{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:26:49Z","timestamp":1790980009771,"version":"4.1.0"},"reference-count":59,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T00:00:00Z","timestamp":1726876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ico Falck Foundation (Milan)","award":["PNC0000007"],"award-info":[{"award-number":["PNC0000007"]}]},{"name":"Italian Ministry of Research","award":["PNC0000007"],"award-info":[{"award-number":["PNC0000007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background\/Objectives: Finding innovative digital solutions is fundamental to ensure prompt and continuous care for patients with chronic neurological disorders, whose demand for rehabilitation also in home-based settings is steadily increasing. The aim is to verify the safety and the effectiveness of two telerehabilitation (TR) models in improving recovery from subacute upper limb (UL) disability after stroke, with and without a robotic device. Methods: One hundred nineteen subjects with subacute post-stroke UL disability were assessed for eligibility. Of them, 30 patients were enrolled in the study and randomly assigned to either the Robotic Group (RG), undergoing a 20-session TR program, using a robotic device, or the Non-Robotic Group (NRG), undergoing a 20-session TR program without robotics. Clinical evaluations were measured at baseline (T0) and post-intervention (T1, 5 weeks after baseline), and included assessments of quality of life, motor skills, and clinical\/functional status. The primary outcome measure was the World Health Organization Disability Assessment Schedule 2.0, evaluating the change in perceived disability. Results: Statistical analysis shows that patients of both groups improved significantly over time in all domains analyzed (mean decrease from baseline in the WHODAS 2.0 of 6.09 \u00b1 2.62% for the NRG, and of 0.76 \u00b1 2.21% for the RG), with a greater improvement of patients in the NRG in motor (Fugl-Meyer Assessment Upper Extremity\u2014motor function, Box and Block Test) and cognitive skills (Trail Making Test-A). Conclusions: This study highlights the potential of TR programs to transform stroke rehabilitation by enhancing accessibility and patient-centered care, promoting autonomy, improving adherence, and leading to better outcomes and quality of life for stroke survivors.<\/jats:p>","DOI":"10.3390\/brainsci14090941","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T09:46:20Z","timestamp":1727343980000},"page":"941","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effectiveness of Two Models of Telerehabilitation in Improving Recovery from Subacute Upper Limb Disability after Stroke: Robotic vs. Non-Robotic"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5214-8248","authenticated-orcid":false,"given":"Arianna","family":"Pavan","sequence":"first","affiliation":[{"name":"Neuromotor Rehabilitation Department, IRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7919-5768","authenticated-orcid":false,"given":"Alessio","family":"Fasano","sequence":"additional","affiliation":[{"name":"Neuromotor Rehabilitation Department, IRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0727-6578","authenticated-orcid":false,"given":"Stefania","family":"Lattanzi","sequence":"additional","affiliation":[{"name":"Neuromotor Rehabilitation Department, IRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0661-6442","authenticated-orcid":false,"given":"Laura","family":"Cortellini","sequence":"additional","affiliation":[{"name":"Neuromotor Rehabilitation Department, IRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Cipollini","sequence":"additional","affiliation":[{"name":"Neuromotor Rehabilitation Department, IRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Insalaco","sequence":"additional","affiliation":[{"name":"Neuromotor Rehabilitation Department, IRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1182-2869","authenticated-orcid":false,"given":"Maria Cristina","family":"Mauro","sequence":"additional","affiliation":[{"name":"Neuromotor Rehabilitation Department, IRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0747-831X","authenticated-orcid":false,"given":"Marco","family":"Germanotta","sequence":"additional","affiliation":[{"name":"Neuromotor Rehabilitation Department, IRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8123-9977","authenticated-orcid":false,"given":"Irene Giovanna","family":"Aprile","sequence":"additional","affiliation":[{"name":"Neuromotor Rehabilitation Department, IRCCS Fondazione Don Carlo Gnocchi ONLUS, 50143 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e12861","DOI":"10.1111\/acel.12861","article-title":"Trends in age-related disease burden and healthcare utilization","volume":"18","author":"Atella","year":"2019","journal-title":"Aging Cell"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Camussi, E., Meneghetti, D., Sbarra, M.L., Rella, R., Barill\u00e0, F., Sassi, C., Montali, L., and Annovazzi, C. 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