{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:49:34Z","timestamp":1769597374099,"version":"3.49.0"},"reference-count":24,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Objectives: To study the correlation between positive cochlin tomoprotein testing (CTP), magnetic resonance (MR) imaging, and the auditory and vestibular function amongst patients with sudden hearing loss. Study Design: Prospective case series. Methods: We prospectively examined eight patients who presented with sudden hearing loss (&gt;60 dB) with or without vertigo or tinnitus. We performed an ELISA-based CTP detection test using middle ear lavage samples. In addition to the CTP examination, a magnetic resonance imaging (MRI) examination was performed using different sequences (T1 and a T1 sequence with a contrast medium (CM), a T2 sequence, 4 h delayed intravenous gadolinium-enhanced three-dimensional fluid-attenuated inversion recovery (3D FLAIR)). Results: All patients with sudden hearing loss (&gt;60 dB) presented a non-specific contrast enhancement in the cochlea and vestibulum on the affected side on delayed 3D-FLAIR MRI. Four patients had a positive CTP test, suggesting a perilymphatic fistula (PLF). However, no specific MRI signal for a PLF was observed. Conclusions: Using multimodal diagnostic measures, such as CTP testing and different MRI sequences, no correlation could be found in patients with a PLF.<\/jats:p>","DOI":"10.3390\/brainsci14070681","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T12:30:59Z","timestamp":1720182659000},"page":"681","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["MRI-Based Inner Ear Assessment and Cochlin Tomoprotein-Based Evaluation of Perilymphatic Fistula in Patients with Sudden Hearing Loss"],"prefix":"10.3390","volume":"14","author":[{"given":"Rayoung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Medical Faculty OWL, Bielefeld University, Campus Klinikum Bielefeld, Teutoburgerstr. 50, 33604 Bielefeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Mihailovic","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical Faculty OWL, Bielefeld University, Campus Klinikum Bielefeld, Teutoburgerstr. 50, 33604 Bielefeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conrad","family":"Riemann","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Medical Faculty OWL, Bielefeld University, Campus Klinikum Bielefeld, Teutoburgerstr. 50, 33604 Bielefeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Kilgu\u00e9","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Medical Faculty OWL, Bielefeld University, Campus Klinikum Bielefeld, Teutoburgerstr. 50, 33604 Bielefeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph Joachim","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Medical Faculty OWL, Bielefeld University, Campus Klinikum Bielefeld, Teutoburgerstr. 50, 33604 Bielefeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Bj\u00f6rn","family":"Gehl","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical Faculty OWL, Bielefeld University, Campus Klinikum Bielefeld, Teutoburgerstr. 50, 33604 Bielefeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars-Uwe","family":"Scholtz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Medical Faculty OWL, Bielefeld University, Campus Klinikum Bielefeld, Teutoburgerstr. 50, 33604 Bielefeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4161-8304","authenticated-orcid":false,"given":"Ingo","family":"Todt","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Medical Faculty OWL, Bielefeld University, Campus Klinikum Bielefeld, Teutoburgerstr. 50, 33604 Bielefeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sarna, B., Abouzari, M., Merna, C., Jamshidi, S., Saber, T., and Djalilian, H.R. 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