{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T07:31:12Z","timestamp":1778225472147,"version":"3.51.4"},"reference-count":70,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T00:00:00Z","timestamp":1727568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia I+D+i","doi-asserted-by":"publisher","award":["PICT 2019-03673"],"award-info":[{"award-number":["PICT 2019-03673"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia I+D+i","doi-asserted-by":"publisher","award":["PIBAA-1234"],"award-info":[{"award-number":["PIBAA-1234"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia I+D+i","doi-asserted-by":"publisher","award":["PIP-2721"],"award-info":[{"award-number":["PIP-2721"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia I+D+i","doi-asserted-by":"publisher","award":["222641018"],"award-info":[{"award-number":["222641018"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","award":["PICT 2019-03673"],"award-info":[{"award-number":["PICT 2019-03673"]}]},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","award":["PIBAA-1234"],"award-info":[{"award-number":["PIBAA-1234"]}]},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","award":["PIP-2721"],"award-info":[{"award-number":["PIP-2721"]}]},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","award":["222641018"],"award-info":[{"award-number":["222641018"]}]},{"name":"German Research Foundation (DFG)","award":["PICT 2019-03673"],"award-info":[{"award-number":["PICT 2019-03673"]}]},{"name":"German Research Foundation (DFG)","award":["PIBAA-1234"],"award-info":[{"award-number":["PIBAA-1234"]}]},{"name":"German Research Foundation (DFG)","award":["PIP-2721"],"award-info":[{"award-number":["PIP-2721"]}]},{"name":"German Research Foundation (DFG)","award":["222641018"],"award-info":[{"award-number":["222641018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Purpose: To assess spatial contrast sensitivity (CS) in suspected primary open-angle glaucoma (POAG) patients. Methods: CS was measured using sinusoidal gratings of 4 cycles\/degree. First, foveal and peripheral CS were assessed in 34 suspected POAG patients and compared with 71 and 28 age-matched healthy individuals for foveal and peripheral conditions, respectively. Second, foveal CS was assessed in 34 early POAG patients age-matched with suspected POAG patients. Analyses were performed considering two age ranges: Under and Over 50 y.o. Correlations were evaluated between CS and clinical parameters. Diagnostic accuracy was also analyzed. Results: Peripheral CS was lower in older suspected POAG patients (23.4 \u00b1 16.1) than the control group (39.1 \u00b1 28.2) (p = 0.040). Foveal CS was reduced in suspected POAG participants (Under 50: 146.8 \u00b1 63.3; p = 0.004. Over 50: 110.5 \u00b1 65.0; p = 0.044) and in early POAG patients (Under 50: 141.2 \u00b1 72.6; p = 0.002. Over 50: 80.2 \u00b1 54.5 p &lt; 0.001), both compared to the control group (Under 50: 213.5 \u00b1 66.2. Over 50: 138.6 \u00b1 71.7). CS was lower in early POAG than in POAG suspected in older patients (p = 0.042). Foveal CS was correlated with age (Early: p = 0.001. Suspect: p = 0.002) and with the cup\u2013disc ratio only in early POAG patients (p &lt; 0.001). Foveal CS had fair (AUC = 0.74) diagnostic accuracy for early POAG patients. Conclusions: CS in suspected POAG patients is lower than in healthy individuals. Our findings evidence the spatial vision loss before the onset of POAG.<\/jats:p>","DOI":"10.3390\/brainsci14100993","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T08:09:52Z","timestamp":1727683792000},"page":"993","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Contrast Sensitivity Is Impaired in Suspected Primary Open-Angle Glaucoma Patients"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4544-8995","authenticated-orcid":false,"given":"Mar\u00eda Constanza","family":"Tripolone","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Luz, Ambiente y Visi\u00f3n, Universidad Nacional de Tucum\u00e1n\u2014Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, San Miguel de Tucum\u00e1n T4000BLR, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Alberto","family":"Issolio","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Luz, Ambiente y Visi\u00f3n, Universidad Nacional de Tucum\u00e1n\u2014Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, San Miguel de Tucum\u00e1n T4000BLR, Argentina"},{"name":"Departamento de Luminotecnia, Luz y Visi\u00f3n, Facultad de Ciencias Exactas y Tecnolog\u00eda, Universidad Nacional de Tucum\u00e1n, San Miguel de Tucum\u00e1n T4000BLR, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Osvaldo","family":"Perez","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Oftalmolog\u00eda, Facultad de Medicina, Universidad Nacional de Tucum\u00e1n, San Miguel de Tucum\u00e1n T4000BLR, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1304-8081","authenticated-orcid":false,"given":"Pablo Alejandro","family":"Barrionuevo","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Luz, Ambiente y Visi\u00f3n, Universidad Nacional de Tucum\u00e1n\u2014Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, San Miguel de Tucum\u00e1n T4000BLR, Argentina"},{"name":"Allgemeine Psychologie, Justus-Liebig-Universit\u00e4t Gie\u00dfen, 35394 Gie\u00dfen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1001\/jama.2020.21899","article-title":"Glaucoma in Adults\u2014Screening, Diagnosis, and Management: A Review","volume":"325","author":"Stein","year":"2021","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Zhang, N., Wang, J., Li, Y., and Jiang, B. 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