{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:59:14Z","timestamp":1792789154023,"version":"4.5.0"},"reference-count":169,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Andrew Russell"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Objectives: This study aimed to elucidate the mechanisms of chiropractic care using resting electroencephalography (EEG), somatosensory evoked potentials (SEPs), clinical health assessments (Fitbit), and Patient-reported Outcomes Measurement Information System (PROMIS-29). Methods: Seventy-six people with chronic low back pain (mean age \u00b1 SD: 45 \u00b1 11 years, 33 female) were randomised into control (n = 38) and chiropractic (n = 38) groups. EEG and SEPs were collected pre and post the first intervention and post 4 weeks of intervention. PROMIS-29 was measured pre and post 4 weeks. Fitbit data were recorded continuously. Results: Spectral analysis of resting EEG showed a significant increase in Theta, Alpha and Beta, and a significant decrease in Delta power in the chiropractic group post intervention. Source localisation revealed a significant increase in Alpha activity within the Default Mode Network (DMN) post intervention and post 4 weeks. A significant decrease in N30 SEP peak amplitude post intervention and post 4 weeks was found in the chiropractic group. Source localisation demonstrated significant changes in Alpha and Beta power within the DMN post-intervention and post 4 weeks. Significant improvements in light sleep stage were observed in the chiropractic group along with enhanced overall quality of life post 4 weeks, including significant reductions in anxiety, depression, fatigue, and pain. Conclusions: These findings indicate that many health benefits of chiropractic care are due to altered brain activity.<\/jats:p>","DOI":"10.3390\/brainsci14111124","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T04:22:56Z","timestamp":1730953376000},"page":"1124","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Neuroplastic Responses to Chiropractic Care: Broad Impacts on Pain, Mood, Sleep, and Quality of Life"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7182-2085","authenticated-orcid":false,"given":"Heidi","family":"Haavik","sequence":"first","affiliation":[{"name":"Centre for Chiropractic Research, New Zealand College of Chiropractic, Auckland 1060, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8752-7224","authenticated-orcid":false,"given":"Imran Khan","family":"Niazi","sequence":"additional","affiliation":[{"name":"Centre for Chiropractic Research, New Zealand College of Chiropractic, Auckland 1060, New Zealand"},{"name":"Faculty of Health & Environmental Sciences, Health & Rehabilitation Research Institute, Auckland University of Technology, Auckland 1010, New Zealand"},{"name":"Centre for Sensory-Motor Interactions, Department of Health Science and Technology, Aalborg University, 9220 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2824-0079","authenticated-orcid":false,"given":"Imran","family":"Amjad","sequence":"additional","affiliation":[{"name":"Centre for Chiropractic Research, New Zealand College of Chiropractic, Auckland 1060, New Zealand"},{"name":"Faculty of Rehabilitation and Allied Health Sciences, Riphah International University, Islamabad 46000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5135-1682","authenticated-orcid":false,"given":"Nitika","family":"Kumari","sequence":"additional","affiliation":[{"name":"Centre for Chiropractic Research, New Zealand College of Chiropractic, Auckland 1060, New Zealand"},{"name":"Faculty of Health & Environmental Sciences, Health & Rehabilitation Research Institute, Auckland University of Technology, Auckland 1010, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usman","family":"Ghani","sequence":"additional","affiliation":[{"name":"Centre for Chiropractic Research, New Zealand College of Chiropractic, Auckland 1060, New Zealand"},{"name":"Faculty of Health & Environmental Sciences, Health & Rehabilitation Research Institute, Auckland University of Technology, Auckland 1010, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moeez","family":"Ashfaque","sequence":"additional","affiliation":[{"name":"School of Physics, Engineering and Computer Science, University of Hertfordshire, Hatfield AL10 9AB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usman","family":"Rashid","sequence":"additional","affiliation":[{"name":"Centre for Chiropractic Research, New Zealand College of Chiropractic, Auckland 1060, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2849-874X","authenticated-orcid":false,"given":"Muhammad Samran","family":"Navid","sequence":"additional","affiliation":[{"name":"Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, 6525 Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6846-2090","authenticated-orcid":false,"given":"Ernest Nlandu","family":"Kamavuako","sequence":"additional","affiliation":[{"name":"Centre for Robotics Research, Department of Informatics, King\u2019s College, London WC2G 4BG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1688-4448","authenticated-orcid":false,"given":"Amit N.","family":"Pujari","sequence":"additional","affiliation":[{"name":"School of Physics, Engineering and Computer Science, University of Hertfordshire, Hatfield AL10 9AB, UK"},{"name":"School of Engineering, University of Aberdeen, Aberdeen AB24 3FX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0046-7260","authenticated-orcid":false,"given":"Kelly","family":"Holt","sequence":"additional","affiliation":[{"name":"Centre for Chiropractic Research, New Zealand College of Chiropractic, Auckland 1060, New 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