{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:46:11Z","timestamp":1760060771722,"version":"build-2065373602"},"reference-count":16,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Veterans Administration (Gordon Mansfield Spinal Cord Injury Collaborative Consortium)","award":["RR&D B7332R","R01 NS104442","R-01 NS105478","R01 NS042291","RGPIN\u20142018\u201406382","R01 NS105478"],"award-info":[{"award-number":["RR&D B7332R","R01 NS104442","R-01 NS105478","R01 NS042291","RGPIN\u20142018\u201406382","R01 NS105478"]}]},{"name":"NIH","award":["RR&D B7332R","R01 NS104442","R-01 NS105478","R01 NS042291","RGPIN\u20142018\u201406382","R01 NS105478"],"award-info":[{"award-number":["RR&D B7332R","R01 NS104442","R-01 NS105478","R01 NS042291","RGPIN\u20142018\u201406382","R01 NS105478"]}]},{"name":"Natural Sciences and Engineering Research Council of Canada","award":["RR&D B7332R","R01 NS104442","R-01 NS105478","R01 NS042291","RGPIN\u20142018\u201406382","R01 NS105478"],"award-info":[{"award-number":["RR&D B7332R","R01 NS104442","R-01 NS105478","R01 NS042291","RGPIN\u20142018\u201406382","R01 NS105478"]}]},{"name":"Canada Foundation for Innovation","award":["RR&D B7332R","R01 NS104442","R-01 NS105478","R01 NS042291","RGPIN\u20142018\u201406382","R01 NS105478"],"award-info":[{"award-number":["RR&D B7332R","R01 NS104442","R-01 NS105478","R01 NS042291","RGPIN\u20142018\u201406382","R01 NS105478"]}]},{"name":"Craig H. 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Adelson Medical Research Foundation","award":["RR&D B7332R","R01 NS104442","R-01 NS105478","R01 NS042291","RGPIN\u20142018\u201406382","R01 NS105478"],"award-info":[{"award-number":["RR&D B7332R","R01 NS104442","R-01 NS105478","R01 NS042291","RGPIN\u20142018\u201406382","R01 NS105478"]}]},{"name":"Michael Smith Health Research BC","award":["RR&D B7332R","R01 NS104442","R-01 NS105478","R01 NS042291","RGPIN\u20142018\u201406382","R01 NS105478"],"award-info":[{"award-number":["RR&D B7332R","R01 NS104442","R-01 NS105478","R01 NS042291","RGPIN\u20142018\u201406382","R01 NS105478"]}]},{"name":"Neilsen Foundation","award":["RR&D B7332R","R01 NS104442","R-01 NS105478","R01 NS042291","RGPIN\u20142018\u201406382","R01 NS105478"],"award-info":[{"award-number":["RR&D B7332R","R01 NS104442","R-01 NS105478","R01 NS042291","RGPIN\u20142018\u201406382","R01 NS105478"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background: A spinal cord contusion injury is among the most clinically relevant models for studying pathophysiology and for developing potential therapeutic interventions for spinal cord injuries (SCI). Methods: In this study, we implemented an intra-operative ultrasound (IOU) approach to precisely locate and examine the lesion site at 5 and 10 min post-injury after a cervical hemi-contusion injury in a non-human primate (NHP) model. We assessed acute lesion progression from 5 to 10 min and then compared that to the lesion extent as measured by MRI 3 weeks later. Results: We observed a small increase in the rostrocaudal and mediolateral lesion area (mm2) from 5 to 10 min and a further 26% increase in the mediolateral lesion extent when comparing 5 and 10 min to 3 weeks post-injury. Conclusions: By enabling high-resolution ultrasound visualization of the hemicontusion lesion in vivo, this approach can provide critical insights into the early progression of SCI. It can help with further refining this preclinical SCI model and provide significant predictive value for the animals\u2019 recovery post-injury.<\/jats:p>","DOI":"10.3390\/brainsci15091005","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T11:00:00Z","timestamp":1758106800000},"page":"1005","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spinal Cord Injury in Real Time: Intra-Operative Ultrasound for Acute Phase Examination in Non-Human Primates"],"prefix":"10.3390","volume":"15","author":[{"given":"Eleni","family":"Sinopoulou","sequence":"first","affiliation":[{"name":"Department of Neurosciences, University of California\u2014San Diego, La Jolla, CA 92093, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8743-7179","authenticated-orcid":false,"given":"Michelle W.","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of California\u2014San Diego, La Jolla, CA 92093, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Numaira","family":"Obaid","sequence":"additional","affiliation":[{"name":"Mechatronic Systems Engineering, Simon Fraser University, Surrey, BC V3TOA3, Canada"},{"name":"International Collaboration on Repair Discoveries (ICORD), Vancouver, BC V5Z 1M9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of California\u2014San Diego, La Jolla, CA 92093, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6583-2308","authenticated-orcid":false,"given":"Yvette S.","family":"Nout-Lomas","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80521, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachele","family":"Wurr","sequence":"additional","affiliation":[{"name":"California National Primate Research Center, University of California, Davis, CA 95616, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Macon","sequence":"additional","affiliation":[{"name":"California National Primate Research Center, University of California, Davis, CA 95616, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Russell","family":"Huie","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of California, San Francisco, CA 94143, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7102-1608","authenticated-orcid":false,"given":"Adam R.","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of California, San Francisco, CA 94143, USA"},{"name":"Veterans Administration Medical Center, San Francisco, CA 94121, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark H.","family":"Tuszynski","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of California\u2014San Diego, La Jolla, CA 92093, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Beattie","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of California, San Francisco, CA 94143, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline C.","family":"Bresnahan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of California, San Francisco, CA 94143, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5524-4577","authenticated-orcid":false,"given":"Carolyn J.","family":"Sparrey","sequence":"additional","affiliation":[{"name":"Mechatronic Systems Engineering, Simon Fraser University, Surrey, BC V3TOA3, Canada"},{"name":"International Collaboration on Repair Discoveries (ICORD), Vancouver, BC V5Z 1M9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Hussain, O., Kaushal, M., Agarwal, N., Kurpad, S., and Shabani, S. 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