{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:10:26Z","timestamp":1760058626015,"version":"build-2065373602"},"reference-count":71,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background and Objectives: Febrile seizures (FS) are neuronal disturbances frequently associated with abnormal electroencephalographic activity (EEG) as spike-wave discharges (SWDs). Fish oil (FO) has high amounts of omega-3 fatty acids (\u03b8-3), and its effects on FS alterations are poorly understood. The aim of this work was to evaluate the effect of long-term FO supplementation on the EEG of the amygdala of adult male rats with early-life FS. Materials and Methods: Progenitor female Wistar rats, from puberty to gestation and delivery, were fed daily with a commercial diet supplemented with either fish oil (FO), palm oil (PO), or deionized water (CTRL). After parturition, male pups were exposed for 30 min to hyperthermia (HP) and then returned to their dams. After weaning, pups were fed a commercial diet and the respective treatments up to 155 days of age when electrodes were implanted in the amygdala. Results: During early life HP, the PO and CTRL groups reached maximal core temperature (CT) in comparison with the FO group. Furthermore, the FO group only has fewer myoclonus and long latency to adopt an uncontrolled posture. At an adult age, the FO group with early-life FS scored shorter periods of SWDs in amygdala EEG but without seizures and presented minor values of absolute power than the PO and CTRL groups. Conclusions: In adult rats, the long-term supplementation of FO minimizes the deleterious behavioral effects caused by early-life FS and decreases the occurrence and amplitude of SWDs in the EEG of the amygdala.<\/jats:p>","DOI":"10.3390\/brainsci15040395","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T09:06:51Z","timestamp":1744621611000},"page":"395","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-Term Fish Oil Supplementation Attenuates Spike Wave Discharges in the Amygdala of Adult Rats with Early-Life Febrile Seizures"],"prefix":"10.3390","volume":"15","author":[{"given":"Leopoldo Eduardo","family":"Flores-Mancilla","sequence":"first","affiliation":[{"name":"Unidad Acad\u00e9mica de Medicina Humana y Ciencias de la Salud, Universidad Aut\u00f3noma de Zacatecas, Ejido la Escondida, Zacatecas 98160, CP, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisela","family":"Hern\u00e1ndez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias, Centro Universitario de Ciencias Biol\u00f3gicas y Agropecuarias, Universidad de Guadalajara, Francisco de Quevedo No. 180, Col. Arcos Vallarta, Guadalajara 44130, CP, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel \u00c1ngel","family":"Guevara-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda de la Reproducci\u00f3n, Divisi\u00f3n Ciencias Biol\u00f3gicas y de la Salud, Universidad Aut\u00f3noma Metropolitana, av. San Rafael Atlixco No. 186, Col. Vicentina, Alcald\u00eda Iztapalapa, Ciudad de M\u00e9xico 09340, CP, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7505-0809","authenticated-orcid":false,"given":"Herlinda","family":"Bonilla-Jaime","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda de la Reproducci\u00f3n, Divisi\u00f3n Ciencias Biol\u00f3gicas y de la Salud, Universidad Aut\u00f3noma Metropolitana, av. San Rafael Atlixco No. 186, Col. Vicentina, Alcald\u00eda Iztapalapa, Ciudad de M\u00e9xico 09340, CP, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4377-3754","authenticated-orcid":false,"given":"Noem\u00ed","family":"Gayt\u00e1n-Pacheco","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma de Zacatecas, Ejido la Escondida, Zacatecas 98160, CP, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2979-6159","authenticated-orcid":false,"given":"Claudia Araceli","family":"Reyes-Estrada","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma de Zacatecas, Ejido la Escondida, Zacatecas 98160, CP, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3769-5649","authenticated-orcid":false,"given":"Ferm\u00edn Paul","family":"Pacheco-Mois\u00e9s","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Centro Universitario de Ciencias Exactas e Ingenier\u00edas, Universidad de Guadalajara, Guadalajara 44430, CP, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s12098-024-05301-z","article-title":"Complex Febrile Seizures: Usual and the Unusual","volume":"92","author":"Whitney","year":"2025","journal-title":"Indian J. 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