179","article-title":"The neurodevelopmental continuum towards a neurodevelopmental gradient hypothesis","volume":"25","author":"Lorenzi","year":"2019","journal-title":"J. Psychopathol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"94","DOI":"10.2174\/1745017901915010094","article-title":"Autistic Traits and Illness Trajectories","volume":"15","author":"Lorenzi","year":"2019","journal-title":"Clin. Pract. Epidemiol. Ment. Health"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1007\/s00787-020-01478-8","article-title":"Co-occurring obsessive compulsive disorder and autism spectrum disorder in young people: Prevalence, clinical characteristics and outcomes","volume":"29","author":"Martin","year":"2020","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s10578-016-0629-4","article-title":"Elevated autism spectrum disorder traits in young children with OCD","volume":"47","author":"Stewart","year":"2016","journal-title":"Child Psychiatry Hum. Dev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1192\/bjp.186.6.525","article-title":"Obsessions and compulsions in Asperger Syndrome and high-functioning Autism","volume":"186","author":"Russell","year":"2005","journal-title":"Br. J. Psychiatry"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/08039480152036047","article-title":"Autistic traits in obsessive-compulsive disorder","volume":"55","author":"Bejerot","year":"2001","journal-title":"Nord. J. Psychiatry"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.janxdis.2007.10.003","article-title":"Autism spectrum traits in children and adolescents with obsessive-compulsive disorder (OCD)","volume":"22","author":"Ivarsson","year":"2008","journal-title":"J. Anxiety Disord."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.3109\/00048674.2010.515561","article-title":"Obsessions and compulsions in children with Asperger\u2019s syndrome or high-functioning autism: A case-control study","volume":"44","author":"Mack","year":"2010","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.psychres.2008.07.015","article-title":"Cross-cutting issues and future directions for the OCD spectrum","volume":"170","author":"Hollander","year":"2009","journal-title":"Psychiatry Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"259","DOI":"10.31887\/dcns.2003.5.3\/aallen","article-title":"Obsessive-compulsive spectrum disorders","volume":"5","author":"Allen","year":"2003","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11920-020-01176-x","article-title":"Co-occurrence, Assessment and Treatment of Obsessive Compulsive Disorder in Children and Adults With Autism Spectrum Disorder","volume":"22","author":"Bedford","year":"2020","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Meier, S.M., Petersen, L., Schendel, D.E., Mattheisen, M., Mortensen, P.B., and Mors, O. (2015). Obsessive-Compulsive Disorder and Autism Spectrum Disorders: Longitudinal and Offspring Risk. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0141703"},{"key":"ref_61","unstructured":"Kerns, C.M., Renno, P., Storch, E.A., Kendall, P.C., and Wood, J.J. (2017). Anxiety in Children and Adolescents with Autism Spectrum Disorder: Evidence-Based Assessment and Treatment, Academic Press."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s10803-006-0123-0","article-title":"Comorbid psychiatric disorders in children with autism: Interview development and rates of disorders","volume":"36","author":"Leyfer","year":"2006","journal-title":"J. Autism Dev. Disord."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s00787-015-0782-5","article-title":"Subclinical autism spectrum symptoms in pediatric obsessive-compulsive disorder","volume":"25","author":"Arildskov","year":"2016","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jocrd.2012.04.002","article-title":"Preschool and current autistic symptoms in children and adolescents with obsessive-compulsive disorder (OCD)","volume":"1","author":"Weidle","year":"2012","journal-title":"J. Obsessive Compuls. Relat. Disord."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s10578-017-0714-3","article-title":"ASD traits among youth with obsessive- compulsive disorder","volume":"48","author":"Griffiths","year":"2017","journal-title":"Child Psychiatry Hum. Dev."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"114498","DOI":"10.1016\/j.psychres.2022.114498","article-title":"Clinical characteristics of adults suffering from high-functioning autism and comorbid obsessive-compulsive disorder","volume":"311","author":"Lamothe","year":"2022","journal-title":"Psychiatry Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.chc.2019.12.003","article-title":"Obsessive-Compulsive Disorder in Autism Spectrum Disorder Across the Lifespan","volume":"29","author":"Pazuniak","year":"2020","journal-title":"Child Adolesc. Psychiatr. Clin. N. Am."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1080\/13651501.2017.1354029","article-title":"Autism spectrum disorders in adult outpatients with obsessive compulsive disorder in the UK","volume":"22","author":"Wikramanayake","year":"2018","journal-title":"Int. J. Psychiatry Clin. Pract."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"113826","DOI":"10.1016\/j.psychres.2021.113826","article-title":"Examining the correlation between symptoms of obsessive compulsive disorder and autism spectrum disorder in a community-based sample of adults","volume":"299","author":"Watkins","year":"2021","journal-title":"Psychiatry Res."},{"key":"ref_70","unstructured":"First, M.B., Williams, J.B.W., Karg, R.S., and Spitzer, R.L. (2015). Structured Clinical Interview for DSM-5\u2014Research Version (SCID-5 for DSM-5, Research Version; SCID-5-RV), American Psychiatric Association."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1157636","DOI":"10.3389\/fpsyg.2023.1157636","article-title":"Validation of the short version of the obsessive compulsive spectrum questionnaire","volume":"14","author":"Nardi","year":"2023","journal-title":"Front. Psychol."},{"key":"ref_72","unstructured":"IBM Corp (IBM SPSS Statistics for Windows, 2019). IBM SPSS Statistics for Windows, Version 26.0."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s10803-009-0922-1","article-title":"Autism and ADHD symptoms in patients with OCD: Are they associated with specific OC symptom dimensions or OC symptom severity?","volume":"40","author":"Anholt","year":"2010","journal-title":"J. Autism Dev. Disord."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3389\/fpsyt.2018.00216","article-title":"White matter features associated with autistic traits in obsessive compulsive disorder","volume":"9","author":"Kuno","year":"2018","journal-title":"Front. Psychiatry"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Liu, D., Cao, H., Kural, K., Fang, Q., and Zhang, F. (2019). Integrative analysis of shared genetic pathogenesis by Autism Spectrum Disorder and Obsessive Compulsive Disorder. Biosci. Rep., 39.","DOI":"10.1042\/BSR20191942"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"5804","DOI":"10.1093\/cercor\/bhx265","article-title":"Shared and Disorder-Specific Neurocomputational Mechanisms of Decision-Making in Autism Spectrum Disorder and Obsessive-Compulsive Disorder","volume":"27","author":"Carlisi","year":"2017","journal-title":"Cereb. Cortex"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1177\/1362361307079606","article-title":"The relationship between executive functioning, central coherence, and repetitive behaviors in the high-functioning autism spectrum","volume":"11","author":"South","year":"2007","journal-title":"Autism"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1177\/1362361309335716","article-title":"Set-shifting in children with autism spectrum disorders: Reversal shifting deficits on the intradimensional\/extradimensional Shift Test correlate with repetitive behaviors","volume":"13","author":"Yerys","year":"2009","journal-title":"Autism"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1001\/archpsyc.63.11.1225","article-title":"Reduced orbitofrontal-striatal activity on a reversal learning task in obsessive-compulsive disorder","volume":"63","author":"Remijnse","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1176\/ajp.2007.164.2.335","article-title":"Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder","volume":"164","author":"Chamberlain","year":"2007","journal-title":"Am. J. Psychiatry"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1162\/jocn_a_00286","article-title":"Prefrontal cortical mechanisms underlying individual differences in cognitive flexibility and stability","volume":"24","author":"Armbruster","year":"2012","journal-title":"J. Cogn. Neurosci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.tins.2015.07.003","article-title":"Demystifying cognitive flexibility: Implications for clinical and developmental neuroscience","volume":"38","author":"Dajani","year":"2015","journal-title":"Trends Neurosci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.2224\/sbp.2013.41.7.1141","article-title":"Perceived social support as moderator of perfectionism, depression, and anxiety in college students","volume":"41","author":"Zhou","year":"2013","journal-title":"Soc. Behav. Pers. Int. J."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"908926","DOI":"10.3389\/fpsyt.2022.908926","article-title":"Mediating Mechanisms of Perfectionism: Clinical Comorbidity of OCD and ED","volume":"13","author":"Icaza","year":"2022","journal-title":"Front. Psychiatry"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1126\/science.1154433","article-title":"Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives","volume":"321","author":"Chamberlain","year":"2008","journal-title":"Science"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/brain\/awm277","article-title":"Neural correlates of cognitive inflexibility during task-switching in obsessive-compulsive disorder","volume":"131","author":"Gu","year":"2008","journal-title":"Brain"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.pnpbp.2009.02.018","article-title":"Cognitive endophenotypes in OCD: A study of unaffected siblings of probands with familial OCD","volume":"33","author":"Viswanath","year":"2009","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1007\/s10803-017-3152-y","article-title":"The Flexibility Scale: Development and Preliminary Validation of a Cognitive Flexibility Measure in Children with Autism Spectrum Disorders","volume":"47","author":"Strang","year":"2017","journal-title":"J. Autism Dev. Disord."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/mp.2017.75","article-title":"Autism spectrum disorders: A meta-analysis of executive function","volume":"23","author":"Demetriou","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1177\/1362361318769176","article-title":"Exploring the neurocognitive correlates of challenging behaviours in young people with autism spectrum disorder","volume":"23","author":"Vitoratou","year":"2019","journal-title":"Autism"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/aur.1361","article-title":"The association between social cognition and executive functioning and symptoms of anxiety and depression in adolescents with autism spectrum disorders","volume":"7","author":"Hollocks","year":"2014","journal-title":"Autism Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/ajmg.b.32235","article-title":"Clinical correlates and genetic linkage of social and communication difficulties in families with obsessive-compulsive disorder: Results from the OCD Collaborative Genetics Study","volume":"165B","author":"Samuels","year":"2014","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"ref_93","first-page":"507","article-title":"Development pragmatics in normal and abnormal children","volume":"68","author":"Bara","year":"1999","journal-title":"Brain"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1017\/S0033291700032918","article-title":"Social language use in parents of autistic individuals","volume":"22","author":"Landa","year":"1992","journal-title":"Psychol. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/(SICI)1096-8628(19970725)74:4<398::AID-AJMG11>3.0.CO;2-D","article-title":"Personality and language characteristics in parents from multiple-inci- dence autism families","volume":"74","author":"Piven","year":"1997","journal-title":"Am. J. Med. Genet."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1007\/s10803-006-0274-z","article-title":"Communicative competence in parents of children with specific language impairment","volume":"37","author":"Ruser","year":"2007","journal-title":"J. Autism Dev. Disord."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1177\/1362361305051398","article-title":"Attention, monotropism and the diagnostic criteria for autism","volume":"9","author":"Murray","year":"2005","journal-title":"Autism"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1111\/j.1469-7610.1994.tb01807.x","article-title":"Executive function abilities in autism and Tourette syndrome: An information processing approach","volume":"35","author":"Ozonoff","year":"1994","journal-title":"J. Child Psychol. Psychiatry"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1177\/13623613211046160","article-title":"Exploring the impact of adolescent cognitive inflexibility on emotional and behavioural problems experienced by autistic adults","volume":"26","author":"Hollocks","year":"2022","journal-title":"Autism"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/aur.1461","article-title":"Obsessive-compulsive disorder in adults with high-functioning autism spectrum disorder: What does self-report with the OCI-R tell us?","volume":"8","author":"Cadman","year":"2015","journal-title":"Autism Res."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Mazzone, L., and Vitiello, B. (2016). Psychiatric Symptoms and Comorbidities in Autism Spectrum Disorder, Springer.","DOI":"10.1007\/978-3-319-29695-1"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s11920-017-0846-y","article-title":"Anxiety Disorders and Obsessive-Compulsive Disorder in Individuals with Autism Spectrum Disorder","volume":"19","author":"Postorino","year":"2017","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s10803-014-2204-9","article-title":"Repetitive behaviors in autism and obsessive-compulsive disorder: New perspectives from a network analysis","volume":"45","author":"Ruzzano","year":"2015","journal-title":"J. Autism Dev. Disord."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1177\/1362361320909177","article-title":"Felt but not seen: Observed restricted repetitive behaviours are associated with self report but not parent report obsessive compulsive disorder","volume":"24","author":"Santore","year":"2020","journal-title":"Autism"},{"key":"ref_105","first-page":"178","article-title":"Differential diagnosis between obsessive compulsive disorder and restrictive and repetitive behavioural patterns, activities and interests in autism spectrum disorders","volume":"6","year":"2013","journal-title":"Rev. Psiquiatr. Salud Ment."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1086\/338241","article-title":"Evidence for a language quantitative trait locus on chromosome 7q in multiplex autism families","volume":"70","author":"Cantor","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/sj.mp.4001465","article-title":"Linkage analysis for autism in a subset families with obsessive-compulsive behaviors: Evidence for an autism susceptibility gene on chromosome 1 and further support for susceptibility genes on chromosome 6 and 19","volume":"9","author":"Buxbaum","year":"2004","journal-title":"Mol. Psychiatry"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1086\/367846","article-title":"Fine mapping of autistic disorder to chromosome 15q11-q13 by use of phenotypic subtypes","volume":"72","author":"Shao","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/aur.108","article-title":"Autism spectrum and obsessive-compulsive disorders: OC behaviors, phenotypes and genetics","volume":"2","author":"Jacob","year":"2009","journal-title":"Autism Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1001\/archgenpsychiatry.2011.1251","article-title":"Brain Anatomy and Its Relationship to Behavior in Adults with Autism Spectrum Disorder","volume":"69","author":"Ecker","year":"2012","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2463\/mrms.2014-0146","article-title":"Correlation between morphologic changes and autism spectrum tendency in obsessive-compulsive disorder","volume":"14","author":"Kobayashi","year":"2015","journal-title":"Magn. Reson. Med. Sci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.biopsych.2016.10.006","article-title":"Comparative multimodal meta-analysis of structural and functional brain abnormalities in autism spectrum disorder and obsessive-compulsive disorder","volume":"82","author":"Carlisi","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.jpsychires.2005.04.010","article-title":"Obsessive-compulsive disorder: A 3-year prospective follow-up study of patients treated with serotonin reuptake inhibitors. OCD follow-up study","volume":"40","author":"Catapano","year":"2006","journal-title":"J. Psychiatr. Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.comppsych.2011.01.001","article-title":"Longitudinal course of obsessive-compulsive disorder in patients with anxiety disorders: A 15-year prospective follow-up study","volume":"52","author":"Marcks","year":"2011","journal-title":"Comp. Psychiatry"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10882-017-9559-8","article-title":"Effectiveness of cognitive behavioral therapy for individuals with Autism Spectrum Disorders and Comorbid Obsessive-Compulsive disorder: A review of the Research","volume":"30","author":"Kose","year":"2018","journal-title":"J. Dev. Phys. Disabil."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.psychres.2015.03.012","article-title":"Outcomes of cognitive behaviour therapy for obsessive-compulsive disorder in young people with and without autism spectrum disorders: A case controlled study","volume":"228","author":"Murray","year":"2015","journal-title":"Psychiatry Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jocrd.2016.06.002","article-title":"Severe pediatric obsessive compulsive disorder and co-morbid autistic symptoms: Effectiveness of cognitive behavioral therapy","volume":"10","author":"Wolters","year":"2016","journal-title":"J. Obs.-Compuls. Relat. Disord."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10578-017-0724-1","article-title":"An initial Case Series of Intensive cognitive\u2013behavioral therapy for obsessive\u2013compulsive disorder in adolescents with Autism Spectrum Disorder","volume":"49","author":"Nadeau","year":"2018","journal-title":"Child Psychiatry Hum. Dev."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1017\/S1092852922000037","article-title":"What misdiagnoses do women with autism spectrum disorder receive in the DSM-5?","volume":"28","author":"Carpita","year":"2023","journal-title":"CNS Spectr."}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/14\/1\/64\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:42:45Z","timestamp":1760103765000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/14\/1\/64"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,9]]},"references-count":119,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["brainsci14010064"],"URL":"https:\/\/doi.org\/10.3390\/brainsci14010064","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,9]]}}}