{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:04:47Z","timestamp":1790244287324,"version":"4.1.0"},"reference-count":215,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"2024 Yeungnam University Research Grants"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Neurological disorders are defined by a deterioration or disruption of the nervous system\u2019s structure and function. These diseases, which include multiple sclerosis, Alzheimer\u2019s disease, Parkinson\u2019s disease, Huntington\u2019s disease, and schizophrenia, are caused by intricate pathological processes that include excitotoxicity, neuroinflammation, oxidative stress, genetic mutations, and compromised neurotrophic signaling. Although current pharmaceutical treatments relieve symptoms, their long-term efficacy is limited due to adverse side effects and weak neuroprotective properties. However, when combined with other neuroprotective drugs or adjunct therapy, they may offer additional benefits and improve treatment outcomes. Phytochemicals have emerged as attractive therapeutic agents due to their ability to regulate essential neurotrophic pathways, especially the brain-derived neurotrophic factor (BDNF) signaling cascade. BDNF is an important target for neurodegenerative disease (ND) treatment since it regulates neuronal survival, synaptic plasticity, neurogenesis, and neuroprotection. This review emphasizes the molecular pathways through which various phytochemicals\u2014such as flavonoids, terpenoids, alkaloids, and phenolic compounds\u2014stimulate BDNF expression and modulate its downstream signaling pathways, including GSK-3\u03b2, MAPK\/ERK, PI3K\/Akt\/mTOR, CREB, and Wnt\/\u03b2-catenin. This paper also highlights how phytochemical combinations may interact to enhance BDNF activity, offering new therapeutic options for ND treatment. Despite their potential for neuroprotection, phytochemicals face challenges related to pharmacokinetics, blood\u2013brain barrier (BBB) permeability, and absorption, highlighting the need for further research into combination therapies and improved formulations. Clinical assessment and mechanistic understanding of BDNF-targeted phytotherapy should be the main goals of future studies. The therapeutic efficacy of natural compounds in regulating neurotrophic signaling is highlighted in this review, providing a viable approach to the prevention and treatment of NDs.<\/jats:p>","DOI":"10.3390\/brainsci15030252","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T08:04:44Z","timestamp":1740643484000},"page":"252","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Phytochemicals Targeting BDNF Signaling for Treating Neurological Disorders"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4049-102X","authenticated-orcid":false,"given":"Alka Ashok","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Life Sciences, Yeungnam University, Gyeongsan 38541, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Katiyar","sequence":"additional","affiliation":[{"name":"Department of Botany, SBN Government PG College, Barwani 451551, MP, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minseok","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Yeungnam University, Gyeongsan 38541, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S1474-4422(17)30299-5","article-title":"GBD 2015 Neurological Disorders Collaborator Group. Global, regional, and national burden of neurological disorders during 1990\u20132015: A systematic analysis for the Global Burden of Disease Study 2015","volume":"16","author":"Feigin","year":"2017","journal-title":"Lancet Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12979-022-00292-x","article-title":"Neurohormetic phytochemicals in the pathogenesis of neurodegenerative diseases","volume":"19","author":"Sahebnasagh","year":"2022","journal-title":"Immun. Ageing"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Green, D.R., and Llambi, F. (2015). Cell death signaling. Cold Spring Harb. Perspect. Biol., 7.","DOI":"10.1101\/cshperspect.a006080"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"FNL9","DOI":"10.2217\/fnl-2018-0028","article-title":"Neuroprotection of multifunctional phytochemicals as novel therapeutic strategy for neurodegenerative disorders: Antiapoptotic and antiamyloidogenic activities by modulation of cellular signal pathways","volume":"14","author":"Naoi","year":"2019","journal-title":"Future Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1582-4934.2010.01010.x","article-title":"Basic mechanisms of neurodegeneration: A critical update","volume":"14","author":"Jellinger","year":"2010","journal-title":"J. Cell Mol. Med."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Singh, A., Kukreti, R., Saso, L., and Kukreti, S. (2019). Oxidative Stress: A Key Modulator in Neurodegenerative Diseases. Molecules, 24.","DOI":"10.3390\/molecules24081583"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"755","DOI":"10.2174\/1381612826666200107161051","article-title":"Novel Therapeutics for the Treatment of Alzheimer\u2019s and Parkinson\u2019s Disease","volume":"26","author":"Singh","year":"2020","journal-title":"Curr. Pharm. Des."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: A review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.tox.2017.06.011","article-title":"Mitochondrial dysfunction in glial cells: Implications for neuronal homeostasis and survival","volume":"391","author":"Rose","year":"2017","journal-title":"Toxicology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.crvi.2005.05.002","article-title":"Regulation of Bcl-2 proteins and of the permeability of the outer mitochondrial membrane","volume":"328","author":"Martinou","year":"2005","journal-title":"C. R. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1017\/S146114571000146X","article-title":"Morphometric post-mortem studies in bipolar disorder: Possible association with oxidative stress and apoptosis","volume":"14","author":"Gigante","year":"2011","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/nep3.43","article-title":"Targeting brain-derived neurotrophic factor in the treatment of neurodegenerative diseases: A review","volume":"2","author":"Wang","year":"2024","journal-title":"Neuroprotection"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"107955","DOI":"10.1016\/j.heares.2020.107955","article-title":"Neurotrophin gene therapy to promote survival of spiral ganglion neurons after deafness","volume":"394","author":"Leake","year":"2020","journal-title":"Hear. Res."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Sahu, M.P., Pazos-Boubeta, Y., Pajanoja, C., Rozov, S., Panula, P., and Castren, E. (2019). Neurotrophin receptor Ntrk2b function in the maintenance of dopamine and serotonin neurons in zebrafish. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-39347-3"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Autry, A.E., and Bambah-Mukku, D. (2020). The role of brain-derived neurotrophic factor in neural circuit development and function. Synapse Development and Maturation, Elsevier.","DOI":"10.1016\/B978-0-12-823672-7.00020-X"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Vilar, M., and Mira, H. (2016). Regulation of neurogenesis by neurotrophins during adulthood: Expected and unexpected roles. Front. Neurosci., 10.","DOI":"10.3389\/fnins.2016.00026"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Manti, S., Xerra, F., Spoto, G., Butera, A., Gitto, E., Di Rosa, G., and Nicotera, A.G. (2023). Neurotrophins: Expression of Brain\u2013Lung Axis Development. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24087089"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1016\/j.bmcl.2011.02.003","article-title":"Furostanol saponins from the rhizomes of Dioscorea japonica and their effects on NGF induction","volume":"21","author":"Kim","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/cns.12824","article-title":"Neurotrophin-3 restores synaptic plasticity in the striatum of a mouse model of Huntington\u2019s disease","volume":"24","year":"2018","journal-title":"CNS Neurosci. Ther."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jpsychires.2016.05.009","article-title":"State-dependent increase in the levels of neurotrophin-3 and neurotrophin-4\/5 in patients with bipolar disorder: A meta-analysis","volume":"79","author":"Tseng","year":"2016","journal-title":"J. Psychiatr. Res."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Cho, T., Ryu, J.K., Taghibiglou, C., Ge, Y., Chan, A.W., Liu, L., Lu, J., McLarnon, J.G., and Wang, Y.T. (2013). Long-term potentiation promotes proliferation\/survival and neuronal differentiation of neural stem\/progenitor cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0076860"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1750-1326-9-25","article-title":"Epigenetic regulation of adult neural stem cells: Implications for Alzheimer\u2019s disease","volume":"9","author":"Fitzsimons","year":"2014","journal-title":"Mol. Neurodegener."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3233\/JHD-170275","article-title":"Modulating neurotrophin receptor signaling as a therapeutic strategy for Huntington\u2019s disease","volume":"6","author":"Simmons","year":"2017","journal-title":"J. Huntington\u2019s Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.phrs.2017.04.024","article-title":"Neurotrophin receptors in the pathogenesis, diagnosis and therapy of neurodegenerative diseases","volume":"121","author":"Meldolesi","year":"2017","journal-title":"Pharmacol. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1703982","DOI":"10.1002\/adfm.201703982","article-title":"Nanoformulation of brain-derived neurotrophic factor with target receptor-triggered-release in the central nervous system","volume":"28","author":"Jiang","year":"2018","journal-title":"Adv. Funct. Mater."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"384","DOI":"10.2174\/1570159X22666240530105516","article-title":"Brain-Derived Neurotrophic Factor (BDNF) in Huntington\u2019s Disease: Neurobiology and Therapeutic Potential","volume":"23","author":"Azman","year":"2025","journal-title":"Curr. Neuropharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neuroscience.2012.09.017","article-title":"Are BDNF and glucocorticoid activities calibrated?","volume":"239","author":"Jeanneteau","year":"2013","journal-title":"Neuroscience"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neures.2023.02.001","article-title":"Astrocytes and brain-derived neurotrophic factor (BDNF)","volume":"197","author":"Albini","year":"2023","journal-title":"Neurosci. Res."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Palasz, E., Wilkaniec, A., Stanaszek, L., Andrzejewska, A., and Adamczyk, A. (2023). Glia-neurotrophic factor relationships: Possible role in pathobiology of neuroinflammation-related brain disorders. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24076321"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/med.22075","article-title":"Indirect influence on the BDNF\/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders","volume":"45","author":"Antonijevic","year":"2025","journal-title":"Med. Res. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1111\/j.1471-4159.2009.06562.x","article-title":"Naturally occurring phytochemicals for the prevention of Alzheimer\u2019s disease","volume":"112","author":"Kim","year":"2010","journal-title":"J. Neurochem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/08977190410001723308","article-title":"Brain-derived neurotrophic factor","volume":"22","author":"Binder","year":"2004","journal-title":"Growth Factors"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/374450a0","article-title":"A BDNF autocrine loop in adult sensory neurons prevents cell death","volume":"374","author":"Acheson","year":"1995","journal-title":"Nature"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1146\/annurev.neuro.24.1.677","article-title":"Neurotrophins: Roles in neuronal development and function","volume":"24","author":"Huang","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.biocel.2017.06.002","article-title":"Neuronal activity-regulated alternative mRNA splicing","volume":"91","author":"Hermey","year":"2017","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0896-6273(00)81010-7","article-title":"Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism","volume":"20","author":"Tao","year":"1998","journal-title":"Neuron"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/jnr.21139","article-title":"Mouse and rat BDNF gene structure and expression revisited","volume":"85","author":"Aid","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"27702","DOI":"10.1074\/jbc.M114.586719","article-title":"Pharmacological profile of brain-derived neurotrophic factor (BDNF) splice variant translation using a novel drug screening assay: A \u201cquantitative code\u201d","volume":"289","author":"Vaghi","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jneuroim.2006.09.001","article-title":"Differential expression of BDNF mRNA splice variants in mouse brain and immune cells","volume":"182","author":"Kruse","year":"2007","journal-title":"J. Neuroimmunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.5114\/aoms.2015.56342","article-title":"Brain-derived neurotrophic factor and its clinical implications","volume":"11","author":"Bathina","year":"2015","journal-title":"Arch. Med. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"122282","DOI":"10.1016\/j.lfs.2023.122282","article-title":"TrkB\/BDNF signaling pathway and its small molecular agonists in CNS injury","volume":"336","author":"Wang","year":"2024","journal-title":"Life Sci."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Jha, M., Pasupalak, J.K., and Gupta, G.L. (2024). Depressive Behavior and BDNF\/TrkB Signaling. Handbook of the Biology and Pathology of Mental Disorders, Springer.","DOI":"10.1007\/978-3-031-32035-4_36-1"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Tejeda, G.S., and D\u00edaz-Guerra, M. (2017). Integral characterization of defective BDNF\/TrkB signalling in neurological and psychiatric disorders leads the way to new therapies. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18020268"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s12079-013-0200-z","article-title":"A network map of BDNF\/TRKB and BDNF\/p75NTR signaling system","volume":"7","author":"Sandhya","year":"2013","journal-title":"J. Cell Commun. Signal."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Azman, K.F., and Zakaria, R. (2022). Recent advances on the role of brain-derived neurotrophic factor (BDNF) in neurodegenerative diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23126827"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"11618","DOI":"10.1523\/JNEUROSCI.0012-13.2013","article-title":"Distinct roles for somatically and dendritically synthesized brain-derived neurotrophic factor in morphogenesis of dendritic spines","volume":"33","author":"Orefice","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.celrep.2014.03.040","article-title":"proBDNF negatively regulates neuronal remodeling, synaptic transmission, and synaptic plasticity in hippocampus","volume":"7","author":"Yang","year":"2014","journal-title":"Cell Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1158\/0008-5472.CAN-10-0163","article-title":"Receptor tyrosine kinase coactivation networks in cancer","volume":"70","author":"Xu","year":"2010","journal-title":"Cancer Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0014-5793(01)02116-0","article-title":"Negative regulation of receptor tyrosine kinase signals","volume":"490","author":"Fiorini","year":"2001","journal-title":"FEBS Lett."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.2174\/0118715273298919240531110022","article-title":"Neurotrophin-3 Rescues Striatal Synaptic Plasticity in Model of Neurodegeneration by PLC Signaling Activation","volume":"23","year":"2024","journal-title":"CNS Neurol. Disord.-Drug Targets"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"9469","DOI":"10.1073\/pnas.1702441114","article-title":"BDNF-TrkB controls cocaine-induced dendritic spines in rodent nucleus accumbens dissociated from increases in addictive behaviors","volume":"114","author":"Anderson","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0959-4388(00)00211-7","article-title":"Transcription-dependent and-independent control of neuronal survival by the PI3K\u2013Akt signaling pathway","volume":"11","author":"Brunet","year":"2001","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0896-6273(02)00942-X","article-title":"Mechanism of TrkB-mediated hippocampal long-term potentiation","volume":"36","author":"Minichiello","year":"2002","journal-title":"Neuron"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1523\/JNEUROSCI.4436-04.2005","article-title":"A truncated tropo-myosine-related kinase B receptor, T1, regulates glial cell morphology via Rho GDP dissociation inhibitor 1","volume":"25","author":"Ohira","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Yang, T., Nie, Z., Shu, H., Kuang, Y., Chen, X., Cheng, J., Yu, S., and Liu, H. (2020). The role of BDNF on neural plasticity in depression. Front. Cell. Neurosci., 14.","DOI":"10.3389\/fncel.2020.00082"},{"key":"ref_56","first-page":"237","article-title":"BDNF function and intracellular signaling in neurons","volume":"25","author":"Numakawa","year":"2010","journal-title":"Histol. Histopathol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jpsychires.2022.10.022","article-title":"Effects of brain-derived neurotrophic factor (BDNF) on the Schizophrenia model of animals","volume":"156","author":"Shi","year":"2022","journal-title":"J. Psychiatr. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/npp.2011.267","article-title":"Abnormal activity of the MAPK-and cAMP-associated signaling pathways in frontal cortical areas in postmortem brain in schizophrenia","volume":"37","author":"Funk","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Bommaraju, S., Dhokne, M.D., Arun, E., Srinivasan, K., Sharma, S.S., and Datusalia, A.K. (2024). An insight into crosstalk among multiple signalling pathways contributing to the pathophysiology of PTSD and depressive disorders. Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 131.","DOI":"10.1016\/j.pnpbp.2024.110943"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e11388","DOI":"10.7717\/peerj.11388","article-title":"Brain-derived neurotrophic factor increases cell number of neural progenitor cells derived from human induced pluripotent stem cells","volume":"9","author":"Pansri","year":"2021","journal-title":"PeerJ"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/clpt.2011.296","article-title":"The roles of neurotrophic factor and Wnt signaling in depression","volume":"91","author":"Voleti","year":"2012","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/jnr.23138","article-title":"Brain-derived neurotrophic factor stimulates proliferation and differentiation of neural stem cells, possibly by triggering the Wnt\/\u03b2-catenin signaling pathway","volume":"91","author":"Chen","year":"2013","journal-title":"J. Neurosci. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s13277-010-0016-x","article-title":"Brain-derived neurotrophic factor induces proliferation, migration, and VEGF secretion in human multiple myeloma cells via activation of MEK-ERK and PI3K\/AKT signaling","volume":"31","author":"Sun","year":"2010","journal-title":"Tumor Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1210\/me.2012-1063","article-title":"BDNF alters ERK\/p38 MAPK activity ratios to promote differentiation in growth plate chondrocytes","volume":"26","author":"Hutchison","year":"2012","journal-title":"Mol. Endocrinol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Krejci, P., Aklian, A., Kaucka, M., Sevcikova, E., Prochazkova, J., Masek, J.K., Mikolka, P., Pospisilova, T., Spoustova, T., and Weis, M. (2012). Receptor tyrosine kinases activate canonical WNT\/\u03b2-catenin signaling via MAP kinase\/LRP6 pathway and direct \u03b2-catenin phosphorylation. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0035826"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.bbrc.2011.05.094","article-title":"MAPK\/ERK and Wnt\/\u03b2-Catenin pathways are synergistically involved in proliferation of Sca-1 positive hepatic progenitor cells","volume":"409","author":"Jin","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1101\/gad.17421911","article-title":"Cooperation between both Wnt\/\u03b2-catenin and PTEN\/PI3K\/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion","volume":"25","author":"Perry","year":"2011","journal-title":"Genes. Dev."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1128\/IAI.01025-10","article-title":"Epithelial phosphatidylinositol-3-kinase signaling is required for \u03b2-catenin activation and host defense against Citrobacter rodentium infection","volume":"79","author":"Brown","year":"2011","journal-title":"Infect. Immun."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1759091415602463","DOI":"10.1177\/1759091415602463","article-title":"Crosstalk Between MAPK\/ERK and PI3K\/AKT Signal Pathways During Brain Ischemia\/Reperfusion","volume":"7","author":"Zhou","year":"2015","journal-title":"ASN Neuro"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Jha, N.K., Chen, W.C., Kumar, S., Dubey, R., Tsai, L.W., Kar, R., Jha, S.K., Gupta, P.K., Sharma, A., and Gundamaraju, R. (2022). Molecular mechanisms of developmental pathways in neurological disorders: A pharmacological and therapeutic review. Open Biol., 12.","DOI":"10.1098\/rsob.210289"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.1471-4159.2009.06171.x","article-title":"Retinoic acid receptor stimulation protects midbrain dopaminergic neurons from inflammatory degeneration via BDNF-mediated signaling","volume":"110","author":"Katsuki","year":"2009","journal-title":"J. Neurochem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s12031-008-9166-3","article-title":"Induction of adult human bone marrow mesenchymal stromal cells into functional astrocyte-like cells: Potential for restorative treatment in Parkinson\u2019s disease","volume":"39","author":"Barhum","year":"2009","journal-title":"J. Mol. Neurosci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"821","DOI":"10.2174\/138945005774574506","article-title":"Reactive astrocytes as potential manipulation targets in novel cell replacement therapy of Parkinson\u2019s disease","volume":"6","author":"Chen","year":"2005","journal-title":"Curr. Drug Targets"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"13594","DOI":"10.1073\/pnas.0901402106","article-title":"Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease","volume":"106","author":"Kitazawa","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00401-008-0440-9","article-title":"Axonal protection by brain-derived neurotrophic factor associated with CREB phosphorylation in tumor necrosis factor-\u03b1-induced optic nerve degeneration","volume":"117","author":"Fujino","year":"2009","journal-title":"Acta Neuropathol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Nieto, R., Kukuljan, M., and Silva, H. (2013). BDNF and schizophrenia: From neurodevelopment to neuronal plasticity, learning, and memory. Front. Psychiatry, 4.","DOI":"10.3389\/fpsyt.2013.00045"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"M\u00fcller, P., Duderstadt, Y., Lessmann, V., and M\u00fcller, N.G. (2020). Lactate and BDNF: Key mediators of exercise induced neuroplasticity?. J. Clin. Med., 9.","DOI":"10.3390\/jcm9041136"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nn.2505","article-title":"Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons","volume":"13","author":"Ji","year":"2010","journal-title":"Nat. Neurosci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-6606-5-14","article-title":"The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB","volume":"5","author":"Kandel","year":"2012","journal-title":"Mol. Brain"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1073\/pnas.0711863105","article-title":"BDNF is essential to promote persistence of long-term memory storage","volume":"105","author":"Bekinschtein","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.schres.2006.05.028","article-title":"Decreased levels of plasma BDNF in first-episode schizophrenia and bipolar disorder patients","volume":"86","author":"Palomino","year":"2006","journal-title":"Schizophr. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1523\/JNEUROSCI.20-08-02809.2000","article-title":"Brain-derived neurotrophic factor causes cAMP response element-binding protein phosphorylation in absence of calcium increases in slices and cultured neurons from rat visual cortex","volume":"20","author":"Pizzorusso","year":"2000","journal-title":"J. Neurosci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"28587","DOI":"10.1074\/jbc.M110.125740","article-title":"Regulation of dendritic development by BDNF requires activation of CRTC1 by glutamate","volume":"285","author":"Finsterwald","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"9735","DOI":"10.1523\/JNEUROSCI.6785-10.2011","article-title":"BDNF-promoted increases in proximal dendrites occur via CREB-dependent transcriptional regulation of cypin","volume":"31","author":"Kwon","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2174\/1566523218666180302163029","article-title":"Dysfunction in brain-derived neurotrophic factor signaling pathway and susceptibility to schizophrenia, Parkinson\u2019s and Alzheimer\u2019s diseases","volume":"18","author":"Mohammadi","year":"2018","journal-title":"Curr. Gene Ther."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Xue, W., Wang, W., Gong, T., Zhang, H., Tao, W., Xue, L., Sun, Y., Wang, F., and Chen, G. (2016). PKA-CREB-BDNF signaling regulated long lasting antidepressant activities of Yueju but not ketamine. Sci. Rep., 6.","DOI":"10.1038\/srep26331"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1017\/S0033291709005248","article-title":"Early adversity and 5-HTT\/BDNF genes: New evidence of gene\u2013environment interactions on depressive symptoms in a general population","volume":"39","author":"Aguilera","year":"2009","journal-title":"Psychol. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jad.2009.02.023","article-title":"Interaction between genetic polymorphisms and stressful life events in first episode depression","volume":"119","author":"Bukh","year":"2009","journal-title":"J. Affect. Disord."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/j.1601-183X.2010.00617.x","article-title":"A haplotype of glycogen synthase kinase 3\u03b2 is associated with early onset of unipolar major depression","volume":"9","author":"Saus","year":"2010","journal-title":"Genes. Brain Behav."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"828","DOI":"10.2174\/1871527316666170518170422","article-title":"Brain-derived neurotrophic factor promotes growth of neurons and neural stem cells possibly by triggering the phosphoinositide 3-kinase\/AKT\/glycogen synthase kinase-3\u03b2\/\u03b2-catenin pathway","volume":"16","author":"Li","year":"2017","journal-title":"CNS Neurol. Disord.-Drug Targets"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1046\/j.1471-4159.2002.00939.x","article-title":"BDNF-mediated signal transduction is modulated by GSK3\u03b2 and mood stabilizing agents","volume":"82","author":"Mai","year":"2002","journal-title":"J. Neurochem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.tibs.2003.12.004","article-title":"The glamour and gloom of glycogen synthase kinase-3","volume":"29","author":"Jope","year":"2004","journal-title":"Trends Biochem. Sci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.coph.2006.07.005","article-title":"Neurotrophic signaling cascades in the pathophysiology and treatment of bipolar disorder","volume":"7","author":"Shaltiel","year":"2007","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000314310","article-title":"Novel insights into lithium\u2019s mechanism of action: Neurotrophic and neuroprotective effects","volume":"62","author":"Quiroz","year":"2010","journal-title":"Neuropsychobiology"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Chiu, C.-H., Chyau, C.-C., Chen, C.-C., Lee, L.-Y., Chen, W.-P., Liu, J.-L., Lin, W.-H., and Mong, M.-C. (2018). Erinacine A-enriched Hericium erinaceus mycelium produces antidepressant-like effects through modulating BDNF\/PI3K\/Akt\/GSK-3\u03b2 signaling in mice. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19020341"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.21037\/atm-21-5849","article-title":"Herba Rhodiolae alleviates depression via the BDNF\/TrkB-GSK-3\u03b2 signaling pathway","volume":"9","author":"Gao","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/sj.mp.4002099","article-title":"The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons","volume":"14","author":"Yasuda","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pnpbp.2013.12.001","article-title":"GSK3\u03b2, CREB, and BDNF in peripheral blood of patients with Alzheimer\u2019s disease and depression","volume":"50","author":"Buchal","year":"2014","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/nen.0b013e31802d6da9","article-title":"Expression of Nrf2 in neurodegenerative diseases","volume":"66","author":"Ramsey","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/157015909787602823","article-title":"Oxidative stress and neurodegenerative diseases: A review of upstream and downstream antioxidant therapeutic options","volume":"7","author":"Uttara","year":"2009","journal-title":"Curr. Neuropharmacol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1111\/febs.14379","article-title":"The role of Nrf2 signaling in counteracting neurodegenerative diseases","volume":"285","author":"Kostov","year":"2018","journal-title":"FEBS J."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1073\/pnas.0408487101","article-title":"Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription","volume":"102","author":"Calkins","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/s41398-021-01261-6","article-title":"Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents","volume":"11","author":"Yao","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"9594","DOI":"10.1073\/pnas.2000278117","article-title":"Seasonal changes in NRF2 antioxidant pathway regulates winter depression-like behavior","volume":"117","author":"Nakayama","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.freeradbiomed.2015.06.006","article-title":"Molecular basis of the Keap1\u2013Nrf2 system","volume":"88","author":"Suzuki","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1111\/jphp.13319","article-title":"By reducing oxidative stress, naringenin mitigates hyperglycaemia-induced upregulation of hepatic nuclear factor erythroid 2-related factor 2 protein","volume":"72","author":"Kometsi","year":"2020","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1152\/physrev.00023.2017","article-title":"The KEAP1-NRF2 system: A thiol-based sensor-effector apparatus for maintaining redox homeostasis","volume":"98","author":"Yamamoto","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s00406-017-0848-0","article-title":"Keap1\u2013Nrf2 signaling pathway confers resilience versus susceptibility to inescapable electric stress","volume":"268","author":"Zhang","year":"2018","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"pyu121","DOI":"10.1093\/ijnp\/pyu121","article-title":"Regional differences in brain-derived neurotrophic factor levels and dendritic spine density confer resilience to inescapable stress","volume":"18","author":"Yang","year":"2015","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.bbrc.2018.09.080","article-title":"The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K","volume":"505","author":"Bruna","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.conb.2009.06.003","article-title":"A synaptic trek to autism","volume":"19","author":"Bourgeron","year":"2009","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.molmed.2010.10.002","article-title":"Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders","volume":"17","author":"Ehninger","year":"2011","journal-title":"Trends Mol. Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0959-4388(00)00092-1","article-title":"Neurotrophin signal transduction in the nervous system","volume":"10","author":"Kaplan","year":"2000","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/dneu.20765","article-title":"Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease","volume":"70","author":"Yoshii","year":"2010","journal-title":"Dev. Neurobiol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4172\/2165-7890.1000143","article-title":"Bridging the gap between genes and behavior: Brain-derived neurotrophic factor and the mTOR pathway in idiopathic autism","volume":"5","author":"Fahnestock","year":"2015","journal-title":"Autism Open Access"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Choi, H.J., Lee, H.L., Kim, I.Y., Ju, Y.H., Heo, Y.M., Na, H.R., Lee, J.Y., Choi, S.-I., and Heo, H.J. (2025). Oral Administration of Lactobacillus gasseri and Lacticaseibacillus rhamnosus Ameliorates Amyloid Beta (A\u03b2)-Induced Cognitive Impairment by Improving Synaptic Function Through Regulation of TLR4\/Akt Pathway. Antioxidants, 14.","DOI":"10.3390\/antiox14020139"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1038\/ncomms2295","article-title":"Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex","volume":"3","author":"Sato","year":"2012","journal-title":"Nat. Commun."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1523\/JNEUROSCI.5685-08.2009","article-title":"Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice","volume":"29","author":"Zhou","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40478-015-0184-4","article-title":"Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid","volume":"3","author":"Nicolini","year":"2015","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1038\/emboj.2013.107","article-title":"Eps8 controls dendritic spine density and synaptic plasticity through its actin-capping activity","volume":"32","author":"Menna","year":"2013","journal-title":"EMBO J."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/NEN.0b013e31824b27e4","article-title":"Altered balance of proteolytic isoforms of pro-brain-derived neurotrophic factor in autism","volume":"71","author":"Garcia","year":"2012","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1007\/s10787-024-01492-1","article-title":"The regulating effect of curcumin on NF-\u03baB pathway in neurodegenerative diseases: A review of the underlying mechanisms","volume":"32","author":"Esmaealzadeh","year":"2024","journal-title":"Inflammopharmacology"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.jnutbio.2012.03.005","article-title":"The Nrf2-antioxidant response element pathway: A target for regulating energy metabolism","volume":"23","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"13291","DOI":"10.1074\/jbc.R900010200","article-title":"The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress","volume":"284","author":"Nguyen","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s00441-020-03177-x","article-title":"Regulation of Nrf2 and NF-\u03baB during lead toxicity in bovine granulosa cells","volume":"380","author":"Aglan","year":"2020","journal-title":"Cell Tissue Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1089\/neu.2019.6749","article-title":"Curcumin protects against white matter injury through NF-\u03baB and Nrf2 cross talk","volume":"37","author":"Daverey","year":"2020","journal-title":"J. Neurotrauma"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1186\/s12935-022-02719-3","article-title":"Disease-associated regulation of gene expression by resveratrol: Special focus on the PI3K\/AKT signaling pathway","volume":"22","author":"Bahroudi","year":"2022","journal-title":"Cancer Cell Int."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Utpal, B.K., Mokhfi, F.Z., Zehravi, M., Sweilam, S.H., Gupta, J.K., Kareemulla, S., Rao, A., Kumar, V.V., Krosuri, P., and Prasad, D. (2024). Resveratrol: A Natural Compound Targeting the PI3K\/Akt\/mTOR Pathway in Neurological Diseases. Mol. Neurobiol., 1\u201330.","DOI":"10.1007\/s12035-024-04608-4"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s12035-019-01803-6","article-title":"Resveratrol activates neuronal autophagy through AMPK in the ischemic brain","volume":"57","author":"Aguilera","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Liu, H., Song, Y., Wang, H., Zhou, Y., Xu, M., and Xian, J. (Phytother. Res., 2025). Deciphering the Power of Resveratrol in Mitophagy: From Molecular Mechanisms to Therapeutic Applications, Phytother. Res., Online ahead of print.","DOI":"10.1002\/ptr.8433"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/biof.1385","article-title":"N europrotective effects of honokiol: From chemistry to medicine","volume":"43","author":"Talarek","year":"2017","journal-title":"Biofactors"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.3233\/JAD-210177","article-title":"Honokiol restores microglial phagocytosis by reversing metabolic reprogramming","volume":"82","author":"Li","year":"2021","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"684","DOI":"10.5603\/FM.a2019.0029","article-title":"Expression of vascular endothelial growth factor and glial fibrillary acidic protein in a rat model of traumatic brain injury treated with honokiol: A biochemical and immunohistochemical study","volume":"78","author":"Deveci","year":"2019","journal-title":"Folia Morphol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neuropharm.2014.06.018","article-title":"Intravenous administration of Honokiol provides neuroprotection and improves functional recovery after traumatic brain injury through cell cycle inhibition","volume":"86","author":"Wang","year":"2014","journal-title":"Neuropharmacology"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1002\/ptr.8192","article-title":"Phytomedicine for neurodegenerative diseases: The road ahead","volume":"38","author":"Madhubala","year":"2024","journal-title":"Phytother. Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12986-024-00800-4","article-title":"Natural products in the management of neurodegenerative diseases","volume":"21","author":"Goyal","year":"2024","journal-title":"Nutr. Metab."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4103\/0973-7847.99898","article-title":"Neuroprotective potential of phytochemicals","volume":"6","author":"Kumar","year":"2012","journal-title":"Pharmacogn. Rev."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejphar.2009.08.016","article-title":"Neurite outgrowth induced by spicatoside A, a steroidal saponin, via the tyrosine kinase A receptor pathway","volume":"620","author":"Hur","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neulet.2014.04.034","article-title":"Spicatoside A enhances memory consolidation through the brain-derived neurotrophic factor in mice","volume":"572","author":"Kwon","year":"2014","journal-title":"Neurosci. Lett."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"9949","DOI":"10.3390\/molecules18089949","article-title":"Neuroprotective, anti-amyloidogenic and neurotrophic effects of apigenin in an Alzheimer\u2019s disease mouse model","volume":"18","author":"Zhao","year":"2013","journal-title":"Molecules"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1007\/s11064-006-9166-z","article-title":"Neuroprotective effects of (\u2212)-epigallocatechin-3-gallate in a transgenic mouse model of amyotrophic lateral sclerosis","volume":"31","author":"Xu","year":"2006","journal-title":"Neurochem. Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.pharep.2018.05.006","article-title":"Protective effects of curcumin on acrolein-induced neurotoxicity in HT22 mouse hippocampal cells","volume":"70","author":"Shi","year":"2018","journal-title":"Pharmacol. Rep."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.3233\/JAD-140444","article-title":"Neuroprotective role of trans-resveratrol in a murine model of familial Alzheimer\u2019s disease","volume":"42","author":"Porquet","year":"2014","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.physbeh.2017.07.023","article-title":"Silibinin ameliorates anxiety\/depression-like behaviors in amyloid \u03b2-treated rats by upregulating BDNF\/TrkB pathway and attenuating autophagy in hippocampus","volume":"179","author":"Song","year":"2017","journal-title":"Physiol. Behav."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s10571-014-0084-3","article-title":"Rutin alleviates prion peptide-induced cell death through inhibiting apoptotic pathway activation in dopaminergic neuronal cells","volume":"34","author":"Na","year":"2014","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1002\/ptr.4946","article-title":"[6]-Shogaol attenuates neuronal apoptosis in hydrogen peroxide-treated astrocytes through the up-regulation of neurotrophic factors","volume":"27","author":"Kim","year":"2013","journal-title":"Phytother. Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.fct.2012.02.014","article-title":"Effects of [6]-shogaol on cholinergic signaling in HT22 cells following neuronal damage induced by hydrogen peroxide","volume":"50","author":"Shim","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1080\/14786419.2014.918977","article-title":"Effects of olive leaf polyphenols on male mouse brain NGF, BDNF and their receptors TrkA, TrkB and p75","volume":"28","author":"Carito","year":"2014","journal-title":"Nat. Prod. Res."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1096\/fj.06-7649com","article-title":"EGb 761 enhances adult hippocampal neurogenesis and phosphorylation of CREB in transgenic mouse model of Alzheimer\u2019s disease","volume":"21","author":"Tchantchou","year":"2007","journal-title":"FASEB J."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.jep.2014.03.038","article-title":"Effect of nigranoic acid on Ca2+ influx and its downstream signal mechanism in NGF-differentiated PC12 cells","volume":"153","author":"Yuan","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1007\/s11064-014-1371-6","article-title":"The neuroprotective effects of \u03b1-iso-cubebene on dopaminergic cell death: Involvement of CREB\/Nrf2 signaling","volume":"39","author":"Park","year":"2014","journal-title":"Neurochem. Res."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Yuan, H., Ni, X., Zheng, M., Han, X., Song, Y., and Yu, M. (2019). Effect of catalpol on behavior and neurodevelopment in an ADHD rat model. Biomed. Pharmacother., 118.","DOI":"10.1016\/j.biopha.2019.109033"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s12013-011-9258-5","article-title":"Treatment with Huperzine A improves cognition in vascular dementia patients","volume":"62","author":"Xu","year":"2012","journal-title":"Cell Biochem. Biophys."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"363985","DOI":"10.1155\/2014\/363985","article-title":"Huperzine A in the Treatment of Alzheimer\u2032 s Disease and Vascular Dementia: A Meta-Analysis","volume":"2014","author":"Xing","year":"2014","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s10072-014-1934-y","article-title":"The exposure to nicotine affects expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in neonate rats","volume":"36","author":"Xiaoyu","year":"2015","journal-title":"Neurol. Sci."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Kwon, S.-H., Ma, S.-X., Joo, H.-J., Lee, S.-Y., and Jang, C.-G. (2013). Inhibitory effects of Eucommia ulmoides Oliv. Bark on scopolamine-induced learning and memory deficits in mice. Biomol. Ther., 21.","DOI":"10.4062\/biomolther.2013.074"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.neulet.2010.10.042","article-title":"Neuroprotective effects of Eucommia ulmoides Oliv. Bark on amyloid beta25\u201335-induced learning and memory impairments in mice","volume":"487","author":"Kwon","year":"2011","journal-title":"Neurosci. Lett."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.neulet.2012.11.052","article-title":"Honokiol inhibits the inflammatory reaction during cerebral ischemia reperfusion by suppressing NF-\u03baB activation and cytokine production of glial cells","volume":"534","author":"Zhang","year":"2013","journal-title":"Neurosci. Lett."},{"key":"ref_159","first-page":"454","article-title":"Potential role of herbal plants and beta sitosterol as a bioactive constituent in circumventing Alzheimer\u2019s Disease","volume":"11","author":"Mishra","year":"2024","journal-title":"Plant Sci. Today"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1039\/C8FO00795K","article-title":"Major compounds of red ginseng oil attenuate A\u03b2 25\u201335-induced neuronal apoptosis and inflammation by modulating MAPK\/NF-\u03baB pathway","volume":"9","author":"Lee","year":"2018","journal-title":"Food Funct."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Lee, S., Youn, K., Jeong, W.-S., Ho, C.-T., and Jun, M. (2017). Protective effects of red ginseng oil against A\u03b225\u201335-induced neuronal apoptosis and inflammation in PC12 Cells. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18102218"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Rahman, M.A., Dash, R., Sohag, A.A.M., Alam, M., Rhim, H., Ha, H., Moon, I.S., Uddin, M.J., and Hannan, M.A. (2021). Prospects of marine sterols against pathobiology of Alzheimer\u2019s disease: Pharmacological insights and technological advances. Mar. Drugs, 19.","DOI":"10.3390\/md19030167"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.foodchem.2012.07.101","article-title":"C-dideoxyhexosyl flavones from the stems and leaves of Passiflora edulis Sims","volume":"136","author":"Xu","year":"2013","journal-title":"Food Chem."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1089\/jmf.2007.722","article-title":"The aqueous extracts of Passiflora alata and Passiflora edulis reduce anxiety-related behaviors without affecting memory process in rats","volume":"11","author":"Barbosa","year":"2008","journal-title":"J. Med. Food"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"728","DOI":"10.2174\/1871520615666150304120643","article-title":"Apigenin and breast cancers: From chemistry to medicine","volume":"15","author":"Habtemariam","year":"2015","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"ref_166","first-page":"43","article-title":"Use of tea extracts (Camelia sinensis) in jelly candies as polyphenols sources in human diet","volume":"16","author":"Regula","year":"2007","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1007\/s12035-013-8608-2","article-title":"(\u2212)-Epigallocatechin-3-gallate ameliorates learning and memory deficits by adjusting the balance of TrkA\/p75 NTR signaling in APP\/PS1 transgenic mice","volume":"49","author":"Liu","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/138161212798918986","article-title":"Protective effects of chronic green tea consumption on age-related neurodegeneration","volume":"18","author":"Assuncao","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.neuroscience.2009.07.014","article-title":"Long-term green tea catechin administration prevents spatial learning and memory impairment in senescence-accelerated mouse prone-8 mice by decreasing A\u03b21-42 oligomers and upregulating synaptic plasticity\u2013related proteins in the hippocampus","volume":"163","author":"Li","year":"2009","journal-title":"Neuroscience"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lfs.2014.08.016","article-title":"Curcumin as a wound healing agent","volume":"116","author":"Akbik","year":"2014","journal-title":"Life Sci."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1021\/jf203290r","article-title":"Curcuminoids promote neurite outgrowth in PC12 cells through MAPK\/ERK-and PKC-dependent pathways","volume":"60","author":"Liao","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1089\/jmf.2013.2965","article-title":"Effects of curcumin (Curcuma longa) on learning and spatial memory as well as cell proliferation and neuroblast differentiation in adult and aged mice by upregulating brain-derived neurotrophic factor and CREB signaling","volume":"17","author":"Nam","year":"2014","journal-title":"J. Med. Food"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.neuint.2013.05.011","article-title":"The protective effects of resveratrol on Schwann cells with toxicity induced by ethanol in vitro","volume":"63","author":"Yuan","year":"2013","journal-title":"Neurochem. Int."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbrc.2014.04.121","article-title":"6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia","volume":"449","author":"Moon","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ejphar.2010.08.002","article-title":"Ginkgolide B protects hippocampal neurons from apoptosis induced by beta-amyloid 25\u201335 partly via up-regulation of brain-derived neurotrophic factor","volume":"647","author":"Xiao","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejps.2009.10.002","article-title":"Blood brain barrier permeability and therapeutic time window of Ginkgolide B in ischemia\u2013reperfusion injury","volume":"39","author":"Fang","year":"2010","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1142\/S0192415X25500077","article-title":"The Pharmacology and Toxicology of Ginkgolic Acids: Secondary Metabolites from Ginkgo biloba","volume":"53","author":"Shao","year":"2025","journal-title":"Am. J. Chin. Med."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"7549","DOI":"10.18632\/aging.202619","article-title":"Preclinical systematic review of ginsenoside Rg1 for cognitive impairment in Alzheimer\u2019s disease","volume":"13","author":"Liang","year":"2021","journal-title":"Aging"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"117345","DOI":"10.1016\/j.jep.2023.117345","article-title":"Catalpol rescues LPS-induced cognitive impairment via inhibition of NF-\u039ab-regulated neuroinflammation and up-regulation of TrkB-mediated BDNF secretion in mice","volume":"319","author":"Hu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1007\/s10571-009-9421-3","article-title":"The neuroprotective effects of ginsenosides on calcineurin activity and tau phosphorylation in SY5Y cells","volume":"29","author":"Tu","year":"2009","journal-title":"Cell Mol. Neurobiol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.brainres.2006.09.058","article-title":"Catalpol increases hippocampal neuroplasticity and up-regulates PKC and BDNF in the aged rats","volume":"1123","author":"Liu","year":"2006","journal-title":"Brain Res."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.2147\/DDDT.S223322","article-title":"Catalpol enhances neurogenesis and inhibits apoptosis of new neurons via BDNF, but not the BDNF\/Trkb pathway","volume":"13","author":"Zhu","year":"2019","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"118448","DOI":"10.1016\/j.jep.2024.118448","article-title":"The role of TrkB signaling-mediated synaptic plasticity in the antidepressant properties of catalpol, the main active compound of Rehmannia glutinosa Libosch","volume":"333","author":"Wu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.tips.2006.10.004","article-title":"Neuroprotective effects of huperzine A: New therapeutic targets for neurodegenerative disease","volume":"27","author":"Zhang","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejphar.2005.06.026","article-title":"Huperzine A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve growth factor production","volume":"519","author":"Tang","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1745-7254.2005.00130.x","article-title":"Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells","volume":"26","author":"Tang","year":"2005","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4196\/kjpp.2012.16.2.79","article-title":"Phellodendron amurense and its major alkaloid compound, berberine ameliorates scopolamine-induced neuronal impairment and memory dysfunction in rats","volume":"16","author":"Lee","year":"2012","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1111\/j.2042-7158.2012.01529.x","article-title":"Berberine suppresses amyloid-beta-induced inflammatory response in microglia by inhibiting nuclear factor-kappaB and mitogen-activated protein kinase signalling pathways","volume":"64","author":"Jia","year":"2012","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.neurobiolaging.2009.04.015","article-title":"Chronic nicotine restores normal A\u03b2 levels and prevents short-term memory and E-LTP impairment in A\u03b2 rat model of Alzheimer\u2019s disease","volume":"32","author":"Srivareerat","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3233\/JAD-2002-4507","article-title":"Nicotine lowers the secretion of the Alzheimer\u2019s amyloid \u03b2-protein precursor that contains amyloid \u03b2-peptide in rat","volume":"4","author":"Utsuki","year":"2002","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Zhang, W., Pan, X., Fu, J., Cheng, W., Lin, H., Zhang, W., and Huang, Z. (2024). Phytochemicals derived from Nicotiana tabacum L. plant contribute to pharmaceutical development. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1372456"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1096\/fj.06-5841com","article-title":"Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse Alzheimer disease model","volume":"21","author":"Liu","year":"2007","journal-title":"FASEB J."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ejphar.2010.09.029","article-title":"Neurotrophic activity of obovatol on the cultured embryonic rat neuronal cells by increase of neurotrophin release through activation of ERK pathway","volume":"649","author":"Lee","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1002\/ptr.3178","article-title":"Neuroprotective effect of honokiol and magnolol, compounds from Magnolia officinalis, on beta-amyloid-induced toxicity in PC12 cells","volume":"24","author":"Hoi","year":"2010","journal-title":"Phytother. Res."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1007\/s11064-009-0024-7","article-title":"Neurite outgrowth effect of 4-O-methylhonokiol by induction of neurotrophic factors through ERK activation","volume":"34","author":"Lee","year":"2009","journal-title":"Neurochem. Res."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/ptr.3706","article-title":"Antidepressant-like effect of magnolol on BDNF up-regulation and serotonergic system activity in unpredictable chronic mild stress treated rats","volume":"26","author":"Li","year":"2012","journal-title":"Phytother. Res."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4062\/biomolther.2010.18.1.039","article-title":"Synergistic increase of BDNF release from rat primary cortical neuron by combination of several medicinal plant-derived compounds","volume":"18","author":"Jeon","year":"2010","journal-title":"Biomol. Ther."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.phymed.2008.12.018","article-title":"Synergy research: Approaching a new generation of phytopharmaceuticals","volume":"16","author":"Wagner","year":"2009","journal-title":"Phytomedicine"},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Hannan, M.A., Dash, R., Sohag, A.A.M., Haque, M.N., and Moon, I.S. (2020). Neuroprotection against oxidative stress: Phytochemicals targeting TrkB signaling and the Nrf2-ARE antioxidant system. Front. Mol. Neurosci., 13.","DOI":"10.3389\/fnmol.2020.00116"},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Liu, X., Wang, D., Zhao, R., Dong, X., Hu, Y., and Liu, P. (2016). Synergistic neuroprotective effects of two herbal ingredients via CREB-dependent pathway. Front. Pharmacol., 7.","DOI":"10.3389\/fphar.2016.00337"},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Sun, Y., Chen, Q., Cui, W., Chen, H., Zhao, J., and Rong, J. (2024). Six-compound combo remedy ameliorates corticosterone-induced depressive behaviors in mice via targeting 5-hydroxytryptamine receptor 1A signaling. J. Leukoc. Biol., 117.","DOI":"10.1093\/jleuko\/qiae167"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.1111\/bph.15847","article-title":"Synergistic effects of two naturally occurring iridoids in eliciting a rapid antidepressant action by up-regulating hippocampal PACAP signalling","volume":"179","author":"Zhang","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/jnr.10443","article-title":"Animal model of dementia induced by entorhinal synaptic damage and partial restoration of cognitive deficits by BDNF and carnitine","volume":"70","author":"Ando","year":"2002","journal-title":"J. Neurosci. Res."},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Pilakka-Kanthikeel, S., Atluri, V.S.R., Sagar, V., Saxena, S.K., and Nair, M. (2013). Targeted brain derived neurotropic factors (BDNF) delivery across the blood-brain barrier for neuro-protection using magnetic nano carriers: An in-vitro study. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0062241"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1073\/pnas.0913572107","article-title":"A selective TrkB agonist with potent neurotrophic activities by 7, 8-dihydroxyflavone","volume":"107","author":"Jang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/ptr.8379","article-title":"Resveratrol Bioavailability After Oral Administration: A Meta-Analysis of Clinical Trial Data","volume":"39","author":"Szymkowiak","year":"2025","journal-title":"Phytother. Res."},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Andrade, S., Ramalho, M.J., Pereira, M.d.C., and Loureiro, J.A. (2018). Resveratrol brain delivery for neurological disorders prevention and treatment. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.01261"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.2174\/1381612822666161227154447","article-title":"Nano-medicine improving the bioavailability of small molecules for the prevention of neurodegenerative diseases","volume":"23","author":"Censi","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"594","DOI":"10.2174\/1381612826666200115101544","article-title":"Nose-to-brain delivery of natural compounds for the treatment of central nervous system disorders","volume":"26","author":"Bicker","year":"2020","journal-title":"Curr. Pharm. Des."},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Di Paolo, M., Papi, L., Gori, F., and Turillazzi, E. (2019). Natural Products in Neurodegenerative Diseases: A Great Promise but an Ethical Challenge. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20205170"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"155272","DOI":"10.1016\/j.phymed.2023.155272","article-title":"Neuroprotective potentials of Lead phytochemicals against Alzheimer\u2019s disease with focus on oxidative stress-mediated signaling pathways: Pharmacokinetic challenges, target specificity, clinical trials and future perspectives","volume":"124","author":"Ayaz","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1021\/acs.jafc.3c07536","article-title":"Therapeutic Potential of Natural Compounds from Herbs and Nutraceuticals in Alleviating Neurological Disorders: Targeting the Wnt Signaling Pathway","volume":"72","author":"Li","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Venkatesan, R., Ji, E., and Kim, S.Y. (2015). Phytochemicals that regulate neurodegenerative disease by targeting neurotrophins: A comprehensive review. BioMed Res. Int., 2015.","DOI":"10.1155\/2015\/814068"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cell.2021.12.003","article-title":"BDNF signaling in context: From synaptic regulation to psychiatric disorders","volume":"185","author":"Wang","year":"2022","journal-title":"Cell"},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Rahman, M.H., Bajgai, J., Fadriquela, A., Sharma, S., Trinh, T.T., Akter, R., Jeong, Y.J., Goh, S.H., Kim, C.-S., and Lee, K.-J. (2021). Therapeutic potential of natural products in treating neurodegenerative disorders and their future prospects and challenges. Molecules, 26.","DOI":"10.3390\/molecules26175327"}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/15\/3\/252\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:43:32Z","timestamp":1760028212000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/15\/3\/252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,27]]},"references-count":215,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["brainsci15030252"],"URL":"https:\/\/doi.org\/10.3390\/brainsci15030252","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,27]]}}}