{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:26:11Z","timestamp":1775064371888,"version":"3.50.1"},"reference-count":36,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council (ERC)","doi-asserted-by":"publisher","award":["76604"],"award-info":[{"award-number":["76604"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council (ERC)","doi-asserted-by":"publisher","award":["91218033"],"award-info":[{"award-number":["91218033"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Netherlands Organization for Health Research and Development","award":["76604"],"award-info":[{"award-number":["76604"]}]},{"name":"The Netherlands Organization for Health Research and Development","award":["91218033"],"award-info":[{"award-number":["91218033"]}]},{"name":"American Tinnitus Association","award":["76604"],"award-info":[{"award-number":["76604"]}]},{"name":"American Tinnitus Association","award":["91218033"],"award-info":[{"award-number":["91218033"]}]},{"name":"Dorhout Mees Family Foundation","award":["76604"],"award-info":[{"award-number":["76604"]}]},{"name":"Dorhout Mees Family Foundation","award":["91218033"],"award-info":[{"award-number":["91218033"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Tinnitus is a common phantom auditory percept believed to be related to plastic changes in the brain due to hearing loss. However, tinnitus can also occur in the absence of any clinical hearing loss. In this case, since there is no hearing loss, the mechanisms that drive plastic changes remain largely enigmatic. Previous studies showed subtle differences in sound-evoked brain activity associated with tinnitus in subjects with tinnitus and otherwise normal hearing, but the results are not consistent across studies. Here, we aimed to investigate these differences using monaural rather than binaural stimuli. Sound-evoked responses were measured using functional magnetic resonance imaging (MRI) in participants with and without tinnitus. All participants had clinically normal audiograms. The stimuli were pure tones with frequencies between 353 and 8000 Hz, presented monaurally. A Principal Component Analysis (PCA) of the response in the auditory cortex revealed no difference in tonotopic organization, which confirmed earlier studies. A GLM analysis showed hyperactivity in the lateral areas of the bilateral auditory cortex. Consistent with the tonotopic map, this hyperactivity mainly occurred in response to low stimulus frequencies. This may be related to hyperacusis. Furthermore, there was an interaction between stimulation side and tinnitus in the parahippocampus. This may reflect an interference between tinnitus and spatial orientation.<\/jats:p>","DOI":"10.3390\/brainsci14060544","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T10:12:27Z","timestamp":1716804747000},"page":"544","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sound-Evoked Neural Activity in Normal-Hearing Tinnitus: Effects of Frequency and Stimulated Ear Side"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9496-4008","authenticated-orcid":false,"given":"Shahin","family":"Safazadeh","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\/Head and Neck Surgery, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands"},{"name":"Graduate School of Medical Sciences (Research School of Behavioral and Cognitive Neurosciences), University of Groningen, 9713 AV Groningen, The Netherlands"},{"name":"Cognitive Neuroscience Center, Biomedical Sciences of Cells and Systems, University of Groningen, 9713 AW Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5484-8467","authenticated-orcid":false,"given":"Marc","family":"Thioux","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\/Head and Neck Surgery, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands"},{"name":"Graduate School of Medical Sciences (Research School of Behavioral and Cognitive Neurosciences), University of Groningen, 9713 AV Groningen, The Netherlands"},{"name":"Cognitive Neuroscience Center, Biomedical Sciences of Cells and Systems, University of Groningen, 9713 AW Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remco J.","family":"Renken","sequence":"additional","affiliation":[{"name":"Graduate School of Medical Sciences (Research School of Behavioral and Cognitive Neurosciences), University of Groningen, 9713 AV Groningen, The Netherlands"},{"name":"Cognitive Neuroscience Center, Biomedical Sciences of Cells and Systems, University of Groningen, 9713 AW Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pim","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\/Head and Neck Surgery, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands"},{"name":"Graduate School of Medical Sciences (Research School of Behavioral and Cognitive Neurosciences), University of Groningen, 9713 AV Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/S0140-6736(13)60142-7","article-title":"Tinnitus","volume":"382","author":"Baguley","year":"2013","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Langguth, B., de Ridder, D., Schlee, W., and Kleinjung, T. 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