{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T06:26:41Z","timestamp":1792823201245,"version":"4.5.0"},"reference-count":113,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Autism spectrum disorder (ASD) deals with several symptoms, including language and speech impairment and developmental delays. The main brain regions affected could be the prefrontal cortex (PFC) or the temporal lobe. The detrimental features could include oxidative stress, mitochondrial dysfunction, and neuroinflammation. Most often, these phenomena are interrelated and can lead to one another, creating a vicious cycle. They also influence the regulation of certain genes involved in the pathogenesis of ASD or related behavior. In the brain regions prone to these detrimental features, a cascade of free radicals, inflammatory cytokines, and mitochondrial energy disruptions is initiated. These actions during the prenatal or developmental stage of the child potentially lead to ASD symptomatic features, such as social isolation, communication difficulty, speech and language impairment, cognitive dysfunction, and intellectual disability. The more recent theories, including genetics, epigenetics, and the gut\u2013brain axis, have been demonstrated to play a greater role in ASD pathology, often being associated with the more common ones as mentioned above. We also introduced some of the neurological disorders possessing shared genetic and behavioral traits with ASD. Many genes playing a role in ASD-like features and their potential targeted drugs were explained briefly. However, there are limited therapeutic options, and molecular pathways related to this disorder are less explored. Currently, researchers and therapists are racing to uncover a concrete remedy. This review also provides a brief outline of potential antioxidant, mitochondrial, and anti-inflammatory therapies. We finally included some novel strategies to diagnose and manage autistic pathology and symptoms.<\/jats:p>","DOI":"10.3390\/brainsci15080853","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T11:02:09Z","timestamp":1754910129000},"page":"853","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The Interplay of Oxidative Stress, Mitochondrial Dysfunction, and Neuroinflammation in Autism Spectrum Disorder: Behavioral Implications and Therapeutic Strategies"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4839-4454","authenticated-orcid":false,"given":"Ansab","family":"Akhtar","sequence":"first","affiliation":[{"name":"LSU Health, Neuroscience Center of Excellence, School of Medicine, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7654-0586","authenticated-orcid":false,"given":"SK Batin","family":"Rahaman","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jamia Hamdard University, New Delhi 110062, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s10803-017-3330-y","article-title":"Language barriers impact access to services for children with autism spectrum disorders","volume":"48","author":"Schrager","year":"2018","journal-title":"J. Autism Dev. Disord."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.neuro.2007.09.010","article-title":"How environmental and genetic factors combine to cause autism: A redox\/methylation hypothesis","volume":"29","author":"Deth","year":"2008","journal-title":"Neurotoxicology"},{"key":"ref_3","first-page":"2314","article-title":"Oxidative stress in autism spectrum disorder","volume":"57","author":"Meguid","year":"2020","journal-title":"Frye"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Ku\u017aniar-Pa\u0142ka, A. (2025). The Role of Oxidative Stress in Autism Spectrum Disorder Pathophysiology, Diagnosis and Treatment. Biomedicines, 13.","DOI":"10.3390\/biomedicines13020388"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"6640206","DOI":"10.1155\/2021\/6640206","article-title":"Potential novel therapies for neurodevelopmental diseases targeting oxidative stress","volume":"2021","author":"Curpan","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_6","first-page":"193","article-title":"Role of oxidative stress and antioxidants in autism","volume":"24","author":"Manivasagam","year":"2020","journal-title":"Pers. Food Interv. Ther. Autism Spectr. Disord. Manag."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3390\/oxygen3010004","article-title":"The Role of Oxidative Stress in Autism Spectrum Disorder: A Narrative Literature Review","volume":"3","author":"Membrino","year":"2023","journal-title":"Oxygen"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"111516","DOI":"10.1016\/j.pscychresns.2022.111516","article-title":"Neuroanatomical correlates of autism spectrum disorders: A meta-analysis of structural magnetic resonance imaging (MRI) studies","volume":"325","author":"Ferracuti","year":"2022","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"100829","DOI":"10.1016\/j.spen.2020.100829","article-title":"Mitochondrial dysfunction in autism spectrum disorder: Unique abnormalities and targeted treatments","volume":"Volume 35","author":"Frye","year":"2020","journal-title":"Seminars in Pediatric Neurology"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Liu, X., Lin, J., Zhang, H., Khan, N.U., Zhang, J., Tang, X., Cao, X., and Shen, L. (2022). Oxidative stress in autism spectrum disorder\u2014Current progress of mechanisms and biomarkers. Front. Psychiatry, 13.","DOI":"10.3389\/fpsyt.2022.813304"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/tp.2012.61","article-title":"Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain","volume":"2","author":"Rose","year":"2012","journal-title":"Transl. Psychiatry"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2174\/1389557515666150324122930","article-title":"Mitochondrial dysfunction and its relationship with mTOR signaling and oxidative damage in autism spectrum disorders","volume":"15","author":"Yui","year":"2015","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/tp.2013.51","article-title":"Redox metabolism abnormalities in autistic children associated with mitochondrial disease","volume":"3","author":"DeLaTorre","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Steffensen, I.-L., Dirven, H., Couderq, S., David, A., D\u2019cruz, S.C., Fern\u00e1ndez, M.F., Mustieles, V., Rodr\u00edguez-Carrillo, A., and Hofer, T. (2020). Bisphenols and oxidative stress biomarkers\u2014Associations found in human studies, evaluation of methods used, and strengths and weaknesses of the biomarkers. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17103609"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.freeradbiomed.2014.07.030","article-title":"Bisphenol A induces oxidative stress and mitochondrial dysfunction in lymphoblasts from children with autism and unaffected siblings","volume":"76","author":"Kaur","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.freeradbiomed.2020.07.017","article-title":"The role of glutathione redox imbalance in autism spectrum disorder: A review","volume":"160","author":"Tinkov","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s12031-018-1237-5","article-title":"The role of vitamins in autism spectrum disorder: What do we know?","volume":"67","author":"Waly","year":"2019","journal-title":"J. Mol. Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/mp.2010.136","article-title":"Mitochondrial dysfunction in autism spectrum disorders: A systematic review and meta-analysis","volume":"17","author":"Rossignol","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"300","DOI":"10.2174\/1389202918666171005100549","article-title":"Decoding Common Features of Neurodegenerative Disorders: From Differentially Expressed Genes to Pathways","volume":"19","author":"Habib","year":"2018","journal-title":"Curr. Genom."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/tp.2015.142","article-title":"Children with autism spectrum disorders, who improved with a luteolin-containing dietary formulation, show reduced serum levels of TNF and IL-6","volume":"5","author":"Tsilioni","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pnpbp.2018.12.015","article-title":"Mitochondrial function and abnormalities implicated in the pathogenesis of ASD","volume":"92","author":"Castora","year":"2019","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s40572-017-0135-2","article-title":"Developmental neurotoxicity of traffic-related air pollution: Focus on autism","volume":"4","author":"Costa","year":"2017","journal-title":"Curr. Environ. Health Rep."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Hodgson, N.W., Trivedi, M.S., Abdolmaleky, H.M., Fournier, M., Cuenod, M., Do, K.Q., Deth, R.C., and Bauer, J.A. (2016). Decreased brain levels of vitamin B12 in aging, autism and schizophrenia. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0146797"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.freeradbiomed.2017.12.009","article-title":"Relevance of 4-F4t-neuroprostane and 10-F4t-neuroprostane to neurological diseases","volume":"115","author":"Signorini","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/NEN.0b013e3181cb5af4","article-title":"Oxidative stress in the progression of Alzheimer disease in the frontal cortex","volume":"69","author":"Ansari","year":"2010","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.conb.2017.05.018","article-title":"Kanellopoulos, and Claudia Bagni. Mitochondrial dysfunction in Autism Spectrum Disorder: Clinical features and perspectives","volume":"45","author":"Hollis","year":"2017","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Liu, Y., Yang, Z., Du, Y., Shi, S., and Cheng, Y. (2022). Antioxidant interventions in autism spectrum disorders: A meta-analysis. Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 113.","DOI":"10.1016\/j.pnpbp.2021.110476"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.freeradbiomed.2013.07.021","article-title":"Impaired synthesis and antioxidant defense of glutathione in the cerebellum of autistic subjects: Alterations in the activities and protein expression of glutathione-related enzymes","volume":"65","author":"Gu","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"307","DOI":"10.9734\/BJMMR\/2013\/2335","article-title":"Oxidative stress markers in children with autism spectrum disorders","volume":"3","author":"Hung","year":"2013","journal-title":"Br. J. Med. Med. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.pathophys.2006.05.007","article-title":"Oxidative stress in autism","volume":"13","author":"Chauhan","year":"2006","journal-title":"Pathophysiology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s11011-020-00585-4","article-title":"The role of lipid peroxidation in individuals with autism spectrum disorders","volume":"35","author":"Yui","year":"2020","journal-title":"Metab. Brain Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"102129","DOI":"10.1016\/j.rasd.2023.102129","article-title":"Analysis of urinary 8-hydroxy-2-deoxyguanosine as a biomarker of oxidative DNA damage in pediatric children with autism spectrum disorder","volume":"102","author":"Zaky","year":"2023","journal-title":"Res. Autism Spectr. Disord."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.plefa.2005.06.002","article-title":"Increased excretion of a lipid peroxidation biomarker in autism","volume":"73","author":"Ming","year":"2005","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12014-017-9138-0","article-title":"Redox proteomic identification of carbonylated proteins in autism plasma: Insight into oxidative stress and its related biomarkers in autism","volume":"14","author":"Feng","year":"2017","journal-title":"Clin. Proteom."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.freeradbiomed.2018.05.070","article-title":"A certain role of SOD\/CAT imbalance in pathogenesis of autism spectrum disorders","volume":"123","author":"Yenkoyan","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s12311-010-0223-4","article-title":"Brain region-specific changes in oxidative stress and neurotrophin levels in autism spectrum disorders (ASD)","volume":"10","author":"Xu","year":"2011","journal-title":"Cerebellum"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Li, M., Long, C., and Yang, L. (2015). Hippocampal-prefrontal circuit and disrupted functional connectivity in psychiatric and neurodegenerative disorders. BioMed Res. Int., 2015.","DOI":"10.1155\/2015\/810548"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"104554","DOI":"10.1016\/j.psyneuen.2019.104554","article-title":"Differential regulation of Nrf2 is linked to elevated inflammation and nitrative stress in monocytes of children with autism","volume":"113","author":"Nadeem","year":"2020","journal-title":"Psychoneuroendocrinology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.2174\/1570159X21666230817085811","article-title":"Antioxidants, hormetic nutrition, and autism","volume":"22","author":"Modafferi","year":"2024","journal-title":"Curr. Neuropharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Penna, E., Pizzella, A., Cimmino, F., Trinchese, G., Cavaliere, G., Catapano, A., Allocca, I., Chun, J.T., Campanozzi, A., and Messina, G. (2020). Neurodevelopmental disorders: Effect of high-fat diet on synaptic plasticity and mitochondrial functions. Brain Sci., 10.","DOI":"10.3390\/brainsci10110805"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3390\/audiolres14010005","article-title":"Incidence of Otolaryngological Manifestations in Individuals with Autism Spectrum Disorder: A Special Focus on Auditory Disorders","volume":"14","author":"McKenna","year":"2024","journal-title":"Audiol. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/s41380-024-02725-z","article-title":"The multifaceted role of mitochondria in autism spectrum disorder","volume":"30","author":"Khaliulin","year":"2024","journal-title":"Mol. Psychiatry"},{"key":"ref_43","first-page":"1000190","article-title":"Mitochondrial dysfunction in autism spectrum disorders","volume":"6","author":"Siddiqui","year":"2016","journal-title":"Autism-Open Access"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Oyarz\u00e1bal, A., Musokhranova, U., Barros, L.F., and Garc\u00eda-Cazorla, A. (2021). Energy metabolism in childhood neurodevelopmental disorders. EBioMedicine, 69.","DOI":"10.1016\/j.ebiom.2021.103474"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12993-018-0135-x","article-title":"Mitochondrial dysfunction and autism: Comprehensive genetic analyses of children with autism and mtDNA deletion","volume":"14","author":"Varga","year":"2018","journal-title":"Behav. Brain Funct."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"K\u0119pka, A., Ochoci\u0144ska, A., Chojnowska, S., Borzym-Kluczyk, M., Skorupa, E., Kna\u015b, M., and Waszkiewicz, N. (2021). Potential role of L-carnitine in autism spectrum disorder. J. Clin. Med., 10.","DOI":"10.3390\/jcm10061202"},{"key":"ref_47","first-page":"431","article-title":"Elevated autophagy and mitochondrial dysfunction in the Smith\u2013Lemli\u2013Opitz syndrome","volume":"1","author":"Chang","year":"2014","journal-title":"Mol. Genet. Metab. Rep."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Alishvandi, A., and Hanaei, S. (2025). Helsmoortel-Van Der Aa Syndrome (HVDAS). Genetic Syndromes: A Comprehensive Reference Guide, Springer Nature.","DOI":"10.1007\/978-3-319-66816-1_334-1"},{"key":"ref_49","first-page":"818","article-title":"Inactivation of the SLC25A1 gene during embryogenesis induces a unique senescence program controlled by p53","volume":"32","author":"Tan","year":"2024","journal-title":"Cell Death Differ."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Gupta, P.K., Feuermann, Y., and Kaphzan, H. (2025). Dynamic shift in localization of UBE3A across developmental stages in an Angelman syndrome mouse model. Neurobiol. Dis., 210.","DOI":"10.1016\/j.nbd.2025.106912"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Caron, C., McCullagh, E.A., and Bertolin, G. (2025). Sex-specific loss of mitochondrial membrane integrity in the auditory brainstem of a mouse model of Fragile X Syndrome. Open Biol., 15.","DOI":"10.1098\/rsob.240384"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Mietto, M., Montanari, S., Falzarano, M.S., Manzati, E., Rimessi, P., Fabris, M., Selvatici, R., Gualandi, F., Neri, M., and Fortunato, F. (2025). MECP2 mRNA Profile in Brain Tissues from a Rett Syndrome Patient and Three Human Controls: Mutated Allele Preferential Transcription and In Situ RNA Mapping. Biomolecules, 15.","DOI":"10.3390\/biom15050687"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Uwibambe, E., Yalcouy\u00e9, A., Aboagye, E.T., Xhakaza, L., Popel, K., Dukuze, N., Bharadwaj, T., de Kock, C., Schrauwen, I., and Leal, S.M. (2025). Exome sequencing revealed a novel homozygous variant in TRMT61 A in a multiplex family with atypical Cornelia de Lange Syndrome from Rwanda. BMC Med. Genom., 18.","DOI":"10.1186\/s12920-025-02153-0"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1038\/s41380-025-02947-9","article-title":"Shank3 modulates Rpl3 expression and protein synthesis via mGlu5: Implications for Phelan McDermid syndrome","volume":"30","author":"Giona","year":"2025","journal-title":"Mol. Psychiatry"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Rossignol, D.A., and Frye, R.E. (2014). Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism. Front. Physiol., 5.","DOI":"10.3389\/fphys.2014.00150"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.molimm.2021.12.009","article-title":"Imbalance in pro-inflammatory and anti-inflammatory cytokines milieu in B cells of children with autism","volume":"141","author":"Nadeem","year":"2022","journal-title":"Mol. Immunol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1038\/s41380-024-02441-8","article-title":"Molecular profiling of the hippocampus of children with autism spectrum disorder","volume":"29","author":"Rexrode","year":"2024","journal-title":"Mol. Psychiatry"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbi.2022.12.001","article-title":"Innate immune dysfunction and neuroinflammation in autism spectrum disorder (ASD)","volume":"108","author":"Hughes","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jpsychires.2019.05.019","article-title":"A meta-analysis of pro-inflammatory cytokines in autism spectrum disorders: Effects of age, gender, and latitude","volume":"115","author":"Saghazadeh","year":"2019","journal-title":"J. Psychiatr. Res."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Gilbert, J., and Man, H.Y. (2017). Fundamental elements in autism: From neurogenesis and neurite growth to synaptic plasticity. Front. Cell. Neurosci., 11.","DOI":"10.3389\/fncel.2017.00359"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s40291-018-0352-x","article-title":"Clinical and molecular characteristics of mitochondrial dysfunction in autism spectrum disorder","volume":"22","author":"Rose","year":"2018","journal-title":"Mol. Diagn. Ther."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1126\/science.aad0314","article-title":"The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring","volume":"351","author":"Choi","year":"2016","journal-title":"Science"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"10695","DOI":"10.1523\/JNEUROSCI.2178-07.2007","article-title":"Maternal immune activation alters fetal brain development through interleukin-6","volume":"27","author":"Smith","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.freeradbiomed.2014.07.033","article-title":"NADPH oxidase-and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: A bipartisan affair?","volume":"76","author":"Bordt","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.expneurol.2017.07.002","article-title":"Beyond infection-Maternal immune activation by environmental factors, microglial development, and relevance for autism spectrum disorders","volume":"299","author":"Bilbo","year":"2018","journal-title":"Exp. Neurol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/jdn.10005","article-title":"The role of GABAergic neural circuits in the pathogenesis of autism spectrum disorder","volume":"80","author":"Di","year":"2020","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Pangrazzi, L., Balasco, L., and Bozzi, Y. (2020). Natural antioxidants: A novel therapeutic approach to autism spectrum disorders?. Antioxidants, 9.","DOI":"10.3390\/antiox9121186"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1016\/j.freeradbiomed.2012.03.011","article-title":"Oxidative stress-related biomarkers in autism: Systematic review and meta-analyses","volume":"52","author":"Frustaci","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"106350","DOI":"10.1016\/j.ejps.2022.106350","article-title":"Epothilone B inactivation of Sirtuin1 promotes mitochondrial reactive oxygen species to induce dysfunction and ferroptosis of Schwann cells","volume":"181","author":"Liang","year":"2023","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1021\/acs.biochem.9b00857","article-title":"Mitochondrion-targeting peptides and peptidomimetics: Recent progress and design principles","volume":"59","author":"Kim","year":"2019","journal-title":"Biochemistry"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Luo, Z., Gao, Y., Duan, Z., Yi, Y., and Wang, H. (2021). Mitochondria-targeted self-assembly of peptide-based nanomaterials. Front. Bioeng. Biotechnol., 9.","DOI":"10.3389\/fbioe.2021.782234"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s40263-023-00993-x","article-title":"Immunoregulatory and\/or anti-inflammatory agents for the management of core and associated symptoms in individuals with autism spectrum disorder: A narrative review of randomized, placebo-controlled trials","volume":"37","author":"Gisbert","year":"2023","journal-title":"CNS Drugs"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Singh, R., Kisku, A., Kungumaraj, H., Nagaraj, V., Pal, A., Kumar, S., and Sulakhiya, K. (2023). Autism spectrum disorders: A recent update on targeting inflammatory pathways with natural anti-inflammatory agents. Biomedicines, 11.","DOI":"10.3390\/biomedicines11010115"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Jyonouchi, H. (2024). Autism spectrum disorder and a possible role of anti-inflammatory treatments: Experience in the pediatric allergy\/immunology clinic. Front. Psychiatry, 15.","DOI":"10.3389\/fpsyt.2024.1333717"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1080\/00207411.1985.11449004","article-title":"Prenatal and early postnatal exposure to lead: Developmental effects, correlates, and implications","volume":"14","author":"Bellinger","year":"1985","journal-title":"Int. J. Ment. Health"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"108148","DOI":"10.1016\/j.envint.2023.108148","article-title":"Prenatal air pollution, maternal immune activation, and autism spectrum disorder","volume":"179","author":"Yu","year":"2023","journal-title":"Environ. Int."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Sato, A., Kotajima-Murakami, H., Tanaka, M., Katoh, Y., and Ikeda, K. (2022). Influence of prenatal drug exposure, maternal inflammation, and parental aging on the development of autism spectrum disorder. Front. Psychiatry, 13.","DOI":"10.3389\/fpsyt.2022.821455"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/2047-9158-2-17","article-title":"Evidence of neurodegeneration in autism spectrum disorder","volume":"2","author":"Kern","year":"2013","journal-title":"Transl. Neurodegener."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.jgg.2021.07.001","article-title":"Microbiota-gut-brain axis in autism spectrum disorder","volume":"48","author":"Yu","year":"2021","journal-title":"J. Genet. Genom."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"M\u0142ynarska, E., Barszcz, E., Budny, E., Gajewska, A., Kope\u0107, K., Wasiak, J., Rysz, J., and Franczyk, B. (2025). The Gut\u2013Brain\u2013Microbiota Connection and Its Role in Autism Spectrum Disorders. Nutrients, 17.","DOI":"10.3390\/nu17071135"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"171","DOI":"10.5409\/wjcp.v12.i4.171","article-title":"Role of gastrointestinal health in managing children with autism spectrum disorder","volume":"12","author":"Saeed","year":"2023","journal-title":"World J. Clin. Pediatr."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"122357","DOI":"10.1016\/j.lfs.2023.122357","article-title":"The many faces of microbiota-gut-brain axis in autism spectrum disorder","volume":"337","author":"Doifode","year":"2024","journal-title":"Life Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/s41593-023-01361-0","article-title":"Multi-level analysis of the gut\u2013brain axis shows autism spectrum disorder-associated molecular and microbial profiles","volume":"26","author":"Morton","year":"2023","journal-title":"Nat. Neurosci."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Eshraghi, A.A., Liu, G., Kay, S.-I.S., Eshraghi, R.S., Mittal, J., Moshiree, B., and Mittal, R. (2018). Epigenetics and autism spectrum disorder: Is there a correlation?. Front. Cell. Neurosci., 12.","DOI":"10.3389\/fncel.2018.00078"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1055\/s-0041-1735540","article-title":"Genetic and epigenetic alterations in autism spectrum disorder","volume":"8","author":"Oztenekecioglu","year":"2021","journal-title":"Glob. Med. Genet."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1093\/brain\/awae264","article-title":"The clinical and genetic spectrum of paediatric speech and language disorders","volume":"148","author":"Magielski","year":"2025","journal-title":"Brain"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s12041-024-01465-x","article-title":"Genetic analysis of a child with severe intellectual disability caused by a novel variant in the FERM domain of the FRMPD4 protein","volume":"103","author":"Pan","year":"2024","journal-title":"J. Genet."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.biopsych.2021.07.018","article-title":"Hyperexcitable phenotypes in induced pluripotent stem cell\u2013derived neurons from patients with 15q11-q13 duplication syndrome, a genetic form of autism","volume":"90","author":"Fink","year":"2021","journal-title":"Biol. Psychiatry"},{"key":"ref_89","unstructured":"Hsu, T.-T., Wang, C.-Y., and Hsueh, P.-P. (2023). Tbr1 autism mouse model displays altered structural and functional amygdalar connectivity and abnormal whole-brain synchronization. bioRxiv, 14."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Kim, Y., Jeon, S.J., Gonzales, E.L., Shin, D., Remonde, C.G., Ahn, T., and Shin, C.Y. (2022). Pirenperone relieves the symptoms of fragile X syndrome in Fmr1 knockout mice. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-25582-8"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Lutz, A.K., P\u00e9rez Ar\u00e9valo, A., Ioannidis, V., Stirmlinger, N., Demestre, M., Delorme, R., Bourgeron, T., and Boeckers, T.M. (2021). SHANK2 mutations result in dysregulation of the ERK1\/2 pathway in human induced pluripotent stem cells-derived neurons and Shank2 (\u2212\/\u2212) mice. Front. Mol. Neurosci., 14.","DOI":"10.3389\/fnmol.2021.773571"},{"key":"ref_92","first-page":"e65393","article-title":"Insulin-like growth factor 1 has the potential to be used as a diagnostic tool and treatment target for autism spectrum disorders","volume":"16","author":"Shen","year":"2024","journal-title":"Cureus"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Yang, Y., Wang, B., Zhong, Z., Chen, H., Ding, W., and Hoi, M.P.M. (2021). Clonazepam attenuates neurobehavioral abnormalities in offspring exposed to maternal immune activation by enhancing GABAergic neurotransmission. Biochem. Pharmacol., 192.","DOI":"10.1016\/j.bcp.2021.114711"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/s41392-023-01431-6","article-title":"CNTNAP2 intracellular domain (CICD) generated by \u03b3-secretase cleavage improves autism-related behaviors","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Bassetti, D., Luhmann, H.J., and Kirischuk, S. (2021). Effects of mutations in TSC genes on neurodevelopment and synaptic transmission. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22147273"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"12854","DOI":"10.1111\/gbb.12854","article-title":"Rapamycin improves social and stereotypic behavior abnormalities induced by pre-mitotic neuronal subset specific Pten deletion","volume":"22","author":"Narvaiz","year":"2023","journal-title":"Genes Brain Behav."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/s41419-023-06219-8","article-title":"Neuron-secreted NLGN3 ameliorates ischemic brain injury via activating G\u03b1i1\/3-Akt signaling","volume":"14","author":"Chen","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/s41380-020-00944-8","article-title":"Neurexins in autism and schizophrenia\u2014A review of patient mutations, mouse models and potential future directions","volume":"26","author":"Tromp","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Fuchs, C., \u2018t Hoen, P.A.C., M\u00fcller, A.R., Ehrhart, F., and Van Karnebeek, C.D.M. (2024). Drug repurposing in Rett and Rett-like syndromes: A promising yet underrated opportunity?. Front. Med., 11.","DOI":"10.3389\/fmed.2024.1425038"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1167\/iovs.65.1.29","article-title":"CX3CL1\/CX3CR1 signaling mediated neuroglia activation is implicated in the retinal degeneration: A potential therapeutic target to prevent photoreceptor death","volume":"65","author":"Huang","year":"2024","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"8373","DOI":"10.1523\/JNEUROSCI.2400-21.2022","article-title":"Conserved and distinct functions of the autism-related chromatin remodeler CHD8 in embryonic and adult forebrain neurogenesis","volume":"42","author":"Dong","year":"2022","journal-title":"J. Neurosci."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Somorai, M.A., Ekins, S.E., Rupprecht, C., Lettl, C., and Mall, V. (2025). Repurposing nicardipine leads to improved development in a young patient with Pitt-Hopkins syndrome. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1592011"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1021\/acs.jmedchem.1c00368","article-title":"Update on the development of MNK inhibitors as therapeutic agents","volume":"65","author":"Xu","year":"2021","journal-title":"J. Med. Chem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00401-017-1736-4","article-title":"Autism spectrum disorder: Neuropathology and animal models","volume":"134","author":"Varghese","year":"2017","journal-title":"Acta Neuropathol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/bs.ctdb.2022.11.001","article-title":"Gene\u00d7 environment interactions in autism spectrum disorders","volume":"152","author":"Lein","year":"2023","journal-title":"Curr. Top. Dev. Biol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s12264-021-00673-0","article-title":"Structural, functional, and molecular imaging of autism spectrum disorder","volume":"37","author":"Li","year":"2021","journal-title":"Neurosci. Bull."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Ahmed, I.A., Senan, E.M., Rassem, T.H., Ali, M.A.H., Shatnawi, H.S.A., Alwazer, S.M., and Alshahrani, M. (2022). Eye tracking-based diagnosis and early detection of autism spectrum disorder using machine learning and deep learning techniques. Electronics, 11.","DOI":"10.3390\/electronics11040530"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Du, G., Guo, Y., and Xu, W. (2024). The effectiveness of applied behavior analysis program training on enhancing autistic children\u2019s emotional-social skills. BMC Psychol., 12.","DOI":"10.1186\/s40359-024-02045-5"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s10578-013-0390-x","article-title":"A head-to-head comparison of aripiprazole and risperidone for safety and treating autistic disorders, a randomized double blind clinical trial","volume":"45","author":"Ghanizadeh","year":"2014","journal-title":"Child Psychiatry Hum. Dev."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1007\/s11065-022-09564-1","article-title":"Treatment response of transcranial magnetic stimulation in intellectually capable youth and young adults with autism spectrum disorder: A systematic review and meta-analysis","volume":"33","author":"Smith","year":"2023","journal-title":"Neuropsychol. Rev."},{"key":"ref_111","first-page":"547","article-title":"Dietary approaches to the management of autism spectrum disorders","volume":"24","author":"Hartman","year":"2020","journal-title":"Pers. Food Interv. Ther. Autism Spectr. Disord. Manag."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1002\/aur.2560","article-title":"Probiotics, prebiotics, synbiotics, and fecal microbiota transplantation in the treatment of behavioral symptoms of autism spectrum disorder: A systematic review","volume":"14","author":"Tan","year":"2021","journal-title":"Autism Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13229-017-0124-1","article-title":"CRISPR\/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells","volume":"8","author":"Wang","year":"2017","journal-title":"Mol. Autism"}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/15\/8\/853\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:27:56Z","timestamp":1760034476000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/15\/8\/853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,11]]},"references-count":113,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["brainsci15080853"],"URL":"https:\/\/doi.org\/10.3390\/brainsci15080853","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,11]]}}}