{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T20:13:55Z","timestamp":1781036035246,"version":"3.54.1"},"reference-count":31,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Government of the Principality of Asturias","award":["PA-21-PF-BP20-122"],"award-info":[{"award-number":["PA-21-PF-BP20-122"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background\/Objectives: Tentonin-3\/TMEM150C is a pore-forming protein of a mechanically activated channel recently identified that typically displays rapid activation followed by slow inactivation. It has been detected in murine dorsal root ganglia, nodose ganglion baroreceptors, and muscle spindles. Nevertheless, primary sensory neurons expressing tentonin-3\/TMEM150C fall into the categories of nociceptors, mechanoreceptors, and proprioceptors. Methods: We used immunohistochemistry and image analysis (examining the size of the neuronal bodies in the dorsal root ganglia) to investigate the distribution of tentonin-3\/TMEM150C in human cervical dorsal root ganglia, sensory nerve formations in the glabrous skin, especially cutaneous end-organ complexes or sensory corpuscles, and muscle spindles. Results: In dorsal root ganglia, 41% of neurons were tentonin-3\/TMEM150C-positive, with a distribution of small (12.0%), intermediate (18.1%), and large (10.9%). In the glabrous skin, tentonin-3\/TMEM150C was observed in the axon of Meissner, Pacinian, and Ruffini corpuscles as well as in the axon of the Merkel cell\u2013axon complexes. Furthermore, tentonin-3\/TMEM150C-positive axons were observed in muscle spindles. No free nerve endings displaying immunoreactivity were found. Conclusions: This is the first report on the distribution of tentonin-3\/TMEM150C immunoreactivity in the human peripheral somatosensory system, and although it is a brief preliminary study, it opens new perspectives for the study of this new mechano-gated ion channel.<\/jats:p>","DOI":"10.3390\/brainsci15040337","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T07:46:50Z","timestamp":1742802410000},"page":"337","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Immunohistochemical Detection of Tentonin-3\/TMEM150C in Human Dorsal Root Ganglion, Cutaneous End-Organ Complexes, and Muscle Spindles"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1689-1632","authenticated-orcid":false,"given":"Iv\u00e1n","family":"Suazo","sequence":"first","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Providencia 7500912, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1442-1095","authenticated-orcid":false,"given":"Yolanda","family":"Garc\u00eda-Mesa","sequence":"additional","affiliation":[{"name":"Grupo SINPOS, Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Universidad de Oviedo, 33006 Oviedo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, ISPA, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4496-6582","authenticated-orcid":false,"given":"Jos\u00e9","family":"Mart\u00edn-Cruces","sequence":"additional","affiliation":[{"name":"Grupo SINPOS, Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Universidad de Oviedo, 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Cuendias","sequence":"additional","affiliation":[{"name":"Grupo SINPOS, Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Universidad de Oviedo, 33006 Oviedo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, ISPA, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Cobo","sequence":"additional","affiliation":[{"name":"Departamento de Cirug\u00eda y Especialidades M\u00e9dico-Quir\u00fargicas, Universidad de Oviedo, 33006 Oviedo, Spain"},{"name":"Instituto Asturiano de Odontolog\u00eda (IAO), 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Garc\u00eda-Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Grupo SINPOS, Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Universidad de Oviedo, 33006 Oviedo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, ISPA, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1276-0018","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"Vega","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Providencia 7500912, Chile"},{"name":"Grupo SINPOS, Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Universidad de Oviedo, 33006 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1126\/science.1254229","article-title":"The gentle touch receptors of mammalian skin","volume":"346","author":"Zimmerman","year":"2014","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Cobo, R., Garc\u00eda-Piqueras, J., Cobo, J., and Vega, J.A. 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