{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:53:43Z","timestamp":1789588423445,"version":"build-2803163510"},"reference-count":174,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Tinnitus is correlated with anomalies of neural plasticity and has been found to be affected by inflammatory status. The current theories on tinnitus, although still somewhat incomplete, are based on maladaptive plasticity mechanisms. Astrocytes play a major role in both neural responses to inflammation and plasticity regulation; moreover, they have recently been discovered to encode \u201ccontext\u201d for neuronal circuits, which is similar to the \u201cexpectation\u201d of Bayesian brain models. Therefore, this narrative review explores the possible and likely roles of astrocytes in the neural mechanisms leading to acute and chronic tinnitus.<\/jats:p>","DOI":"10.3390\/brainsci14121213","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T05:43:43Z","timestamp":1733118223000},"page":"1213","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Astrocytes and Tinnitus"],"prefix":"10.3390","volume":"14","author":[{"given":"Paola","family":"Perin","sequence":"first","affiliation":[{"name":"Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4884-8265","authenticated-orcid":false,"given":"Roberto","family":"Pizzala","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy"},{"name":"Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"McFerran, D.J., Stockdale, D., Holme, R., Large, C.H., and Baguley, D.M. (2019). Why Is There No Cure for Tinnitus?. Front. Neurosci., 13.","DOI":"10.3389\/fnins.2019.00802"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Koops, E.A., and Eggermont, J.J. (2021). The thalamus and tinnitus: Bridging the gap between animal data and findings in humans. Hear. Res., 407.","DOI":"10.1016\/j.heares.2021.108280"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s10162-023-00914-1","article-title":"Review and Perspective on Brain Bases of Tinnitus","volume":"24","author":"Husain","year":"2023","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s10162-023-00916-z","article-title":"Eavesdropping on Tinnitus Using MEG: Lessons Learned and Future Perspectives","volume":"24","author":"Reisinger","year":"2023","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.otc.2020.03.001","article-title":"Animal Models of Tinnitus: A Review","volume":"53","author":"Galazyuk","year":"2020","journal-title":"Otolaryngol. Clin. N. Am."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.heares.2012.01.005","article-title":"Hearing loss, hyperacusis, or tinnitus: What is modeled in animal research?","volume":"295","author":"Eggermont","year":"2013","journal-title":"Hear. Res."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Wake, N., Shiramatsu, T.I., and Takahashi, H. (2024). Map plasticity following noise exposure in auditory cortex of rats: Implications for disentangling neural correlates of tinnitus and hyperacusis. Front. Neurosci., 18.","DOI":"10.3389\/fnins.2024.1385942"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.neuroscience.2009.12.063","article-title":"Neural changes in the auditory cortex of awake guinea pigs after two tinnitus inducers: Salicylate and acoustic trauma","volume":"166","author":"Moffat","year":"2010","journal-title":"Neuroscience"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/7854_2020_156","article-title":"Functional Neuroanatomy of Salicylate- and Noise-Induced Tinnitus and Hyperacusis","volume":"Volume 51","author":"Salvi","year":"2021","journal-title":"The Behavioral Neuroscience of Tinnitus"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.heares.2012.09.010","article-title":"Tinnitus-related neural activity: Theories of generation, propagation, and centralization","volume":"295","author":"Farley","year":"2013","journal-title":"Hear. Res."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Auerbach, B.D., Rodrigues, P.V., and Salvi, R.J. (2014). Central gain control in tinnitus and hyperacusis. Front. Neurol., 5.","DOI":"10.3389\/fneur.2014.00206"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"De Ridder, D., Vanneste, S., Langguth, B., and Llinas, R. (2015). Thalamocortical Dysrhythmia: A Theoretical Update in Tinnitus. Front. Neurol., 6.","DOI":"10.3389\/fneur.2015.00124"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.tics.2015.08.002","article-title":"Frontostriatal Gating of Tinnitus and Chronic Pain","volume":"19","author":"Rauschecker","year":"2015","journal-title":"Trends Cogn. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.tins.2016.10.004","article-title":"An Integrative Tinnitus Model Based on Sensory Precision","volume":"39","author":"Sedley","year":"2016","journal-title":"Trends Neurosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4809","DOI":"10.1093\/brain\/awad255","article-title":"Predictive coding and stochastic resonance as fundamental principles of auditory phantom perception","volume":"146","author":"Schilling","year":"2023","journal-title":"Brain"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.neuroscience.2018.12.038","article-title":"Enhanced Central Neural Gain Compensates Acoustic Trauma-induced Cochlear Impairment, but Unlikely Correlates with Tinnitus and Hyperacusis","volume":"407","author":"Hofmeier","year":"2019","journal-title":"Neuroscience"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nrn2787","article-title":"The free-energy principle: A unified brain theory?","volume":"11","author":"Friston","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.tins.2022.09.007","article-title":"Where is the error? Hierarchical predictive coding through dendritic error computation","volume":"46","author":"Mikulasch","year":"2023","journal-title":"Trends Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-5955(81)90024-1","article-title":"Eighth-nerve action potentials evoked by tone bursts in cats before and after inducement of an acute noise trauma","volume":"5","author":"Smoorenburg","year":"1981","journal-title":"Hear. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1098\/rspb.1967.0047","article-title":"Neuroglial cells: Physiological properties and a potassium mediated effect of neuronal activity on the glial membrane potential","volume":"168","author":"Kuffler","year":"1967","journal-title":"Proc. R. Soc. Lond. B Biol. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Stedehouder, J., Roberts, B.M., Raina, S., Bossi, S., Liu, A.K.L., Doig, N.M., McGerty, K., Magill, P.J., Parkkinen, L., and Cragg, S.J. (2024). Rapid modulation of striatal cholinergic interneurons and dopamine release by satellite astrocytes. Nat. Commun., 15.","DOI":"10.1038\/s41467-024-54253-7"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.neuron.2019.05.008","article-title":"Mechanisms of Noise-Induced Tinnitus: Insights from Cellular Studies","volume":"103","author":"Shore","year":"2019","journal-title":"Neuron"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1152\/physrev.00029.2020","article-title":"What\u2019s the buzz? The neuroscience and the treatment of tinnitus","volume":"101","author":"Henton","year":"2021","journal-title":"Physiol. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/jnc.15811","article-title":"Milestone Review: Metabolic dynamics of glutamate and GABA mediated neurotransmission\u2014The essential roles of astrocytes","volume":"166","author":"Andersen","year":"2023","journal-title":"J. Neurochem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nrn1722","article-title":"Astrocytes, from brain glue to communication elements: The revolution continues","volume":"6","author":"Volterra","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.neuron.2008.10.013","article-title":"The mystery and magic of glia: A perspective on their roles in health and disease","volume":"60","author":"Barres","year":"2008","journal-title":"Neuron"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.heares.2015.06.005","article-title":"Tinnitus: Maladaptive auditory-somatosensory plasticity","volume":"334","author":"Wu","year":"2016","journal-title":"Hear. Res."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Mennink, L.M., Aalbers, M.W., van Dijk, P., and van Dijk, J.M.C. (2022). The Role of Inflammation in Tinnitus: A Systematic Review and Meta-Analysis. J. Clin. Med., 11.","DOI":"10.3390\/jcm11041000"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Wang, W., Zhang, L.S., Zinsmaier, A.K., Patterson, G., Leptich, E.J., Shoemaker, S.L., Yatskievych, T.A., Gibboni, R., Pace, E., and Luo, H. (2019). Neuroinflammation mediates noise-induced synaptic imbalance and tinnitus in rodent models. PLoS Biol., 17.","DOI":"10.1371\/journal.pbio.3000307"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Ferro, A., Auguste, Y.S.S., and Cheadle, L. (2021). Microglia, Cytokines, and Neural Activity: Unexpected Interactions in Brain Development and Function. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.703527"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/glia.24266","article-title":"Loss of oligodendrocyte ErbB receptor signaling leads to hypomyelination, reduced density of parvalbumin-expressing interneurons, and inhibitory function in the auditory cortex","volume":"71","author":"Borges","year":"2023","journal-title":"Glia"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00401-009-0619-8","article-title":"Astrocytes: Biology and pathology","volume":"119","author":"Sofroniew","year":"2010","journal-title":"Acta Neuropathol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Schiera, G., Di Liegro, C.M., Schir\u00f2, G., Sorbello, G., and Di Liegro, I. (2024). Involvement of Astrocytes in the Formation, Maintenance, and Function of the Blood-Brain Barrier. Cells, 13.","DOI":"10.3390\/cells13020150"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.it.2020.07.004","article-title":"Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity","volume":"41","author":"Sofroniew","year":"2020","journal-title":"Trends Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nature17623","article-title":"Astrocyte scar formation aids central nervous system axon regeneration","volume":"532","author":"Anderson","year":"2016","journal-title":"Nature"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Mishra, A., Gordon, G.R., MacVicar, B.A., and Newman, E.A. (2024). Astrocyte Regulation of Cerebral Blood Flow in Health and Disease. Cold Spring Harb. Perspect. Biol., 16.","DOI":"10.1101\/cshperspect.a041354"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1097\/MCO.0b013e328312c368","article-title":"Brain energetics (thought needs food)","volume":"11","author":"Pellerin","year":"2008","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1042\/EBC20220075","article-title":"Cross-talk between energy and redox metabolism in astrocyte-neuron functional cooperation","volume":"67","author":"Almeida","year":"2023","journal-title":"Essays Biochem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/jne.12283","article-title":"Thyroid hormone and astroglia: Endocrine control of the neural environment","volume":"27","author":"Dezonne","year":"2015","journal-title":"J. Neuroendocrinol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Reemst, K., Noctor, S., Lucassen, P., and Hol, E. (2016). The indispensable roles of microglia and astrocytes during brain development. Front. Hum. Neurosci., 10.","DOI":"10.3389\/fnhum.2016.00566"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Wang, F., Smith, N.A., Xu, Q., Fujita, T., Baba, A., Matsuda, T., Takano, T., Bekar, L., and Nedergaard, M. (2012). Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+. Sci. Signal., 5.","DOI":"10.1126\/scisignal.2002334"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1007\/s11064-015-1581-6","article-title":"The Glymphatic System: A Beginner\u2019s Guide","volume":"40","author":"Jessen","year":"2015","journal-title":"Neurochem. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0166-2236(98)01349-6","article-title":"Tripartite synapses: Glia, the unacknowledged partner","volume":"22","author":"Araque","year":"1999","journal-title":"Trends Neurosci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/glia.1107","article-title":"Immune function of astrocytes","volume":"36","author":"Dong","year":"2001","journal-title":"Glia"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Oberheim, N., and Goldman, S. (2011). Heterogeneity of Astrocytic Form and Function, Springer.","DOI":"10.1007\/978-1-61779-452-0_3"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/glia.440010302","article-title":"The perinodal astrocyte","volume":"1","author":"Black","year":"1988","journal-title":"Glia"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1002\/cbin.10326","article-title":"Mechanisms of hippocampal astrocytes mediation of spatial memory and theta rhythm by gliotransmitters and growth factors","volume":"38","author":"Hassanpoor","year":"2014","journal-title":"Cell Biol. Int."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Lefton, K.B., Wu, Y., Yen, A., Okuda, T., Zhang, Y., Dai, Y., Walsh, S., Manno, R., Dougherty, J.D., and Samineni, V.K. (2024). Norepinephrine Signals Through Astrocytes To Modulate Synapses. bioRxiv.","DOI":"10.1101\/2024.05.21.595135"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Aydin, A.G., Alexander Lemenze, A., and Bieszczad, K.M. (2024). Functional diversities within neurons and astrocytes in the adult rat auditory cortex revealed by single-nucleus RNA sequencing. bioRxiv.","DOI":"10.1101\/2024.04.16.589831"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Palay, S., and Chan-Palay, V. (1974). Cerebellar Cortex, Springer.","DOI":"10.1007\/978-3-642-65581-4"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nrn.2016.159","article-title":"Functional diversity of astrocytes in neural circuit regulation","volume":"18","author":"Haim","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0301-0082(92)90022-7","article-title":"The CNS-PNS transitional zone of the rat. Morphometric studies at cranial and spinal levels","volume":"38","author":"Fraher","year":"1992","journal-title":"Prog. Neurobiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3171\/2010.2.JNS091817","article-title":"Mechanical stress-induced reactive gliosis in the auditory nerve and cochlear nucleus","volume":"114","author":"Sekiya","year":"2011","journal-title":"J. Neurosurg."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3109\/00016489409126076","article-title":"Gliosis of the eighth nerve transitional region in patients with cerebellopontine angle schwannoma","volume":"114","author":"Matsunaga","year":"1994","journal-title":"Acta Otolaryngol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"King, A.M., Cooper, J.N., Oganezova, K., Mittal, J., McKenna, K., Godur, D.A., Zalta, M., Danesh, A.A., Mittal, R., and Eshraghi, A.A. (2024). Vestibular Schwannoma and Tinnitus: A Systematic Review of Microsurgery Compared to Gamma Knife Radiosurgery. J. Clin. Med., 13.","DOI":"10.3390\/jcm13113065"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neures.2008.05.005","article-title":"GFAP aggregates in the cochlear nerve increase the noise vulnerability of sensory cells in the organ of Corti in the murine model of Alexander disease","volume":"62","author":"Masuda","year":"2008","journal-title":"Neurosci. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.pneurobio.2013.08.001","article-title":"Origin, lineage and function of cerebellar glia","volume":"109","author":"Buffo","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Goodman, T., and Hajihosseini, M.K. (2015). Hypothalamic tanycytes-masters and servants of metabolic, neuroendocrine, and neurogenic functions. Front. Neurosci., 9.","DOI":"10.3389\/fnins.2015.00387"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.tins.2003.12.001","article-title":"What\u2019s a cerebellar circuit doing in the auditory system?","volume":"27","author":"Oertel","year":"2004","journal-title":"Trends Neurosci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s10162-015-0520-1","article-title":"The Structural Development of the Mouse Dorsal Cochlear Nucleus","volume":"16","author":"Mao","year":"2015","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Perin, P., Rossetti, R., Ricci, C., Cossellu, D., Lazzarini, S., Bethge, P., Voigt, F.F., Helmchen, F., Batti, L., and Gantar, I. (2021). 3D Reconstruction of the Clarified Rat Hindbrain Choroid Plexus. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.692617"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s10162-011-0290-3","article-title":"Bilateral dorsal cochlear nucleus lesions prevent acoustic-trauma induced tinnitus in an animal model","volume":"13","author":"Brozoski","year":"2011","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.heares.2017.04.016","article-title":"Chronic tinnitus and unipolar brush cell alterations in the cerebellum and dorsal cochlear nucleus","volume":"350","author":"Brozoski","year":"2017","journal-title":"Hear. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nn.4201","article-title":"Astrocyte calcium signaling: The third wave","volume":"19","author":"Bazargani","year":"2016","journal-title":"Nat. Neurosci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1523\/JNEUROSCI.17-01-00171.1997","article-title":"Specialized membrane domains for water transport in glial cells: High-resolution immunogold cytochemistry of aquaporin-4 in rat brain","volume":"17","author":"Nielsen","year":"1997","journal-title":"J. Neurosci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1002\/glia.20990","article-title":"The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction","volume":"58","author":"Mathiisen","year":"2010","journal-title":"Glia"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/ni.3666","article-title":"The movers and shapers in immune privilege of the CNS","volume":"18","author":"Engelhardt","year":"2017","journal-title":"Nat. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.brainres.2012.06.045","article-title":"Connexin-based intercellular communication and astrocyte heterogeneity","volume":"1487","author":"Theis","year":"2012","journal-title":"Brain Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/glia.22924","article-title":"Gap junction coupling confers isopotentiality on astrocyte syncytium","volume":"64","author":"Ma","year":"2016","journal-title":"Glia"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"6897","DOI":"10.1523\/JNEUROSCI.19-16-06897.1999","article-title":"Three-dimensional relationships between hippocampal synapses and astrocytes","volume":"19","author":"Ventura","year":"1999","journal-title":"J. Neurosci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/BF01184072","article-title":"Astrocyte associations with nodes of Ranvier: Ultrastructural analysis of HRP-filled astrocytes in the mouse optic nerve","volume":"23","author":"Butt","year":"1994","journal-title":"J. Neurocytol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1002\/glia.24040","article-title":"The many ways astroglial connexins regulate neurotransmission and behavior","volume":"69","author":"Mazaud","year":"2021","journal-title":"Glia"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Ikezu, T., Yang, Y., Verderio, C., and Kr\u00e4mer-Albers, E.M. (2024). Extracellular Vesicle-Mediated Neuron-Glia Communications in the Central Nervous System. J. Neurosci., 44.","DOI":"10.1523\/JNEUROSCI.1170-24.2024"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Mohammad, Z.B., Yudin, S.C.Y., Goldberg, B.J., Serra, K.L., and Klegeris, A. (2024). Exploring neuroglial signaling: Diversity of molecules implicated in microglia-to-astrocyte neuroimmune communication. Rev. Neurosci.","DOI":"10.1515\/revneuro-2024-0081"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nrn2757","article-title":"Astroglial networks: A step further in neuroglial and gliovascular interactions","volume":"11","author":"Giaume","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s12264-022-00992-w","article-title":"The Structure and Function of Glial Networks: Beyond the Neuronal Connections","volume":"39","author":"Peng","year":"2023","journal-title":"Neurosci. Bull."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.neubiorev.2019.12.013","article-title":"A neuroscientist\u2019s guide to transgenic mice and other genetic tools","volume":"108","author":"Navabpour","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.neuron.2016.01.040","article-title":"DREADDs for Neuroscientists","volume":"89","author":"Roth","year":"2016","journal-title":"Neuron"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Heffernan, K.S., Martinez, I., Jaeger, D., Khakh, B.S., Smith, Y., and Galvan, A. (2024). Scaled Complexity of Mammalian Astrocytes: Insights From Mouse and Macaque. J. Comp. Neurol., 532.","DOI":"10.1002\/cne.25665"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/s41583-020-0361-8","article-title":"Making sense of astrocytic calcium signals\u2014From acquisition to interpretation","volume":"21","author":"Semyanov","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Schoknecht, K., and Eilers, J. (2024). Brain-to-blood transport of fluorescein in vitro. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-77040-2"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"8025","DOI":"10.1073\/pnas.1718582115","article-title":"Astrocytes restore connectivity and synchronization in dysfunctional cerebellar networks","volume":"115","author":"Kanner","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1523\/JNEUROSCI.4707-08.2009","article-title":"Uniquely hominid features of adult human astrocytes","volume":"29","author":"Oberheim","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Verkhratsky, A., Butt, A., Li, B., Illes, P., Zorec, R., Semyanov, A., Tang, Y., and Sofroniew, M.V. (2023). Astrocytes in human central nervous system diseases: A frontier for new therapies. Signal Transduct. Target. Ther., 8.","DOI":"10.1038\/s41392-023-01628-9"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.clinph.2007.10.026","article-title":"Human brain mapping: Hemodynamic response and electrophysiology","volume":"119","author":"Shibasaki","year":"2008","journal-title":"Clin. Neurophysiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1002\/glia.23454","article-title":"Optogenetic astrocyte activation evokes BOLD fMRI response with oxygen consumption without neuronal activity modulation","volume":"66","author":"Takata","year":"2018","journal-title":"Glia"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s10334-015-0518-z","article-title":"Segmentation of human brain using structural MRI","volume":"29","author":"Helms","year":"2016","journal-title":"MAGMA"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1038\/s41380-022-01460-7","article-title":"Cell type-specific manifestations of cortical thickness heterogeneity in schizophrenia","volume":"27","author":"Geaghan","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Schmidt, S., Gull, S., Herrmann, K.-H., Boehme, M., Irintchev, A., Urbach, A., Reichenbach, J.R., Klingner, C.M., Gaser, C., and Witte, O.W. (2021). Experience-dependent structural plasticity in the adult brain: How the learning brain grows. Neuroimage, 225.","DOI":"10.1016\/j.neuroimage.2020.117502"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Farhy-Tselnicker, I., and Allen, N.J. (2018). Astrocytes, neurons, synapses: A tripartite view on cortical circuit development. Neural Dev., 13.","DOI":"10.1186\/s13064-018-0104-y"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1007\/s11064-021-03317-x","article-title":"Sensing and Regulating Synaptic Activity by Astrocytes at Tripartite Synapse","volume":"46","author":"Araque","year":"2021","journal-title":"Neurochem. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1038\/nn.4649","article-title":"Synapse-specific astrocyte gating of amygdala-related behavior","volume":"20","author":"Jamison","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1093\/cercor\/bhu231","article-title":"Endocannabinoids Induce Lateral Long-Term Potentiation of Transmitter Release by Stimulation of Gliotransmission","volume":"25","author":"Navarrete","year":"2015","journal-title":"Cereb. Cortex."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.neuron.2010.08.043","article-title":"Endocannabinoids potentiate synaptic transmission through stimulation of astrocytes","volume":"68","author":"Navarrete","year":"2010","journal-title":"Neuron"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e32237","DOI":"10.7554\/eLife.32237","article-title":"Neuronal activity determines distinct gliotransmitter release from a single astrocyte","volume":"7","author":"Covelo","year":"2018","journal-title":"Elife"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.biopsych.2022.10.013","article-title":"Retraction of Astrocyte Leaflets from the Synapse Enhances Fear Memory","volume":"94","author":"Heistek","year":"2023","journal-title":"Biol. Psychiatry"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1523\/JNEUROSCI.22-01-00183.2002","article-title":"Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains","volume":"22","author":"Bushong","year":"2002","journal-title":"J. Neurosci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ceca.2018.12.007","article-title":"Spatiotemporal pattern of calcium activity in astrocytic network","volume":"78","author":"Semyanov","year":"2019","journal-title":"Cell Calcium."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Ahmadpour, N., Kantroo, M., and Stobart, J.L. (2021). Extracellular Calcium Influx Pathways in Astrocyte Calcium Microdomain Physiology. Biomolecules, 11.","DOI":"10.3390\/biom11101467"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1126\/science.1967852","article-title":"Glutamate induces calcium waves in cultured astrocytes: Long-range glial signaling","volume":"247","author":"Finkbeiner","year":"1990","journal-title":"Science"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Hastings, N., Yu, Y., Huang, B., Middya, S., Inaoka, M., Erkamp, N.A., Mason, R.J., Carnicer-Lombarte, A., Rahman, S., and Knowles, T.P.J. (2023). Electrophysiological In Vitro Study of Long-Range Signal Transmission by Astrocytic Networks. Adv. Sci., 10.","DOI":"10.1002\/advs.202301756"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Lines, J., Baraibar, A., Nanclares, C., Mart\u00edn, E.D., Aguilar, J., Kofuji, P., Navarrete, M., and Araque, A. (2024). A spatial threshold for astrocyte calcium surge. bioRxiv.","DOI":"10.7554\/eLife.90046.2"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Peterson, E.J. (2021). What can astrocytes compute?. bioRxiv.","DOI":"10.1101\/2021.10.20.465192"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.immuni.2021.01.013","article-title":"Astrocyte-immune cell interactions in physiology and pathology","volume":"54","author":"Han","year":"2021","journal-title":"Immunity"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Naveed, M., Smedlund, K., Zhou, Q.-G., Cai, W., and Hill, J.W. (2024). Astrocyte involvement in metabolic regulation and disease. Trends Endocrinol. Metab., S1043\u2013S2760.","DOI":"10.1016\/j.tem.2024.08.001"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.tins.2023.03.003","article-title":"Astrocytes: Integrators of arousal state and sensory context","volume":"46","author":"Rasmussen","year":"2023","journal-title":"Trends Neurosci."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Hansel, C., and Yuste, R. (2024). Neural ensembles: Role of intrinsic excitability and its plasticity. Front. Cell Neurosci., 18.","DOI":"10.3389\/fncel.2024.1440588"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Grella, S.L., and Donaldson, T.N. (2024). Contextual memory engrams, and the neuromodulatory influence of the locus coeruleus. Front. Mol. Neurosci., 17.","DOI":"10.3389\/fnmol.2024.1342622"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.tins.2005.09.002","article-title":"Network reset: A simplified overarching theory of locus coeruleus noradrenaline function","volume":"28","author":"Bouret","year":"2005","journal-title":"Trends Neurosci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ceca.2013.09.001","article-title":"\u03b11-Adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice","volume":"54","author":"Ding","year":"2013","journal-title":"Cell Calcium"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/jnc.13447","article-title":"Causes, consequences, and cures for neuroinflammation mediated via the locus coeruleus: Noradrenergic signaling system","volume":"139","author":"Feinstein","year":"2016","journal-title":"J. Neurochem."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1196\/annals.1410.059","article-title":"Degeneration of the locus ceruleus noradrenergic neurons in the stress-induced depression of rats","volume":"1148","author":"Kitayama","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Natalini, E., Fioretti, A., Riedl, D., Moschen, R., and Eibenstein, A. (2020). Tinnitus and Metacognitive Beliefs-Results of a Cross-Sectional Observational Study. Brain Sci., 11.","DOI":"10.3390\/brainsci11010003"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.heares.2011.04.004","article-title":"Inhibitory neurotransmission in animal models of tinnitus: Maladaptive plasticity","volume":"279","author":"Wang","year":"2011","journal-title":"Hear. Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.heares.2016.08.009","article-title":"Auditory thalamic circuits and GABAA receptor function: Putative mechanisms in tinnitus pathology","volume":"349","author":"Caspary","year":"2017","journal-title":"Hear. Res."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Morais, T.P., Coelho, D., Vaz, S.H., Sebasti\u00e3o, A.M., and Valente, C.A. (2018). Glycine Receptor Activation Impairs ATP-Induced Calcium Transients in Cultured Cortical Astrocytes. Front. Mol. Neurosci., 10.","DOI":"10.3389\/fnmol.2017.00444"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.neuron.2020.08.013","article-title":"Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus","volume":"108","author":"Kwak","year":"2020","journal-title":"Neuron"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1002\/glia.23644","article-title":"GABAergic-astrocyte signaling: A refinement of inhibitory brain networks","volume":"67","author":"Mederos","year":"2019","journal-title":"Glia"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neulet.2018.01.012","article-title":"The signaling role for chloride in the bidirectional communication between neurons and astrocytes","volume":"689","author":"Wilson","year":"2019","journal-title":"Neurosci. Lett."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Untiet, V., and Verkhratsky, A. (2024). How astrocytic chloride modulates brain states. Bioessays, 46.","DOI":"10.1002\/bies.202400004"},{"key":"ref_121","first-page":"2141","article-title":"Pathophysiology and puzzles of the volume-sensitive outwardly rectifying anion channel","volume":"587","author":"Okada","year":"2009","journal-title":"J. Physiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"6939","DOI":"10.1113\/JP275053","article-title":"Molecular composition and heterogeneity of the LRRC8-containing swelling-activated osmolyte channels in primary rat astrocytes","volume":"595","author":"Schober","year":"2017","journal-title":"J. Physiol."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Tighilet, B., Dutheil, S., Siponen, M.I., and Nore\u00f1a, A.J. (2016). Reactive Neurogenesis and Down-Regulation of the Potassium-Chloride Cotransporter KCC2 in the Cochlear Nuclei after Cochlear Deafferentation. Front. Pharmacol., 7.","DOI":"10.3389\/fphar.2016.00281"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Parameshwarappa, V., Siponen, M.I., Watabe, I., Karkaba, A., Galazyuk, A., and Nore\u00f1a, A.J. (2024). Noise-induced hearing loss alters potassium-chloride cotransporter KCC2 and GABA inhibition in the auditory centers. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-60858-1"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/nature01868","article-title":"Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain","volume":"424","author":"Coull","year":"2003","journal-title":"Nature"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Kitayama, T. (2020). The Role of Astrocytes in the Modulation ofK+-Cl\u2212-Cotransporter-2 Function. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21249539"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1111\/epi.17784","article-title":"Astrocytic NKCC1 inhibits seizures by buffering Cl\u2212 and antagonizing neuronal NKCC1 at GABAergic synapses","volume":"64","author":"Nguyen","year":"2023","journal-title":"Epilepsia"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Nambu, M.F., Lin, Y.J., Reuschenbach, J., and Tanaka, K.Z. (2022). What does engram encode?: Heterogeneous memory engrams for different aspects of experience. Curr. Opin. Neurobiol., 75.","DOI":"10.1016\/j.conb.2022.102568"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Murthy, B.K.B., Somatakis, S., Ulivi, A.F., Klimmt, H., Castello-Waldow, T.P., Haynes, N., Huettl, R.E., Chen, A., and Attardo, A. (2023). Arc-driven mGRASP highlights CA1 to CA3 synaptic engrams. Front. Behav. Neurosci., 16.","DOI":"10.3389\/fnbeh.2022.1072571"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Kim, J., Sung, Y., and Park, H. (2023). Astrocytic connection to engram neurons Increased after learning. bioRxiv.","DOI":"10.1101\/2023.01.25.525617"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Pacholko, A.G., Wotton, C.A., and Bekar, L.K. (2020). Astrocytes-The Ultimate Effectors of Long-Range Neuromodulatory Networks?. Front. Cell Neurosci., 14.","DOI":"10.3389\/fncel.2020.581075"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1002\/glia.23283","article-title":"Brain metabolic sensing and metabolic signaling at the level of an astrocyte","volume":"66","author":"Marina","year":"2018","journal-title":"Glia"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1038\/s41593-023-01448-8","article-title":"A conceptual framework for astrocyte function","volume":"26","author":"Ching","year":"2023","journal-title":"Nat. Neurosci."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Goldberg, M., De Pitt\u00e0, M., Volman, V., Berry, H., and Ben-Jacob, E. (2010). Nonlinear gap junctions enable long-distance propagation of pulsating calcium waves in astrocyte networks. PLoS Comput. Biol., 6.","DOI":"10.1371\/journal.pcbi.1000909"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Foley, J., Blutstein, T., Lee, S., Erneux, C., Halassa, M.M., and Haydon, P. (2017). Astrocytic IP3\/Ca2+ Signaling Modulates Theta Rhythm and REM Sleep. Front. Neural Circuits., 11.","DOI":"10.3389\/fncir.2017.00003"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Makovkin, S., Kozinov, E., Ivanchenko, M., and Gordleeva, S. (2022). Controlling synchronization of gamma oscillations by astrocytic modulation in a model hippocampal neural network. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-10649-3"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Mapunda, J.A., Tibar, H., Regragui, W., and Engelhardt, B. (2022). How Does the Immune System Enter the Brain?. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.805657"},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Mathias, K., Machado, R.S., Cardoso, T., Tiscoski, A.D.B., Piacentini, N., Prophiro, J.S., Generoso, J.S., Barichello, T., and Petronilho, F. (2024). The Blood-Cerebrospinal Fluid Barrier Dysfunction in Brain Disorders and Stroke: Why, How, What For?. Neuromol. Med., 26.","DOI":"10.1007\/s12017-024-08806-0"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.molmed.2018.04.003","article-title":"Advances in Meningeal Immunity","volume":"24","author":"Rua","year":"2018","journal-title":"Trends Mol. Med."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1007\/s00018-020-03706-5","article-title":"Cerebrospinal Fluid Outflow: A Review of the Historical and Contemporary Evidence for Arachnoid Villi, Perineural Routes, and Dural Lymphatics","volume":"78","author":"Proulx","year":"2021","journal-title":"Cell Mol Life Sci"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Galea, E., and Graeber, M.B. (2023). Neuroinflammation: The Abused Concept. ASN Neuro, 15.","DOI":"10.1177\/17590914231197523"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Oliver, D.L., Cant, N.B., Fay, R.R., and Popper, A.N. (2018). The Mammalian Auditory Pathways, Springer.","DOI":"10.1007\/978-3-319-71798-2"},{"key":"ref_143","first-page":"6043","article-title":"Neuroglial activation in the auditory cortex and medial geniculate body of salicylate-induced tinnitus rats","volume":"12","author":"Xia","year":"2020","journal-title":"Am. J. Transl. Res."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Almasabi, F., Alosaimi, F., Corrales-Terr\u00f3n, M., Wolters, A., Strikwerda, D., Smit, J.V., Temel, Y., Janssen, M.L.F., and Jahanshahi, A. (2022). Post-Mortem Analysis of Neuropathological Changes in Human Tinnitus. Brain Sci., 12.","DOI":"10.3390\/brainsci12081024"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.it.2007.01.005","article-title":"Astrocytes are active players in cerebral innate immunity","volume":"28","author":"Farina","year":"2007","journal-title":"Trends Immunol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1007\/s11481-013-9480-6","article-title":"Immune players in the CNS: The astrocyte","volume":"8","author":"Jensen","year":"2013","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Wiese, S., Karus, M., and Faissner, A. (2012). Astrocytes as a source for extracellular matrix molecules and cytokines. Front. Pharmacol., 3.","DOI":"10.3389\/fphar.2012.00120"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.it.2024.08.008","article-title":"Emerging roles of astrocytes as immune effectors in the central nervous system","volume":"45","author":"Fisher","year":"2024","journal-title":"Trends Immunol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.it.2020.07.006","article-title":"Microglia and Astrocytes in Disease: Dynamic Duo or Partners in Crime?","volume":"41","author":"Liddelow","year":"2020","journal-title":"Trends Immunol."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Matejuk, A., and Ransohoff, R.M. (2020). Crosstalk Between Astrocytes and Microglia: An Overview. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.01416"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte-endothelial interactions at the blood-brain barrier","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1111\/j.1460-9568.2006.05223.x","article-title":"Degeneration of noradrenergic fibres from the locus coeruleus causes tight-junction disorganisation in the rat brain","volume":"24","author":"Kalinin","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Rostami, J., Fotaki, G., Sirois, J., Mzezewa, R., Bergstr\u00f6m, J., Essand, M., Healy, L., and Erlandsson, A. (2020). Astrocytes have the capacity to act as antigen-presenting cells in the Parkinson\u2019s disease brain. J. Neuroinflamm., 17.","DOI":"10.1186\/s12974-020-01776-7"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Sutter, P.A., and Crocker, S.J. (2022). Glia as antigen-presenting cells in the central nervous system. Curr. Opin. Neurobiol., 77.","DOI":"10.1016\/j.conb.2022.102646"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Perin, P., Tagne, A.M., Enrico, P., Marino, F., Cosentino, M., Pizzala, R., and Boselli, C. (2020). Cannabinoids, inner ear, hearing, and tinnitus: A neuroimmunological perspective. Front. Neurol., 11.","DOI":"10.3389\/fneur.2020.505995"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"251","DOI":"10.4049\/jimmunol.1900908","article-title":"Glial Cells as Regulators of Neuroimmune Interactions in the Central Nervous System","volume":"204","author":"Antel","year":"2020","journal-title":"J. Immunol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/1073858418783959","article-title":"Microglia-Astrocyte Crosstalk: An Intimate Molecular Conversation","volume":"25","author":"Jha","year":"2019","journal-title":"Neuroscientist"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Rupareliya, V.P., Singh, A.A., Butt, A.M., Hariharan, A., and Kumar, H. (2023). The \u201cmolecular soldiers\u201d of the CNS: Astrocytes, a comprehensive review on their roles and molecular signatures. Eur. J. Pharmacol., 959.","DOI":"10.1016\/j.ejphar.2023.176048"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cmet.2023.03.006","article-title":"Molecular and metabolic heterogeneity of astrocytes and microglia","volume":"35","author":"Hasel","year":"2023","journal-title":"Cell Metab."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/glia.23877","article-title":"Regionally encoded functional heterogeneity of astrocytes in health and disease: A perspective","volume":"69","author":"Clarke","year":"2021","journal-title":"Glia"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.tem.2022.03.001","article-title":"Metabolic changes favor the activity and heterogeneity of reactive astrocytes","volume":"33","author":"Xiong","year":"2022","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/s41593-021-00905-6","article-title":"Neuroinflammatory astrocyte subtypes in the mouse brain","volume":"24","author":"Hasel","year":"2021","journal-title":"Nat. Neurosci."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Mennink, L.M., Albakri, L.B.M., Aalbers, M.W., Dijk, P.V., and van Dijk, J.M.C. (2024). Cross-sectional screening for inflammation in tinnitus with near-normal hearing. Hear. Res., 453.","DOI":"10.1016\/j.heares.2024.109124"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41586-020-03116-4","article-title":"Gut-licensed IFN\u03b3 + NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes","volume":"590","author":"Sanmarco","year":"2021","journal-title":"Nature"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1096\/fj.05-4297fje","article-title":"Proinflammatory cytokines released from microglia inhibit gap junctions in astrocytes: Potentiation by beta-amyloid","volume":"20","author":"Calvo","year":"2006","journal-title":"FASEB J."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Huang, Y., Cao, Y., and Yang, J. (2024). Astrocyte-Mediated Neuroinflammation in Neurological Conditions. Biomolecules, 14.","DOI":"10.3390\/biom14101204"},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Geloso, M.C., Zupo, L., and Corvino, V. (2024). Crosstalk between peripheral inflammation and brain: Focus on the responses of microglia and astrocytes to peripheral challenge. Neurochem. Int., 180.","DOI":"10.1016\/j.neuint.2024.105872"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Zhou, X., Xiao, Q., Xie, L., Yang, F., Wang, L., and Tu, J. (2019). Astrocyte, a promising target for mood disorder interventions. Front. Mol. Neurosci., 12.","DOI":"10.3389\/fnmol.2019.00136"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jad.2019.11.141","article-title":"Association between major depressive disorder and subsequent tinnitus: A population-based study","volume":"263","author":"Kao","year":"2019","journal-title":"J. Affect. Disord."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Yang, D., Zhang, D., Zhang, X., and Li, X. (2024). Tinnitus-associated cognitive and psychological impairments: A comprehensive review meta-analysis. Front. Neurosci., 18.","DOI":"10.3389\/fnins.2024.1275560"},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Li, Y., Que, M., Wang, X., Zhan, G., Zhou, Z., Luo, X., and Li, S. (2023). Exploring Astrocyte-Mediated Mechanisms in Sleep Disorders and Comorbidity. Biomedicines, 11.","DOI":"10.3390\/biomedicines11092476"},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Wang, C., Li, S., Shi, M., Qin, Z., Wang, D., Li, W.M., Wang, R.M., Xie, L., and Li, Y. (2024). Association between sleep and tinnitus in US adults: Data from the NHANES (2007\u20132012). Medicine, 103.","DOI":"10.1097\/MD.0000000000040303"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Hsu, A., Tsou, Y.-A., Wang, T.-C., Chang, W.-D., Lin, C.-L., and Tyler, R.S. (2022). Hypothyroidism and related comorbidities on the risks of developing tinnitus. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-07457-0"},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Wang, T.-C., Chiu, C.-J., Chen, P.-C., Chang, T.-Y., Tyler, R.S., Rojas-Roncancio, E., Coelho, C.B., Mancini, P.C., Lin, C.-L., and Lin, C.-D. (2021). Increased Incidence of Tinnitus Following a Hyperthyroidism Diagnosis: A Population-Based Longitudinal Study. Front. 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