{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:59:28Z","timestamp":1792803568441,"version":"4.5.0"},"reference-count":110,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF)","doi-asserted-by":"publisher","award":["RS-2025-00515755"],"award-info":[{"award-number":["RS-2025-00515755"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF)","doi-asserted-by":"publisher","award":["NRF-2021R1F1A1061527"],"award-info":[{"award-number":["NRF-2021R1F1A1061527"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF)","doi-asserted-by":"publisher","award":["O2514421"],"award-info":[{"award-number":["O2514421"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korea University Anam Hospital","award":["RS-2025-00515755"],"award-info":[{"award-number":["RS-2025-00515755"]}]},{"name":"Korea University Anam Hospital","award":["NRF-2021R1F1A1061527"],"award-info":[{"award-number":["NRF-2021R1F1A1061527"]}]},{"name":"Korea University Anam Hospital","award":["O2514421"],"award-info":[{"award-number":["O2514421"]}]},{"name":"National Institute for Health and Care Research","award":["RS-2025-00515755"],"award-info":[{"award-number":["RS-2025-00515755"]}]},{"name":"National Institute for Health and Care Research","award":["NRF-2021R1F1A1061527"],"award-info":[{"award-number":["NRF-2021R1F1A1061527"]}]},{"name":"National Institute for Health and Care Research","award":["O2514421"],"award-info":[{"award-number":["O2514421"]}]},{"name":"University College London Hospitals Biomedical Research Centre","award":["RS-2025-00515755"],"award-info":[{"award-number":["RS-2025-00515755"]}]},{"name":"University College London Hospitals Biomedical Research Centre","award":["NRF-2021R1F1A1061527"],"award-info":[{"award-number":["NRF-2021R1F1A1061527"]}]},{"name":"University College London Hospitals Biomedical Research Centre","award":["O2514421"],"award-info":[{"award-number":["O2514421"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Acute vertigo or dizziness that is accompanied by a sudden sensorineural hearing loss (SSNHL) often poses a diagnostic challenge. While a combined audiovestibular deficit makes an inner ear pathology most likely, this does not necessarily exclude a vascular pathology that may be a harbinger of future sinister events. This is especially true for strokes within the territory of the anterior inferior cerebellar artery (AICA), because the labyrinth receives its vascular supply most often by branches of the AICA. Thus, acute labyrinthine ischemia may present in combination with focal neurologic deficits, but also in isolation or as a warning sign before focal stroke signs arise. How can labyrinthine ischemia be differentiated from an idiopathic SSNHL? In this critical review, we discuss both the pathophysiology and the differential diagnosis of acute audiovestibular deficits. We will also address the value of state-of-the-art MR imaging in visualizing labyrinthine ischemia. Finally, we will discuss treatment options and review the prognosis of acute audiovestibular deficits.<\/jats:p>","DOI":"10.3390\/brainsci15070725","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T10:03:27Z","timestamp":1751882607000},"page":"725","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Challenge of Diagnosing Labyrinthine Stroke\u2014A Critical Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6984-6958","authenticated-orcid":false,"given":"Alexander A.","family":"Tarnutzer","sequence":"first","affiliation":[{"name":"Neurology, Cantonal Hospital of Baden, 5404 Baden, Switzerland"},{"name":"Faculty of Medicine, University of Zurich, 8006 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8660-7759","authenticated-orcid":false,"given":"Sun-Uk","family":"Lee","sequence":"additional","affiliation":[{"name":"Neurotology and Neuro-Ophthalmology Laboratory, Korea University Medical Center, Seoul 02841, Republic of Korea"},{"name":"Department of Neurology, Korea University Medical Center, Seoul 02841, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1508-2024","authenticated-orcid":false,"given":"Ji-Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Dizziness Center, Clinical Neuroscience Center, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea"},{"name":"Department of Neurology, Seoul National University College of Medicine, Seoul 13620, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0591-646X","authenticated-orcid":false,"given":"Diego","family":"Kaski","sequence":"additional","affiliation":[{"name":"SENSE Research Unit, Department of Clinical and Movement Neurosciences, Institute of Neurology, University College London, 33 Queen Square, London WC1N 3BG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/B978-0-444-53486-6.00046-6","article-title":"Vertigo and hearing loss","volume":"136","author":"Blitz","year":"2016","journal-title":"Handb. 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