{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:06:48Z","timestamp":1760144808727,"version":"build-2065373602"},"reference-count":0,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Japan Agency for Medical Research and Development","award":["JP23ek0109529","JP23ek0109548","24ek0109617","24ek0109735","24ek0109759","JPMH22FC1013","JP21K11321","JP22H02987"],"award-info":[{"award-number":["JP23ek0109529","JP23ek0109548","24ek0109617","24ek0109735","24ek0109759","JPMH22FC1013","JP21K11321","JP22H02987"]}]},{"name":"Rare and Intractable Diseases from the Ministry of Health, Labour and Welfare of Japan","award":["JP23ek0109529","JP23ek0109548","24ek0109617","24ek0109735","24ek0109759","JPMH22FC1013","JP21K11321","JP22H02987"],"award-info":[{"award-number":["JP23ek0109529","JP23ek0109548","24ek0109617","24ek0109735","24ek0109759","JPMH22FC1013","JP21K11321","JP22H02987"]}]},{"name":"Japan Society for the Promotion of Science (JSPS) KAKENHI","award":["JP23ek0109529","JP23ek0109548","24ek0109617","24ek0109735","24ek0109759","JPMH22FC1013","JP21K11321","JP22H02987"],"award-info":[{"award-number":["JP23ek0109529","JP23ek0109548","24ek0109617","24ek0109735","24ek0109759","JPMH22FC1013","JP21K11321","JP22H02987"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>The utility of transcranial sonography (TCS) remains unclarified for the auxiliary diagnosis of Parkinson\u2019s disease (PD). We investigated iodine-123 metaiodobenzylguanidine (MIBG) and TCS during the examination and diagnosis of high-signal-intensity substantia nigra lesion (HSI-SNL) incidence in PD patients previously diagnosed with dopamine transporter scintigraphy (DAT). The subjects were 67 patients with definitively diagnosed PD after DAT evaluation. Patients with midbrain substantia nigra visible during TCS who previously underwent MIBG were analyzed. The SN+ group comprised patients with extensive pathological HSI-SNL of Okawa class III\/IV observed during TCS. The MIBG+ group comprised patients with a heart-to-mediastinum ratio of \u22642.2 during MIBG. TCS was performed to divide patients into the SN+ and SN\u2212 groups, and patient characteristics and MIBG findings were compared between the groups. PD was definitively diagnosed in 67 patients, among whom midbrain was visualized during TCS in 43 (64.1%) patients and pathological HSI-SNL was observed in 24 (35.8%). The MIBG findings were normal in six patients (27.3%) with HSI-SNL, and abnormal in seven (63.6%) without HSI-SNL. No significant differences were noted by Okawa classification in clinical characteristics based on the presence or absence of HSI-SNL. Multiple patients with normal findings during MIBG may have HSI-SNL. Thus, confirmatory imaging of HSI-SNL with TCS may be useful for diagnosis.<\/jats:p>","DOI":"10.3390\/brainsci14060524","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T07:56:11Z","timestamp":1716364571000},"page":"524","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Utility of Combining Transcranial Sonography and MIBG Myocardial Scintigraphy to Evaluate Substantia Nigra in Patients with Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"14","author":[{"given":"Heisuke","family":"Mizukami","sequence":"first","affiliation":[{"name":"Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakae","family":"Hino","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Kaburagi","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Yamano","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,21]]},"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/14\/6\/524\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:46:05Z","timestamp":1760107565000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/14\/6\/524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,21]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["brainsci14060524"],"URL":"https:\/\/doi.org\/10.3390\/brainsci14060524","relation":{},"ISSN":["2076-3425"],"issn-type":[{"type":"electronic","value":"2076-3425"}],"subject":[],"published":{"date-parts":[[2024,5,21]]}}}