{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T08:58:50Z","timestamp":1782377930649,"version":"3.54.5"},"reference-count":46,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the European Research Council (ERC) under the European Union\u2019s Horizon 2020 Research and Innovation Programme","award":["764604, TIN-ACT"],"award-info":[{"award-number":["764604, TIN-ACT"]}]},{"name":"the European Research Council (ERC) under the European Union\u2019s Horizon 2020 Research and Innovation Programme","award":["91218033"],"award-info":[{"award-number":["91218033"]}]},{"name":"the Heinsius Houbolt Foundation","award":["764604, TIN-ACT"],"award-info":[{"award-number":["764604, TIN-ACT"]}]},{"name":"the Heinsius Houbolt Foundation","award":["91218033"],"award-info":[{"award-number":["91218033"]}]},{"name":"the Netherlands Organization for Health Research and Development (ZonMW)","award":["764604, TIN-ACT"],"award-info":[{"award-number":["764604, TIN-ACT"]}]},{"name":"the Netherlands Organization for Health Research and Development (ZonMW)","award":["91218033"],"award-info":[{"award-number":["91218033"]}]},{"name":"the American Tinnitus Associate under the Innovative Grants Research Program 2021","award":["764604, TIN-ACT"],"award-info":[{"award-number":["764604, TIN-ACT"]}]},{"name":"the American Tinnitus Associate under the Innovative Grants Research Program 2021","award":["91218033"],"award-info":[{"award-number":["91218033"]}]},{"name":"the Dorhout Mees Family Foundation","award":["764604, TIN-ACT"],"award-info":[{"award-number":["764604, TIN-ACT"]}]},{"name":"the Dorhout Mees Family Foundation","award":["91218033"],"award-info":[{"award-number":["91218033"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Recent evidence suggests a connection between hyperacusis and the motor system of the brain. For instance, our recent study reported that hyperacusis in participants with tinnitus and hearing loss is associated with smaller gray matter volumes in the supplementary motor area (SMA). Given that hearing loss can affect gray matter changes in tinnitus, this study aimed to determine if the changes reported in our previous findings of smaller SMA gray matter volumes in hyperacusis persist in the absence of hearing loss. Data for this study were gathered from four prior studies conducted between 2004 and 2019 at the University Medical Centre Groningen (UMCG). A total of 101 participants with tinnitus and either clinically normal hearing (normal hearing with tinnitus or NHT, n = 35) or bilateral sensorineural hearing loss (hearing loss with tinnitus or HLT, n = 66) were included across four studies. Hyperacusis was determined by a score of \u226522 on the Hyperacusis Questionnaire (HQ). In the NHT group, 22 (63%) participants scored \u226522 on the HQ (NHT with hyperacusis: mean age 44.1 years, 12 females), while in the HLT group, 25 (38%) participants scored \u226522 on the HQ (HLT with hyperacusis: mean age 59.5 years, 10 females). The 2 \u00d7 2 between-group ANOVAs revealed that hyperacusis is associated with smaller SMA gray matter volumes, regardless of hearing levels. Notably, the smaller SMA gray matter volumes in hyperacusis were primarily influenced by the attentional subscales of the HQ. The association between hyperacusis and the motor system may indicate a constant alertness to sounds and a readiness for motor action.<\/jats:p>","DOI":"10.3390\/brainsci14070726","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T09:14:53Z","timestamp":1721380493000},"page":"726","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hyperacusis in Tinnitus Individuals Is Associated with Smaller Gray Matter Volumes in the Supplementary Motor Area Regardless of Hearing Levels"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3435-6198","authenticated-orcid":false,"given":"Punitkumar","family":"Makani","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands"},{"name":"Graduate School of Medical Sciences (Research School of Behavioral and Cognitive Neurosciences), University of Groningen, 9713 AV Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5484-8467","authenticated-orcid":false,"given":"Marc","family":"Thioux","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands"},{"name":"Graduate School of Medical Sciences (Research School of Behavioral and Cognitive Neurosciences), University of Groningen, 9713 AV Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4105-4254","authenticated-orcid":false,"given":"Elouise A.","family":"Koops","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands"},{"name":"Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1873-2707","authenticated-orcid":false,"given":"Sonja J.","family":"Pyott","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands"},{"name":"Graduate School of Medical Sciences (Research School of Behavioral and Cognitive Neurosciences), University of Groningen, 9713 AV Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8023-7571","authenticated-orcid":false,"given":"Pim","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands"},{"name":"Graduate School of Medical Sciences (Research School of Behavioral and Cognitive Neurosciences), University of Groningen, 9713 AV Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1080\/010503999424653","article-title":"Hypersensitivity to sound--questionnaire data, audiometry and classification","volume":"28","author":"Anari","year":"1999","journal-title":"Scand. 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