{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T22:02:18Z","timestamp":1775685738305,"version":"3.50.1"},"reference-count":40,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T00:00:00Z","timestamp":1745712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background\/Objectives: Mild behavioral impairment (MBI) is an early marker of Alzheimer\u2019s disease (AD) and other neurodegenerative diseases, often preceding cognitive decline. The MBI Checklist (MBI-C) is a 34-item tool designed to detect MBI. This study aimed to assess the psychometric properties of the Greek version of the MBI-C and its ability to differentiate patients with mild cognitive impairment due to AD (MCI-AD) from cognitively unimpaired older adults (healthy participants, HPs). Methods: A total of 181 participants (104 MCI-AD, 77 HPs) were recruited from the Third Age Day Care Center IASIS (2019\u20132023), accompanied by a close informant. Participants underwent neuropsychological assessment [Mini-Mental State Examination (MMSE), Addenbrooke\u2019s Cognitive Examination-Revised (ACE-R)], and informants completed the MBI-C. Internal consistency was evaluated using Cronbach\u2019s \u03b1 and known-group validity was assessed via comparing MBI-C between the MCI-AD and HPs groups. Diagnostic accuracy was determined via receiver operating characteristic (ROC) analysis. Results: The Greek MBI-C showed excellent internal consistency (Cronbach\u2019s \u03b1 = 0.899). Among its domains, impulse dyscontrol demonstrated the highest reliability (\u03b1 = 0.901), whereas decreased motivation (\u03b1 = 0.564) and abnormal perception\/thought content (\u03b1 = 0.617) exhibited lower reliability. MBI-C total and domain scores were significantly higher in patients with MCI-AD than HPs (p &lt; 0.001). The area under the curve (AUC) was 0.871 (optimal cutoff = 9.5), indicating excellent diagnostic performance. Conclusions: Overall, the Greek MBI-C has strong psychometric properties for MCI-AD. Sociocultural factors might influence symptom identification and reporting, particularly in the domains of decreased motivation and abnormal perception\/thought content. Future research should investigate its predictive value for dementia conversion and its applicability to other populations, including individuals with subjective cognitive decline and non-AD causes of MCI.<\/jats:p>","DOI":"10.3390\/brainsci15050462","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T09:00:39Z","timestamp":1745917239000},"page":"462","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Greek Version of the Mild Behavioral Impairment Checklist (MBI-C): Psychometric Properties in Mild Cognitive Impairment Due to Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1426-3384","authenticated-orcid":false,"given":"Efthalia","family":"Angelopoulou","sequence":"first","affiliation":[{"name":"1st Department of Neurology, Aiginition University Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5448-3675","authenticated-orcid":false,"given":"Evangelia","family":"Stanitsa","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Aiginition University Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Hatzopoulou","sequence":"additional","affiliation":[{"name":"Third Age Day Care Center IASIS, 16562 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akylina","family":"Despoti","sequence":"additional","affiliation":[{"name":"Third Age Day Care Center IASIS, 16562 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niki","family":"Tsinia","sequence":"additional","affiliation":[{"name":"Third Age Day Care Center IASIS, 16562 Athens, Greece"},{"name":"1st Department of Psychiatry, Aiginition University Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasiliki","family":"Kamtsadeli","sequence":"additional","affiliation":[{"name":"Third Age Day Care Center IASIS, 16562 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Papadogiani","sequence":"additional","affiliation":[{"name":"Third Age Day Care Center IASIS, 16562 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7948-2018","authenticated-orcid":false,"given":"Vasilis","family":"Kyriakidis","sequence":"additional","affiliation":[{"name":"Third Age Day Care Center IASIS, 16562 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8863-3635","authenticated-orcid":false,"given":"Sokratis","family":"Papageorgiou","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Aiginition University Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7835-2706","authenticated-orcid":false,"given":"John D.","family":"Papatriantafyllou","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Aiginition University Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece"},{"name":"Third Age Day Care Center IASIS, 16562 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/gps.1858","article-title":"Cache County Investigators Point and 5-Year Period Prevalence of Neuropsychiatric Symptoms in Dementia: The Cache County Study","volume":"23","author":"Steinberg","year":"2008","journal-title":"Int. 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