{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:53:37Z","timestamp":1793372017975,"version":"4.5.0"},"reference-count":102,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH\/National Institute on Deafness and Other Communication Disorders (NIH\/NIDCD)","award":["R01 DC05375"],"award-info":[{"award-number":["R01 DC05375"]}]},{"name":"NIH\/National Institute on Deafness and Other Communication Disorders (NIH\/NIDCD)","award":["R01 DC015466"],"award-info":[{"award-number":["R01 DC015466"]}]},{"name":"NIH\/National Institute on Deafness and Other Communication Disorders (NIH\/NIDCD)","award":["P50 DC014664"],"award-info":[{"award-number":["P50 DC014664"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Here, we review the literature on neurotypical individuals and individuals with post-stroke aphasia showing that right-hemisphere regions homologous to language network and other regions, like the right cerebellum, are activated in language tasks and support language even in healthy people. We propose that language recovery in post-stroke aphasia occurs largely by potentiating the right hemisphere network homologous to the language network and other networks that previously supported language to a lesser degree and by modulating connection strength between nodes of the right-hemisphere language network and undamaged nodes of the left-hemisphere language network. Based on this premise (supported by evidence we review), we propose that interventions should be aimed at potentiating the right-hemisphere language network through Hebbian learning or by augmenting connections between network nodes through neuroplasticity, such as non-invasive brain stimulation and perhaps modulation of neurotransmitters involved in neuroplasticity. We review aphasia treatment studies that have taken this approach. We conclude that further aphasia rehabilitation with this aim is justified.<\/jats:p>","DOI":"10.3390\/brainsci14050419","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T08:08:32Z","timestamp":1714032512000},"page":"419","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Remapping and Reconnecting the Language Network after Stroke"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1752-6693","authenticated-orcid":false,"given":"Victoria","family":"Tilton-Bolowsky","sequence":"first","affiliation":[{"name":"Departments of Neurology, Physical Medicine & Rehabilitation, and Cognitive Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9069-1236","authenticated-orcid":false,"given":"Melissa D.","family":"Stockbridge","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Physical Medicine & Rehabilitation, and Cognitive Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5192-1171","authenticated-orcid":false,"given":"Argye E.","family":"Hillis","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Physical Medicine & Rehabilitation, and Cognitive Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e84716","DOI":"10.7554\/eLife.84716","article-title":"Against Cortical Reorganisation","volume":"12","author":"Makin","year":"2023","journal-title":"eLife"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"106327","DOI":"10.1016\/j.jcomdis.2023.106327","article-title":"Theory-Driven Treatment Modifications: A Discussion on Meeting the Linguistic, Cognitive, and Psychosocial Needs of Individual Clients with Aphasia","volume":"103","author":"Nunn","year":"2023","journal-title":"J. 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