{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T16:19:05Z","timestamp":1764260345521,"version":"build-2065373602"},"reference-count":72,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T00:00:00Z","timestamp":1712361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Dandy\u2013Walker complex (DWC) consists of a continuum of brain malformations involving the posterior fossa, often leading to psychiatric manifestations during adulthood. We discussed the case of a young woman with Dandy\u2013Walker variant (DWV) and a comorbid complex neuropsychiatric presentation, who was diagnosed with an eating disorder, obsessive\u2013compulsive disorder, and a tic disorder. Afterwards, we conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020-compliant systematic review reappraising all evidence of psychiatric outcomes in adults with DWC. Overall, 34 studies were eligible for data extraction, comprising 36 patients. Psychiatric profiles were more common among young adult males, with DWC lesions, especially DWV subtype, being often discovered incidentally after admission to mental health inpatient facilities. Most patients were diagnosed with psychosis and bipolar disorder, often comorbid with cognitive impairment. Psychotropic polypharmacy was frequently prescribed, generally leading to complete recovery. Evidence from our case report and systematic review indicates the importance of monitoring long-term psychiatric sequelae among adult patients with DWC malformations.<\/jats:p>","DOI":"10.3390\/brainsci14040362","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T09:31:23Z","timestamp":1712568683000},"page":"362","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tic-Related Obsessive\u2013Compulsive and Eating Disorders in Dandy\u2013Walker Variant: A Case Report and Systematic Reappraisal of Psychiatric Profiles"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0125-4112","authenticated-orcid":false,"given":"Riccardo","family":"Bortoletto","sequence":"first","affiliation":[{"name":"Unit of Psychiatry, Department of Medicine (DMED), University of Udine, 33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Candolo","sequence":"additional","affiliation":[{"name":"Unit of Psychiatry, Department of Medicine (DMED), University of Udine, 33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Nicotra","sequence":"additional","affiliation":[{"name":"Unit of Psychiatry, Department of Medicine (DMED), University of Udine, 33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luana","family":"Saetti","sequence":"additional","affiliation":[{"name":"Unit of Psychiatry, Department of Medicine (DMED), University of Udine, 33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Perini","sequence":"additional","affiliation":[{"name":"Unit of Psychiatry, Department of Medicine (DMED), University of Udine, 33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Balestrieri","sequence":"additional","affiliation":[{"name":"Unit of Psychiatry, Department of Medicine (DMED), University of Udine, 33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6139-1920","authenticated-orcid":false,"given":"Marco","family":"Colizzi","sequence":"additional","affiliation":[{"name":"Unit of Psychiatry, Department of Medicine (DMED), University of Udine, 33100 Udine, Italy"},{"name":"Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London, London SE5 8AF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Comacchio","sequence":"additional","affiliation":[{"name":"Unit of Psychiatry, Department of Medicine (DMED), University of Udine, 33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,6]]},"reference":[{"key":"ref_1","first-page":"977","article-title":"Revised classification of posterior fossa cysts and cystlike malformations based on the results of multiplanar MR imaging","volume":"10","author":"Barkovich","year":"1989","journal-title":"Am. 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