{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T04:59:12Z","timestamp":1792299552223,"version":"4.4.0"},"reference-count":79,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Deep Brain Stimulation (DBS) is an effective treatment option for patients with dopaminergic complications of Parkinson\u2019s disease (PD) and drug-refractory PD tremor. However, DBS and its indications can be challenging, and they are not often debated in the medical community. Through a critical narrative review, the objective of this paper is to improve the comprehension of DBS indications and help to solve the puzzle that this process can be. Proper patient selection is the first step for a good surgical outcome. In this review, then, relevant considerations are discussed, involving PD genes, PD phenotypes, indications of early stages, non-motor symptoms, neuroimaging predictors, comorbidities, and age. Individualized approaches are encouraged, including clinical and radiological factors. Social support during the whole follow-up and expectations alignment are necessary through this process and are also debated.<\/jats:p>","DOI":"10.3390\/brainsci14070638","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T12:18:31Z","timestamp":1719404311000},"page":"638","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["New Perspectives of Deep Brain Stimulation Indications for Parkinson\u2019s Disease: A Critical Review"],"prefix":"10.3390","volume":"14","author":[{"given":"Renata Montes Garcia","family":"Barbosa","sequence":"first","affiliation":[{"name":"Movement Disorders Center, Department of Neurology, School of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo 05403-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3725-4464","authenticated-orcid":false,"given":"Miriam Carvalho","family":"Soares","sequence":"additional","affiliation":[{"name":"Movement Disorders Center, Department of Neurology, School of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo 05403-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Maria Meneses Cury","family":"Portela","sequence":"additional","affiliation":[{"name":"Movement Disorders Center, Department of Neurology, School of Medicine, Centro Universit\u00e1rio Uninovafapi (UNINOVAFAPI), Teresina 64073505, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8460-6867","authenticated-orcid":false,"given":"Thiago Gon\u00e7alves","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Movement Disorders Center, Department of Neurology, School of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo 05403-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6305-3327","authenticated-orcid":false,"given":"Rubens Gisbert","family":"Cury","sequence":"additional","affiliation":[{"name":"Movement Disorders Center, Department of Neurology, School of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo 05403-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41582-018-0128-2","article-title":"Deep brain stimulation: Current challenges and future directions","volume":"15","author":"Lozano","year":"2019","journal-title":"Nat. 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