{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:07:30Z","timestamp":1787162850886,"version":"build-2736575974"},"reference-count":124,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development (CNPq, MCTI, Brazil)","doi-asserted-by":"publisher","award":["305647\/2019-9"],"award-info":[{"award-number":["305647\/2019-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development (CNPq, MCTI, Brazil)","doi-asserted-by":"publisher","award":["406484\/2022-8"],"award-info":[{"award-number":["406484\/2022-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Coordination for the Improvement of Higher Education Personnel","award":["305647\/2019-9"],"award-info":[{"award-number":["305647\/2019-9"]}]},{"name":"Coordination for the Improvement of Higher Education Personnel","award":["406484\/2022-8"],"award-info":[{"award-number":["406484\/2022-8"]}]},{"name":"Center for Advanced Neurology and Neurosurgery (CEANNE)","award":["305647\/2019-9"],"award-info":[{"award-number":["305647\/2019-9"]}]},{"name":"Center for Advanced Neurology and Neurosurgery (CEANNE)","award":["406484\/2022-8"],"award-info":[{"award-number":["406484\/2022-8"]}]},{"name":"Children\u2019s Cancer Institute","award":["305647\/2019-9"],"award-info":[{"award-number":["305647\/2019-9"]}]},{"name":"Children\u2019s Cancer Institute","award":["406484\/2022-8"],"award-info":[{"award-number":["406484\/2022-8"]}]},{"name":"Mackenzie Evangelical University","award":["305647\/2019-9"],"award-info":[{"award-number":["305647\/2019-9"]}]},{"name":"Mackenzie Evangelical University","award":["406484\/2022-8"],"award-info":[{"award-number":["406484\/2022-8"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Medulloblastoma (MB) is the most common malignant brain tumor in children and typically arises in the cerebellum, likely due to disruptions in neuronal precursor development. The primary inhibitory neurotransmitter in the central nervous system (CNS), \u03b3-aminobutyric acid (GABA), exerts its effects through GABAA, GABAB, and GABAC receptors. GABA receptor activity regulates the development and function of cerebellar neurons, including glutamatergic cerebellar granule cells (CGCs). Beyond the nervous system, GABA is also a common metabolite in non-neuronal cell types. An increasing body of evidence indicates that GABA can influence cell proliferation, differentiation, and migration in several types of adult solid tumors, including brain cancers. GABA and GABAA receptor agonists can impair the viability and survival of MB cells, primarily acting on GABAA receptors containing the \u03b15 subunit. A marked expression of the gene encoding the \u03b15 subunit is found across all MB tumor molecular subgroups, particularly Group 3 MB, which has a poor prognosis. Importantly, high levels of the \u03b3-aminobutyric acid type A receptor subunit \u03b15 (GABRA5) gene are associated with shorter patient overall survival in Group 3 and Group 4 MB. In contrast, high \u03b3-aminobutyric acid type A receptor subunit \u03b21 (GABRB1) gene expression is related to longer survival in all MB subgroups. The GABAergic system may, therefore, regulate MB cell function and tumor progression and influence patient prognosis, and is worthy of further investigation as a biomarker and therapeutic target in MB.<\/jats:p>","DOI":"10.3390\/brainsci15070746","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T14:22:36Z","timestamp":1752243756000},"page":"746","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["GABAergic Influences on Medulloblastoma"],"prefix":"10.3390","volume":"15","author":[{"given":"Viviane Aline","family":"Buffon","sequence":"first","affiliation":[{"name":"Graduate Program in Principles of Surgery, Mackenzie Evangelical University, Curitiba 80730-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurandir M. Ribas","family":"Filho","sequence":"additional","affiliation":[{"name":"Graduate Program in Principles of Surgery, Mackenzie Evangelical University, Curitiba 80730-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo","family":"Malafaia","sequence":"additional","affiliation":[{"name":"Graduate Program in Principles of Surgery, Mackenzie Evangelical University, Curitiba 80730-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7745-6423","authenticated-orcid":false,"given":"Isadora D.","family":"Tassinari","sequence":"additional","affiliation":[{"name":"Laboratory of Neurobiology and Metabolism (NeuroMet), Department of Physiology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90035-003, Brazil"},{"name":"Graduate Program in Physiology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90035-003, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6016-2261","authenticated-orcid":false,"given":"Rafael","family":"Roesler","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90035-003, Brazil"},{"name":"Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre 90035-003, Brazil"},{"name":"National Science and Technology Institute for Children\u2019s Cancer Biology and Pediatric Oncology\u2013INCT BioOncoPed, Porto Alegre 90035-003, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo R.","family":"Isolan","sequence":"additional","affiliation":[{"name":"Graduate Program in Principles of Surgery, Mackenzie Evangelical University, Curitiba 80730-000, Brazil"},{"name":"National Science and Technology Institute for Children\u2019s Cancer Biology and Pediatric Oncology\u2013INCT BioOncoPed, Porto Alegre 90035-003, Brazil"},{"name":"The Center for Advanced Neurology and Neurosurgery (CEANNE), Porto Alegre 90560-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41572-019-0063-6","article-title":"Medulloblastoma","volume":"5","author":"Northcott","year":"2019","journal-title":"Nat. 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