{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:33:11Z","timestamp":1785882791761,"version":"3.56.0"},"reference-count":58,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil (CAPES)","award":["400869\/2019-5"],"award-info":[{"award-number":["400869\/2019-5"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil (CAPES)","award":["309256\/2022-4"],"award-info":[{"award-number":["309256\/2022-4"]}]},{"name":"National Council of Technological and Scientific Development (CNPq)","award":["400869\/2019-5"],"award-info":[{"award-number":["400869\/2019-5"]}]},{"name":"National Council of Technological and Scientific Development (CNPq)","award":["309256\/2022-4"],"award-info":[{"award-number":["309256\/2022-4"]}]},{"name":"UNIPAMPA","award":["400869\/2019-5"],"award-info":[{"award-number":["400869\/2019-5"]}]},{"name":"UNIPAMPA","award":["309256\/2022-4"],"award-info":[{"award-number":["309256\/2022-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background: Parkinson\u2019s disease (PD) is a neurodegenerative disorder marked by motor deficits and non-motor symptoms, such as depression, which are associated with dopaminergic loss and \u03b1-synuclein aggregation in the brain. Objectives: This study investigated the neuroprotective effects of a hydroalcoholic extract of the purple fruit of Eugenia uniflora (PFEU) on motor ability and depressive-like behaviors in a PD model induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in female Wistar rats. Methods: Rats received intranasal administration of MPTP or vehicle, followed by 14 days of oral administration of PFEU (300 or 2000 mg\/kg, administered once daily) or vehicle. Depressive-like behavior was assessed using the splash and forced swimming tests, while motor ability was evaluated using the rotarod and open field tests. On day 15, hippocampal tissue was collected for immunoreactivity analysis. Results: MPTP treatment induced depressive-like behavior, which was significantly reversed by PFEU, as evidenced by increased grooming and decreased immobility. No motor coordination or locomotion deficits were observed. Furthermore, PFEU treatment prevented the MPTP-induced increase in hippocampal \u03b1-synuclein, p-p53, and Bax while restoring Bcl-2 levels, suggesting neuroprotective effects through the modulation of apoptotic pathways and \u03b1-synuclein. Conclusions: These findings support PFEU\u2019s potential as a neuroprotective agent for MPTP-induced depressive-like behavior in female rats, highlighting its molecular mechanisms.<\/jats:p>","DOI":"10.3390\/brainsci15010041","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T07:10:17Z","timestamp":1735888217000},"page":"41","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Eugenia uniflora Effects on the Depressive-like Behavior of MPTP-Exposed Female Rats: Apoptosis and \u03b1-Synuclein Modulation"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3151-9510","authenticated-orcid":false,"given":"Anne Su\u00e9ly Pinto","family":"Savall","sequence":"first","affiliation":[{"name":"Research Group on Biochemistry and Toxicology in Eukaryotes, Federal University of Pampa\u2014Campus Uruguaiana, Uruguaiana 97500-970, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhuly Dorneles","family":"De Mello","sequence":"additional","affiliation":[{"name":"Research Group on Biochemistry and Toxicology in Eukaryotes, Federal University of Pampa\u2014Campus Uruguaiana, Uruguaiana 97500-970, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7890-1659","authenticated-orcid":false,"given":"Eduarda Monteiro","family":"Fidelis","sequence":"additional","affiliation":[{"name":"Research Group on Biochemistry and Toxicology in Eukaryotes, Federal University of Pampa\u2014Campus Uruguaiana, Uruguaiana 97500-970, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandreza Cardoso","family":"Bortolotto","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules (LaftamBio), Federal University of Pampa\u2014Campus Itaqui, Itaqui 97650-000, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5850-6739","authenticated-orcid":false,"given":"Mustafa Munir Mustafa","family":"Dahleh","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules (LaftamBio), Federal University of Pampa\u2014Campus Itaqui, Itaqui 97650-000, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6995-5348","authenticated-orcid":false,"given":"Gustavo Petri","family":"Guerra","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules (LaftamBio), Federal University of Pampa\u2014Campus Itaqui, Itaqui 97650-000, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Prigol","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules (LaftamBio), Federal University of Pampa\u2014Campus Itaqui, Itaqui 97650-000, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robson","family":"Puntel","sequence":"additional","affiliation":[{"name":"Research Group on Biochemistry and Toxicology in Eukaryotes, Federal University of Pampa\u2014Campus Uruguaiana, Uruguaiana 97500-970, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Ramos","family":"Boldori","sequence":"additional","affiliation":[{"name":"Research Group on Biochemistry and Toxicology of Bioactive Compounds (GBTOXBIO), Federal University of Pampa\u2014Campus Uruguaiana, Uruguaiana 97500-970, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0912-1357","authenticated-orcid":false,"given":"Cristiane Casagrande","family":"Denardin","sequence":"additional","affiliation":[{"name":"Research Group on Biochemistry and Toxicology of Bioactive Compounds (GBTOXBIO), Federal University of Pampa\u2014Campus Uruguaiana, Uruguaiana 97500-970, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6149-9226","authenticated-orcid":false,"given":"Tuane Bazanella","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, State University of Centro-Oeste\u2014Campus Cedeteg, Guarapuava 85040-167, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6630-7329","authenticated-orcid":false,"given":"Simone","family":"Pinton","sequence":"additional","affiliation":[{"name":"Research Group on Biochemistry and Toxicology in Eukaryotes, Federal University of Pampa\u2014Campus Uruguaiana, Uruguaiana 97500-970, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"da Costa, J.S., Barroso, A.S., Mour\u00e3o, R.H.V., da Silva, J.K.R., Maia, J.G.S., and Figueiredo, P.L.B. 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