{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:57:55Z","timestamp":1791824275491,"version":"4.3.4"},"reference-count":59,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01NS082347"],"award-info":[{"award-number":["R01NS082347"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01EY032284"],"award-info":[{"award-number":["R01EY032284"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["F31HD116491"],"award-info":[{"award-number":["F31HD116491"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Multiple Sclerosis Society Research Grant","award":["R01NS082347"],"award-info":[{"award-number":["R01NS082347"]}]},{"name":"National Multiple Sclerosis Society Research Grant","award":["R01EY032284"],"award-info":[{"award-number":["R01EY032284"]}]},{"name":"National Multiple Sclerosis Society Research Grant","award":["F31HD116491"],"award-info":[{"award-number":["F31HD116491"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Introduction: The cerebellum is a common lesion site in persons with multiple sclerosis (PwMS). Physiologic and anatomic studies have identified a topographic organization of the cerebellum including functionally distinct motor and cognitive areas. In this study, a recent parcellation algorithm was applied to a sample of PwMS and healthy controls to examine the relationships among specific cerebellar regions, fall status, and common clinical measures of motor and cognitive functions. Methods: Thirty-one PwMS and twenty-nine age- and sex-matched controls underwent an MRI scan and motor and cognitive testing. The parcellation algorithm was applied to all images and divided the cerebellum into 28 regions. Mann\u2013Whitney U tests were used to compare cerebellar volumes among PwMS and controls, and MS fallers and MS non-fallers. Relationships between cerebellar volumes and motor and cognitive function were evaluated using Spearman correlations. Results: PwMS performed significantly worse on functional measures compared to controls. We found significant differences in volumetric measures between PwMS and controls in the corpus medullare, lobules I\u2013III, and lobule V. Volumetric differences seen between the PwMS and controls were primarily driven by the MS fallers. Finally, functional performance on motor and cognitive tasks was associated with cerebellar volumes. Conclusions: Using the parcellation tool, our results showed that the volumes of motor and cognitive lobules impact both motor and cognitive performance, and that functional performance and cerebellar volumes distinguishes the MS fallers from non-fallers. Future studies should explore the potential of cerebellar imaging to predict falls in PwMS.<\/jats:p>","DOI":"10.3390\/brainsci15010077","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T10:44:23Z","timestamp":1737024263000},"page":"77","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cerebellar Volume Measures Differentiate Multiple Sclerosis Fallers from Non-Fallers"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-5752","authenticated-orcid":false,"given":"Taylor N.","family":"Takla","sequence":"first","affiliation":[{"name":"Translational Neuroscience Program, Wayne State University, Detroit, MI 48201, USA"},{"name":"Department of Health Care Sciences, Wayne State University, Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennie","family":"Feldpausch","sequence":"additional","affiliation":[{"name":"Department of Health Care Sciences, Wayne State University, Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin M.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Translational Neuroscience Program, Wayne State University, Detroit, MI 48201, USA"},{"name":"Department of Health Care Sciences, Wayne State University, Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Han","sequence":"additional","affiliation":[{"name":"Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7776-6472","authenticated-orcid":false,"given":"Peter A.","family":"Calabresi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA"},{"name":"Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6553-0876","authenticated-orcid":false,"given":"Jerry","family":"Prince","sequence":"additional","affiliation":[{"name":"Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Zackowski","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA"},{"name":"Center for Movement Studies, Kennedy Krieger Institute, Baltimore, MD 21205, USA"},{"name":"Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4548-1077","authenticated-orcid":false,"given":"Nora E.","family":"Fritz","sequence":"additional","affiliation":[{"name":"Translational Neuroscience Program, Wayne State University, Detroit, MI 48201, USA"},{"name":"Department of Health Care Sciences, Wayne State University, Detroit, MI 48201, USA"},{"name":"Center for Movement Studies, Kennedy Krieger Institute, Baltimore, MD 21205, USA"},{"name":"Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA"},{"name":"Department of Neurology, Wayne State University, Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.3892\/etm.2017.4410","article-title":"Multiple sclerosis: Pathology, diagnosis and treatments","volume":"13","author":"Huang","year":"2017","journal-title":"Exp. 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