{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T01:09:50Z","timestamp":1772500190033,"version":"3.50.1"},"reference-count":55,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Nebraska Foundation\u2019s Orthostatic Tremor Research and Education Fund","award":["RO1 AG064247"],"award-info":[{"award-number":["RO1 AG064247"]}]},{"name":"University of Nebraska Foundation\u2019s Orthostatic Tremor Research and Education Fund","award":["NIH\/NIGMS P20 GM130447"],"award-info":[{"award-number":["NIH\/NIGMS P20 GM130447"]}]},{"name":"University of Nebraska Foundation\u2019s Orthostatic Tremor Research and Education Fund","award":["NIH T32 AG076407"],"award-info":[{"award-number":["NIH T32 AG076407"]}]},{"DOI":"10.13039\/100000049","name":"UNMC\/Nebraska Medicine Clinical and Translational Research Support Fund","doi-asserted-by":"publisher","award":["RO1 AG064247"],"award-info":[{"award-number":["RO1 AG064247"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"UNMC\/Nebraska Medicine Clinical and Translational Research Support Fund","doi-asserted-by":"publisher","award":["NIH\/NIGMS P20 GM130447"],"award-info":[{"award-number":["NIH\/NIGMS P20 GM130447"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"UNMC\/Nebraska Medicine Clinical and Translational Research Support Fund","doi-asserted-by":"publisher","award":["NIH T32 AG076407"],"award-info":[{"award-number":["NIH T32 AG076407"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UNMC Cognitive Neuroscience of Development and Aging Center","award":["RO1 AG064247"],"award-info":[{"award-number":["RO1 AG064247"]}]},{"name":"UNMC Cognitive Neuroscience of Development and Aging Center","award":["NIH\/NIGMS P20 GM130447"],"award-info":[{"award-number":["NIH\/NIGMS P20 GM130447"]}]},{"name":"UNMC Cognitive Neuroscience of Development and Aging Center","award":["NIH T32 AG076407"],"award-info":[{"award-number":["NIH T32 AG076407"]}]},{"name":"The UNMC Training Program in Alzheimer\u2019s Disease and Related Dementia Drug Discovery","award":["RO1 AG064247"],"award-info":[{"award-number":["RO1 AG064247"]}]},{"name":"The UNMC Training Program in Alzheimer\u2019s Disease and Related Dementia Drug Discovery","award":["NIH\/NIGMS P20 GM130447"],"award-info":[{"award-number":["NIH\/NIGMS P20 GM130447"]}]},{"name":"The UNMC Training Program in Alzheimer\u2019s Disease and Related Dementia Drug Discovery","award":["NIH T32 AG076407"],"award-info":[{"award-number":["NIH T32 AG076407"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Orthostatic tremor is a rare movement disorder characterized by a sensation of unsteadiness and leg tremor while standing. It has been hypothesized that the disorder is attributable to dysregulation of a central oscillatory network in the brain. This putative network includes primary motor cortex, supplementary motor area, cerebellum, thalamus, and pontine tegmentum. We studied this brain network by recording resting-state functional MRI data from individuals with orthostatic tremor. For each participant, we measured resting-state functional connectivity using a seed-based approach. Regions of interest included were components of the putative central oscillatory network and a primary motor thumb region (identified via transcranial magnetic stimulation). A non-central oscillatory network region of interest\u2014posterior cingulate cortex\u2014was included for comparative analysis of a well-characterized intrinsic network, the default mode network. Demographic information, medical history, and tremor characteristics were collected to test associations with functional connectivity. For normative context, data from the 1000 Functional Connectomes Project were analyzed using an identical approach. We observed that tremor and demographic variables were correlated with functional connectivity of central oscillatory network components. Furthermore, relative to healthy comparison participants, patients with orthostatic tremor exhibited qualitatively different patterns of cerebellar resting state functional connectivity. Our study enhances the current understanding of brain network differences related to orthostatic tremor and is consistent with a hypothesized selective decoupling of cerebellum. Additionally, associations observed between functional connectivity and factors including medical history and tremor features may suggest targets for treatment of orthostatic tremor.<\/jats:p>","DOI":"10.3390\/brainsci14030219","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T03:35:48Z","timestamp":1709004948000},"page":"219","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Measurement of Functional Brain Network Connectivity in People with Orthostatic Tremor"],"prefix":"10.3390","volume":"14","author":[{"given":"Connor J.","family":"Phipps","sequence":"first","affiliation":[{"name":"Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Whitney","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Shou","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Torres-Russotto","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0539-2587","authenticated-orcid":false,"given":"David E.","family":"Warren","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/mds.27121","article-title":"Consensus Statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society","volume":"33","author":"Bhatia","year":"2017","journal-title":"Mov. 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