{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T01:54:30Z","timestamp":1781920470427,"version":"3.54.5"},"reference-count":76,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background: Idiopathic intracranial hypertension (IIH) is, by definition, of unknown cause. Davson\u2019s equation indicates that the increased intracranial pressure (ICP) found in IIH could be due to an increase in the CSF formation rate (CSFfr), the CSF outflow resistance (Rout) or the venous sinus pressure. Studies simultaneously measuring the ICP and sagittal sinus pressures in IIH suggest that there is either a reduction in the Rout and\/or the CSFfr. The latter suggests that the increased venous pressure can be the only variable causing this disease process. A study maintaining the ICP at zero showed a significantly elevated CSFfr in this disease. The purpose of the current study is to define the most feasible explanation for these findings and to suggest a viable pathophysiology for IIH. Methods: A lumped parameter vascular model, originally developed to study normal pressure hydrocephalus, was extended to investigate IIH. The model used the simultaneously obtained ICP and sagittal sinus pressure measurements from five experiments published in the literature to estimate the CSFfr and the capillary transmural pressure (TMP). The assumptions made during this study were those of a normal mean arterial pressure, a normal total Rout and a normal blood flow rate. Results: When the CSF formation rates were plotted against the estimated capillary transmural pressures, a straight line was returned, suggesting that the CSFfr and capillary TMP are related. Conclusions: The novel findings of this study suggest that the CSFfr in IIH varies with the capillary TMP. A reduced capillary TMP in IIH can moderate the ICP if there is net CSF absorption across the capillaries. This would require the blood\u2013brain barrier (BBB) to be disrupted. The model suggests that drugs which stabilise the BBB may trigger IIH by blocking CSF absorption across the capillaries, increasing the apparent CSF formation rate back toward normal and increasing the ICP. Anaemia will promote IIH by increasing the cerebral blood flow, the capillary TMP and the CSFfr.<\/jats:p>","DOI":"10.3390\/brainsci15050527","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T04:48:18Z","timestamp":1747716498000},"page":"527","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Lumped Parameter Modelling Study of Idiopathic Intracranial Hypertension Suggests the CSF Formation Rate Varies with the Capillary Transmural Pressure"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3095-9047","authenticated-orcid":false,"given":"Grant A.","family":"Bateman","sequence":"first","affiliation":[{"name":"Department of Medical Imaging, John Hunter Hospital, Newcastle, NSW 2310, Australia"},{"name":"School of Medicine and Public Health, College of Health, Medicine and Wellbeing, Newcastle University, Callaghan Campus, Newcastle, NSW 2308, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6090-5344","authenticated-orcid":false,"given":"Alexander R.","family":"Bateman","sequence":"additional","affiliation":[{"name":"School of Engineering, College of Engineering, Science and Environment, Newcastle University, Callaghan Campus, Newcastle, NSW 2308, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1001\/archneur.1991.00530190088020","article-title":"The pseudotumor syndrome. Disorders of cerebrospinal fluid circulation causing intracranial hypertension without ventriculomegaly","volume":"48","author":"Johnston","year":"1991","journal-title":"Arch. Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1212\/WNL.0b013e3182a55f17","article-title":"Revised diagnostic criteria for the pseudotumor cerebri syndrome in adults and children","volume":"81","author":"Friedman","year":"2013","journal-title":"Neurology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S1474-4422(15)00298-7","article-title":"Understanding idiopathic intracranial hypertension: Mechanisms, management, and future directions","volume":"15","author":"Markey","year":"2016","journal-title":"Lancet Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12987-020-00221-4","article-title":"The incidence of obesity, venous sinus stenosis and cerebral hyperaemia in children referred for MRI to rule out idiopathic intracranial hypertension at a tertiary referral hospital: A 10 year review","volume":"17","author":"Bateman","year":"2020","journal-title":"Fluids Barriers CNS"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.3171\/2016.8.JNS16879","article-title":"Venous sinus stenting for reduction of intracranial pressure in IIH: A prospective pilot study","volume":"127","author":"Liu","year":"2017","journal-title":"J. Neurosurg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s00701-019-04095-w","article-title":"Coupling of CSF and sagittal sinus pressure in adult patients with pseudotumour cerebri","volume":"162","author":"Lalou","year":"2020","journal-title":"Acta Neurochir."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s10194-024-01865-5","article-title":"Concordance between venous sinus pressure and intracranial pressure in patients investigated for idiopathic intracranial hypertension","volume":"25","author":"Cagnazzo","year":"2024","journal-title":"J. Headache Pain"},{"key":"ref_8","first-page":"623","article-title":"Cerebral venous pressure, sinus pressure and intracranial pressure","volume":"20","author":"Benabid","year":"1974","journal-title":"Neurochirurgie"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1743-8454-7-9","article-title":"The function and structure of the cerebrospinal fluid outflow system","volume":"7","author":"Pollay","year":"2010","journal-title":"Cerebrospinal Fluid. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1007\/s00701-023-05650-2","article-title":"Cerebrospinal fluid production rate in various pathological conditions: A preliminary study","volume":"165","author":"Tariq","year":"2023","journal-title":"Acta Neurochir."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Bateman, G.A., and Bateman, A.R. (2024). A lumped parameter modelling study of cerebral autoregulation in normal pressure hydrocephalus suggests the brain chooses to be ischemic. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-75214-6"},{"key":"ref_12","unstructured":"Davson, H., Welch, K., and Segal, M.B. (1987). Physiology and Pathophysiology of the Cerebrospinal Fluid, Churchill Livingstone."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Zislin, V., and Rosenfeld, M. (2018). Impedance Pumping and Resonance in a Multi-Vessel System. Bioengineering, 5.","DOI":"10.3390\/bioengineering5030063"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/BF02364625","article-title":"A mathematical study of human intracranial hydrodynamics. Part 1\u2014The cerebrospinal fluid pulse pressure","volume":"16","author":"Ursino","year":"1988","journal-title":"Ann. Biomed. Eng."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1136\/jnnp.34.6.687","article-title":"Effect of intracranial hypotension on cerebral blood flow","volume":"34","author":"Salmon","year":"1971","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/BF02345321","article-title":"Mathematical study of the role of non-linear venous compliance in the cranial volume-pressure test","volume":"41","author":"Cirovic","year":"2003","journal-title":"Med. Biol. Eng. Comput."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Fleischman, D., Berdahl, J.P., Zaydlarova, J., Stinnett, S., Fautsch, M.P., and Allingham, R.R. (2012). Cerebrospinal fluid pressure decreases with older age. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0052664"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/2045-8118-11-11","article-title":"Cerebrospinal fluid absorption block at the vertex in chronic hydrocephalus: Obstructed arachnoid granulations or elevated venous pressure?","volume":"11","author":"Bateman","year":"2014","journal-title":"Fluids Barriers CNS"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1136\/jnnp.37.4.392","article-title":"Raised intracranial pressure and cerebral blood flow. 3. Venous outflow tract pressures and vascular resistances in experimental intracranial hypertension","volume":"37","author":"Johnston","year":"1974","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neuroimage.2018.02.027","article-title":"MRI techniques to measure arterial and venous cerebral blood volume","volume":"187","author":"Hua","year":"2019","journal-title":"Neuroimage"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Men\u00e9ndez Gonz\u00e1lez, M. (2023). CNS Compartments: The Anatomy and Physiology of the Cerebrospinal Fluid. Liquorpheresis: Cerebrospinal Fluid Filtration to Treat CNS Conditions, Springer Nature.","DOI":"10.1007\/978-3-031-43482-2"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12987-024-00560-6","article-title":"CSF formation rate-a potential glymphatic flow parameter in hydrocephalus?","volume":"21","author":"Qvarlander","year":"2024","journal-title":"Fluids Barriers CNS"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1152\/physrev.00022.2020","article-title":"Regulation of cerebral blood flow in humans: Physiology and clinical implications of autoregulation","volume":"101","author":"Claassen","year":"2021","journal-title":"Physiol. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/jcbfm.1993.129","article-title":"Changes in brain capillary diameter during hypocapnia and hypercapnia","volume":"13","author":"Duelli","year":"1993","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"ref_25","first-page":"76","article-title":"Starling resistors, autoregulation of cerebral perfusion and the pathogenesis of idiopathic intracranial hypertension","volume":"59","author":"Roberto","year":"2017","journal-title":"Panminerva Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12987-023-00465-w","article-title":"A scoping review of the discrepancies in the measurement of cerebral blood flow in idiopathic intracranial hypertension: Oligemia, euvolemia or hyperemia?","volume":"20","author":"Bateman","year":"2023","journal-title":"Fluids Barriers CNS"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/jmri.25857","article-title":"Quantifying response to intracranial pressure normalization in idiopathic intracranial hypertension via dynamic neuroimaging","volume":"47","author":"Lublinsky","year":"2018","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.3174\/ajnr.A2575","article-title":"Transverse sinus stenting for idiopathic intracranial hypertension: A review of 52 patients and of model predictions","volume":"32","author":"Ahmed","year":"2011","journal-title":"Am. J. Neuroradiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1093\/brain\/83.3.454","article-title":"The cerebrospinal fluid valves","volume":"83","author":"Welch","year":"1960","journal-title":"Brain"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1111\/head.14776","article-title":"Arachnoid granulations in idiopathic intracranial hypertension: Do they have an influence?","volume":"64","author":"Schievelkamp","year":"2024","journal-title":"Headache"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1001\/archneur.1978.00500320047010","article-title":"Modulation of CSF production by alterations in cerebral perfusion pressure","volume":"35","author":"Weiss","year":"1978","journal-title":"Arch. Neurol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1152\/physrev.1971.51.2.273","article-title":"Physiology of the choroid plexus","volume":"51","author":"Cserr","year":"1971","journal-title":"Physiol. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.neuroscience.2004.07.033","article-title":"Water homeostasis in the brain: Basic concepts","volume":"129","author":"Kimelberg","year":"2004","journal-title":"Neuroscience"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s10877-006-9047-7","article-title":"Comparison of intracranial pressure measured simultaneously within the brain parenchyma and cerebral ventricles","volume":"20","author":"Brean","year":"2006","journal-title":"J. Clin. Monit. Comput."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1227\/01.NEU.0000156609.95596.24","article-title":"Clinical experience with the intraparenchymal intracranial pressure monitoring Codman MicroSensor system","volume":"56","author":"Koskinen","year":"2005","journal-title":"Neurosurgery"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Xiang, J., Hua, Y., Xi, G., and Keep, R.F. (2023). Mechanisms of cerebrospinal fluid and brain interstitial fluid production. Neurobiol. Dis., 183.","DOI":"10.1016\/j.nbd.2023.106159"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Roterman, I., Stapor, K., Dulak, D., Szoniec, G., and Konieczny, L. (2025). Aquaporins as Membrane Proteins: The Current Status. Front Biosci., 17.","DOI":"10.31083\/FBS27967"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1528-1167.2012.03472.x","article-title":"Are you in or out? Leukocyte, ion, and neurotransmitter permeability across the epileptic blood-brain barrier","volume":"53","author":"Janigro","year":"2012","journal-title":"Epilepsia"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Eide, P.K., and Hansson, H.A. (2022). A New Perspective on the Pathophysiology of Idiopathic Intracranial Hypertension: Role of the Glia-Neuro-Vascular Interface. Front. Mol. Neurosci., 15.","DOI":"10.3389\/fnmol.2022.900057"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s11357-019-00110-1","article-title":"Cerebral venous congestion promotes blood-brain barrier disruption and neuroinflammation, impairing cognitive function in mice","volume":"41","author":"Fulop","year":"2019","journal-title":"Geroscience"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Bateman, G.A., and Bateman, A.R. (2025). Brain Ischemia in Alzheimer\u2019s Disease May Partly Counteract the Disruption of the Blood\u2013Brain Barrier. Brain Sci., 15.","DOI":"10.3390\/brainsci15030269"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Bateman, G.A., and Bateman, A.R. (2024). A Lumped Parameter Model Suggests That Infusion Studies Overestimate the Cerebrospinal Fluid Outflow Resistance in Normal Pressure Hydrocephalus. Brain Sci., 14.","DOI":"10.20944\/preprints202411.1975.v1"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1161\/01.RES.49.3.557","article-title":"Capillary fluid filtration. Starling forces and lymph flow","volume":"49","author":"Taylor","year":"1981","journal-title":"Circ. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3171\/jns.1987.67.4.0535","article-title":"Relationships between intracranial pressure, ventricular size, and resistance to CSF outflow","volume":"67","author":"Borgesen","year":"1987","journal-title":"J. Neurosurg."},{"key":"ref_45","unstructured":"Parker, J.C., Perry, M.A., and Taylor, A.E. (1984). Permeability of the Microvascular Barrier, Raven Press."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1365-2990.1996.tb01111.x","article-title":"Drainage of CSF through lymphatic pathways and arachnoid villi in sheep: Measurement of 125I-albumin clearance","volume":"22","author":"Boulton","year":"1996","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_47","first-page":"R88","article-title":"Determination of volumetric cerebrospinal fluid absorption into extracranial lymphatics in sheep","volume":"274","author":"Boulton","year":"1998","journal-title":"Am. J. Physiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2176\/jns-nmc.2022-0331","article-title":"Cerebrospinal Fluid Production and Absorption and Ventricular Enlargement Mechanisms in Hydrocephalus","volume":"63","author":"Yamada","year":"2023","journal-title":"Neurol. Med. Chir."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1586\/14737175.2015.1066675","article-title":"Acetazolamide for the treatment of idiopathic intracranial hypertension","volume":"15","author":"Supuran","year":"2015","journal-title":"Expert. Rev. Neurother."},{"key":"ref_50","first-page":"CD003434","article-title":"Interventions for idiopathic intracranial hypertension","volume":"2015","author":"Piper","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.tips.2004.10.001","article-title":"Neuroprotection by tetracyclines","volume":"25","author":"Domercq","year":"2004","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Robinson, B.D., Isbell, C.L., Melge, A.R., Lomas, A.M., Shaji, C.A., Mohan, C.G., Huang, J.H., and Tharakan, B. (2022). Doxycycline prevents blood-brain barrier dysfunction and microvascular hyperpermeability after traumatic brain injury. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-09394-4"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.phrs.2015.05.014","article-title":"Retinoic acid ameliorates blood-brain barrier disruption following ischemic stroke in rats","volume":"99","author":"Kong","year":"2015","journal-title":"Pharmacol. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/00127893-200107010-00002","article-title":"Idiopathic Intracranial Hypertension (Pseudotumor Cerebri): A Reappraisal","volume":"7","author":"Digre","year":"2001","journal-title":"Neurologist"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1212\/WNL.62.12.2297","article-title":"Doxycycline and intracranial hypertension","volume":"62","author":"Friedman","year":"2004","journal-title":"Neurology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11940-012-0207-4","article-title":"Idiopathic intracranial hypertension (pseudotumor cerebri): Recognition, treatment, and ongoing management","volume":"15","author":"Thurtell","year":"2013","journal-title":"Curr. Treat. Options Neurol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00441-013-1762-z","article-title":"Glucocorticoids and endothelial cell barrier function","volume":"355","author":"Salvador","year":"2014","journal-title":"Cell Tissue Res."},{"key":"ref_58","first-page":"605","article-title":"Corticosteroid action on choroid plexus: Reduction in Na+\u2014K+-ATPase activity, choline transport capacity, and rate of CSF formation","volume":"77","author":"Hedner","year":"1989","journal-title":"Exp. Brain Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"690","DOI":"10.3171\/jns.1975.42.6.0690","article-title":"Experimental effects of steroids and steroid withdrawal on cerebrospinal fluid absorption","volume":"42","author":"Johnston","year":"1975","journal-title":"J. Neurosurg."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Peng, S.L., and Chen, C.M. (2020). The influence of obesity on cerebral blood flow in young adults using arterial spin labeling MRI. NMR Biomed., 33.","DOI":"10.1002\/nbm.4375"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e78","DOI":"10.1097\/WNO.0000000000001408","article-title":"Anemia and Idiopathic Intracranial Hypertension: A Systematic Review and Meta-analysis","volume":"42","author":"Yu","year":"2022","journal-title":"J. Neuroophthalmol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1007\/s00701-021-04940-x","article-title":"Cerebrospinal fluid dynamics in idiopathic intracranial hypertension: A literature review and validation of contemporary findings","volume":"163","author":"Kaipainen","year":"2021","journal-title":"Acta Neurochir."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1212\/WNL.35.7.1030","article-title":"Regional cerebral oxygen utilization, blood flow, and blood volume in benign intracranial hypertension studied by positron emission tomography","volume":"35","author":"Brooks","year":"1985","journal-title":"Neurology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1600-0404.2006.00702.x","article-title":"Perfusion and diffusion magnetic resonance imaging in idiopathic intracranial hypertension","volume":"114","author":"Bicakci","year":"2006","journal-title":"Acta Neurol. Scand."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/ana.410040203","article-title":"Cerebral hemodynamics and metabolism in pseudotumor cerebri","volume":"4","author":"Raichle","year":"1978","journal-title":"Ann. Neurol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/ana.410040407","article-title":"Measurement of regional cerebral blood volume by emission tomography","volume":"4","author":"Grubb","year":"1978","journal-title":"Ann. Neurol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Liu, H., Lan, L., Abrigo, J., Ip, H.L., Soo, Y., Zheng, D., Wong, K.S., Wang, D., Shi, L., and Leung, T.W. (2021). Comparison of Newtonian and Non-newtonian Fluid Models in Blood Flow Simulation in Patients with Intracranial Arterial Stenosis. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.718540"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1016\/j.ultrasmedbio.2014.05.022","article-title":"Middle cerebral artery blood flows by combining TCD velocities and MRA diameters: In vitro and in vivo validations","volume":"40","author":"Yonan","year":"2014","journal-title":"Ultrasound Med. Biol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Iyer, A.M., Midtlien, J.P., Kittel, C., Klever, L.A., Wiater, A., Chang, E., Margraf, C., and Fargen, K.M. (2025). The correlation between intracranial pressure and venous sinus pressures changes after venous sinus stenting. J. NeuroInterventional Surg.","DOI":"10.1136\/jnis-2024-022250"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1212\/01.wnl.0000299893.43918.a8","article-title":"Long-term follow-up of idiopathic intracranial hypertension: The Iowa experience","volume":"70","author":"Shah","year":"2008","journal-title":"Neurology"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jns.2004.05.009","article-title":"Clinical characterization of idiopathic intracranial hypertension at the Detroit Medical Center","volume":"223","author":"Galvin","year":"2004","journal-title":"J. Neurol. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1172\/JCI101996","article-title":"The Effects of Increased Intracranial Pressure on Cerebral Circulatory Functions in Man","volume":"27","author":"Kety","year":"1948","journal-title":"J. Clin. Invest."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12987-025-00640-1","article-title":"Is the ischemia found in normal pressure hydrocephalus secondary to venous compression or arterial constriction? A comment on Ohmura et al","volume":"22","author":"Bateman","year":"2025","journal-title":"Fluids Barriers CNS"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3171\/jns.1975.43.4.0385","article-title":"Effects of increased intracranial pressure on cerebral blood volume, blood flow, and oxygen utilization in monkeys","volume":"43","author":"Grubb","year":"1975","journal-title":"J. Neurosurg."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.rpor.2018.09.007","article-title":"Estimation of microvascular capillary physical parameters using MRI assuming a pseudo liquid drop as model of fluid exchange on the cellular level","volume":"24","author":"Ashoor","year":"2019","journal-title":"Rep. Pract. Oncol. Radiother."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Saiga, R., Uesugi, M., Takeuchi, A., Uesugi, K., Suzuki, Y., Takekoshi, S., Inomoto, C., Nakamura, N., Torii, Y., and Kushima, I. (2021). Brain capillary structures of schizophrenia cases and controls show a correlation with their neuron structures. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-91233-z"}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/15\/5\/527\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:35:28Z","timestamp":1760031328000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/15\/5\/527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,20]]},"references-count":76,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["brainsci15050527"],"URL":"https:\/\/doi.org\/10.3390\/brainsci15050527","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,20]]}}}