{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T20:34:03Z","timestamp":1793738043680,"version":"4.6.1"},"reference-count":55,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T00:00:00Z","timestamp":1729900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Neurological Disorders &amp; Stroke","award":["RF1NS033310-27"],"award-info":[{"award-number":["RF1NS033310-27"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background: Alzheimer\u2019s disease (AD), the most prevalent form of dementia, is a leading neurodegenerative disorder currently affecting approximately 55 million individuals globally, a number projected to escalate to 139 million by 2050. Despite extensive research spanning several decades, the cure for AD remains at a developing stage. The only existing therapeutic options are limited to symptom management, and are often accompanied by adverse side effects. The pathological features of AD, including the accumulation of beta-amyloid plaques and tau protein tangles, result in progressive neuronal death, synaptic loss, and brain atrophy, leading to significant cognitive decline and a marked reduction in quality of life. Objective: In light of the shortcomings of existing pharmacological interventions, this review explores the potential of photobiomodulation (PBM) as a non-invasive therapeutic option for AD. PBM employs infrared light to facilitate cellular repair and regeneration, focusing on addressing the disease\u2019s underlying biomechanical mechanisms. Method: This paper presents a comprehensive introduction to the mechanisms of PBM and an analysis of preclinical studies evaluating its impact on cellular health, cognitive function, and disease progression in AD.The review provides a comprehensive overview of the various wavelengths and application methods, evaluating their efficacy in mitigating AD-related symptoms. Conclusions: The findings underscore the significant potential of PBM as a safe and effective alternative treatment for Alzheimer\u2019s disease, emphasizing the necessity for further research and clinical trials to establish its therapeutic efficacy conclusively.<\/jats:p>","DOI":"10.3390\/brainsci14111064","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T04:15:02Z","timestamp":1730088902000},"page":"1064","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Photobiomodulation as a Potential Treatment for Alzheimer\u2019s Disease: A Review Paper"],"prefix":"10.3390","volume":"14","author":[{"given":"Miaomiao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, University of North Texas, Denton, TX 76207, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deeba","family":"Dinarvand","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of North Texas, Denton, TX 76207, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement T. Y.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of North Texas, Denton, TX 76207, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1207-8481","authenticated-orcid":false,"given":"Anatol","family":"Bragin","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA"},{"name":"Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of North Texas, Denton, TX 76207, USA"},{"name":"Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Brown, C.S., Ning, X., Money, A., Alford, M., Pan, Y., Miller, M., and Lohman, M. 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