{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:43:39Z","timestamp":1760035419203,"version":"build-2065373602"},"reference-count":68,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background\/Objectives: Multiple sclerosis (MS) is a complex neurological disease that is associated with a broad spectrum of physical and psychological symptoms. Psychosocial adjustment (PSA) refers to the ability to cope with these challenges, which influence quality of life (QoL) and depressiveness in ways not yet fully understood. This study explores the relationship of PSA and disease-specific symptoms in MS, including fatigue, a prominent MS symptom. Additionally, PSA was compared to Amyotrophic Lateral Sclerosis (ALS) to disentangle the impact of disease trajectory on PSA. Methods: We interviewed 77 MS patients using patient-reported outcome measures on QoL and depression and compared them to 30 ALS patients. Confirmatory factor analysis and regression analysis were used to identify PSA indicators and predictors in MS, while t-tests assessed PSA differences across diseases. Results: Key PSA indicators in MS included physical (PQoL), mental (MQoL), and subjective (SQoL) quality of life, as well as depressiveness, with cognitive and motor fatigue emerging as significant predictors. MS patients had higher PQoL and SQoL and lower levels of depression compared to ALS patients, while both groups were comparable with regard to MQoL. Conclusions: PSA in MS is supported by high QoL and low depression levels, with fatigue being a significant predictor. Despite different disease trajectories, patients with MS and ALS showed comparable MQoL, indicating that both diseases similarly impact mental QoL, reflecting a partial overlap in psychosocial adjustment. Overall, psychosocial adjustment was more favorable in MS, likely due to its slower disease progression compared to ALS.<\/jats:p>","DOI":"10.3390\/brainsci15070745","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T13:44:19Z","timestamp":1752241459000},"page":"745","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quality of Life in Multiple Sclerosis Compared to Amyotrophic Lateral Sclerosis: Fatigue and Fast Disease Progression Interferes with the Ability to Psychosocially Adjust"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8088-3386","authenticated-orcid":false,"given":"Luisa T.","family":"Balz","sequence":"first","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Ulm University, D-89081 Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo","family":"Uttner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Ulm University, D-89081 Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Weishaupt","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Ulm University, D-89081 Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert C.","family":"Ludolph","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Ulm University, D-89081 Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9165-4437","authenticated-orcid":false,"given":"Daniela","family":"Taranu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Ulm University, D-89081 Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5443-1142","authenticated-orcid":false,"given":"Ioannis","family":"Vardakas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Ulm University, D-89081 Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Ulm University, D-89081 Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Fangerau","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Ulm University, D-89081 Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3003-4119","authenticated-orcid":false,"given":"Deborah K.","family":"Erhart","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Ulm University, D-89081 Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2737-7495","authenticated-orcid":false,"given":"Makbule","family":"Senel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Ulm University, D-89081 Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1647-6201","authenticated-orcid":false,"given":"Hayrettin","family":"Tumani","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Ulm University, D-89081 Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doroth\u00e9e E.","family":"Lul\u00e9","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Ulm University, D-89081 Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/j.1468-1331.2006.01342.x","article-title":"The epidemiology of multiple sclerosis in Europe","volume":"13","author":"Pugliatti","year":"2006","journal-title":"Eur. 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