{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:56:01Z","timestamp":1789750561149,"version":"4.0.1"},"reference-count":69,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T00:00:00Z","timestamp":1725062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009045","name":"Faculty of Medicine, Jagiellonian University Medical College in Krakow, Poland","doi-asserted-by":"publisher","award":["U1C\/W41\/NO\/28.21"],"award-info":[{"award-number":["U1C\/W41\/NO\/28.21"]}],"id":[{"id":"10.13039\/100009045","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009045","name":"Faculty of Medicine, Jagiellonian University Medical College in Krakow, Poland","doi-asserted-by":"publisher","award":["N41\/DBS\/000535"],"award-info":[{"award-number":["N41\/DBS\/000535"]}],"id":[{"id":"10.13039\/100009045","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009045","name":"Jagiellonian University Medical College","doi-asserted-by":"publisher","award":["U1C\/W41\/NO\/28.21"],"award-info":[{"award-number":["U1C\/W41\/NO\/28.21"]}],"id":[{"id":"10.13039\/100009045","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009045","name":"Jagiellonian University Medical College","doi-asserted-by":"publisher","award":["N41\/DBS\/000535"],"award-info":[{"award-number":["N41\/DBS\/000535"]}],"id":[{"id":"10.13039\/100009045","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Anhedonia constitutes a core symptom of major depressive disorder (MDD) mediating the ultimate goal of MDD treatment: functional remission. Anhedonia is also present in other clinical populations, including patients with chronic pain. Recent data links anhedonia to insulin resistance (IR). Some researchers have underlined a different dimension of anhedonia as a temperament\/personality trait. The objective of this post-hoc analysis was to explore the links between anhedonia (main outcome) and (1) IR, (2) temperamental, personality, and schizotypy traits (exposures). The study population included patients with MDD, fibromyalgia, and healthy controls. Participants were split into groups: (1) insulin resistant (IR[+] n = 69, HOMA-IR \u2265 2.1) and (2) insulin sensitive (IR[\u2212] n = 69, HOMA-IR &lt; 2.1). Anhedonia was significantly higher in the IR[+] group than the IR[\u2212] group. IR was a predictor of higher anhedonia levels. IR[+] vs. IR[\u2212] participants showed higher levels of anxiety and lower levels of hyperthymic affective temperaments, as well as conscientiousness and emotional stability personality traits. Depressive, irritable, and anxious temperaments, cognitive disorganization, and introvertive anhedonia positively predicted anhedonia, while hyperthymic temperament, conscientiousness, extraversion, and emotional stability traits negatively predicted anhedonia. IR partially mediated the relationship between depressive temperament and anhedonia. In sum, IR, affective temperaments, and personality traits are predictors of anhedonia.<\/jats:p>","DOI":"10.3390\/brainsci14090890","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T09:56:42Z","timestamp":1725357402000},"page":"890","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Insulin Resistance, Temperament and Personality Traits Are Associated with Anhedonia in a Transdiagnostic Sample"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3109-1895","authenticated-orcid":false,"given":"Marcin","family":"Siwek","sequence":"first","affiliation":[{"name":"Department of Affective Disorders, Jagiellonian University Medical College, Kopernika St. 21a, 31-501 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2107-9980","authenticated-orcid":false,"given":"Adrian A.","family":"Chrobak","sequence":"additional","affiliation":[{"name":"Department of Adult Psychiatry, Jagiellonian University Medical College, Kopernika St. 21a, 31-501 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0656-8505","authenticated-orcid":false,"given":"Zbigniew","family":"So\u0142tys","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Neuropathology, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, 30-387 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"Dudek","sequence":"additional","affiliation":[{"name":"Department of Adult Psychiatry, Jagiellonian University Medical College, Kopernika St. 21a, 31-501 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3291-9663","authenticated-orcid":false,"given":"Anna J.","family":"Krupa","sequence":"additional","affiliation":[{"name":"Department of Affective Disorders, Jagiellonian University Medical College, Kopernika St. 21a, 31-501 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,31]]},"reference":[{"key":"ref_1","first-page":"216","article-title":"Anhedonia in Depressive Disorders","volume":"17","author":"Siwek","year":"2017","journal-title":"J. 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