{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:05:22Z","timestamp":1791201922409,"version":"4.2.0"},"reference-count":99,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background: Psoriasis is a chronic skin disorder affecting 2\u20133% of the global population, and is associated with several comorbidities, including psychiatric disorders. This study aimed to identify factors influencing anxiety, depression, and quality of life (QoL) in patients with psoriasis. Methods: This observational study included 112 patients diagnosed with psoriasis. Dermatological and psychiatric assessments were conducted using Psodisk, the Hamilton Anxiety Rating Scale (HAM-A), Hamilton Depression Rating Scale (HAM-D), Symptom Checklist-90-Revised (SCL-90-R), and 36-Item Short Form Health Survey (SF-36). Descriptive statistics, correlation analyses, and multivariate regression models were employed. Results: The sample was predominantly middle-aged males (mean age 48.91 years). Females (p &lt; 0.001), patients with arthritis (p &lt; 0.05), and those with a sedentary lifestyle (p &lt; 0.05) showed higher anxiety and depression scores. Psodisk subscales significantly correlated with psychiatric symptoms and QoL measures (p &lt; 0.001). Pain (B: 0.63, p &lt; 0.05; B: \u22122.03, p &lt; 0.01) and sleep disturbances (B: 0.68, p &lt; 0.01; B: 0.60, p &lt; 0.01; B: \u22121.46, p &lt; 0.01; B: \u22121.57, p &lt; 0.05; B: 3.91, p &lt; 0.05) emerged as major predictors of poor mental health and reduced QoL. Conclusions. The study underscores the complex relationship between psoriasis, psychiatric comorbidities, and QoL. Key factors exacerbating anxiety and depression include female gender, arthritis, and sedentary lifestyle. Comprehensive management of psoriasis should address both dermatological and psychological aspects, with a focus on pain relief and improving sleep quality to enhance overall patient well-being.<\/jats:p>","DOI":"10.3390\/brainsci14090865","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T11:58:46Z","timestamp":1724759926000},"page":"865","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Factors Associated with Anxiety, Depression, and Quality of Life in Patients with Psoriasis: A Cross-Sectional Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8995-9020","authenticated-orcid":false,"given":"Salvatore","family":"Cipolla","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Campania \u201cLuigi Vanvitelli\u201d, Largo Madonna delle Grazie 1, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Catapano","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Campania \u201cLuigi Vanvitelli\u201d, Largo Madonna delle Grazie 1, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Fiorino","family":"Bonamico","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Campania \u201cLuigi Vanvitelli\u201d, Largo Madonna delle Grazie 1, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"De Santis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Campania \u201cLuigi Vanvitelli\u201d, Largo Madonna delle Grazie 1, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Murolo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Campania \u201cLuigi Vanvitelli\u201d, Largo Madonna delle Grazie 1, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Romano","sequence":"additional","affiliation":[{"name":"Dermatology Unit, University of Campania \u201cLuigi Vanvitelli\u201d, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Volpicelli","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Campania \u201cLuigi Vanvitelli\u201d, Largo Madonna delle Grazie 1, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Perris","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Campania \u201cLuigi Vanvitelli\u201d, Largo Madonna delle Grazie 1, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada","family":"Lo Schiavo","sequence":"additional","affiliation":[{"name":"Dermatology Unit, University of Campania \u201cLuigi Vanvitelli\u201d, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0231-4025","authenticated-orcid":false,"given":"Michele","family":"Fabrazzo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Campania \u201cLuigi Vanvitelli\u201d, Largo Madonna delle Grazie 1, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Catapano","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Campania \u201cLuigi Vanvitelli\u201d, Largo Madonna delle Grazie 1, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1001\/jamadermatol.2021.2007","article-title":"Psoriasis Prevalence in Adults in the United States","volume":"157","author":"Armstrong","year":"2021","journal-title":"JAMA Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1080\/08820139.2024.2302823","article-title":"Etiopathogenesis of Psoriasis: Integration of Proposed Theories","volume":"53","year":"2024","journal-title":"Immunol. 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