{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T16:02:11Z","timestamp":1791734531665,"version":"4.3.4"},"reference-count":143,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T00:00:00Z","timestamp":1749859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Agence Nationale de la Recherche","award":["ANR-21-CE37-0022 HippoXia"],"award-info":[{"award-number":["ANR-21-CE37-0022 HippoXia"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>The hippocampus is one of the brain\u2019s most vulnerable structures to hypoxia, playing a crucial role in memory and spatial navigation. This sensitivity makes it a key region for understanding the effects of hypoxia on brain connectivity. This review examines the effects of both acute and chronic hypoxia on resting-state networks (RSNs) that contribute to hippocampal functional connectivity (FC). Hypoxia, characterized by a reduced oxygen supply to the brain, can result from environmental factors (such as high-altitude exposure) or hypoxia-induced pathological conditions (including obstructive sleep apnea and hypoxic\u2013ischemic encephalopathy). The hippocampus\u2019s susceptibility to hypoxic damage significantly impairs brain connectivity. This review examines through rs-fMRI studies how hypoxia alters hippocampal FC, focusing on its effects on RSNs involved in hippocampal functions, and compares acute and chronic hypoxic states. We seek to determine whether distinct or shared patterns of FC changes exist between acute and chronic hypoxia, and how hypoxia indirectly changes hippocampal FC, given the challenges of studying it in isolation. By addressing these questions, this review aims to deepen our understanding of hypoxia-induced changes in hippocampal FC and provide insights into potential therapeutic strategies to mitigate its effects on cognitive functions.<\/jats:p>","DOI":"10.3390\/brainsci15060643","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T10:47:22Z","timestamp":1750070842000},"page":"643","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hypoxia\u2019s Impact on Hippocampal Functional Connectivity: Insights from Resting-State fMRI Studies"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1602-6278","authenticated-orcid":false,"given":"Julia","family":"Micaux","sequence":"first","affiliation":[{"name":"University Paris-Saclay, CEA, Joliot Institute, NeuroSpin, Clinical and Translational Applied NeuroImaging Research Unit (UNIACT), 91191 Gif-sur-Yvette, France"},{"name":"University of Paris Cit\u00e9, Inserm, U1141 NeuroDiderot, InDev Team, 75019 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9107-3923","authenticated-orcid":false,"given":"Abir","family":"Troudi Habibi","sequence":"additional","affiliation":[{"name":"University Paris-Saclay, CEA, Joliot Institute, NeuroSpin, Clinical and Translational Applied NeuroImaging Research Unit (UNIACT), 91191 Gif-sur-Yvette, France"},{"name":"University of Paris Cit\u00e9, Inserm, U1141 NeuroDiderot, InDev Team, 75019 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0128-061X","authenticated-orcid":false,"given":"Franck","family":"Mauconduit","sequence":"additional","affiliation":[{"name":"CEA, NeuroSpin, CNRS, University of Paris-Saclay, 91191 Gif-sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2832-0332","authenticated-orcid":false,"given":"Marion","family":"Noulhiane","sequence":"additional","affiliation":[{"name":"University Paris-Saclay, CEA, Joliot Institute, NeuroSpin, Clinical and Translational Applied NeuroImaging Research Unit (UNIACT), 91191 Gif-sur-Yvette, France"},{"name":"University of Paris Cit\u00e9, Inserm, U1141 NeuroDiderot, InDev Team, 75019 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,14]]},"reference":[{"key":"ref_1","unstructured":"West, J.B. 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