{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:59:25Z","timestamp":1789761565765,"version":"4.0.1"},"reference-count":81,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T00:00:00Z","timestamp":1740268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004748","name":"research council of the Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["4000351"],"award-info":[{"award-number":["4000351"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]},{"name":"INTERNATIONAL GROUP OF ALI AKBAR MOHADDES company","award":["4000351"],"award-info":[{"award-number":["4000351"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Introduction: Rheumatoid arthritis (RA) is a systemic inflammatory and autoimmune disease characterized by joint swelling, pain, damage to the cartilage, and disability. In the present study, we aimed to evaluate the anti-oxidant, anti-inflammatory, and immune-modulatory properties of Quantum Health Accelerator\u00ae as water enriched with vital bio-quantum information\/energy (EW) following complete Freund\u2019s adjuvant (CFA)-induced RA in rats. Methods: Forty adult male Wistar rats (180\u2013220 g) were divided into five groups. Arthritis was induced on day one using a single subcutaneous injection of CFA into the left hind footpad of the rat. Rats were assigned to receive methotrexate (MTX, 2 mg\/kg\/week, intraperitoneally), EW (orally, instead of normal water ad libitum), or their combination for 29 days. The anti-RA activities were determined by paw edema, joint diameter, arthritis score, and several nociceptive behavioral tests (thermal hyperalgesia, cold allodynia, and tactile allodynia). The levels of inflammatory (TNF-\u03b1, CRP, RF, and anti-CCP), anti-inflammatory (IL-10), and oxidative stress (NO, MDA, and GSH) markers were measured in serum. In addition, the levels of IFN-\u03b3, IL-4, IL-17, and TGF-\u03b2 were assessed in the spleen-isolated lymphocytes. Results: We found that treatment with MTX, EW, and their combination remarkably ameliorated thermal hyperalgesia, cold allodynia, and tactile allodynia results following CFA-induced RA in rats. In addition, EW also notably attenuated arthritis score, joint diameter, inflammatory cytokines, and oxidative markers while propagating anti-inflammatory and anti-oxidative mediators. Conclusions: We reveal that EW possesses anti-arthritic effects, possibly through anti-oxidative, anti-inflammatory, and immunomodulatory properties. Collectively, EW may be a promising therapeutic agent for treating RA.<\/jats:p>","DOI":"10.3390\/brainsci15030232","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:47:17Z","timestamp":1740379637000},"page":"232","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Quantum Health Accelerator\u00ae Ameliorates CFA-Induced Animal Model of Rheumatoid Arthritis: Investigating the Role of Immunomodulatory and Anti-Oxidative Effects"],"prefix":"10.3390","volume":"15","author":[{"given":"Ali Akbar","family":"Mohaddes","sequence":"first","affiliation":[{"name":"International Group of Ali Akbar Mohaddes Company, License NO 1090645, Dubai 35360-97797, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Ali","family":"Saatchi","sequence":"additional","affiliation":[{"name":"International Group of Ali Akbar Mohaddes Company, License NO 1090645, Dubai 35360-97797, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marziyeh","family":"Afshari Chamanabadi","sequence":"additional","affiliation":[{"name":"International Group of Ali Akbar Mohaddes Company, License NO 1090645, Dubai 35360-97797, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Saatchi","sequence":"additional","affiliation":[{"name":"International Group of Ali Akbar Mohaddes Company, License NO 1090645, Dubai 35360-97797, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadra","family":"Rostami","sequence":"additional","affiliation":[{"name":"International Group of Ali Akbar Mohaddes Company, License NO 1090645, Dubai 35360-97797, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9268-6270","authenticated-orcid":false,"given":"Vahid Reza","family":"Askari","sequence":"additional","affiliation":[{"name":"Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1001\/jama.2018.13103","article-title":"Diagnosis and Management of Rheumatoid Arthritis: A Review","volume":"320","author":"Aletaha","year":"2018","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"K\u00f6hler, B.M., G\u00fcnther, J., Kaudewitz, D., and Lorenz, H.M. 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